Research graph
References from A histidine-mediated supramolecular mechanism links temperature and pH activation of the sperm channel CatSper. Local targets link to admitted publications; unresolved targets remain external evidence.
A sperm ion channel required for sperm motility and male fertility
10.1038/35098027 · 2001 · External reference
A voltage-gated ion channel expressed specifically in spermatozoa
10.1073/pnas.221454998 · 2001 · External reference
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
10.1073/pnas.2536658100 · 2003 · External reference
10.1186/1477-7827-1-53 · 2003 · Admitted local publication
CATSPER2, a human autosomal nonsyndromic male infertility gene
10.1038/sj.ejhg.5200991 · 2003 · External reference
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
10.1038/nature04417 · 2006 · External reference
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
10.1073/pnas.0610286104 · 2007 · External reference
Control of hyperactivation in sperm
10.1093/humupd/dmn029 · 2008 · External reference
Ion channels that control fertility in mammalian spermatozoa
10.1387/ijdb.072554bn · 2008 · External reference
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta
2008 · External reference
Unresolved reference
External reference
The role of Hv1 and CatSper channels in sperm activation
10.1113/jphysiol.2010.194142 · 2010 · External reference
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa
10.1038/ncomms1153 · 2011 · External reference
Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility
10.1016/j.cell.2014.02.056 · 2014 · External reference
Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex
10.1093/molbev/msu218 · 2014 · External reference
Hyperactivated sperm motility driven by CatSper2 is required for fertilization
10.1073/pnas.2136654100 · 2003 · External reference
The essential calcium channel of sperm CatSper is temperature-gated
10.1038/s41467-025-58824-0 · 2025 · External reference
Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel
10.1016/j.cell.2009.12.053 · 2010 · External reference
Progesterone activates the principal Ca2+ channel of human sperm
10.1038/nature09767 · 2011 · External reference
CatSper Calcium Channels: 20 Years On
2023 · External reference
3D structure and in situ arrangements of CatSper channel in the sperm flagellum
10.1038/s41467-022-31050-8 · 2022 · External reference
Dual sensing of physiologic pH and calcium by EFCAB9 regulates sperm motility
10.1016/j.cell.2019.03.047 · 2019 · External reference
CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
2017 · External reference
The CatSper channel: a polymodal chemosensor in human sperm
10.1038/emboj.2012.30 · 2012 · External reference
A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
10.1095/biolreprod.109.077107 · 2009 · External reference
CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir
10.1071/rd08183 · 2009 · External reference
CatSperbeta, a novel transmembrane protein in the CatSper channel complex
10.1074/jbc.m701083200 · 2007 · External reference
CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
10.1095/biolreprod.107.061358 · 2007 · External reference
Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse
10.1095/biolreprod.107.060186 · 2007 · External reference
Identical phenotypes of CatSper1 and CatSper2 null sperm
10.1074/jbc.m501430200 · 2005 · External reference
Structure of a mammalian sperm cation channel complex
10.1038/s41586-021-03742-6 · 2021 · External reference
ARMH2 is a cytosolic component of CatSper crucial for sperm function
10.1038/s41467-025-65952-0 · 2025 · External reference
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
10.1073/pnas.2304409120 · 2023 · External reference
Ancestral Ca2 signaling machinery in early animal and fungal evolution
2011 · External reference
Observations on the penetration of the sperm in the mammalian egg
10.1071/bi9510581 · 1951 · External reference
Fertilizing capacity of spermatozoa deposited into the fallopian tubes
10.1038/168697b0 · 1951 · External reference
Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway
10.1242/dev.121.4.1139 · 1995 · External reference
Ion channels, phosphorylation and mammalian sperm capacitation
10.1038/aja.2010.69 · 2011 · External reference
