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References from Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening. Local targets link to admitted publications; unresolved targets remain external evidence.
The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study
10.1136/annrheumdis-2013-204627 · 2014 · External reference
Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis
10.1016/j.berh.2018.10.005 · 2018 · External reference
Rheumatoid arthritis - common origins, divergent mechanisms
10.1056/nejmra2103726 · 2023 · External reference
Novel treatment strategies in rheumatoid arthritis
10.1016/s0140-6736(17)31491-5 · 2017 · External reference
Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial
10.1136/ard-2023-224476 · 2023 · External reference
A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview
10.1503/cmaj.091391 · 2009 · External reference
Changes in the use patterns of bDMARDs in patients with rheumatic diseases over the past 13 years
10.1038/s41598-021-94504-x · 2021 · External reference
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review
10.1016/j.ejmech.2018.09.027 · 2018 · External reference
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
10.1038/nrcardio.2017.78 · 2017 · External reference
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
10.1093/hmg/ddu328 · 2014 · External reference
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement
10.1001/jama.2021.18236 · 2021 · External reference
FinnGen provides genetic insights from a well-phenotyped isolated population
10.1038/s41586-022-05473-8 · 2023 · External reference
Plasma proteomic associations with genetics and health in the UK Biobank
10.1038/s41586-023-06592-6 · 2023 · External reference
Large-scale integration of the plasma proteome with genetics and disease
10.1038/s41588-021-00978-w · 2021 · External reference
Genetics of rheumatoid arthritis contributes to biology and drug discovery
10.1038/nature12873 · 2014 · External reference
Common genetic associations between age-related diseases
10.1038/s43587-021-00051-5 · 2021 · External reference
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
10.1002/gepi.21965 · 2016 · External reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
10.1093/ije/dyv080 · 2015 · External reference
False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies
10.1016/j.jclinepi.2014.03.012 · 2014 · External reference
Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses
10.1016/j.xcrm.2023.101174 · 2023 · External reference
SRplot: A free online platform for data visualization and graphing
10.1371/journal.pone.0294236 · 2023 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Reflux esophagitis and its role in the pathogenesis of Barrett’s metaplasia
10.1007/s00535-017-1342-1 · 2017 · External reference
Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations
10.1186/s13059-016-0948-6 · 2016 · External reference
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
10.1038/s41467-018-05044-4 · 2018 · External reference
Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs
10.1038/s41598-023-36999-0 · 2023 · External reference
Transcriptome analysis describing new immunity and defense genes in peripheral blood mononuclear cells of rheumatoid arthritis patients
10.1371/journal.pone.0006803 · 2009 · External reference
Heterogeneity of synovial molecular patterns in patients with arthritis
10.1371/journal.pone.0122104 · 2015 · External reference
Disease-Regulated Gene Therapy with Anti-Inflammatory Interleukin-10 Under the Control of the CXCL10 Promoter for the Treatment of Rheumatoid Arthritis
10.1089/hum.2015.127 · 2016 · External reference
CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case-control study
10.1186/s13075-015-0590-9 · 2015 · External reference
Rank-in: enabling integrative analysis across microarray and RNA-seq for cancer
10.1093/nar/gkab554 · 2021 · External reference
pROC: an open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · 2011 · External reference
Basic principles of ROC analysis
10.1016/s0001-2998(78)80014-2 · 1978 · External reference
Use of ROC curves in clinical and experimental studies
2020 · External reference
Novel Linear Peptides with High Affinity to αvβ3 Integrin for Precise Tumor Identification
10.7150/thno.18401 · 2017 · External reference
DSigDB: drug signatures database for gene set analysis
10.1093/bioinformatics/btv313 · 2015 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
PubChem 2023 update
2022 · External reference
RCSB Protein Data Bank (RCSB.org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from artificial intelligence/machine learning
10.1093/nar/gkac1077 · 2023 · External reference
AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences
10.1093/nar/gkad1011 · 2024 · External reference
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
10.1093/nar/gkab1061 · 2022 · External reference
CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting
2022 · External reference
Ligand docking and binding site analysis with PyMOL and Autodock/Vina
10.1007/s10822-010-9352-6 · 2010 · External reference
Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling
10.3389/fphar.2023.1107507 · 2023 · External reference
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers
10.3389/fimmu.2024.1394438 · 2024 · External reference
