Research graph
References from Cell type-agnostic transcriptomic signatures enable uniform comparisons of neural maturation. Local targets link to admitted publications; unresolved targets remain external evidence.
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
10.1038/s41576-018-0004-3 · 2018 · External reference
Universal DNA methylation age across mammalian tissues
10.1038/s43587-023-00462-6 · 2023 · External reference
DNA methylation age of human tissues and cell types
10.1186/gb-2013-14-10-r115 · 2013 · External reference
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
2018 · External reference
Cell stress in cortical organoids impairs molecular subtype specification
10.1038/s41586-020-1962-0 · 2020 · External reference
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
10.1016/j.cell.2022.09.039 · 2022 · External reference
Benchmarking brain organoid recapitulation of fetal corticogenesis
10.1038/s41398-022-02279-0 · 2022 · External reference
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
10.1126/science.aap8809 · 2017 · External reference
Spatiotemporal transcriptomic divergence across human and macaque brain development
2018 · External reference
Real age prediction from the transcriptome with RAPToR
10.1038/s41592-022-01540-0 · 2022 · External reference
A comparison of single-cell trajectory inference methods
10.1038/s41587-019-0071-9 · 2019 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Diffusion pseudotime robustly reconstructs lineage branching
10.1038/nmeth.3971 · 2016 · External reference
Concepts and limitations for learning developmental trajectories from single cell genomics
10.1242/dev.170506 · 2019 · External reference
Alignment of single-cell trajectories to compare cellular expression dynamics
10.1038/nmeth.4628 · 2018 · External reference
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
10.1016/j.cell.2022.09.010 · 2022 · External reference
Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures
10.1093/nar/gkq636 · 2010 · External reference
A quantitative framework to evaluate modeling of cortical development by neural stem cells
10.1016/j.neuron.2014.05.035 · 2014 · External reference
Synthetic analyses of single-cell transcriptomes from multiple brain organoids and fetal brain
10.1016/j.celrep.2020.01.038 · 2020 · External reference
An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics
10.1038/s41467-022-34975-2 · 2022 · External reference
Multi-omic profiling of the developing human cerebral cortex at the single-cell level
2023 · External reference
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus
2023 · External reference
Single-cell analysis of prenatal and postnatal human cortical development
10.1126/science.adf0834 · 2023 · External reference
Comprehensive cell atlas of the first-trimester developing human brain
10.1126/science.adf1226 · 2023 · External reference
Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development
2020 · External reference
An atlas of cortical arealization identifies dynamic molecular signatures
10.1038/s41586-021-03910-8 · 2021 · External reference
Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development
10.1016/j.stem.2021.11.009 · 2022 · External reference
Chromatin accessibility dynamics in a model of human forebrain development
10.1126/science.aay1645 · 2020 · External reference
Mouse and human share conserved transcriptional programs for interneuron development
2021 · External reference
A single-cell transcriptomic atlas of human neocortical development during mid-gestation
10.1016/j.neuron.2019.06.011 · 2019 · External reference
Interneuron origin and molecular diversity in the human fetal brain
10.1038/s41593-021-00940-3 · 2021 · External reference
Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex
10.1016/j.celrep.2021.108788 · 2021 · External reference
Developmental genetics of vertebrate glial-cell specification
10.1038/nature09611 · 2010 · External reference
Neurogenic radial glia in the outer subventricular zone of human neocortex
10.1038/nature08845 · 2010 · External reference
Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
10.1038/s41467-018-03282-0 · 2018 · External reference
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
10.1038/s43587-022-00335-4 · 2023 · External reference
Profiling the transcriptomic age of single-cells in humans
10.1038/s42003-024-07094-5 · 2024 · External reference
Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturation
10.1186/s12864-018-4649-2 · 2018 · External reference
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
10.1126/science.aav2522 · 2019 · External reference
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development
2025 · External reference
Temporal control of mammalian cortical neurogenesis by m6A methylation
2017 · External reference
m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation
10.1038/s41467-024-49139-7 · 2024 · External reference
Isoform-level profiling of m6A epitranscriptomic signatures in human brain
10.1126/sciadv.adp0783 · 2025 · External reference
Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex
10.1016/j.cub.2015.04.028 · 2015 · External reference
Concurrent temporal patterning of neural stem cells in the fly visual system
10.1038/s41467-025-63416-z · 2025 · External reference
The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila
10.1016/j.cub.2023.12.020 · 2024 · External reference
Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability
