Research graph
References from Collagen I promotes cancer cell survival via amino acid import and mTORC1/S6 activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Unveiling collagen’s role in breast cancer: insights into expression patterns, functions and clinical implications
10.2147/ijgm.s463649 · 2024 · External reference
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
10.1038/embor.2009.276 · 2010 · External reference
Dynamic interplay between the collagen scaffold and tumor evolution
10.1016/j.ceb.2010.08.015 · 2010 · External reference
Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study
10.1038/modpathol.3880555 · 2002 · External reference
Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest
10.1002/bies.10230 · 2003 · External reference
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
10.1126/science.1131000 · 2006 · External reference
Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture
10.1073/pnas.79.15.4672 · 1982 · External reference
Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules
10.1016/j.cub.2013.03.032 · 2013 · External reference
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage
10.1038/onc.2009.299 · 2009 · External reference
Collagen reorganization at the tumor-stromal interface facilitates local invasion
10.1186/1741-7015-4-38 · 2006 · External reference
Matrix crosslinking forces tumor progression by enhancing integrin signaling
10.1016/j.cell.2009.10.027 · 2009 · External reference
Aligned collagen is a prognostic signature for survival in human breast carcinoma
10.1016/j.ajpath.2010.11.076 · 2011 · External reference
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells
10.1073/pnas.1908626116 · 2019 · External reference
Type I collagen can function as a reservoir of basic fibroblast growth factor
10.1016/j.jconrel.2004.07.008 · 2004 · External reference
The extracellular matrix modulates the hallmarks of cancer
10.15252/embr.201439246 · 2014 · External reference
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take
10.15252/embr.202050635 · 2020 · External reference
Influence of the tumor microenvironment on cancer cells metabolic reprogramming
10.3389/fonc.2018.00117 · 2018 · External reference
Genetics and biology of pancreatic ductal adenocarcinoma
10.1101/gad.1415606 · 2006 · External reference
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
10.1242/dmm.035758 · 2018 · External reference
Metabolic reprogramming in cancer: mechanisms and therapeutics
2023 · External reference
Metabolites profiling of melanoma interstitial fluids reveals uridine diphosphate as potent immune modulator capable of limiting tumor growth
10.3389/fcell.2021.730726 · 2021 · External reference
The hallmarks of cancer metabolism: still emerging
10.1016/j.cmet.2022.01.007 · 2022 · External reference
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism
10.1371/journal.pbio.3002406 · 2024 · External reference
Structural basis of collagen recognition by integrin alpha2beta1
10.1016/s0092-8674(00)80622-4 · 2000 · External reference
Adhesion signalling complexes
10.1016/j.cub.2010.10.059 · 2010 · External reference
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration
10.1371/journal.pbio.3002930 · 2024 · External reference
How does mTOR sense glucose starvation? AMPK is the usual suspect
10.1038/s41420-020-0260-9 · 2020 · External reference
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
10.1016/s0303-7207(99)00061-1 · 1999 · External reference
mTORC1 activity is supported by spatial association with focal adhesions
10.1083/jcb.202004010 · 2021 · External reference
LC3 and autophagy
10.1007/978-1-59745-157-4_4 · 2008 · External reference
The interconnections between autophagy and integrin-mediated cell adhesion
10.1016/j.jmb.2016.11.027 · 2017 · External reference
An autophagic flux probe that releases an internal control
10.1016/j.molcel.2016.09.037 · 2016 · External reference
mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes
10.1016/j.molcel.2024.10.009 · 2024 · External reference
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
10.1074/jbc.273.37.23629 · 1998 · External reference
Bidirectional transport of amino acids regulates mTOR and autophagy
10.1016/j.cell.2008.11.044 · 2009 · External reference
ROCplot.org: validating predictive biomarkers of chemotherapy/hormonal therapy/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients
10.1002/ijc.32369 · 2019 · External reference
Glucose deprivation induces cancer cell death through failure of ROS regulation
10.3390/ijms241511969 · 2023 · External reference
Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization
10.1083/jcb.149.2.431 · 2000 · External reference
Connecting single-cell ATP dynamics to overflow metabolism, cell growth, and the cell cycle in Escherichia coli
2022 · External reference
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
10.1038/ncomms16031 · 2017 · External reference
The utilization of extracellular proteins as nutrients is suppressed by mTORC1
10.1016/j.cell.2015.06.017 · 2015 · External reference
Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology
10.1091/mbc.e19-12-0709 · 2020 · External reference
Twenty-five years of mTOR: uncovering the link from nutrients to growth
10.1073/pnas.1716173114 · 2017 · External reference
Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells
10.1007/s00424-014-1583-2 · 2015 · External reference
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
10.1038/s41588-020-00753-3 · 2021 · External reference
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
10.1161/circresaha.112.265587 · 2012 · External reference
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway
10.1038/s41598-025-98170-1 · 2025 · External reference
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
10.1016/j.devcel.2021.05.010 · 2021 · External reference
Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis
