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References from Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients. Local targets link to admitted publications; unresolved targets remain external evidence.
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis
10.1016/s2214-109x(19)30482-6 · 2020 · External reference
Landscape of genomic alterations in cervical carcinomas
10.1038/nature12881 · 2014 · External reference
Integrated genomic and molecular characterization of cervical cancer
10.1038/nature21386 · 2017 · External reference
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance
10.1038/s41467-022-33544-x · 2022 · External reference
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development
10.1016/j.celrep.2014.05.012 · 2014 · External reference
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes
10.1038/s41588-020-0673-7 · 2020 · External reference
PARP inhibitors in gynecologic cancers: what is the next big development?
10.1007/s11912-020-0873-4 · 2020 · External reference
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
10.1038/s41586-023-05940-w · 2023 · External reference
Integrated proteogenomic characterization of HBV-related hepatocellular carcinoma
2019 · External reference
Integrated proteogenomic characterization of clear cell renal cell carcinoma
10.1016/j.cell.2019.10.007 · 2019 · External reference
A comprehensive review of protein kinase inhibitors for cancer therapy
10.1080/14737140.2018.1527688 · 2018 · External reference
PKIDB: a curated, annotated and updated database of protein kinase inhibitors in clinical trials
10.3390/molecules23040908 · 2018 · External reference
LncSpA: LncRNA spatial atlas of expression across normal and cancer tissues
10.1158/0008-5472.can-19-2687 · 2020 · External reference
Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition
10.1038/s41419-021-04229-y · 2021 · External reference
xCell: digitally portraying the tissue cellular heterogeneity landscape
10.1186/s13059-017-1349-1 · 2017 · External reference
Large-scale public data reuse to model immunotherapy response and resistance
10.1186/s13073-020-0721-z · 2020 · External reference
Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q
10.1002/(sici)1098-2264(199708)19:4<233::aid-gcc5>3.0.co;2-y · 1997 · External reference
Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours
10.1016/0140-6736(92)90662-m · 1992 · External reference
PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy
10.1016/j.ygyno.2012.12.019 · 2013 · External reference
Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma
10.1016/j.ygyno.2007.01.045 · 2007 · External reference
TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer
10.1177/17588359211038477 · 2021 · External reference
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
10.1038/s41586-018-0018-1 · 2018 · External reference
Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer
10.1186/1471-230x-13-122 · 2013 · External reference
Single-cell dissection of transcriptional heterogeneity in human colon tumors
10.1038/nbt.2038 · 2011 · External reference
YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4
10.1016/j.celrep.2022.110970 · 2022 · External reference
ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis
10.1038/s41467-023-39901-8 · 2023 · External reference
Let’s talk about Secs: Sec61, Sec62 and Sec63 in signal transduction, oncology and personalized medicine
10.1038/sigtrans.2017.2 · 2017 · External reference
Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance
10.1038/s41588-023-01570-0 · 2023 · External reference
MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4
10.1016/j.biopha.2017.09.143 · 2018 · External reference
Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells
10.1038/onc.2016.54 · 2016 · External reference
Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target
10.1002/cac2.12240 · 2022 · External reference
Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation
10.1186/s12935-017-0420-z · 2017 · External reference
LAMC2 regulates key transcriptional and targetable effectors to support pancreatic cancer growth
10.1158/1078-0432.ccr-22-0794 · 2023 · External reference
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
10.1186/s13046-022-02516-w · 2022 · External reference
Single-nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma
2022 · External reference
The broken cycle: E2F dysfunction in cancer
10.1038/s41568-019-0143-7 · 2019 · External reference
NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer
10.1186/s13046-022-02412-3 · 2022 · External reference
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
10.1038/s41467-022-30264-0 · 2022 · External reference
CDK7-dependent transcriptional addiction in triple-negative breast cancer
10.1016/j.cell.2015.08.063 · 2015 · External reference
CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
10.1016/j.ccell.2019.11.003 · 2020 · External reference
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
10.1038/s41590-021-01047-4 · 2021 · External reference
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 · External reference
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
10.1038/nchembio.2238 · 2017 · External reference
Targeting ferroptosis as a vulnerability in cancer
10.1038/s41568-022-00459-0 · 2022 · External reference
TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5
10.1186/s12967-022-03370-2 · 2022 · External reference
Multi-omics characterization of silent and productive HPV integration in cervical cancer
10.1016/j.xgen.2022.100211 · 2023 · External reference
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
10.1038/nbt.1511 · 2008 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs
10.1093/bioinformatics/bts271 · 2012 · External reference
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing
10.1101/gr.129684.111 · 2012 · External reference
SomaticSniper: identification of somatic point mutations in whole genome sequencing data
10.1093/bioinformatics/btr665 · 2012 · External reference
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
10.1101/gr.107524.110 · 2010 · External reference
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
10.1093/nar/gkq603 · 2010 · External reference
CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing
10.1371/journal.pcbi.1004873 · 2016 · External reference
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
10.1186/gb-2011-12-4-r41 · 2011 · External reference
Mutational heterogeneity in cancer and the search for new cancer-associated genes
10.1038/nature12213 · 2013 · External reference
Pvclust: an R package for assessing the uncertainty in hierarchical clustering
10.1093/bioinformatics/btl117 · 2006 · External reference
Migrating the SNP array-based homologous recombination deficiency measures to next generation sequencing data of breast cancer
10.1038/s41523-018-0066-6 · 2018 · External reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
10.1038/nprot.2016.095 · 2016 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · 2011 · External reference
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
10.1093/bioinformatics/btq170 · 2010 · External reference
Inferring tumour purity and stromal and immune cell admixture from expression data
10.1038/ncomms3612 · 2013 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
