Research graph
References from Breadth of ACE2 receptor usage predicts host range and antigenic relatedness across bat sarbecoviruses. Local targets link to admitted publications; unresolved targets remain external evidence.
Bats are natural reservoirs of SARS-like coronaviruses
10.1126/science.1118391 · 2005 · External reference
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
2017 · External reference
Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin
10.1128/jvi.01085-07 · 2008 · External reference
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
10.1038/s41467-021-21240-1 · 2021 · External reference
Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses
10.1016/j.cell.2021.06.008 · 2021 · External reference
Isolation of bat sarbecoviruses, Japan
10.3201/eid2812.220801 · 2022 · External reference
Detection and characterization of bat sarbecovirus phylogenetically related to SARS-CoV-2, Japan
10.3201/eid2612.203386 · 2020 · External reference
A novel SARS-CoV-2 related coronavirus in bats from Cambodia
10.1038/s41467-021-26809-4 · 2021 · External reference
The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
2021 · External reference
Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential
10.1038/s41467-023-38717-w · 2023 · External reference
Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains
10.1371/journal.pbio.3001738 · 2022 · External reference
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
10.1038/nature12711 · 2013 · External reference
ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
10.1038/s41586-022-04464-z · 2022 · External reference
Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
2023 · External reference
The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins
10.1371/journal.pbio.3001016 · 2020 · External reference
Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients
10.1038/s42003-022-03325-9 · 2022 · External reference
Bat coronaviruses related to SARS-CoV-2 and infectious for human cells
10.1038/s41586-022-04532-4 · 2022 · External reference
The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
10.1093/ve/veab007 · 2021 · External reference
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species
10.1038/s41559-021-01407-1 · 2021 · External reference
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
10.1126/scitranslmed.adg7404 · 2023 · External reference
SARS-CoV-2 variants of concern alpha, beta, gamma and delta have extended ACE2 receptor host ranges
10.1099/jgv.0.001735 · 2022 · External reference
Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
10.1016/j.celrep.2022.110558 · 2022 · External reference
Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway
10.1016/j.celrep.2022.110344 · 2022 · External reference
N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding
10.1038/s41392-021-00704-2 · 2021 · External reference
Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission
10.1038/s41564-022-01268-9 · 2022 · External reference
Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer
10.1073/pnas.2121644119 · 2022 · External reference
SARS-CoV-2 infection in free-ranging white-tailed deer
10.1038/s41586-021-04353-x · 2022 · External reference
Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion
10.1099/jgv.0.001506 · 2021 · External reference
Production of recombinant replication-defective lentiviruses bearing the SARS-CoV or SARS-CoV-2 attachment spike glycoprotein and their application in receptor tropism and neutralisation assays
10.21769/bioprotoc.4249 · 2021 · External reference
Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2
10.1038/s41564-022-01163-3 · 2022 · External reference
Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
2023 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Likelihood-based docking of models into cryo-EM maps
10.1107/s2059798323001602 · 2023 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
UCSF ChimeraX: Tools for structure building and analysis
2023 · External reference
Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
10.1080/22221751.2021.1956373 · 2021 · External reference
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
10.1038/s41467-021-21240-1 · 2021 · External reference
A novel SARS-CoV-2 related coronavirus in bats from Cambodia
10.1038/s41467-021-26809-4 · 2021 · External reference
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein
10.1126/science.abd3255 · 2020 · External reference
SARS-related coronavirus S-protein structures reveal synergistic RBM interactions underpinning high-affinity human ACE2 binding
10.1126/sciadv.adr8772 · 2025 · External reference
Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
10.1038/s42003-023-05436-3 · 2023 · External reference
From SARS to MERS, thrusting coronaviruses into the spotlight
10.3390/v11010059 · 2019 · External reference
Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater
10.1038/s41467-022-28246-3 · 2022 · External reference
Transmission of SARS-CoV-2 from humans to animals and potential host adaptation
10.1038/s41467-022-30698-6 · 2022 · External reference
Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong
10.1080/22221751.2022.2040922 · 2022 · External reference
Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection
10.1128/mbio.01206-23 · 2023 · External reference
ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants
10.1016/j.celrep.2022.110757 · 2022 · External reference
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
10.1016/j.immuni.2021.03.023 · 2021 · External reference
Mechanisms for cross-neutralisation of diverse bat sarbecoviruses
2025 · External reference
Molecular basis of sarbecovirus evolution and receptor tropism in natural hosts, potential intermediate hosts, and humans
10.1016/j.celrep.2025.116220 · 2025 · External reference
Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness
10.1038/s41467-024-53029-3 · 2024 · External reference
Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains
10.1371/journal.pbio.3001738 · 2022 · External reference
An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines
10.1371/journal.ppat.1010828 · 2022 · External reference
Structural basis for Sarbecovirus Rc-o319 spike adaptation to Rhinolophus cornutus bat ACE2 and constraints on switching to human ACE2
2026 · External reference
A comprehensive survey of bat sarbecoviruses across China in relation to the origins of SARS-CoV and SARS-CoV-2
2022 · External reference
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells
10.1038/s41586-026-10394-x · 2026 · External reference
Structural basis for raccoon dog receptor recognition by SARS-CoV-2
2024 · External reference
Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage
10.1371/journal.ppat.1012044 · 2024 · External reference
Comparative ACE2 variation and primate COVID-19 risk
10.1038/s42003-020-01370-w · 2020 · External reference
Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine
10.1038/s41467-024-45495-6 · 2024 · External reference
The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2
10.1016/j.scib.2021.01.011 · 2021 · External reference
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
10.1038/s41594-020-0468-7 · 2020 · External reference
