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References from A computational framework for the investigation of phosphoinositide regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Phosphoinositides: tiny lipids with giant impact on cell regulation
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Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell
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A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation
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Modeling and analysis of the molecular basis of pain in sensory neurons
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A mathematical modelling framework for understanding chemorepulsive signal transduction in Dictyostelium
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Targeted phosphoinositides analysis using high-performance ion chromatography-coupled selected reaction monitoring mass spectrometry
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A mathematical model of the phosphoinositide pathway
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Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells
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Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling
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Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling
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Evidence of sinks and sources in the phospholipase C-activated PIP2 cycle
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A model of the PI cycle reveals the regulating roles of lipid-binding proteins and pitfalls of using mosaic biological data
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Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach
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Regulation of platelet plug formation by phosphoinositide metabolism
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Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation
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Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor
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A new approach to measuring phosphoinositides in cells by mass spectrometry
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Imaging of Intracellular and Plasma Membrane Pools of PI(4,5)P2 and PI4P in Human Platelets
2021 · External reference
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation
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The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor γ-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
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GPVI and integrin alphaIIb beta3 signaling in platelets
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Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay
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A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples
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SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels
10.1042/bj20030581 · 2003 · External reference
Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
10.1182/blood-2008-11-188516 · 2009 · External reference
Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42
10.1074/jbc.m312737200 · 2004 · External reference
Phosphoinositides in cell regulation and membrane dynamics
10.1038/nature05185 · 2006 · External reference
Phosphoinositides as membrane organizers
10.1038/s41580-022-00490-x · 2022 · External reference
Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis
10.1038/s41467-017-01181-4 · 2017 · External reference
Membrane recognition by phospholipid-binding domains
10.1038/nrm2328 · 2008 · External reference
Move along, nothing to see here: Btk inhibitors stop platelets sticking to plaques
10.1111/jth.14201 · 2018 · External reference
Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane
10.1073/pnas.1819301116 · 2019 · External reference
Plasma membrane phosphoinositide organization by protein electrostatics
10.1038/nature04398 · 2005 · External reference
MARCKS mediates vascular contractility through regulating interactions between voltage-gated Ca2+ channels and PIP2
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Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites
10.1016/j.cell.2010.12.034 · 2011 · External reference
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10.1016/s0021-9258(18)45672-4 · 1990 · External reference
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase
10.1042/bj2840039 · 1992 · External reference
Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
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Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome
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Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets
10.1042/bj2260831 · 1985 · External reference
Comparison of Akaike information criterion and consistent Akaike information criterion for model selection and statistical inference from capture-recapture studies
10.1080/02664769823250 · 1998 · External reference
Orai1-induced store-operated Ca2+ entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets
10.1111/jth.12525 · 2014 · External reference
Essential role of class II PI3K-C2α in platelet membrane morphology
10.1182/blood-2015-03-636670 · 2015 · External reference
Beyond PI3Ks: targeting phosphoinositide kinases in disease
10.1038/s41573-022-00582-5 · 2023 · External reference
Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4, 5-bisphosphate levels
10.1074/jbc.m113.531426 · 2014 · External reference
Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes
10.1042/bj2180785 · 1984 · External reference
Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function
10.1016/0143-4160(82)90031-8 · 1982 · External reference
Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells
10.1085/jgp.202113074 · 2022 · External reference