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References from Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors. Local targets link to admitted publications; unresolved targets remain external evidence.
The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance
10.2174/156652412799218921 · 2012 · External reference
Taming vessels to treat cancer
10.1038/scientificamerican0108-56 · 2008 · External reference
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
10.1200/jco.2012.46.3653 · 2013 · External reference
Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside
10.1016/j.trecan.2018.02.005 · 2018 · External reference
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
10.1038/nm.1971 · 2009 · External reference
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
10.1016/j.neo.2024.100990 · 2024 · External reference
The role of mechanical forces in tumor growth and therapy
10.1146/annurev-bioeng-071813-105259 · 2014 · External reference
The Solid Mechanics of Cancer and Strategies for Improved Therapy
10.1115/1.4034991 · 2017 · External reference
Beyond matrix stiffness: targeting force-induced cancer drug resistance
10.1016/j.trecan.2023.07.006 · 2023 · External reference
Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II
10.1158/1541-7786.mcr-21-0266 · 2022 · External reference
Pathology: cancer cells compress intratumour vessels
10.1038/427695a · 2004 · External reference
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
10.1073/pnas.1213353109 · 2012 · External reference
Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
10.1158/0008-5472.can-12-4521 · 2013 · External reference
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
10.1016/j.ccell.2014.10.006 · 2014 · External reference
Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression
10.3389/fonc.2019.00992 · 2019 · External reference
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition
10.1038/s42003-024-07268-1 · 2024 · External reference
Pancreatic cancer provides testbed for first mechanotherapeutics
10.1038/d41587-019-00019-2 · 2019 · External reference
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
10.1016/j.jconrel.2017.06.022 · 2017 · External reference
TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity
10.7150/thno.36936 · 2020 · External reference
Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
10.1038/srep46140 · 2017 · External reference
Pirfenidone normalizes the tumor microenvironment to improve chemotherapy
10.18632/oncotarget.15534 · 2017 · External reference
Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano-immunotherapy in Breast Cancer Lung Metastasis
10.1002/advs.202001917 · 2020 · External reference
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
10.1038/ncomms3516 · 2013 · External reference
Endothelin inhibition potentiates cancer immunotherapy revealing mechanical biomarkers predictive of response
2021 · External reference
Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models
10.1038/s41467-022-34744-1 · 2022 · External reference
Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models
10.1021/acsnano.3c03305 · 2023 · External reference
Stress alleviation strategy in cancer treatment: Insights from a mathematical model
2018 · External reference
Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
10.1158/1078-0432.ccr-24-0246 · 2024 · External reference
Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas
10.1158/1535-7163.mct-23-0772 · 2024 · External reference
Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
10.1371/journal.pone.0193801 · 2018 · External reference
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
10.1073/pnas.1018892108 · 2011 · External reference
Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy
10.1016/j.actbio.2023.06.007 · 2023 · External reference
Sonopermeation with nanoparticle-stabilized microbubbles reduces solid stress and improves nanomedicine delivery to tumors
10.1002/adtp.202100147 · 2021 · External reference
Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
10.1016/j.ultrasmedbio.2020.12.026 · 2021 · External reference
Non-viral nitric oxide-based gene therapy improves perfusion and liposomal doxorubicin sonopermeation in neuroblastoma models
10.7150/thno.81700 · 2023 · External reference
Sonopermeation With Size-sorted Microbubbles Synergistically Increases Survival and Enhances Tumor Apoptosis With L-DOX by Increasing Vascular Permeability and Perfusion in Neuroblastoma Xenografts
10.1016/j.ultrasmedbio.2024.10.014 · 2025 · External reference
Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells
10.3390/pharmaceutics12111058 · 2020 · External reference
Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation
10.1080/17425247.2018.1547279 · 2018 · External reference
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
10.1016/j.addr.2021.113847 · 2021 · External reference
Clinical trial of blood-brain barrier disruption by pulsed ultrasound
10.1126/scitranslmed.aaf6086 · 2016 · External reference
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer
10.1016/j.jconrel.2016.10.007 · 2016 · External reference
Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study
10.1118/1.4808149 · 2013 · External reference
Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors
10.1016/j.nano.2011.10.005 · 2012 · External reference
Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes
10.1016/j.jconrel.2020.06.024 · 2020 · External reference
Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study
10.1121/1.4817843 · 2013 · External reference
A mathematical model of sonoporation using a liquid-crystalline shelled microbubble
10.1016/j.ultras.2019.01.004 · 2019 · External reference
Modeling low-intensity ultrasound mechanotherapy impact on growing cancer stem cells
10.1016/j.matcom.2024.08.030 · 2025 · External reference
Modeling interactions among migration, growth and pressure in tumor dynamics
10.3390/math9121376 · 2021 · External reference
Mechanotransduction in tumor dynamics modeling
10.1016/j.plrev.2023.01.017 · 2023 · External reference
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
10.1007/s10237-015-0682-0 · 2015 · External reference
Role of vascular normalization in benefit from metronomic chemotherapy
10.1073/pnas.1700340114 · 2017 · External reference
Combining microenvironment normalization strategies to improve cancer immunotherapy
10.1073/pnas.1919764117 · 2020 · External reference
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
10.1073/pnas.1818357116 · 2019 · External reference
