Research graph
References from Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk. Local targets link to admitted publications; unresolved targets remain external evidence.
The Fanconi Anemia Pathway in Cancer
10.1146/annurev-cancerbio-030617-050422 · 2019 · External reference
DNA interstrand crosslink repair and cancer
10.1038/nrc3088 · 2011 · External reference
Fanconi anaemia and cancer: an intricate relationship
10.1038/nrc.2017.116 · 2018 · External reference
Head and neck squamous cell carcinoma
10.1038/s41572-020-00224-3 · 2020 · External reference
Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up
10.3324/haematol.2017.178111 · 2018 · External reference
10.3389/fgene.2023.1254966
10.3389/fgene.2023.1254966 · External reference
Cancer incidence in persons with Fanconi anemia
10.1182/blood-2002-05-1498 · 2003 · External reference
Tumour predisposition and cancer syndromes as models to study gene-environment interactions
10.1038/s41568-020-0265-y · 2020 · External reference
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer
10.1038/s41586-022-05253-4 · 2022 · External reference
Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients
10.1093/jnci/djn366 · 2008 · External reference
Fanconi anemia-isogenic head and neck cancer cell line pairs: A basic and translational science resource
10.1002/ijc.34506 · 2023 · External reference
Why otolaryngologists need to be aware of Fanconi anemia
10.1016/j.otc.2013.04.002 · 2013 · External reference
Natural history and management of Fanconi anemia patients with head and neck cancer: A 10-year follow-up
10.1002/lary.25726 · 2016 · External reference
Modern management of Fanconi anemia
10.1182/hematology.2022000393 · 2022 · External reference
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia
10.1038/s41591-019-0550-z · 2019 · External reference
Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials
10.1016/s0140-6736(24)01880-4 · 2024 · External reference
Adenine base editing efficiently restores the function of Fanconi anemia hematopoietic stem and progenitor cells
10.1038/s41467-022-34479-z · 2022 · External reference
Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia
10.3324/haematol.2022.282418 · 2023 · External reference
Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34 cells from Fanconi anemia patients
10.1182/blood-2017-03-774174 · 2017 · External reference
Spatial constraints control cell proliferation in tissues
10.1073/pnas.1323016111 · 2014 · External reference
Growth regulatory effects of cellular interaction
10.1038/2131102a0 · 1967 · External reference
State-dependent evolutionary models reveal modes of solid tumour growth
10.1038/s41559-023-02000-4 · 2023 · External reference
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
10.1038/s41588-020-0624-3 · 2020 · External reference
Spatial constraints govern competition of mutant clones in human epidermis
10.1038/s41467-017-00993-8 · 2017 · External reference
Spatial structure governs the mode of tumour evolution
10.1038/s41559-021-01615-9 · 2022 · External reference
10.1038/s41588-022-01280-z
10.1038/s41588-022-01280-z · External reference
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition
10.1038/s41467-022-33945-y · 2022 · External reference
A “late-but-fitter revertant cell” explains the high frequency of revertant mosaicism in epidermolysis bullosa
10.1371/journal.pone.0192994 · 2018 · External reference
Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion
10.1016/s0092-8674(00)81894-2 · 1997 · External reference
Revertant Mosaicism in Genodermatoses: Natural Gene Therapy Right before Your Eyes
10.3390/biomedicines10092118 · 2022 · External reference
Microneedle-mediated vaccine delivery to the oral mucosa
10.1002/adhm.201801180 · 2019 · External reference
Oral mucosal vaccination using integrated fiber microneedles
10.1016/j.jconrel.2024.01.062 · 2024 · External reference
Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays
10.1208/s12248-014-9606-7 · 2014 · External reference
Microneedle patches: usability and acceptability for self-vaccination against influenza
10.1016/j.vaccine.2014.01.076 · 2014 · External reference
Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity
10.1007/s11095-014-1335-1 · 2014 · External reference
10.1016/j.jconrel.2014.09.028
10.1016/j.jconrel.2014.09.028 · 2014 · External reference
Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data
10.1371/journal.pcbi.1007243 · 2019 · External reference
From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response
10.1371/journal.pcbi.1007672 · 2020 · External reference
Agent-based methods facilitate integrative science in cancer
10.1016/j.tcb.2022.10.006 · 2023 · External reference
Homeostasis limits keratinocyte evolution
10.1073/pnas.2006487119 · 2022 · External reference
A single progenitor population switches behavior to maintain and repair esophageal epithelium
10.1126/science.1218835 · 2012 · External reference
A single type of progenitor cell maintains normal epidermis
10.1038/nature05574 · 2007 · External reference
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
10.1038/s41467-020-15258-0 · 2020 · External reference
In Vivo Selection of Wild-Type Hematopoietic Stem Cells in a Murine Model of Fanconi Anemia
10.1182/blood.v94.6.2151 · 1999 · External reference
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
10.1038/nature08129 · 2009 · External reference
Impairment of fetal hematopoietic stem cell function in the absence of Fancd2
10.1016/j.exphem.2016.11.006 · 2017 · External reference
Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models
2025 · External reference
Somatic mutant clones colonize the human esophagus with age
10.1126/science.aau3879 · 2018 · External reference
A quantitative measurement of the human somatic mutation rate
10.1158/0008-5472.can-04-1198 · 2005 · External reference
Frequencies of HPRT− lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors
10.1016/0027-5107(93)90137-5 · 1993 · External reference
Use of the glycophorin A somatic mutation assay for rapid, unambiguous identification of Fanconi anemia homozygotes regardless of GPA genotype
10.1002/ajmg.a.30687 · 2005 · External reference
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells
10.1016/j.stem.2012.05.013 · 2012 · External reference
Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation
10.1016/j.stemcr.2017.12.006 · 2018 · External reference
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
10.1182/blood-2003-03-0971 · 2003 · External reference
Heterozygosity for p53 (Trp53 /−) accelerates epithelial tumor formation in Fanconi anemia complementation group D2 (Fancd2) knockout mice
10.1158/0008-5472.85.65.1 · 2005 · External reference
The age distribution of cancer and a multi-stage theory of carcinogenesis
10.1038/bjc.1954.1 · 1954 · External reference
Branching Process Models of Cancer.