3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice
2020 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity
10.1093/humrep/dey278 · 2018 · External reference
Uncovering non-random binary patterns within sequences of intrinsically disordered proteins
10.1016/j.jmb.2021.167373 · 2022 · External reference
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
10.1016/j.cell.2025.10.019 · 2026 · External reference
Temperature dependence of hydrophobic and hydrophilic forces and interactions
10.1021/acs.jpcb.1c07802 · 2021 · External reference
CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation
10.1126/sciadv.adw3414 · 2026 · External reference
Molecular basis of the higher-order assembly of CatSper
2026 · External reference
Aromatic residues in proteins: re-evaluating the geometry and energetics of π-π, Cation-π, and CH-π Interactions
10.1021/acs.jpcb.4c04774 · 2024 · External reference
Histidine in proteins: pH-dependent interplay between π-π, Cation-π, and CH-π Interactions
10.1021/acs.jctc.4c00606 · 2024 · External reference
A pH-dependent coarse-grained model for disordered proteins: histidine interactions modulate conformational ensembles
10.1021/acs.jpclett.4c02314 · 2024 · External reference
pKa’s of ionizable groups in proteins: atomic detail from a continuum electrostatic model
10.1021/bi00496a010 · 1990 · External reference
The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm
2016 · External reference
Progesterone accelerates the completion of sperm capacitation and activates CatSper channel in spermatozoa from the rhesus macaque
10.1095/biolreprod.115.129783 · 2015 · External reference
The control of male fertility by spermatozoan ion channels
10.1146/annurev-physiol-020911-153258 · 2012 · External reference
Sperm patch-clamp
10.1016/b978-0-12-397944-5.00004-3 · 2013 · External reference
The pH as an important determinant of sperm-mucus interaction
10.1016/s0015-0282(16)55810-5 · 1993 · External reference
PO2 and pH measurements within the rabbit oviduct following tubal microsurgery: reanastomosis of previously dissected tubes
10.1007/978-1-4684-1188-1_50 · 1984 · External reference
Hydrogen ion and carbon dioxide content of the oviductal fluid of the rhesus monkey (Macaca mulatta)
10.1016/s0015-0282(16)42801-3 · 1977 · External reference
Ion channels as gatekeepers of fertility: from uterine Kir7.1 to sperm CatSper
2026 · External reference
Environmental influences on extended spawning of rainbow trout (Salmo gairdneri)
10.1577/1548-8659(1971)100<312:eioeso>2.0.co;2 · 1971 · External reference
Development of Atlantic salmon (Salmo salar) eggs and alevins under varied temperature regimes
10.1139/f77-004 · 1977 · External reference
Lamellibrachia anaximandrin. sp., a new vestimentiferan tubeworm (Annelida) from the Mediterranean, with notes on frenulate tubeworms from the same habitat
10.5252/z2011n3a1 · 2011 · External reference
Early developmental stages of native populations of Ciona intestinalis under increased temperature are affected by local habitat history
10.1242/jeb.233403 · 2021 · External reference
Thermal tolerance of Strongylocentrotus purpuratus early life history stages: mortality, stress-induced gene expression and biogeographic patterns
10.1007/s00227-010-1528-z · 2010 · External reference
Bioenergetic responses of sub-adult sea cucumber Apostichopus japonicus (Selenka) (Echinodermata: Holothuroidea) to temperature with special discussion regarding its southernmost distribution limit in China
10.1016/j.jtherbio.2009.05.001 · 2009 · External reference
Collecting, rearing, spawning and inducing regeneration of the starlet sea anemone, Nematostella vectensis
10.1038/nprot.2013.044 · 2013 · External reference
Exploring the response of a key Mediterranean gorgonian to heat stress across biological and spatial scales
10.1038/s41598-022-25565-9 · 2022 · External reference
Temperature-induced plasticity in membrane and storage lipid composition: thermal reaction norms across five different temperatures
10.1016/j.jinsphys.2010.11.018 · 2011 · External reference
Effect of temperature on the settlement choice and photophysiology of larvae from the reef coral Stylophora pistillata
10.2307/25470694 · 2008 · External reference
Ecology of inarticulated brachiopods.