Evolution of osmotic pressure in solid tumors
10.1016/j.jbiomech.2014.09.019 · 2014 · External reference
Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI
10.1016/j.nicl.2018.08.032 · 2018 · External reference
The enigmatic role of angiopoietin-1 in tumor angiogenesis
10.1038/sj.cr.7290176 · 2003 · External reference
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
10.1126/science.1104819 · 2005 · External reference
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
10.1038/nrc2346 · 2008 · External reference
Vascular normalization as an emerging strategy to enhance cancer immunotherapy
10.1158/0008-5472.can-12-4354 · 2013 · External reference
Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression
10.1038/s41467-017-01651-9 · 2017 · External reference
A validated mathematical model of cell-mediated immune response to tumor growth
10.1158/0008-5472.can-05-0564 · 2005 · External reference
Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
10.1186/s40425-017-0313-7 · 2018 · External reference
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications
1999 · External reference
Normalization of the vasculature for treatment of cancer and other diseases
10.1152/physrev.00038.2010 · 2011 · External reference
Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology
10.1073/pnas.1203794109 · 2012 · External reference
Molecular mechanisms and clinical applications of angiogenesis
10.1038/nature10144 · 2011 · External reference
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
10.1126/science.284.5422.1994 · 1999 · External reference
Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo
10.1073/pnas.172161899 · 2002 · External reference
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
10.1126/science.1171362 · 2009 · External reference
Combining two strategies to improve perfusion and drug delivery in solid tumors
10.1073/pnas.1318415110 · 2013 · External reference
Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies
10.2165/00003088-200342050-00002 · 2003 · External reference
Hindered transport of large molecules in liquid-filled pores
10.1002/aic.690330902 · 1987 · External reference
Microbubble-induced sonoporation involved in ultrasound-mediated DNA transfection in vitro at low acoustic pressures
10.1016/j.jbiomech.2012.03.011 · 2012 · External reference
Ultrasonically triggered drug delivery: breaking the barrier
10.1016/j.colsurfb.2014.07.051 · 2014 · External reference
Acoustic behavior of microbubbles and implications for drug delivery
10.1016/j.addr.2014.03.003 · 2014 · External reference
Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system
10.21147/j.issn.1000-9604.2018.05.09 · 2018 · External reference
Sonopermeation combined with stroma normalization enables complete cure using nano-immunotherapy in murine breast tumors
10.1016/j.jconrel.2025.113722 · 2025 · External reference
Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes
10.1371/journal.pcbi.1011740 · 2023 · External reference
Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors
2025 · External reference
Ultrasound–biophysics mechanisms
10.1016/j.pbiomolbio.2006.07.010 · 2007 · External reference
Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound
10.1016/j.neuropharm.2016.02.014 · 2017 · External reference
Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes
10.1016/j.chemphyslip.2009.08.003 · 2009 · External reference
Sonochemotherapy: from bench to bedside
2015 · External reference
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
10.1148/radiol.2202001804 · 2001 · External reference
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
10.1016/j.neuroimage.2004.06.046 · 2005 · External reference
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
10.1016/j.ultrasmedbio.2007.11.009 · 2008 · External reference
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
10.1016/j.ultrasmedbio.2007.10.016 · 2008 · External reference
Dependence of the reversibility of focused- ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo
10.1109/tuffc.2013.6644731 · 2013 · External reference
Rapid short-pulse sequences enhance the spatiotemporal uniformity of acoustically driven microbubble activity during flow conditions
10.1121/1.4964271 · 2016 · External reference
Low-frequency sonophoresis enhances rivastigmine permeation in vitro and in vivo
2015 · External reference
Sonoporation induces apoptosis and cell cycle arrest in human promyelocytic leukemia cells
10.1016/j.ultrasmedbio.2011.09.012 · 2011 · External reference
Gauging the likelihood of stable cavitation from ultrasound contrast agents
10.1088/0031-9155/58/1/127 · 2013 · External reference
Acoustically induced shear stresses in the vicinity of microbubbles in tissue
10.1121/1.387549 · 1982 · External reference
Shear as a mechanism for sonically induced biological effects
10.1121/1.1913306 · 1972 · External reference
Molecular basis of the effects of shear stress on vascular endothelial cells
10.1016/j.jbiomech.2004.09.030 · 2005 · External reference
Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes
10.1016/j.ultrasmedbio.2012.06.002 · 2012 · External reference
Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study
10.1186/ar2451 · 2008 · External reference
Low-intensity pulsed ultrasound activates integrin-mediated mechanotransduction pathway in synovial cells
10.1007/s10439-014-1081-x · 2014 · External reference
Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
10.3390/ijms231911222 · 2022 · External reference
Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer
10.1158/0008-5472.can-15-0296 · 2015 · External reference
Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound
10.1016/j.jconrel.2017.02.035 · 2017 · External reference
Solid stress generated by spheroid growth estimated using a linear poroelasticity model
10.1016/s0026-2862(03)00057-8 · 2003 · External reference
Characterization of multicellular breast tumor spheroids using image data-driven biophysical mathematical modeling
10.1038/s41598-020-68324-4 · 2020 · External reference
A mathematical model for predicting the spatiotemporal response of breast cancer cells treated with doxorubicin
10.1080/15384047.2024.2321769 · 2024 · External reference
Calibrating a Predictive Model of Tumor Growth and Angiogenesis with Quantitative MRI
10.1007/s10439-019-02262-9 · 2019 · External reference
Modeling cancer progression: an integrated workflow extending data-driven kinetic models to bio-mechanical PDE models
10.1088/1478-3975/ad2777 · 2024 · External reference