10.1007/978-3-319-16065-8_1 · 2015 · External reference
Mutant clones in normal epithelium outcompete and eliminate emerging tumours
10.1038/s41586-021-03965-7 · 2021 · External reference
Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations
10.1016/j.stem.2018.08.017 · 2018 · External reference
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change
10.1038/ncb2963 · 2014 · External reference
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10
10.1126/science.1192280 · 2010 · External reference
Quantitative clonal analysis and single-cell transcriptomics reveal division kinetics, hierarchy, and fate of oral epithelial progenitor cells
10.1016/j.stem.2018.10.015 · 2019 · External reference
The distribution of cellular turnover in the human body
10.1038/s41591-020-01182-9 · 2021 · External reference
Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus
10.1053/j.gastro.2012.12.022 · 2013 · External reference
The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
10.3390/genes11050585 · 2020 · External reference
Fanconi anemia and the underlying causes of genomic instability
10.1002/em.22358 · 2020 · External reference
Chromosome instability syndromes
2019 · External reference
The impact of clonal diversity and mosaicism on haematopoietic function in Fanconi anaemia
10.1111/bjh.17653 · 2022 · External reference
Spontaneous functional correction of homozygous fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism
10.1038/11956 · 1999 · External reference
10.3389/fgene.2023.1240758
10.3389/fgene.2023.1240758 · External reference
Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway
10.1182/blood-2004-05-1852 · 2005 · External reference
Somatic mosaicism in Fanconi anemia: molecular basis and clinical significance
10.1159/000484749 · 1997 · External reference
Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction
10.1159/000069805 · 2003 · External reference
Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype
10.1002/mgg3.350 · 2018 · External reference
Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia
10.1016/j.oraloncology.2022.106184 · 2022 · External reference
p53 downregulates the Fanconi anaemia DNA repair pathway
10.1038/ncomms11091 · 2016 · External reference
The p53 DNA damage response and Fanconi anemia DNA repair pathway protect against acetaldehyde-induced replication stress in esophageal keratinocytes
10.1080/15384101.2023.2261740 · 2023 · External reference
High burden and pervasive positive selection of somatic mutations in normal human skin
10.1126/science.aaa6806 · 2015 · External reference
The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma
10.3390/cancers13184507 · 2021 · External reference
Mutant p53 partners in crime
10.1038/cdd.2017.185 · 2018 · External reference
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
10.1016/j.molcel.2023.05.035 · 2023 · External reference
Targeted nonviral delivery of genome editors in vivo
10.1073/pnas.2307796121 · 2024 · External reference
The NIH Somatic Cell Genome Editing program
10.1038/s41586-021-03191-1 · 2021 · External reference
Grand Challenges at the Interface of Engineering and Medicine
10.1109/ojemb.2024.3351717 · 2024 · External reference
Patient-specific in vivo gene editing to treat a rare genetic disease
10.1056/nejmoa2504747 · 2025 · External reference
Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization
10.1371/journal.pcbi.1007635 · 2020 · External reference
Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis
10.1073/pnas.1516123113 · 2016 · External reference
Gattaca: Base-Pair Resolution Mutation Tracking for Somatic Evolution Studies Using Agent-Based Models
10.1093/molbev/msac058 · 2022 · External reference
A systematic p53 mutation library links differential functional impact to cancer mutation pattern and evolutionary conservation
10.1016/j.molcel.2018.06.012 · 2018 · External reference
Fitdistrplus: An R package for fitting distributions
10.18637/jss.v064.i04 · 2015 · External reference
Unresolved reference
External reference
