Research graph
References from multi-GPA-Tree: Statistical approach for pleiotropy informed and functional annotation tree guided prioritization of GWAS results. Local targets link to admitted publications; unresolved targets remain external evidence.
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
10.1093/nar/gky1120 · 2019 · External reference
Finding the missing heritability of complex diseases
10.1038/nature08494 · 2009 · External reference
Estimating missing heritability for disease from genome-wide association studies
10.1016/j.ajhg.2011.02.002 · 2011 · External reference
Personal genomes: The case of the missing heritability
10.1038/456018a · 2008 · External reference
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
10.1038/ng.3396 · 2015 · External reference
Progress and promise in understanding the genetic basis of common diseases
10.1098/rspb.2015.1684 · 2015 · External reference
Integrative analysis of 111 reference human epigenomes
10.1038/nature14248 · 2015 · External reference
Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
10.1016/j.ajhg.2013.01.001 · 2013 · External reference
One hundred years of pleiotropy: a retrospective
10.1534/genetics.110.122549 · 2010 · External reference
graph-GPA: a graphical model for prioritizing GWAS results and investigating pleiotropic architecture
10.1371/journal.pcbi.1005388 · 2017 · External reference
The NCBI dbGaP database of genotypes and phenotypes
10.1038/ng1007-1181 · 2007 · External reference
Into the wild: GWAS exploration of non-coding RNAs
10.3389/fcvm.2018.00181 · 2018 · External reference
Genetic and epigenetic fine mapping of causal autoimmune disease variants
10.1038/nature13835 · 2015 · External reference
Systematic localization of common disease-associated variation in regulatory DNA
10.1126/science.1222794 · 2012 · External reference
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs
10.1371/journal.pgen.1003449 · 2013 · External reference
LSMM: a statistical approach to integrating functional annotations with genome-wide association studies
10.1093/bioinformatics/bty187 · 2018 · External reference
Covariate-modulated local false discovery rate for genome-wide association studies
10.1093/bioinformatics/btu145 · 2014 · External reference
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation
10.1371/journal.pgen.1004787 · 2014 · External reference
LPM: a latent probit model to characterize the relationship among complex traits using summary statistics from multiple GWASs and functional annotations
10.1093/bioinformatics/btz947 · 2020 · External reference
GPA-Tree: statistical approach for functional-annotation-tree-guided prioritization of GWAS results
10.1093/bioinformatics/btab802 · 2022 · External reference
Multivariate regression trees: a new technique for modeling species–environment relationships
2002 · External reference
The expectation-maximization algorithm
10.1109/79.543975 · 1996 · External reference
Detecting differential gene expression with a semiparametric hierarchical mixture method
10.1093/biostatistics/5.2.155 · 2004 · External reference
Transancestral mapping and genetic load in systemic lupus erythematosus
10.1038/ncomms16021 · 2017 · External reference
Genetics of rheumatoid arthritis contributes to biology and drug discovery
10.1038/nature12873 · 2014 · External reference
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
10.1038/ng.3760 · 2017 · External reference
Integrative tissue-specific functional annotations in the human genome provide novel insights on many complex traits and improve signal prioritization in genome wide association studies
10.1371/journal.pgen.1005947 · 2016 · External reference
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease
10.1371/journal.pgen.1006933 · 2017 · External reference
The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
10.1126/science.1262110 · 2015 · External reference
PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis
10.1186/s42358-022-00252-5 · 2022 · External reference
Contrasting genetic association of IL2RA with SLE and ANCA–associated vasculitis
2009 · External reference
Biological significance of soluble IL-2 receptor
10.1155/s0962935193000018 · 1993 · External reference
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
10.1038/ng.468 · 2009 · External reference
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
10.1038/ng.79 · 2008 · External reference
Study of functional variants of the BANK1 gene in rheumatoid arthritis
10.1002/art.24244 · 2009 · External reference
Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity
10.1074/jbc.m113.492611 · 2013 · External reference
Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort
10.1136/annrheumdis-2011-200802 · 2012 · External reference
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
10.1038/ng.3985 · 2017 · External reference
Thyrotrophin and thyroxine support immune homeostasis in humans
10.1111/imm.13306 · 2021 · External reference
Phenotype and tissue expression as a function of genetic risk in polycystic ovary syndrome
10.1371/journal.pone.0168870 · 2017 · External reference
ATG16L1: a multifunctional susceptibility factor in Crohn disease
10.1080/15548627.2015.1017187 · 2015 · External reference
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
10.1038/ng1954 · 2007 · External reference
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
10.1053/j.gastro.2015.07.065 · 2015 · External reference
Gene expression-genotype analysis implicates GSDMA, GSDMB, and LRRC3C as contributors to inflammatory bowel disease susceptibility
10.1155/2015/834805 · 2015 · External reference
Variations in the IBD5 locus confer the risk of inflammatory bowel disease in a Manitoban Caucasian Cohort
2018 · External reference
An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?
