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References from Paralogs of Slitrk cell adhesion molecules configure excitatory synapse specificity via distinct cellular mechanisms. Local targets link to admitted publications; unresolved targets remain external evidence.
Proper synaptic adhesion signaling in the control of neural circuit architecture and brain function
10.1016/j.pneurobio.2020.101983 · 2021 · External reference
The cell biology of synapse formation
10.1083/jcb.202103052 · 2021 · External reference
Transcellular nanoalignment of synaptic function
10.1016/j.neuron.2017.10.006 · 2017 · External reference
Trans-synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules
2022 · External reference
Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins
10.1126/science.aav7969 · 2019 · External reference
Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks
10.1126/science.abg1774 · 2021 · External reference
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum
2020 · External reference
Role of leucine-rich repeat proteins in the development and function of neural circuits
10.1146/annurev-cellbio-092910-154111 · 2011 · External reference
Control of neural circuit formation by leucine-rich repeat proteins
10.1016/j.tins.2014.07.004 · 2014 · External reference
Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases
10.1073/pnas.1209881110 · 2013 · External reference
Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction
10.1038/nn.3040 · 2012 · External reference
The leucine-rich repeat superfamily of synaptic adhesion molecules: LRRTMs and Slitrks
10.1007/s10059-012-0113-3 · 2012 · External reference
Molecular dissection of neuroligin 2 and Slitrk3 reveals an essential framework for GABAergic synapse development
2017 · External reference
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions
10.1038/s41598-019-53519-1 · 2019 · External reference
Slitrk5 mediates BDNF-dependent TrkB receptor trafficking and signaling
10.1016/j.devcel.2015.04.009 · 2015 · External reference
Slitrks as emerging candidate genes involved in neuropsychiatric disorders
10.1016/j.tins.2011.01.001 · 2011 · External reference
SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice
10.1038/s41467-022-31566-z · 2022 · External reference
A modular organization of LRR protein-mediated synaptic adhesion defines synapse identity
10.1016/j.neuron.2018.06.026 · 2018 · External reference
Slitrk missense mutations associated with neuropsychiatric disorders distinctively impair slitrk trafficking and synapse formation
10.3389/fnmol.2016.00104 · 2016 · External reference
Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders
10.3389/fnmol.2022.1080739 · 2023 · External reference
Sequence variants in SLITRK1 are associated with Tourette’s syndrome
10.1126/science.1116502 · 2005 · External reference
Optogenetic modulation of TrkB signaling in the mouse brain
10.1016/j.jmb.2020.01.010 · 2020 · External reference
PTPσ drives excitatory presynaptic assembly via various extracellular and intracellular mechanisms
10.1523/jneurosci.0672-18.2018 · 2018 · External reference
Neurotrophin-3 regulates synapse development by modulating TrkC-PTPσ synaptic adhesion and intracellular signaling pathways
10.1523/jneurosci.4024-15.2016 · 2016 · External reference
Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53
10.1523/jneurosci.4306-08.2009 · 2009 · External reference
LAR-RPTPs directly interact with neurexins to coordinate bidirectional assembly of molecular machineries
10.1523/jneurosci.1091-20.2020 · 2020 · External reference
Protocol for quantitative analysis of synaptic vesicle clustering in axons of cultured neurons
10.1016/j.xpro.2020.100095 · 2020 · External reference
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons
10.1083/jcb.201101072 · 2011 · External reference
LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits
2022 · External reference
MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus
2022 · External reference
Molecular decrowding by tissue expansion allows precise determination of the spatial distribution of synaptic proteins at a nanometer scale by exTEM
10.1021/acsnano.2c10664 · 2023 · External reference
Epitope-preserving magnified analysis of proteome (eMAP)
10.1126/sciadv.abf6589 · 2021 · External reference
DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis
10.1016/j.ymeth.2016.11.016 · 2017 · External reference
Bidirectional control of quantal size by synaptic activity in the hippocampus
10.1126/science.271.5253.1294 · 1996 · External reference
Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons
10.1111/j.1469-7793.1999.227aa.x · 1999 · External reference
Electrophysiological identification of medial and lateral perforant path inputs to the dentate gyrus
10.1016/j.neuroscience.2013.07.063 · 2013 · External reference
Slitrk1 is localized to excitatory synapses and promotes their development
10.1038/srep27343 · 2016 · External reference
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release
10.1146/annurev-physiol-021113-170338 · 2014 · External reference
Nano-Organization at the synapse: segregation of distinct forms of neurotransmission
10.3389/fnsyn.2021.796498 · 2021 · External reference
Differential expression of Slitrk family members in the mouse nervous system
10.1002/dvdy.22160 · 2009 · External reference
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
10.1038/nature01755 · 2003 · External reference
Neuroligins determine synapse maturation and function
10.1016/j.neuron.2006.09.003 · 2006 · External reference
Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit
10.1038/s41467-023-40526-0 · 2023 · External reference
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo
10.1073/pnas.1114028108 · 2011 · External reference
LAR-RPTPs: synaptic adhesion molecules that shape synapse development
10.1016/j.tcb.2013.07.004 · 2013 · External reference
Emergent synapse organizers: LAR-RPTPs and their companions
10.1016/bs.ircmb.2016.01.002 · 2016 · External reference
Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization
10.1016/j.tins.2013.06.002 · 2013 · External reference
Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons
10.1038/s41467-024-45695-0 · 2024 · External reference
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion
10.1038/ncomms6423 · 2014 · External reference
Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2
10.1016/j.mcn.2019.103465 · 2020 · External reference
SLITRK2, an X-linked modifier of the age at onset in C9orf72 frontotemporal lobar degeneration
10.1093/brain/awab171 · 2021 · External reference
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia
10.1038/mp.2010.54 · 2011 · External reference
Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments
10.1073/pnas.0706919104 · 2007 · External reference
Opposite control of excitatory and inhibitory synapse formation by Slitrk2 and Slitrk5 on dopamine neurons modulates hyperactivity behavior
10.1016/j.celrep.2020.01.084 · 2020 · External reference
SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner
10.1016/j.biopsych.2009.05.033 · 2009 · External reference
Identification of novel 14-3-3 residues that are critical for isoform-specific interaction with GluN2C to Regulate N-methyl-D-aspartate (NMDA) Receptor Trafficking
10.1074/jbc.m115.648436 · 2015 · External reference
14-3-3 proteins promote synaptic localization of N-methyl d-aspartate receptors (NMDARs) in mouse hippocampal and cortical neurons
2021 · External reference
14-3-3 proteins in glutamatergic synapses
10.1155/2018/8407609 · 2018 · External reference
NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons
10.1016/j.neuron.2012.10.013 · 2012 · External reference
Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons
10.1073/pnas.1803280115 · 2018 · External reference
Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
10.1038/s41467-023-36042-w · 2023 · External reference
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus
10.1038/s41467-023-40419-2 · 2023 · External reference