Research graph
References from Transcriptome-wide root causal inference. Local targets link to admitted publications; unresolved targets remain external evidence.
Discovering root causal genes with high throughput perturbations
2025 · External reference
An expanded view of complex traits: from polygenic to omnigenic
10.1016/j.cell.2017.05.038 · 2017 · External reference
A compendium of mutational cancer driver genes
10.1038/s41568-020-0290-x · 2020 · External reference
Genomic analysis of the hierarchical structure of regulatory networks
10.1073/pnas.0508637103 · 2006 · External reference
Mitigating pathogenesis for target discovery and disease subtyping
10.1016/j.compbiomed.2024.108122 · 2024 · External reference
Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens
10.1016/j.cell.2016.11.038 · 2016 · External reference
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
10.1016/j.cell.2022.05.013 · 2022 · External reference
Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine
10.1186/gm524 · 2014 · External reference
A gene-based association method for mapping traits using reference transcriptome data
10.1038/ng.3367 · 2015 · External reference
Mendelian randomization
10.1038/s43586-021-00092-5 · 2022 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Quantifying genetic effects on disease mediated by assayed gene expression levels
10.1038/s41588-020-0625-2 · 2020 · External reference
Probabilistic fine-mapping of transcriptome-wide association studies
10.1038/s41588-019-0367-1 · 2019 · External reference
An introduction to instrumental variable assumptions, validation and estimation
10.1186/s12982-018-0069-7 · 2018 · External reference
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
10.1038/s41588-018-0081-4 · 2018 · External reference
The GTEx Consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
A new liver expression quantitative trait locus map from 1,183 individuals provides evidence for novel expression quantitative trait loci of drug response, metabolic, and sex-biased phenotypes
10.1002/cpt.1751 · 2020 · External reference
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
10.1016/j.ajhg.2024.07.017 · 2024 · External reference
Drug-induced regulation of target expression
10.1371/journal.pcbi.1000925 · 2010 · External reference
Sequencing technologies - the next generation
10.1038/nrg2626 · 2010 · External reference
Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits
10.1038/s41588-023-01648-9 · 2024 · External reference
Genetics of global gene expression
10.1038/nrg1964 · 2006 · External reference
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
10.1371/journal.pgen.1004383 · 2014 · External reference
A simple new approach to variable selection in regression, with application to genetic fine mapping
10.1111/rssb.12388 · 2020 · External reference
A two-stage penalized least squares method for constructing large systems of structural equations
2018 · External reference
SIGNET: transcriptome-wide causal inference for gene regulatory networks
10.1038/s41598-023-46295-6 · 2023 · External reference
10.1145/3535508.3545553
10.1145/3535508.3545553 · External reference
Identifying patient-specific root causes with the heteroscedastic noise model
10.1016/j.jocs.2023.102099 · 2023 · External reference
10.7551/mitpress/1754.001.0001
10.7551/mitpress/1754.001.0001 · External reference
Applying causal discovery to single-cell analyses using CausalCell
2023 · External reference
10.1201/9781315139470
10.1201/9781315139470 · External reference
A cross-population atlas of genetic associations for 220 human phenotypes
10.1038/s41588-021-00931-x · 2021 · External reference
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease
10.1016/j.jaci.2016.05.011 · 2016 · External reference
A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis
10.1038/s41588-020-0706-2 · 2020 · External reference
COPD immunopathology
10.1007/s00281-016-0561-5 · 2016 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
2020 · External reference
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
10.1038/s41588-021-00913-z · 2021 · External reference
The role of innate and adaptive immune cells in the immunopathogenesis of chronic obstructive pulmonary disease
10.4046/trd.2016.79.1.5 · 2016 · External reference
Complement and the regulation of T cell responses
10.1146/annurev-immunol-042617-053245 · 2018 · External reference
The complement cascade in lung injury and disease
10.1186/s12931-023-02657-2 · 2024 · External reference
Association between psoriasis and chronic obstructive pulmonary disease: a systematic review and meta-analysis
2015 · External reference
Umap: uniform manifold approximation and projection for dimension reduction
2018 · External reference
Hierarchical grouping to optimize an objective function
10.1080/01621459.1963.10500845 · 1963 · External reference
The MRC IEU OpenGWAS data infrastructure
2020 · External reference
Ischemic heart disease: an update
10.1053/j.semnuclmed.2020.02.007 · 2020 · External reference
The UK Biobank resource with deep phenotyping and genomic data
10.1038/s41586-018-0579-z · 2018 · External reference
KEGG: new perspectives on genomes, pathways, diseases and drugs
10.1093/nar/gkw1092 · 2017 · External reference
The role of oxidative stress in atherosclerosis
10.3390/cells11233843 · 2022 · External reference
Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components
10.1046/j.1432-1033.2002.03226.x · 2002 · External reference
T cell subsets and functions in atherosclerosis
10.1038/s41569-020-0352-5 · 2020 · External reference
CRISPR knockout screen implicates three genes in lysosome function
10.1038/s41598-019-45939-w · 2019 · External reference
Systematic differences in discovery of genetic effects on gene expression and complex traits
10.1038/s41588-023-01529-1 · 2023 · External reference
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
10.1038/s41467-021-25805-y · 2021 · External reference
An integrative genomics approach to infer causal associations between gene expression and disease
10.1038/ng1589 · 2005 · External reference
Foundations of structural causal models with cycles and latent variables
10.1214/21-aos2064 · 2021 · External reference
Causal discovery with a mixture of DAGs
10.1007/s10994-022-06159-y · 2022 · External reference
Promoter-sharing by different genes in human genome–CPNE1 and RBM12 gene pair as an example
10.1186/1471-2164-9-456 · 2008 · External reference
Independence properties of directed markov fields
10.1002/net.3230200503 · 1990 · External reference
Topological domains in mammalian genomes identified by analysis of chromatin interactions
10.1038/nature11082 · 2012 · External reference
Super-enhancers in the control of cell identity and disease
10.1016/j.cell.2013.09.053 · 2013 · External reference
Comparison and evaluation of statistical error models for scRNA-seq
10.1186/s13059-021-02584-9 · 2022 · External reference
Separating measurement and expression models clarifies confusion in single-cell RNA sequencing analysis
10.1038/s41588-021-00873-4 · 2021 · External reference
The standard deviation of the correlation coefficient
10.1080/01621459.1928.10502991 · 1928 · External reference
Cross-validatory choice and assessment of statistical predictions
10.1111/j.2517-6161.1974.tb00994.x · 1974 · External reference
The positive false discovery rate: a Bayesian interpretation and the q-value
10.1214/aos/1074290335 · 2003 · External reference
Ridge regression revisited: debiasing, thresholding and bootstrap
10.1214/21-aos2156 · 2022 · External reference
Order-independent constraint-based causal structure learning
2014 · External reference
10.1017/cbo9780511801389
10.1017/cbo9780511801389 · External reference
Approximate Kernel-based conditional independence tests for fast non-parametric causal discovery
10.1515/jci-2018-0017 · 2018 · External reference
A linear non-Gaussian acyclic model for causal discovery
2006 · External reference
Nonlinear causal discovery with additive noise models
2008 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
Systematic identification of trans eQTLs as putative drivers of known disease associations
10.1038/ng.2756 · 2013 · External reference
Comparison of the predicted and observed secondary structure of T4 phage lysozyme
10.1016/0005-2795(75)90109-9 · 1975 · External reference
Searching for Bayesian network structures in the space of restricted acyclic partially directed graphs
10.1613/jair.1061 · 2003 · External reference