10.1038/s41374-019-0281-2 · 2019 · External reference
Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK
10.1016/j.cellsig.2021.110170 · 2022 · External reference
Role of AMPK in autophagy
10.3389/fphys.2022.1015500 · 2022 · External reference
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
10.1016/j.cmet.2023.01.011 · 2023 · External reference
DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling
10.1002/ctm2.70361 · 2025 · External reference
Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation
10.1016/j.isci.2022.105739 · 2022 · External reference
The human LAT1-4F2hc (SLC7A5-SLC3A2) transporter complex: physiological and pathophysiological implications
10.1111/bcpt.13821 · 2023 · External reference
N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)
10.1038/s41598-022-18779-4 · 2022 · External reference
The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2
10.3390/ijms21207573 · 2020 · External reference
Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex
10.1038/s41586-019-1011-z · 2019 · External reference
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
10.1074/jbc.270.5.2320 · 1995 · External reference
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior
10.1186/1476-4598-12-169 · 2013 · External reference
CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling
10.1074/jbc.m702877200 · 2007 · External reference
CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation
10.1074/jbc.m408700200 · 2004 · External reference
CD98hc (SLC3A2) mediates integrin signaling
10.1073/pnas.0404852102 · 2005 · External reference
CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia
10.1074/jbc.m105077200 · 2001 · External reference
mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of ATF4
10.1016/j.celrep.2017.04.042 · 2017 · External reference
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway
10.3892/or.2017.5530 · 2017 · External reference
Elevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas
10.1038/s41598-024-66484-1 · 2024 · External reference
The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer
10.3390/ijms20102428 · 2019 · External reference
SLC7A5 correlated with malignancies and immunotherapy response in bladder cancer
10.1186/s12935-024-03365-7 · 2024 · External reference
Prognostic value of large amino acid transporter type 1 (LAT1) expression in pulmonary adenocarcinoma: A tissue microarray study
2024 · External reference
Estrous cycle dependent expression of oxycodone conditioned reward in rats
10.1038/s41598-023-40971-3 · 2023 · External reference
Co-expression effect of SLC7A5/SLC3A2 to predict response to endocrine therapy in oestrogen-receptor-positive breast cancer
10.3390/ijms21041407 · 2020 · External reference
SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer
10.3892/or.2021.8228 · 2022 · External reference
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
10.1074/jbc.m117.798405 · 2017 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest
10.1002/bies.10230 · ExternalCitation · doi-reference
DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling
10.1002/ctm2.70361 · ExternalCitation · doi-reference
ROCplot.org: validating predictive biomarkers of chemotherapy/hormonal therapy/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients
10.1002/ijc.32369 · ExternalCitation · doi-reference
LC3 and autophagy
10.1007/978-1-59745-157-4_4 · ExternalCitation · doi-reference
Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells
10.1007/s00424-014-1583-2 · ExternalCitation · doi-reference
Aligned collagen is a prognostic signature for survival in human breast carcinoma
10.1016/j.ajpath.2010.11.076 · ExternalCitation · doi-reference
Dynamic interplay between the collagen scaffold and tumor evolution
10.1016/j.ceb.2010.08.015 · ExternalCitation · doi-reference
Bidirectional transport of amino acids regulates mTOR and autophagy
10.1016/j.cell.2008.11.044 · ExternalCitation · doi-reference
Matrix crosslinking forces tumor progression by enhancing integrin signaling
10.1016/j.cell.2009.10.027 · ExternalCitation · doi-reference
The utilization of extracellular proteins as nutrients is suppressed by mTORC1
10.1016/j.cell.2015.06.017 · ExternalCitation · doi-reference
Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK
10.1016/j.cellsig.2021.110170 · ExternalCitation · doi-reference
mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of ATF4
10.1016/j.celrep.2017.04.042 · ExternalCitation · doi-reference
The hallmarks of cancer metabolism: still emerging
10.1016/j.cmet.2022.01.007 · ExternalCitation · doi-reference
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
10.1016/j.cmet.2023.01.011 · ExternalCitation · doi-reference
Adhesion signalling complexes
10.1016/j.cub.2010.10.059 · ExternalCitation · doi-reference
Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules
10.1016/j.cub.2013.03.032 · ExternalCitation · doi-reference
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
10.1016/j.devcel.2021.05.010 · ExternalCitation · doi-reference
Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation
10.1016/j.isci.2022.105739 · ExternalCitation · doi-reference
Type I collagen can function as a reservoir of basic fibroblast growth factor
10.1016/j.jconrel.2004.07.008 · ExternalCitation · doi-reference
The interconnections between autophagy and integrin-mediated cell adhesion
10.1016/j.jmb.2016.11.027 · ExternalCitation · doi-reference
An autophagic flux probe that releases an internal control
10.1016/j.molcel.2016.09.037 · ExternalCitation · doi-reference
mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes
10.1016/j.molcel.2024.10.009 · ExternalCitation · doi-reference
Structural basis of collagen recognition by integrin alpha2beta1
10.1016/s0092-8674(00)80622-4 · ExternalCitation · doi-reference
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
10.1016/s0303-7207(99)00061-1 · ExternalCitation · doi-reference
