Research graph
References from Uracil-driven ROS signaling and larval TrpA1-B neuron activation are required for priming the adult Drosophila gustatory response to bacteria. Local targets link to admitted publications; unresolved targets remain external evidence.
Animals in a bacterial world, a new imperative for the life sciences
10.1073/pnas.1218525110 · 2013 · External reference
Roles for the gut microbiota in regulating neuronal feeding circuits
2021 · External reference
Homeostasis between gut-associated microorganisms and the immune system in Drosophila
10.1016/j.coi.2014.06.006 · 2014 · External reference
Parental microbiota modulates offspring development, body mass and fecundity in a polyphagous fruit fly
10.3390/microorganisms8091289 · 2020 · External reference
Microbiome interactions shape host fitness
10.1073/pnas.1809349115 · 2018 · External reference
Invertebrate immunity and the limits of mechanistic immunology
10.1038/ni1219 · 2005 · External reference
Reproduction–Immunity trade-offs in insects
10.1146/annurev-ento-010715-023924 · 2016 · External reference
MEF2 is an in vivo immune-metabolic switch
10.1016/j.cell.2013.09.007 · 2013 · External reference
Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens
10.1016/j.cell.2006.01.034 · 2006 · External reference
Insect pathogenic properties of Serratia marcescens: Phage-resistant mutants with a decreased resistance to Cecropia immunity and a decreased virulence to Drosophila
1980 · External reference
A model of bacterial intestinal infections in Drosophila melanogaster
10.1371/journal.ppat.0030173 · 2007 · External reference
Sensing the world and its dangers: An evolutionary perspective in neuroimmunology
10.7554/elife.66706 · 2021 · External reference
Neural anticipation of virtual infection triggers an immune response
10.1038/s41593-025-02008-y · 2025 · External reference
Social communication of predator-induced changes in Drosophila behavior and germ line physiology
10.7554/elife.07423 · 2015 · External reference
How bacteria impact host nervous system and behaviors: Lessons from flies and worms
10.1016/j.tins.2020.09.007 · 2020 · External reference
Impact of microorganisms and parasites on neuronally controlled Drosophila behaviours
10.3390/cells10092350 · 2021 · External reference
Organisational immunity in social insects
10.1016/j.cois.2014.09.001 · 2014 · External reference
Social immunity
10.1016/j.cub.2007.06.008 · 2007 · External reference
The neglected potential of invertebrates in detecting disease via olfaction
10.3389/fevo.2022.960757 · 2023 · External reference
A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila
10.1016/j.cell.2012.09.046 · 2012 · External reference
The vomeronasal system mediates sick conspecific avoidance
10.1016/j.cub.2014.11.061 · 2015 · External reference
Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
10.1038/s41467-021-22712-0 · 2021 · External reference
Hygienic grooming is induced by contact chemicals in Drosophila melanogaster
10.3389/fnbeh.2014.00254 · 2014 · External reference
The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila
10.1371/journal.pone.0185370 · 2017 · External reference
Grooming behavior as a mechanism of insect disease defense
10.3390/insects4040609 · 2013 · External reference
Recognition of bacterial peptidoglycan by the innate immune system
10.1007/s00018-003-3019-6 · 2003 · External reference
Innate immune recognition: Mechanisms and pathways
10.1034/j.1600-065x.2000.917309.x · 2000 · External reference
How the immune system discriminates infectious nonself from noninfectious self.
10.1007/978-3-642-77405-8_5 · 1993 · External reference
Pathogen recognition and innate immunity
10.1016/j.cell.2006.02.015 · 2006 · External reference
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons
10.1186/s12974-015-0239-2 · 2015 · External reference
Bacteria-derived peptidoglycan triggers a noncanonical nuclear factor-κB-dependent response in Drosophila gustatory neurons
2022 · External reference
Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition
10.7554/elife.50559 · 2019 · External reference
Peptidoglycan recognition proteins in Drosophila immunity
10.1016/j.dci.2013.06.006 · 2014 · External reference
Immune receptor signaling and the mushroom body mediate post-ingestion pathogen avoidance
10.1016/j.cub.2020.09.022 · 2020 · External reference
Bacterial detection by Drosophila peptidoglycan recognition proteins
10.1016/j.micinf.2009.03.004 · 2009 · External reference
Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila
10.1016/j.bbi.2024.05.009 · 2024 · External reference
Larval microbiota primes the Drosophila adult gustatory response
10.1038/s41467-024-45532-4 · 2024 · External reference
Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition
2017 · External reference
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes
10.1016/j.chom.2014.12.012 · 2015 · External reference
Uridine catabolism breaks the bonds of commensalism
10.1016/j.chom.2020.02.008 · 2020 · External reference
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila
10.1016/j.cell.2013.04.009 · 2013 · External reference
Bacterial nucleoside catabolism controls quorum sensing and commensal-to-pathogen transition in the Drosophila gut
2020 · External reference
The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria
10.1371/journal.ppat.1007279 · 2018 · External reference
Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae
10.7554/elife.98716.3 · 2024 · External reference
Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila
10.1016/j.cell.2013.04.009 · 2013 · External reference
Polymodal nociception in Drosophila requires alternative splicing of TrpA1
2019 · External reference
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence
2016 · External reference
Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal
10.1016/j.cub.2010.08.016 · 2010 · External reference
Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons
10.1073/pnas.1001425107 · 2010 · External reference
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis
10.1101/gad.1278205 · 2005 · External reference
The TRP superfamily of cation channels
10.1126/stke.2722005re3 · 2005 · External reference
Polymodal nociception in Drosophila requires alternative splicing of TrpA1
10.1016/j.cub.2019.09.070 · 2019 · External reference
TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae
10.1038/nn.4416 · 2017 · External reference
H2O2-Sensitive isoforms of Drosophila melanogaster TRPA1 act in bitter-sensing gustatory neurons to promote avoidance of UV during egg-laying
10.1534/genetics.116.195172 · 2017 · External reference
Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila
10.7554/elife.13133 · 2016 · External reference
The molecular and cellular basis of bitter taste in Drosophila
10.1016/j.neuron.2011.01.001 · 2011 · External reference
TrpA1 regulates defecation of food-borne pathogens under the control of the duox pathway
2016 · External reference
The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria
10.1371/journal.ppat.1007279 · 2018 · External reference
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
10.1073/pnas.0705923104 · 2007 · External reference
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
10.1038/nature05544 · 2007 · External reference
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress
10.1523/jneurosci.5369-07.2008 · 2008 · External reference
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
10.1113/jp270935 · 2016 · External reference
Role of Rab5 early endosomes in regulating Drosophila gut antibacterial response
10.1016/j.isci.2023.107335 · 2023 · External reference
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila
10.1038/s42255-023-00765-3 · 2023 · External reference
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
10.1073/pnas.97.7.3376 · 2000 · External reference
Bacterial nucleoside catabolism controls quorum sensing and commensal-to-pathogen transition in the Drosophila gut
2020 · External reference
The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine
10.1371/journal.pgen.1004659 · 2014 · External reference
Peripheral coding of bitter taste in Drosophila
10.1002/neu.10235 · 2003 · External reference
