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References from Spatial distribution of cytoskeleton-mediated feedback controls cell polarization: A computational study. Local targets link to admitted publications; unresolved targets remain external evidence.
G protein signaling events are activated at the leading edge of chemotactic cells
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Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
10.1073/pnas.0402152101 · 2004 · External reference
Eukaryotic chemotaxis: distinctions between directional sensing and polarization
10.1074/jbc.r300010200 · 2003 · External reference
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration
10.1038/ncb2859 · 2013 · External reference
Mechanochemical feedback loops in development and disease
10.1016/j.cell.2019.05.052 · 2019 · External reference
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
10.1038/ncb811 · 2002 · External reference
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
10.1038/ncb810 · 2002 · External reference
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
10.1083/jcb.200208179 · 2003 · External reference
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
10.1083/jcb.200406177 · 2004 · External reference
Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass
10.1182/blood-2004-03-0781 · 2004 · External reference
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis
10.1371/journal.pbio.0040038 · 2006 · External reference
Big roles for small GTPases in the control of directed cell movement
10.1042/bj20061432 · 2007 · External reference
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility
10.1083/jcb.200611138 · 2007 · External reference
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
10.1371/journal.pone.0003068 · 2008 · External reference
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish
10.1016/j.devcel.2009.11.015 · 2010 · External reference
Wave patterns organize cellular protrusions and control cortical dynamics
10.15252/msb.20188585 · 2019 · External reference
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration
10.1038/s41556-022-00997-7 · 2022 · External reference
Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation
10.1529/biophysj.107.114702 · 2008 · External reference
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis
10.1091/mbc.e10-01-0009 · 2010 · External reference
Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
10.1038/s41467-021-26622-z · 2021 · External reference
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells
10.1083/jcb.200705068 · 2007 · External reference
Rap1 controls cell adhesion and cell motility through the regulation of myosin II
10.1083/jcb.200607072 · 2007 · External reference
Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions
10.1083/jcb.200710111 · 2008 · External reference
Complementary cytoskeletal feedback loops control signal transduction excitability and cell polarity
10.1038/s41467-025-62799-3 · 2025 · External reference
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An actin-based wave generator organizes cell motility
10.1371/journal.pbio.0050221 · 2007 · External reference
Transformation from spots to waves in a model of actin pattern formation
10.1103/physrevlett.102.198103 · 2009 · External reference
Excitable actin dynamics in lamellipodial protrusion and retraction
10.1016/j.bpj.2012.03.005 · 2012 · External reference
Transient localized patterns in noise-driven reaction-diffusion systems
10.1103/physrevlett.104.158301 · 2010 · External reference
Cells navigate with a local-excitation, global-inhibition-biased excitable network
10.1073/pnas.1011271107 · 2010 · External reference
Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells
10.1073/pnas.1218025110 · 2013 · External reference
Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis
10.1016/j.bpj.2013.12.023 · 2014 · External reference
Feedback mechanisms in a mechanical model of cell polarization
10.1088/1478-3975/11/6/066002 · 2014 · External reference
Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells
2019 · External reference
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells
2013 · External reference
Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium
10.1038/ncb3251 · 2015 · External reference
Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement
10.1091/mbc.e16-10-0733 · 2017 · External reference
Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis
10.1242/jcs.214775 · 2018 · External reference
Computational model for cell morphodynamics
10.1103/physrevlett.105.108104 · 2010 · External reference
Coupling actin flow, adhesion, and morphology in a computational cell motility model
10.1073/pnas.1203252109 · 2012 · External reference
A computational model of amoeboid cell motility in the presence of obstacles
10.1039/c8sm00457a · 2018 · External reference
Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour
10.1371/journal.pbio.1000618 · 2011 · External reference
Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells
10.1371/journal.pone.0201977 · 2018 · External reference
Crawling and turning in a minimal reaction-diffusion cell motility model: coupling cell shape and biochemistry
10.1103/physreve.95.012401 · 2017 · External reference
Influence of myosin activity and mechanical impact on keratocyte polarization
10.1039/d0sm00473a · 2020 · External reference
Tuning cell motility via cell tension with a mechanochemical cell migration model
10.1016/j.bpj.2020.04.030 · 2020 · External reference
A minimal computational model for three-dimensional cell migration
10.1098/rsif.2019.0619 · 2019 · External reference
How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility
2012 · External reference
Mathematical modelling in cell migration: tackling biochemistry in changing geometries
10.1042/bst20190311 · 2020 · External reference
Dynacortin facilitates polarization of chemotaxing cells
10.1186/1741-7007-5-53 · 2007 · External reference
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration
10.1016/j.cell.2011.10.050 · 2012 · External reference
Cell protrusions and contractions generate long-range membrane tension propagation
10.1016/j.cell.2023.05.014 · 2023 · External reference
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration
10.1038/s41556-024-01453-4 · 2024 · External reference
Mutually inhibitory Ras-PI(3,4)P 2 feedback loops mediate cell migration
2018 · External reference
Signaling and actin waves at a glance
10.1242/jcs.263634 · 2025 · External reference
PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration
2024 · External reference
A mechanistic model for eukaryotic gradient sensing: spontaneous and induced phosphoinositide polarization
10.1016/j.jtbi.2004.05.024 · 2004 · External reference
A mass conserved reaction-diffusion system captures properties of cell polarity
10.1371/journal.pcbi.0030108 · 2007 · External reference
Navigating through models of chemotaxis
10.1016/j.ceb.2007.11.011 · 2008 · External reference
Wave-pinning and cell polarity from a bistable reaction-diffusion system
10.1529/biophysj.107.120824 · 2008 · External reference
A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues
10.1371/journal.pcbi.1001121 · 2011 · External reference
Network crosstalk dynamically changes during neutrophil polarization
10.1016/j.cell.2012.03.044 · 2012 · External reference
Mechanisms of cell polarization
10.1016/j.coisb.2017.03.005 · 2017 · External reference
Orientation of chemotactic cells and growth cones: models and mechanisms
10.1242/jcs.112.17.2867 · 1999 · External reference
A dynamic partitioning mechanism polarizes membrane protein distribution
10.1038/s41467-023-43615-2 · 2023 · External reference
Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis
10.1038/ncomms6175 · 2014 · External reference
Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement
10.3389/fcell.2023.1195806 · 2023 · External reference
Actuation of single downstream nodes in growth factor network steers immune cell migration
2023 · External reference
An excitable Ras/PI3K/ERK signaling network controls migration and oncogenic transformation in epithelial cells
10.1016/j.devcel.2020.08.001 · 2020 · External reference
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration
10.1016/j.devcel.2010.03.017 · 2010 · External reference
The chemical Langevin equation
10.1063/1.481811 · 2000 · External reference
Self-organization of the phosphatidylinositol lipids signaling system for random cell migration
10.1073/pnas.0908278107 · 2010 · External reference
Enhanced chemotaxis through spatially regulated absolute concentration robustness
10.1002/rnc.6049 · 2022 · External reference
Modeling cellular deformations using the level set formalism
10.1186/1752-0509-2-68 · 2008 · External reference