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References from Integrated pan-cancer analysis of RNA binding protein HuR investigates its biomarker potential in prognosis, immunotherapy, and drug sensitivity. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Cancer statistics, 2025
2025 · External reference
Global cancer statistics: A healthy population relies on population health
2024 · External reference
Cancer incidence and mortality in China, 2022
2024 · External reference
Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020
10.1097/cm9.0000000000001474 · 2021 · External reference
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms
10.1016/j.molcel.2020.03.011 · 2020 · External reference
The nexus between RNA-binding proteins and their effectors
10.1038/s41576-022-00550-0 · 2023 · External reference
Inhibition of RNA-binding proteins with small molecules
10.1038/s41570-020-0201-4 · 2020 · External reference
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
10.1016/j.semcancer.2022.03.025 · 2022 · External reference
RNA-binding proteins: Underestimated contributors in tumorigenesis
10.1016/j.semcancer.2022.01.010 · 2022 · External reference
Cancer the’RBP’eutics-RNA-binding proteins as therapeutic targets for cancer
10.1016/j.pharmthera.2019.07.001 · 2019 · External reference
RNA-binding proteins in tumor progression
10.1186/s13045-020-00927-w · 2020 · External reference
RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis
10.1038/s41392-022-01033-8 · 2022 · External reference
RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing
10.1038/s41467-023-44126-w · 2023 · External reference
Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway
10.1038/s41388-023-02687-6 · 2023 · External reference
Targeting the RNA-Binding Protein HuR in Cancer
10.1158/0008-5472.can-23-0972 · 2023 · External reference
Understanding and targeting the disease-related RNA binding protein human antigen R (HuR)
10.1002/wrna.1581 · 2020 · External reference
Human antigen R regulates autophagic flux by stabilizing autophagy-associated mRNA in calcific aortic valve disease
10.1093/cvr/cvad077 · 2023 · External reference
MicroRNA exporter HuR clears the internalized pathogens by promoting pro-inflammatory response in infected macrophages
10.15252/emmm.201911011 · 2020 · External reference
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis
10.1158/0008-5472.can-15-1726 · 2017 · External reference
Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN
10.1038/s41419-021-03514-0 · 2021 · External reference
Emerging role of HuR in inflammatory response in kidney diseases
10.1093/abbs/gmx071 · 2017 · External reference
Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis
10.1186/s12967-023-04298-x · 2023 · External reference
10.1038/s41467-024-49874-x
10.1038/s41467-024-49874-x · 2024 · External reference
HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer
10.1038/s41388-021-01689-6 · 2021 · External reference
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma
10.1515/jtim-2025-0009 · 2025 · External reference
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis
10.1172/jci130379 · 2020 · External reference
The RNA-binding protein HuR in human cancer: A friend or foe?
10.1016/j.addr.2022.114179 · 2022 · External reference
Drug delivery approaches for HuR-targeted therapy for lung cancer
10.1016/j.addr.2021.114068 · 2022 · External reference
The genotype-tissue expression (GTEx) project
10.1038/ng.2653 · 2013 · External reference
ggplot2: Elegant Graphics for Data Analysis
10.1111/j.1467-985x.2010.00676_9.x · 2011 · External reference
Quantitative Proteomics of the Cancer Cell Line Encyclopedia
10.1016/j.cell.2019.12.023 · 2020 · External reference
UCSCXenaShiny: an R/CRAN package for interactive analysis of UCSC Xena data
10.1093/bioinformatics/btab561 · 2022 · External reference
Unresolved reference
2016 · External reference
pROC: an open-source package for R and S+ to analyze and compare ROC curves
10.1186/1471-2105-12-77 · 2011 · External reference
Current treatment and recent progress in gastric cancer
2021 · External reference
Unresolved reference
2016 · External reference
Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer
10.3389/fimmu.2022.827921 · 2022 · External reference
Unresolved reference
2016 · External reference
Inferring tumour purity and stromal and immune cell admixture from expression data
10.1038/ncomms3612 · 2013 · External reference
Unresolved reference
2017 · External reference
Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis
10.3389/fimmu.2022.1008146 · 2022 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Unresolved reference
2015 · External reference
Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression
10.1186/s13059-016-1070-5 · 2016 · External reference
Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis
