Research graph
References from AI-driven discovery of novel extracellular matrix biomarkers in pelvic organ prolapse. Local targets link to admitted publications; unresolved targets remain external evidence.
Artificial intelligence in early drug discovery enabling precision medicine
10.1080/17460441.2021.1918096 · 2021 · External reference
Applications of machine learning in human microbiome studies: a review on feature selection, biomarker identification, disease prediction and treatment
10.3389/fmicb.2021.634511 · 2021 · External reference
Bioinformatics applications in chronic diseases: A comprehensive review of genomic, transcriptomics, proteomic, metabolomics, and machine learning approaches
2024 · External reference
Identification of novel diagnostic and prognostic gene signature biomarkers for breast cancer using artificial intelligence and machine learning assisted transcriptomics analysis
10.3390/cancers15123237 · 2023 · External reference
Multimodal AI/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases
10.1038/s41598-024-78553-6 · 2024 · External reference
Advancements in artificial intelligence and machine learning in revolutionising biomarker discovery
2023 · External reference
Evolutionary-scale prediction of atomic-level protein structure with a language model
10.1126/science.ade2574 · 2023 · External reference
Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences
10.1073/pnas.2016239118 · 2021 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Pelvic organ prolapse and sexual function
10.1038/s41585-020-0334-8 · 2020 · External reference
Pelvic organ prolapse
10.1016/j.gtc.2021.10.011 · 2022 · External reference
Molecular landscape of pelvic organ prolapse provides insights into disease etiology
10.3390/ijms24076087 · 2023 · External reference
Advances in molecular mechanisms of pelvic organ prolapse (review)
10.3892/etm.2021.10442 · 2021 · External reference
Role of fibroblasts and myofibroblasts on the pathogenesis and treatment of pelvic organ prolapse
10.3390/biom12010094 · 2022 · External reference
A guide to the composition and functions of the extracellular matrix
10.1111/febs.15776 · 2021 · External reference
The difference in extracellular matrix metabolism in women with and without pelvic organ prolapse: a systematic review and meta-analysis
10.1111/1471-0528.17768 · 2024 · External reference
Oxidative stress: a possible trigger for pelvic organ prolapse
10.1155/2020/3791934 · 2020 · External reference
Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice
10.18632/aging.203777 · 2021 · External reference
Ten years of extracellular matrix proteomics: accomplishments, challenges, and future perspectives
10.1016/j.mcpro.2023.100528 · 2023 · External reference
Unresolved reference
External reference
Tissue composition of the vaginal wall in women with pelvic organ prolapse
10.1159/000341709 · 2013 · External reference
Collagen changes in pelvic support tissues in women with pelvic organ prolapse
10.1016/j.ejogrb.2019.01.012 · 2019 · External reference
Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles
10.1016/j.ajog.2016.02.018 · 2016 · External reference
Machine learning-guided protein engineering
10.1021/acscatal.3c02743 · 2023 · External reference
10.4018/979-8-3693-3192-7.ch005
10.4018/979-8-3693-3192-7.ch005 · External reference
Unresolved reference
2025 · External reference
The historical evolution and significance of multiple sequence alignment in molecular structure and function prediction
10.3390/biom14121531 · 2024 · External reference
Fine-tuning protein language models boosts predictions across diverse tasks
2023 · External reference
Improving protein function prediction by learning and integrating representations of protein sequences and function labels
2024 · External reference
UniProt: the universal protein knowledgebase in 2025
2025 · External reference
The Gene Ontology (GO) database and informatics resource
2004 · External reference
SignalP 6.0 predicts all five types of signal peptides using protein language models
10.1038/s41587-021-01156-3 · 2022 · External reference
DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks
2022 · External reference
CD-HIT: accelerated for clustering the next-generation sequencing data
10.1093/bioinformatics/bts565 · 2012 · External reference
The PRIDE database resources in 2022 : a hub for mass spectrometry-based proteomics evidences
10.1093/nar/gkab1038 · 2022 · External reference
MaxQuant software for ion mobility enhanced shotgun proteomics
10.1074/mcp.tir119.001720 · 2020 · External reference
Decoupled weight decay regularization
2017 · External reference
Crystal and molecular structure of a collagen-like peptide at 1.9 A resolution
10.1126/science.7695699 · 1994 · External reference
Collagen structure and stability
10.1146/annurev.biochem.77.032207.120833 · 2009 · External reference
Gly-X-Y tripeptide frequencies in collagen: a context for host-guest triple-helical peptides
10.1006/jsbi.1998.3977 · 1998 · External reference
