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References from The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay. Local targets link to admitted publications; unresolved targets remain external evidence.
What is normal in normal aging? Effects of aging, amyloid and Alzheimer’s disease on the cerebral cortex and the hippocampus
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Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging
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Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer’s disease
10.1016/s0079-6123(02)36039-4 · 2002 · External reference
Neural plasticity in the ageing brain
10.1038/nrn1809 · 2006 · External reference
Communication breakdown: the impact of ageing on synapse structure
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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
10.1038/nn.3512 · 2013 · External reference
Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release
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Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila
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Structural aspects of the aging invertebrate brain
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Some highlights of research on aging with invertebrates, 2008
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Promoting health and longevity through diet: from model organisms to humans
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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
10.1038/nature01135 · 2002 · External reference
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
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Endocrine regulation of ageing
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Nutrient control of Drosophila longevity
10.1016/j.tem.2014.02.006 · 2014 · External reference
Functional senescence in Drosophila melanogaster
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Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed
10.1016/j.exger.2008.04.011 · 2008 · External reference
Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila
10.18632/aging.101880 · 2019 · External reference
Biological aging of two innate behaviors of Drosophila melanogaster: escape climbing versus courtship learning and memory
10.1371/journal.pone.0293252 · 2024 · External reference
Spermidine boosts autophagy to protect from synapse aging
10.1080/15548627.2016.1265193 · 2017 · External reference
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner
10.1038/s41467-019-09262-2 · 2019 · External reference
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
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The flavonoid 4,4’-dimethoxychalcone promotes autophagy-dependent longevity across species
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The dipteran ‘Giant fibre’ pathway: neurons and signals
10.1007/bf00603798 · 1986 · External reference
Feature integration drives probabilistic behavior in the Drosophila escape response
10.1016/j.neuron.2017.05.036 · 2017 · External reference
Neural basis for looming size and velocity encoding in the Drosophila giant fiber escape pathway
2019 · External reference
A novel neuronal pathway for visually guided escape in Drosophila melanogaster
10.1152/jn.00073.2009 · 2009 · External reference
Responses of Drosophila giant descending neurons to visual and mechanical stimuli
2014 · External reference
Feature integration drives probabilistic behavior in the Drosophila escape response
10.1016/j.neuron.2017.05.036 · 2017 · External reference
Separation of receptor and lamina potentials in the electroretinogram of normal and mutant Drosophila
10.1242/jeb.55.1.85 · 1971 · External reference
Electroretinograms in Drosophila: a robust and genetically accessible electrophysiological system for the undergraduate laboratory
2012 · External reference
Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse
10.1523/jneurosci.1654-08.2008 · 2008 · External reference
Graded responses and spiking properties of identified first-order visual interneurons of the fly compound eye
10.1152/jn.1995.73.5.1782 · 1995 · External reference
The neural network behind the eyes of a fly
10.1016/j.cophys.2020.05.004 · 2020 · External reference
Synaptic gradients transform object location to action
10.1038/s41586-022-05562-8 · 2023 · External reference
Unresolved reference
2024 · External reference
A connectome and analysis of the adult Drosophila central brain
10.7554/elife.57443 · 2020 · External reference
Passover eliminates gap junctional communication between neurons of the giant fiber system in Drosophila
10.1002/(sici)1097-4695(199607)30:3<340::aid-neu3>3.0.co;2-4 · 1996 · External reference
Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila
10.1523/jneurosci.19-21-09374.1999 · 1999 · External reference
Null mutation inshaking-B eliminates electrical, but not chemical, synapses in the Drosophila giant fiber system: a structural study
10.1002/(sici)1096-9861(19990222)404:4<449::aid-cne3>3.0.co;2-d · 1999 · External reference
Mutations in shaking-B prevent electrical synapse formation in the Drosophila giant fiber system
10.1523/jneurosci.16-03-01101.1996 · 1996 · External reference
The chemical component of the mixed GF-TTMn synapse in Drosophila melanogaster uses acetylcholine as its neurotransmitter
10.1111/j.1460-9568.2007.05686.x · 2007 · External reference
Motor outputs of giant nerve fiber in Drosophila
10.1152/jn.1980.44.2.405 · 1980 · External reference
Electrophysiological recordings from the Drosophila giant fiber system (GFS)
10.1101/pdb.prot5453 · 2010 · External reference
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies
2017 · External reference
Unresolved reference
2024 · External reference
Newly identified electrically coupled neurons support development of the Drosophila giant fiber model circuit