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
10.1038/embor.2009.276 · ExternalCitation · doi-reference
Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study
10.1038/modpathol.3880555 · ExternalCitation · doi-reference
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
10.1038/ncomms16031 · ExternalCitation · doi-reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · ExternalCitation · doi-reference
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage
10.1038/onc.2009.299 · ExternalCitation · doi-reference
Thy-1 depletion and integrin β3 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis
10.1038/s41374-019-0281-2 · ExternalCitation · doi-reference
How does mTOR sense glucose starvation? AMPK is the usual suspect
10.1038/s41420-020-0260-9 · ExternalCitation · doi-reference
Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex
10.1038/s41586-019-1011-z · ExternalCitation · doi-reference
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
10.1038/s41588-020-00753-3 · ExternalCitation · doi-reference
N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)
10.1038/s41598-022-18779-4 · ExternalCitation · doi-reference
Estrous cycle dependent expression of oxycodone conditioned reward in rats
10.1038/s41598-023-40971-3 · ExternalCitation · doi-reference
Elevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas
10.1038/s41598-024-66484-1 · ExternalCitation · doi-reference
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway
10.1038/s41598-025-98170-1 · ExternalCitation · doi-reference
CD98hc (SLC3A2) mediates integrin signaling
10.1073/pnas.0404852102 · ExternalCitation · doi-reference
Twenty-five years of mTOR: uncovering the link from nutrients to growth
10.1073/pnas.1716173114 · ExternalCitation · doi-reference
Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells
10.1073/pnas.1908626116 · ExternalCitation · doi-reference
Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture
10.1073/pnas.79.15.4672 · ExternalCitation · doi-reference
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
10.1074/jbc.270.5.2320 · ExternalCitation · doi-reference
Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
10.1074/jbc.273.37.23629 · ExternalCitation · doi-reference
CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia
10.1074/jbc.m105077200 · ExternalCitation · doi-reference
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
10.1074/jbc.m117.798405 · ExternalCitation · doi-reference
CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation
10.1074/jbc.m408700200 · ExternalCitation · doi-reference
CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling
10.1074/jbc.m702877200 · ExternalCitation · doi-reference
Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization
10.1083/jcb.149.2.431 · ExternalCitation · doi-reference
mTORC1 activity is supported by spatial association with focal adhesions
10.1083/jcb.202004010 · ExternalCitation · doi-reference
Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology
10.1091/mbc.e19-12-0709 · ExternalCitation · doi-reference
Genetics and biology of pancreatic ductal adenocarcinoma
10.1101/gad.1415606 · ExternalCitation · doi-reference
The human LAT1-4F2hc (SLC7A5-SLC3A2) transporter complex: physiological and pathophysiological implications
10.1111/bcpt.13821 · ExternalCitation · doi-reference
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
10.1126/science.1131000 · ExternalCitation · doi-reference
Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
10.1161/circresaha.112.265587 · ExternalCitation · doi-reference
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior
10.1186/1476-4598-12-169 · ExternalCitation · doi-reference
Collagen reorganization at the tumor-stromal interface facilitates local invasion
10.1186/1741-7015-4-38 · ExternalCitation · doi-reference
SLC7A5 correlated with malignancies and immunotherapy response in bladder cancer
10.1186/s12935-024-03365-7 · ExternalCitation · doi-reference
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
10.1242/dmm.035758 · ExternalCitation · doi-reference
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism
10.1371/journal.pbio.3002406 · ExternalCitation · doi-reference
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration
10.1371/journal.pbio.3002930 · ExternalCitation · doi-reference
The extracellular matrix modulates the hallmarks of cancer
10.15252/embr.201439246 · ExternalCitation · doi-reference
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take
10.15252/embr.202050635 · ExternalCitation · doi-reference
Unveiling collagen’s role in breast cancer: insights into expression patterns, functions and clinical implications
10.2147/ijgm.s463649 · ExternalCitation · doi-reference
Metabolites profiling of melanoma interstitial fluids reveals uridine diphosphate as potent immune modulator capable of limiting tumor growth
10.3389/fcell.2021.730726 · ExternalCitation · doi-reference
Influence of the tumor microenvironment on cancer cells metabolic reprogramming
10.3389/fonc.2018.00117 · ExternalCitation · doi-reference
Role of AMPK in autophagy
10.3389/fphys.2022.1015500 · ExternalCitation · doi-reference
The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer
10.3390/ijms20102428 · ExternalCitation · doi-reference
Co-expression effect of SLC7A5/SLC3A2 to predict response to endocrine therapy in oestrogen-receptor-positive breast cancer
10.3390/ijms21041407 · ExternalCitation · doi-reference
The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2
10.3390/ijms21207573 · ExternalCitation · doi-reference
Glucose deprivation induces cancer cell death through failure of ROS regulation
10.3390/ijms241511969 · ExternalCitation · doi-reference
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway
10.3892/or.2017.5530 · ExternalCitation · doi-reference
SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer
10.3892/or.2021.8228 · ExternalCitation · doi-reference