Triple-helical peptides: an approach to collagen conformation, stability, and self-association
10.1002/bip.20958 · 2008 · External reference
Mutations in collagen genes: causes of rare and some common diseases in humans
10.1096/fasebj.5.7.2010058 · 1991 · External reference
Microfibrillar structure of type I collagen in situ
10.1073/pnas.0502718103 · 2006 · External reference
Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse
10.1177/1933719113512529 · 2014 · External reference
Unresolved reference
2018 · External reference
The influence of animal species, gender and tissue on the structural, biophysical, biochemical and biological properties of collagen sponges
10.1007/s10856-020-06485-4 · 2021 · External reference
The mechanics of fibrillar collagen extracellular matrix
10.1016/j.xcrp.2021.100515 · 2021 · External reference
Unresolved reference
2002 · External reference
Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases
10.1016/j.gene.2019.05.003 · 2019 · External reference
Collagen fibril formation in vitro: from origin to opportunities
10.1016/j.mtbio.2022.100322 · 2022 · External reference
Language models enable zero-shot prediction of the effects of mutations on protein function
2021 · External reference
Cellular and molecular mechanisms of fibrosis
10.1002/path.2277 · 2008 · External reference
The pathogenesis of cardiac fibrosis
10.1007/s00018-013-1349-6 · 2014 · External reference
The extracellular matrix modulates the hallmarks of cancer
10.15252/embr.201439246 · 2014 · External reference
KEGG: biological systems database as a model of the real world
10.1093/nar/gkae909 · 2025 · External reference
The reactome pathway knowledgebase 2024
10.1093/nar/gkad1025 · 2024 · External reference
Gene set knowledge discovery with enrichr
2021 · External reference
Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse
10.1038/s41467-020-20358-y · 2021 · External reference
Changes of glycoprotein and collagen immunolocalization in the uterine artery wall of postmenopausal women with and without pelvic organ prolapse
10.1016/j.acthis.2010.02.001 · 2011 · External reference
Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro
10.1096/fj.09-140491 · 2010 · External reference
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse
10.4252/wjsc.v8.i5.202 · 2016 · External reference
Identification of potential drug targets for pelvic organ prolapse using a proteome-wide Mendelian randomization approach
10.1038/s41598-025-92800-4 · 2025 · External reference
Proteomics of uterosacral ligament connective tissue from women with and without pelvic organ prolapse
2019 · External reference
Effects of collagen unwinding and cleavage on the mechanical integrity of the collagen network in bone
2002 · External reference
The effects of mechanical stability on the macromolecules of the connective tissue matrices produced during fracture healing. I. The collagens
10.1007/bf01676235 · 1986 · External reference
Regulation of Collagen I and Collagen III in tissue injury and regeneration
10.26502/fccm.92920302 · 2023 · External reference
Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair
10.1007/s12079-009-0057-3 · 2009 · External reference
Mast cell proteases: multifaceted regulators of inflammatory disease
10.1182/blood-2010-01-257287 · 2010 · External reference
Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells
10.1016/j.jaci.2022.05.028 · 2022 · External reference
Extracellular superoxide dismutase deficiency impairs wound healing in advanced age by reducing neovascularization and fibroblast function
10.1111/exd.12909 · 2016 · External reference
Rab GTPases: switching to human diseases
10.3390/cells8080909 · 2019 · External reference
Rab GTPases: central coordinators of membrane trafficking in cancer
10.3389/fcell.2021.648384 · 2021 · External reference
MatrisomeDB: the ECM-protein knowledge database
10.1093/nar/gkz849 · 2020 · External reference
Overview of the matrisome–an inventory of extracellular matrix constituents and functions
10.1101/cshperspect.a004903 · 2012 · External reference
Cell adhesion molecules as modulators of the epidermal growth factor receptor
10.3390/cells13221919 · 2024 · External reference
Guanylyl cyclase C signaling axis and colon cancer prevention
10.3748/wjg.v22.i36.8070 · 2016 · External reference
Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy
10.1016/j.fmre.2022.07.004 · 2022 · External reference
The dystrophin node as integrator of cytoskeletal organization, lateral force transmission, fiber stability and cellular signaling in skeletal muscle
10.3390/proteomes9010009 · 2021 · External reference
The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition
10.1016/j.ebiom.2022.103991 · 2022 · External reference
Role of transglutaminase 2 in cell death, survival, and fibrosis
10.3390/cells10071842 · 2021 · External reference
The design of a quantitative western blot experiment
10.1155/2014/361590 · 2014 · External reference
Fibroblasts in mechanically stressed collagen lattices assume a “synthetic” phenotype
10.1074/jbc.m101602200 · 2001 · External reference