10.1371/journal.pgen.1009684 · 2021 · External reference
Crohn’s disease and genetic hitchhiking at IBD5
10.1093/molbev/msr151 · 2012 · External reference
Systemic lupus erythematosus: old and new susceptibility genes versus clinical manifestations
10.2174/138920291501140306113715 · 2014 · External reference
FYB gene polymorphisms are associated with susceptibility for systemic lupus erythemathosus (SLE)
10.1016/j.humimm.2013.04.026 · 2013 · External reference
A BACH2 gene variant is associated with postoperative recurrence of Crohn’s disease
10.1016/j.jamcollsurg.2018.01.052 · 2018 · External reference
Transcription factors that regulate the pathogenesis of ulcerative colitis
2020 · External reference
DOCK8 regulates signal transduction events to control immunity
10.1038/cmi.2017.9 · 2017 · External reference
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
10.1093/hmg/ddh008 · 2004 · External reference
A pleiotropic missense variant in SLC39A8 is associated with Crohn’s disease and human gut microbiome composition
10.1053/j.gastro.2016.06.051 · 2016 · External reference
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
10.1038/nature11582 · 2012 · External reference
TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and-6: implications for Crohn’s disease
10.1152/ajpgi.00347.2013 · 2014 · External reference
Clinical M2 macrophages-related genes to aid therapy in pancreatic ductal adenocarcinoma
2021 · External reference
Identification of hub genes associated with immune infiltration in cardioembolic stroke by whole blood transcriptome analysis
2022 · External reference
Epithelial-specific ETS-1 (ESE1∖ELF3) regulates apoptosis of intestinal epithelial cells in ulcerative colitis via accelerating NF−κB activation
10.1007/s12026-015-8651-3 · 2015 · External reference
Pathophysiology of fistula formation in Crohn’s disease
10.4291/wjgp.v5.i3.205 · 2014 · External reference
Translating GWAS findings to novel therapeutic targets for coronary artery disease
10.3389/fcvm.2018.00056 · 2018 · External reference
Translating genome-wide association findings into new therapeutics for psychiatry
10.1038/nn.4411 · 2016 · External reference
Five years of GWAS discovery
10.1016/j.ajhg.2011.11.029 · 2012 · External reference
Epigenetics as a unifying principle in the aetiology of complex traits and diseases
10.1038/nature09230 · 2010 · External reference
Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits
2019 · External reference
Immunopathogenic mechanisms of systemic autoimmune disease
10.1016/s0140-6736(13)60954-x · 2013 · External reference
Rheumatoid arthritis—a molecular understanding
10.7326/0003-4819-136-12-200206180-00012 · 2002 · External reference
Human leucocyte antigens in Crohn’s disease and ulcerative colitis
10.1136/gut.13.6.438 · 1972 · External reference
T cells as a therapeutic target in SLE
10.1177/0961203314556139 · 2015 · External reference
Regulatory T cells in systemic lupus erythematosus
10.1002/eji.201344280 · 2015 · External reference
T cells in the pathogenesis of systemic lupus erythematosus
10.1016/j.clim.2004.05.001 · 2004 · External reference
The role of T cells in rheumatoid arthritis: new subsets and new targets
10.1097/bor.0b013e32805e87e0 · 2007 · External reference
Regulatory T cells in rheumatoid arthritis
10.1186/ar1718 · 2005 · External reference
Functional impairment of natural killer cells in active ulcerative colitis: reversion of the defective natural killer activity by interleukin 2
10.1136/gut.33.2.246 · 1992 · External reference
Imbalance of NKp44+ NKp46 and NKp44 NKp46+ natural killer cells in the intestinal mucosa of patients with Crohn’s disease
10.1053/j.gastro.2010.05.040 · 2010 · External reference
Human gut-associated natural killer cells in health and disease
10.3389/fimmu.2019.00961 · 2019 · External reference
Immune status in Crohn’s disease. V. Decreased in vitro natural killer cell activity in peripheral blood
1980 · External reference
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
10.1371/journal.pgen.1002406 · 2011 · External reference
Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach
10.1371/journal.pone.0183842 · 2017 · External reference
Shared genetic architecture between rheumatoid arthritis and varying osteoporotic phenotypes
10.1002/jbmr.4491 · 2022 · External reference
Association of the IL2RACD25 gene with juvenile idiopathic arthritis
10.1002/art.24187 · 2009 · External reference
Contrasting genetic association of IL2RAwith SLE and ANCA–associated vasculitis
2009 · External reference
Genes associated with SLE are targets of recent positive selection
10.1155/2014/203435 · 2014 · External reference
Recent findings on genetics of systemic autoimmune diseases
10.1016/j.coi.2010.09.002 · 2010 · External reference
New IBD genetics: common pathways with other diseases
10.1136/gut.2009.199679 · 2011 · External reference
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn’s disease in the German population
10.1111/j.1572-0241.2007.01694.x · 2008 · External reference
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn’s disease
10.1038/ng.145 · 2008 · External reference
Novel associations between genome-wide single nucleotide polymorphisms and MR enterography features in Crohn’s disease patients
10.1002/jmri.27250 · 2021 · External reference
Blood and intestine eQTLs from an anti-TNF-resistant Crohn’s disease cohort inform IBD genetic association loci
10.1038/ctg.2016.34 · 2016 · External reference