10.7554/elife.51529 · 2020 · External reference
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis
2025 · External reference
Unresolved reference
2022 · External reference
Bi-allelic variants in BCAT1 impair mitochondrial function and are associated with a candidate neurometabolic disorder
2026 · External reference
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome
10.1016/j.ajhg.2014.09.014 · 2014 · External reference
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
10.1186/s13041-023-01044-8 · 2023 · External reference
An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis
10.1038/s42255-023-00956-y · 2024 · External reference
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
2025 · External reference
CoCoCoNet: conserved and comparative co-expression across a diverse set of species
2020 · External reference
SynGO: an evidence-based, expert-curated knowledge base for the synapse
10.1016/j.neuron.2019.05.002 · 2019 · External reference
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
10.1038/s41586-019-1289-x · 2019 · External reference
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
10.1073/pnas.1520760112 · 2015 · External reference
Cerebral organoids model human brain development and microcephaly
10.1038/nature12517 · 2013 · External reference
A nomenclature consensus for nervous system organoids and assembloids
10.1038/s41586-022-05219-6 · 2022 · External reference
Human astrocyte maturation captured in 3D cerebral cortical spheroids derived from pluripotent stem cells
10.1016/j.neuron.2017.07.035 · 2017 · External reference
Transcriptomic and morphological maturation of human astrocytes in cerebral organoids
10.1002/glia.24479 · 2024 · External reference
BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids
10.1016/j.crmeth.2023.100409 · 2023 · External reference
Meta-analysis of single-cell RNA sequencing co-expression in human neural organoids reveals their high variability in recapitulating primary tissue
10.1371/journal.pbio.3002912 · 2024 · External reference
Reconstitution of human brain cell diversity in organoids via four protocols
2024 · External reference
Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
10.1038/s41467-021-27464-5 · 2021 · External reference
Maturation and circuit integration of transplanted human cortical organoids
10.1038/s41586-022-05277-w · 2022 · External reference
Autism genes converge on asynchronous development of shared neuron classes
10.1038/s41586-021-04358-6 · 2022 · External reference
An integrated transcriptomic cell atlas of human neural organoids
10.1038/s41586-024-08172-8 · 2024 · External reference
A molecular and cellular perspective on human brain evolution and tempo
10.1038/s41586-024-07521-x · 2024 · External reference
An epigenetic barrier sets the timing of human neuronal maturation
10.1038/s41586-023-06984-8 · 2024 · External reference
Molecular architecture of the developing mouse brain
10.1038/s41586-021-03775-x · 2021 · External reference
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
10.1126/sciadv.abg6082 · 2021 · External reference
OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes
10.1093/nar/gkae987 · 2025 · External reference
Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids
10.1101/gr.280219.124 · 2025 · External reference
Interspecies organoids reveal human-specific molecular features of dopaminergic neuron development and vulnerability
2024 · External reference
Organoid single-cell genomic atlas uncovers human-specific features of brain development
10.1038/s41586-019-1654-9 · 2019 · External reference
Missing data and technical variability in single-cell RNA-sequencing experiments
10.1093/biostatistics/kxx053 · 2018 · External reference
Deep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencing
10.1038/s41592-024-02511-3 · 2025 · External reference
A comprehensive human embryo reference tool using single-cell RNA-sequencing data
10.1038/s41592-024-02493-2 · 2025 · External reference
Transcriptional neoteny in the human brain
10.1073/pnas.0900544106 · 2009 · External reference
A cross-species proteomic map reveals neoteny of human synapse development
10.1038/s41586-023-06542-2 · 2023 · External reference
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals
10.1016/j.stem.2023.05.014 · 2023 · External reference
Species-specific pace of development is associated with differences in protein stability
10.1126/science.aba7667 · 2020 · External reference
Mitochondria metabolism sets the species-specific tempo of neuronal development
10.1126/science.abn4705 · 2023 · External reference
Timing and tempo in development
10.1016/j.gde.2024.102202 · 2024 · External reference
Timing mechanisms: insights from comparative neural differentiation systems
10.1016/j.gde.2024.102197 · 2024 · External reference
Nature of epigenetic aging from a single-cell perspective
10.1038/s43587-024-00616-0 · 2024 · External reference
Profiling epigenetic age in single cells
10.1038/s43587-021-00134-3 · 2021 · External reference
All models are wrong, but many are useful: learning a variable’s importance by studying an entire class of prediction models simultaneously
2019 · External reference
Random forests
10.1023/a:1010933404324 · 2001 · External reference
EGAD: ultra-fast functional analysis of gene networks
10.1093/bioinformatics/btw695 · 2017 · External reference
Complex heatmap visualization
2022 · External reference