10.1523/eneuro.0346-18.2018 · 2018 · External reference
A complete electron microscopy volume of the brain of adult Drosophila melanogaster
10.1016/j.cell.2018.06.019 · 2018 · External reference
The head involution defective gene of Drosophila melanogaster functions in programmed cell death
10.1101/gad.9.14.1694 · 1995 · External reference
Altered habituation of an identified escape circuit in Drosophila memory mutants
10.1523/jneurosci.16-10-03486.1996 · 1996 · External reference
Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila
10.1523/jneurosci.18-06-02254.1998 · 1998 · External reference
Postnatal increases in axonal conduction velocity of an identified Drosophila interneuron require fast sodium, l-type calcium and shaker potassium channels
10.1523/eneuro.0181-19.2019 · 2019 · External reference
Progress in functional neuroanatomy: precise automatic geometric reconstruction of neuronal morphology from confocal image stacks
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New methods for the computer-assisted 3-D reconstruction of neurons from confocal image stacks
10.1016/j.neuroimage.2004.06.047 · 2004 · External reference
The nicotinic acetylcholine receptor Dα7 is required for an escape behavior in Drosophila
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Drep-2 is a novel synaptic protein important for learning and memory
2014 · External reference
Maturation of active zone assembly by Drosophila Bruchpilot
10.1083/jcb.200812150 · 2009 · External reference
Neurogenetic approaches to habituation and dishabituation in Drosophila
10.1016/j.nlm.2008.08.003 · 2009 · External reference
Habituation: a model phenomenon for the study of neuronal substrates of behavior
10.1037/h0022681 · 1966 · External reference
Distinct aging-vulnerable and -resilient trajectories of specific motor circuit functions in oxidation- and temperature-stressed Drosophila
10.1523/eneuro.0443-21.2021 · 2022 · External reference
Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior
10.1073/pnas.1416247111 · 2014 · External reference
Dendritic regression dissociated from neuronal death but associated with partial deafferentation in aging rat supraoptic nucleus
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Increased dendritic extent in hippocampal CA1 neurons from aged F344 rats
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Age-related and laminar-specific dendritic changes in the medial frontal cortex of the rat
10.1016/s0006-8993(02)02457-5 · 2002 · External reference
Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body
10.1371/journal.pone.0175894 · 2017 · External reference
A directional tuning map of Drosophila elementary motion detectors
10.1038/nature12320 · 2013 · External reference
A visual motion detection circuit suggested by Drosophila connectomics
10.1038/nature12450 · 2013 · External reference
Biomarkers and evolution in Alzheimer disease
10.1016/j.pneurobio.2011.07.006 · 2011 · External reference
Should Alzheimer’s disease be equated with human brain ageing? A maladaptive interaction between brain evolution and senescence
10.1016/j.arr.2011.06.004 · 2012 · External reference
Balancing structure and function at hippocampal dendritic spines
10.1146/annurev.neuro.31.060407.125646 · 2008 · External reference
Elimination of dendritic spines with long-term memory is specific to active circuits
10.1523/jneurosci.1131-12.2012 · 2012 · External reference
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex
10.1523/jneurosci.0839-11.2011 · 2011 · External reference
Impermanence of dendritic spines in live adult CA1 hippocampus
10.1038/nature14467 · 2015 · External reference
Loss of thin spines and small synapses contributes to defective hippocampal function in aged mice
10.1016/j.neurobiolaging.2018.07.010 · 2018 · External reference
Learning-dependent dendritic spine plasticity is reduced in the aged mouse cortex
10.3389/fncir.2020.581435 · 2020 · External reference
Cognitive aging is associated with redistribution of synaptic weights in the hippocampus
2021 · External reference
Morphological alterations in neurons forming corticocortical projections in the neocortex of aged Patas monkeys
10.1016/s0304-3940(01)02428-4 · 2002 · External reference
Altered synaptic dynamics during normal brain aging
10.1523/jneurosci.4825-12.2013 · 2013 · External reference
Exploring the role of neuroplasticity in development, aging, and neurodegeneration
10.3390/brainsci13121610 · 2023 · External reference
Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs
2016 · External reference
Intra-neuronal competition for synaptic partners conserves the amount of dendritic building material
10.1016/j.neuron.2016.12.043 · 2017 · External reference
Reviewing Otsu’s method for image thresholding
10.37622/ijaer/10.9.2015.21777-21783 · 2015 · External reference
Unresolved reference
2025 · External reference
Gap junctions desynchronize a neural circuit to stabilize insect flight
10.1038/s41586-023-06099-0 · 2023 · External reference
Constitutive activation of Ca2+/calmodulin-dependent protein kinase II during development impairs central cholinergic transmission in a circuit underlying escape behavior in Drosophila
10.1523/jneurosci.6583-10.2012 · 2012 · External reference
Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster
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neuPrint: an open access tool for EM connectomics
10.3389/fninf.2022.896292 · 2022 · External reference
Unresolved reference
2025 · External reference
Whole-brain annotation and multi-connectome cell typing of Drosophila
10.1038/s41586-024-07686-5 · 2024 · External reference
Neuronal wiring diagram of an adult brain
10.1038/s41586-024-07558-y · 2024 · External reference
Network statistics of the whole-brain connectome of Drosophila
10.1038/s41586-024-07968-y · 2024 · External reference
Unresolved reference
2023 · External reference
10.25080/tcwv9851
10.25080/tcwv9851 · 2008 · External reference