Molecular basis for the targeted binding of RGD-containing peptide to integrin αVβ3
10.1016/j.biomaterials.2013.10.072 · 2014 · External reference
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
10.1021/ct700301q · 2008 · External reference
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
10.1038/nmeth.4067 · 2017 · External reference
Strain fluctuations and elastic constants
10.1063/1.443248 · 1982 · External reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · 1984 · External reference
L. donovani XPRT: Molecular characterization and evaluation of inhibitors
10.1016/j.bbapap.2017.12.002 · 2018 · External reference
Ubiquitin D promotes the progression of rheumatoid arthritis via activation of the p38 MAPK pathway
10.3892/mmr.2023.12940 · 2023 · External reference
E3 ubiquitin ligase gene BIRC3 modulates TNF-induced cell death pathways and promotes aberrant proliferation in rheumatoid arthritis fibroblast-like synoviocytes
10.3389/fimmu.2024.1433898 · 2024 · External reference
The role of interleukin-17 in the pathogenesis of rheumatoid arthritis
10.1007/s11926-009-0052-y · 2009 · External reference
NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential
10.1007/s12035-024-04634-2 · 2025 · External reference
Regulation of TNF-α with a focus on rheumatoid arthritis
10.1038/icb.2013.15 · 2013 · External reference
FCRL3 gene polymorphisms as risk factors for rheumatoid arthritis
10.1016/j.humimm.2015.12.007 · 2016 · External reference
Fc receptor-like 3 -169 C/T polymorphism and RA susceptibility: a meta-analysis
10.1007/s00296-009-1082-5 · 2010 · External reference
FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians
10.1136/ard.2006.064949 · 2007 · External reference
Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population
10.1002/art.22270 · 2006 · External reference
Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association
10.1210/jc.2006-2183 · 2007 · External reference
Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis
10.1136/ard.2005.048454 · 2006 · External reference
Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis
10.1038/nrrheum.2010.23 · 2010 · External reference
Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
10.1016/j.jaut.2009.02.020 · 2009 · External reference
The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
10.1136/ard.2007.077826 · 2008 · External reference
Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population
10.1038/gene.2011.30 · 2011 · External reference
CD4 and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in patients with untreated early arthritis: implications for causal gene identification
10.1002/art.40393 · 2018 · External reference
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
10.1016/j.it.2009.05.007 · 2009 · External reference
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
10.1038/ng.874 · 2011 · External reference
Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
2022 · External reference
A20 controls RANK-dependent osteoclast formation and bone physiology
10.15252/embr.202255233 · 2022 · External reference
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
10.1038/ng.233 · 2008 · External reference
Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
10.1136/annrheumdis-2011-201225 · 2012 · External reference
Associations between TNFAIP3 Polymorphisms and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Update with Trial Sequential Analysis
2022 · External reference
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
10.1186/s13059-021-02460-6 · 2021 · External reference
Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis
10.1074/jbc.m111.248039 · 2011 · External reference
Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes
10.1186/s40634-017-0081-9 · 2017 · External reference
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
10.1186/s40634-019-0179-3 · 2019 · External reference
Expression of CILP-2 and DDR2 and ultrastructural changes in the articular cartilage of patients with knee osteoarthritis undergoing total knee arthroplasty: a pilot morphological study
10.1007/s00795-022-00339-4 · 2023 · External reference
ERK1/2 activation induced by inflammatory cytokines compromises effective host tissue integration of engineered cartilage
10.1089/ten.tea.2008.0663 · 2009 · External reference
Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons
10.1111/jnc.14571 · 2018 · External reference
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area
10.1016/j.biopsych.2010.07.035 · 2011 · External reference
Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders
10.1093/schbul/sbad100 · 2023 · External reference
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy
10.1016/j.nbd.2023.106324 · 2023 · External reference
Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I
10.1016/j.ymgme.2014.09.012 · 2015 · External reference
EHBP1 SNPs, Their Haplotypes, and Gene-Environment Interactive Effects on Serum Lipid Levels
10.1021/acsomega.9b03522 · 2020 · External reference
SUGP1 is a novel regulator of cholesterol metabolism
2016 · External reference
Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study
10.1186/s12967-023-04474-z · 2023 · External reference
A large-scale genetic correlation scan between rheumatoid arthritis and human plasma protein
10.1302/2046-3758.112.bjr-2021-0270.r1 · 2022 · External reference