References

Stem cell aging: mechanisms, regulators and therapeutic opportunities

10.1038/nm.3651 · 2014 · External reference

Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

10.1038/s41580-022-00568-6 · 2023 · External reference

Canonical Wnt signaling ameliorates aging of intestinal stem cells

10.1016/j.celrep.2017.02.056 · 2017 · External reference

Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging

10.1016/j.stem.2018.04.001 · 2018 · External reference

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

10.1038/s41586-019-1383-0 · 2019 · External reference

IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

10.1038/s41467-023-41683-y · 2023 · External reference

Aging of intestinal stem cells

10.1016/j.stemcr.2022.02.003 · 2022 · External reference

The peroxisome: an up-and-coming organelle in immunometabolism

10.1016/j.tcb.2022.06.001 · 2023 · External reference

Peroxisomes as cellular adaptors to metabolic and environmental stress

10.1016/j.tcb.2021.02.005 · 2021 · External reference

The physiological functions of human peroxisomes

10.1152/physrev.00051.2021 · 2023 · External reference

Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway

10.1016/j.celrep.2020.01.013 · 2020 · External reference

Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism

2020 · External reference

Hypervulnerability to sound exposure through impaired adaptive proliferation of peroxisomes

10.1016/j.cell.2015.10.023 · 2015 · External reference

Peroxisome-mediated metabolism is required for immune response to microbial infection

10.1016/j.immuni.2017.06.016 · 2017 · External reference

Peroxisome elevation induces stem cell differentiation and intestinal epithelial repair

10.1016/j.devcel.2020.03.002 · 2020 · External reference

Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration

2024 · External reference

Very long chain fatty acids

10.1016/j.plipres.2022.101180 · 2022 · External reference

The various roles of fatty acids

10.3390/molecules23102583 · 2018 · External reference

Very long-chain fatty acids: elongation, physiology and related disorders

10.1093/jb/mvs105 · 2012 · External reference

A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes

10.1016/j.cub.2008.08.061 · 2008 · External reference

Stearate-derived very long-chain fatty acids are indispensable to tumor growth

2023 · External reference

Membrane disruption by very long chain fatty acids during necroptosis

2019 · External reference

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues

10.1038/s41598-021-85603-w · 2021 · External reference

Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress

2021 · External reference

Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction

2020 · External reference

Quercetin prevents intestinal stem cell aging via scavenging ROS and inhibiting insulin signaling in Drosophila

2022 · External reference

Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

2021 · External reference

Intestinal stem cell aging: origins and interventions

10.1146/annurev-physiol-021119-034359 · 2020 · External reference

The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol

10.1016/s0092-8674(01)00310-5 · 2001 · External reference

Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata

10.1038/ng0497-369 · 1997 · External reference

Multiple paths to peroxisomes: mechanism of peroxisome maintenance in mammals

10.1016/j.bbamcr.2015.09.026 · 2016 · External reference

Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases

10.1038/s12276-020-00503-9 · 2020 · External reference

Loss- or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms

2020 · External reference

Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation

10.1007/s10545-012-9471-4 · 2012 · External reference

A Sox transcription factor is a critical regulator of adult stem cell proliferation in the Drosophila intestine

10.1016/j.celrep.2015.09.061 · 2015 · External reference

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

10.1038/s41392-022-01251-0 · 2022 · External reference

Using aspirin to prevent and treat cancer

10.1007/s10787-023-01346-2 · 2024 · External reference

Low-dose aspirin for the prevention of atherosclerotic cardiovascular disease

10.1093/eurheartj/ehae324 · 2024 · External reference

Progress on the mechanism for aspirin’s anti-tumor effects

10.2174/1389450121999201013152931 · 2021 · External reference

Aspirin in the prevention of colorectal neoplasia

10.1146/annurev-med-060319-120913 · 2021 · External reference

Aspirin and colorectal cancer: the promise of precision chemoprevention

10.1038/nrc.2016.4 · 2016 · External reference

The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

10.7554/elife.55896 · 2020 · External reference

Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

10.1016/j.cmet.2014.09.017 · 2014 · External reference

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

10.1038/s41467-019-14176-0 · 2020 · External reference

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission

10.1172/jci120606 · 2019 · External reference

Very long-chain fatty acids in yeast

10.1128/jb.115.1.464-466.1973 · 1973 · External reference

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response

10.1091/mbc.e19-07-0392 · 2020 · External reference

Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response

10.1038/s42003-022-03867-y · 2022 · External reference

X-linked adrenoleukodystrophy: pathology, pathophysiology, diagnostic testing, newborn screening and therapies

10.1002/jdn.10003 · 2020 · External reference

Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan

10.1016/j.chom.2016.01.008 · 2016 · External reference

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

10.1038/nature07935 · 2009 · External reference

A protocol for lentiviral transduction and downstream analysis of intestinal organoids

2015 · External reference

Author correction: efficient genetic engineering of human intestinal organoids using electroporation

10.1038/s41596-018-0107-5 · 2019 · External reference