10.1186/s12943-023-01752-8 · 2023 · External reference
Make interactive complex heatmaps in R
2021 · External reference
Perturbation-response genes reveal signaling footprints in cancer gene expression
10.1038/s41467-017-02391-6 · 2018 · External reference
Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors
10.1158/2159-8290.cd-20-0522 · 2020 · External reference
PD-L1 degradation pathway and immunotherapy for cancer
10.1038/s41419-020-03140-2 · 2020 · External reference
Regulatory mechanisms of PD-1/PD-L1 in cancers
10.1186/s12943-024-02023-w · 2024 · External reference
The tumor microenvironment innately modulates cancer progression
10.1158/0008-5472.can-18-3962 · 2019 · External reference
RNA-binding proteins in human genetic disease
10.1038/s41576-020-00302-y · 2021 · External reference
A brave new world of RNA-binding proteins
10.1038/nrm.2017.130 · 2018 · External reference
Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia
10.1016/j.ccell.2019.01.010 · 2019 · External reference
A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy
10.1016/j.ebiom.2020.103074 · 2020 · External reference
A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
10.1186/s12929-023-00915-5 · 2023 · External reference
Oncogenic and immunological values of RBM34 in osteosarcoma and its pan-cancer analysis
2023 · External reference
Comprehensive pan-cancer analysis identifies the RNA-binding protein LRPPRC as a novel prognostic and immune biomarker
10.1016/j.lfs.2024.122527 · 2024 · External reference
HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells
10.1158/1541-7786.mcr-15-0448 · 2016 · External reference
The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
10.1186/s12943-017-0751-3 · 2018 · External reference
Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration
10.1186/s12951-016-0201-1 · 2016 · External reference
Prognostic role of HuR in hereditary breast cancer
10.1158/1078-0432.ccr-07-1432 · 2007 · External reference
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation
10.1186/s12943-020-01208-3 · 2020 · External reference
Complex HuR function in pancreatic cancer cells
10.1002/wrna.1469 · 2018 · External reference
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis
10.1186/s13062-023-00397-3 · 2023 · External reference
Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
10.1016/j.celrep.2023.112419 · 2023 · External reference
TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis
10.1038/s41418-021-00925-6 · 2022 · External reference
Post-transcriptional Regulation of Immunological Responses through Riboclustering
10.3389/fimmu.2016.00161 · 2016 · External reference
Control of RNA Stability in Immunity
10.1146/annurev-immunol-101819-075147 · 2021 · External reference
Roles of RNA-binding proteins in immune diseases and cancer
10.1016/j.semcancer.2022.03.017 · 2022 · External reference
RNA-binding proteins regulate the expression of the immune activating ligand MICB
10.1038/ncomms5186 · 2014 · External reference
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA
10.1016/j.apsb.2023.04.002 · 2023 · External reference
TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR
10.1007/s11427-021-2085-9 · 2022 · External reference
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
10.1038/s41419-022-05164-2 · 2022 · External reference
RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA
10.1074/jbc.ra120.014894 · 2021 · External reference
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression
10.1083/jcb.202305026 · 2024 · External reference
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
10.1172/jci45021 · 2012 · External reference
RNA-binding proteins in cancer drug discovery
10.1016/j.drudis.2023.103580 · 2023 · External reference
Targeting the “undruggable”: RNA-binding proteins in the spotlight in cancer therapy
10.1016/j.semcancer.2022.06.008 · 2022 · External reference
Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis
10.1093/nar/gkac139 · 2022 · External reference
Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28
10.1186/s12885-023-11791-5 · 2024 · External reference
The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6
10.1158/1535-7163.mct-18-0945 · 2019 · External reference
Translational control of TOP2A influences doxorubicin efficacy
10.1128/mcb.05639-11 · 2011 · External reference
MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
10.1093/nar/gky696 · 2018 · External reference
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer
10.1093/nar/gky214 · 2018 · External reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · 2020 · External reference
The Cancer Genome Atlas Pan-Cancer analysis project
10.1038/ng.2764 · 2013 · External reference
Next-generation characterization of the Cancer Cell Line Encyclopedia
10.1038/s41586-019-1186-3 · 2019 · External reference
The GTEx Consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