1997 · External reference
Slight thermal stress exerts genetic diversity selection at coral (Acropora digitifera) larval stages
10.1186/s12864-024-11194-1 · 2025 · External reference
Optimising conditions for in vitro fertilization success of Acropora tenuis, A. millepora and Favites colemani corals in northwestern Philippines
10.1016/j.jembe.2019.151286 · 2020 · External reference
Unresolved reference
2018 · External reference
Temperature of egg incubation determines sex in Alligator mississippiensis
10.1038/296850a0 · 1982 · External reference
Circadian rhythms of body temperature and metabolic rate in naked mole-rats
10.1016/s0031-9384(00)00280-8 · 2000 · External reference
Temperature regulation in the platypus, Ornithorhynchus anatinus (Shaw)
10.1016/0300-9629(73)90074-1 · 1973 · External reference
Lizards in the wind: the impact of wind on the thermoregulation of the common wall lizard
10.1016/j.jtherbio.2024.103855 · 2024 · External reference
Long-term measurement of body temperature in the southern hairy-nosed wombat (Lasiorhinus latifrons)
10.1071/am15041 · 2016 · External reference
Torpor at high ambient temperature in a neotropical didelphid, the grey short-tailed opossum (Monodelphis domestica)
10.1007/s00114-014-1226-7 · 2014 · External reference
Body temperature and thermoregulation of Komodo dragons in the field
10.1016/j.jtherbio.2010.07.002 · 2010 · External reference
Body temperature patterns in two syntopic elephant shrew species during winter
10.1016/j.cbpa.2011.09.007 · 2012 · External reference
Body temperatures and activity patterns of Tasmanian devils (Sarcophilus harrisii) and eastern quolls (Dasyurus viverrinus) through a subalpine winter
10.1086/639541 · 1997 · External reference
Body temperature patterns and rhythmicity in free-ranging subterranean Damaraland mole-rats, Fukomys damarensis
10.1371/journal.pone.0026346 · 2011 · External reference
Body temperature of free-ranging koalas (Phascolarctos cinereus) in south-east Queensland
10.1007/s00484-020-01907-y · 2020 · External reference
Artificially rearing the Baiji, Lipotes vexillifer, for twenty-one years
2018 · External reference
Savanna elephants maintain homeothermy under African heat
10.1007/s00360-018-1170-5 · 2018 · External reference
Oxygen transport and acid-base balance during exercise in the tammar wallaby
10.1016/s0034-5687(99)00037-7 · 1999 · External reference
Thermal reference points as an index for monitoring body temperature in marine mammals
10.1186/s13104-015-1383-6 · 2015 · External reference
Temperature of embryo culture for assisted reproduction
2019 · External reference
Impact of a controlled culture temperature gradient on mouse embryo development and morphokinetics
10.1016/j.rbmo.2019.12.015 · 2020 · External reference
A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques
10.1016/j.physbeh.2011.03.023 · 2011 · External reference
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10.2307/1377793 · 1967 · External reference
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10.1590/s1519-69842004000400021 · 2004 · External reference
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10.1016/0300-9629(71)90305-7 · 1971 · External reference
Temperature regulation and thermal environment
2004 · External reference
The brown bear and hibernating mammals as a translational model for human resilience: insights for space medicine, critical care, and austere environments
10.3390/biology14101434 · 2025 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Positive relationship of rectal temperature at fixed timed artificial insemination on pregnancy outcomes in beef cattle
10.1093/jas/skac100 · 2022 · External reference
Capricornis crispus
10.1644/750 · 2004 · External reference
Relationship between ear temperature, behaviour and stress hormones in guinea pigs (Cavia porcellus) during different interactive activities in zoos
10.3390/ani14071111 · 2024 · External reference
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10.1139/z73-002 · 1973 · External reference
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10.1186/1471-2105-5-113 · 2004 · External reference
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10.1073/pnas.2007670117 · 2020 · External reference
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10.1016/j.bpj.2016.11.3200 · 2017 · External reference
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10.1093/nar/gku982 · 2015 · External reference
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