Research graph
References from Elucidating reaction dynamics in a model of human brain energy metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolic costs and evolutionary implications of human brain development
10.1073/pnas.1323099111 · 2014 · External reference
Synaptic energy use and supply
10.1016/j.neuron.2012.08.019 · 2012 · External reference
The expensive-tissue hypothesis: the brain and the digestive system in human and primate evolution
10.1086/204350 · 1995 · External reference
Energetics and the evolution of human brain size
10.1038/nature10629 · 2011 · External reference
Extraneous factors in judicial decisions
10.1073/pnas.1018033108 · 2011 · External reference
Metabolic constraint imposes tradeoff between body size and number of brain neurons in human evolution
10.1073/pnas.1206390109 · 2012 · External reference
Attention and capacity limits in perception: a cellular metabolism account
10.1523/jneurosci.2368-19.2020 · 2020 · External reference
Energy-efficient information transfer by visual pathway synapses
10.1016/j.cub.2015.10.063 · 2015 · External reference
10.1109/iedm.2017.8268370
10.1109/iedm.2017.8268370 · External reference
Energy-efficient information transfer at thalamocortical synapses
10.1371/journal.pcbi.1007226 · 2019 · External reference
Local design principles at hippocampal synapses revealed by an energy-information trade-off
10.1523/eneuro.0521-19.2020 · 2020 · External reference
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
10.1038/ncb1881 · 2009 · External reference
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
10.1073/pnas.91.22.10625 · 1994 · External reference
Lactate is a preferential oxidative energy substrate over glucose for neurons in culture
10.1097/01.wcb.0000091761.61714.25 · 2003 · External reference
Comment on recent modeling studies of astrocyte-neuron metabolic interactions
10.1038/jcbfm.2010.132 · 2010 · External reference
In vivo evidence for a lactate gradient from astrocytes to neurons
10.1016/j.cmet.2015.10.010 · 2016 · External reference
Lactate in the brain: from metabolic end-product to signalling molecule
10.1038/nrn.2018.19 · 2018 · External reference
AMPK-regulated astrocytic lactate shuttle plays a non-cell-autonomous role in neuronal survival
10.1016/j.celrep.2020.108092 · 2020 · External reference
Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity
10.1073/pnas.1702739114 · 2017 · External reference
Astrocyte-neuron lactate transport is required for long-term memory formation
10.1016/j.cell.2011.02.018 · 2011 · External reference
Lactate produced by glycogenolysis in astrocytes regulates memory processing
10.1371/journal.pone.0028427 · 2011 · External reference
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
10.1073/pnas.1322912111 · 2014 · External reference
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
10.1126/science.1096485 · 2004 · External reference
A process for digitizing and simulating biologically realistic oligocellular networks demonstrated for the neuro-glio-vascular ensemble
2018 · External reference
Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble
10.1371/journal.pcbi.1004036 · 2015 · External reference
Modeling the contribution of neuron-astrocyte cross talk to slow blood oxygenation level-dependent signal oscillations
10.1152/jn.00416.2011 · 2011 · External reference
Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism
10.1038/sj.jcbfm.9600144 · 2005 · External reference
A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
10.1073/pnas.0605864104 · 2007 · External reference
A spatially distributed model of brain metabolism highlights the role of diffusion in brain energy metabolism
10.1016/j.jtbi.2023.111567 · 2023 · External reference
Understanding complex chemical kinetics with computational singular perturbation. In:
1989 · External reference
Asymptotic solution of stiff PDEs with the CSP method: the reaction diffusion equation
10.1137/s1064827596303995 · 1998 · External reference
CSP analysis of a transient flame-vortex interaction: time scales and manifolds
10.1016/s0010-2180(03)00067-1 · 2003 · External reference
Model reduction and physical understanding of slowly oscillating processes: the circadian cycle
10.1137/060649768 · 2006 · External reference
A new Michaelis-Menten equation valid everywhere multi-scale dynamics prevails
10.1016/j.mbs.2019.108220 · 2019 · External reference
Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
10.1007/s11538-016-0176-y · 2016 · External reference
The use of CO2 as an additive for ignition delay and pollutant control in CH4/air autoignition
10.1016/j.fuel.2017.09.022 · 2018 · External reference
Computational singular perturbation analysis of brain lactate metabolism
10.1371/journal.pone.0226094 · 2019 · External reference
Nonoxidative glucose consumption during focal physiologic neural activity
10.1126/science.3260686 · 1988 · External reference
Quasi steady state and partial equilibrium approximations: their relation and their validity
10.1080/13647830.2012.680502 · 2012 · External reference
A note on the kinetics of enzyme action
10.1042/bj0190338 · 1925 · External reference
Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex
10.1038/sj.jcbfm.9600401 · 2007 · External reference
A universal model for spike-frequency adaptation
10.1162/089976603322385063 · 2003 · External reference
10.1007/978-0-387-30411-3_14
10.1007/978-0-387-30411-3_14 · 2007 · External reference
Deciphering neuron-glia compartmentalization in cortical energy metabolism
10.3389/neuro.14.004.2009 · 2009 · External reference
Non-signalling energy use in the developing rat brain
10.1177/0271678x16648710 · 2017 · External reference
Lactate supply overtakes glucose when neural computational and cognitive loads scale up
10.1073/pnas.2212004119 · 2022 · External reference
Putting big data to good use in neuroscience
10.1038/nn.3839 · 2014 · External reference
Neurophysiological investigation of the basis of the fMRI signal
10.1038/35084005 · 2001 · External reference
[18F]FDG PET signal is driven by astroglial glutamate transport
10.1038/nn.4492 · 2017 · External reference
Creatine phosphate: pharmacological and clinical perspectives
10.1007/s12325-011-0091-4 · 2012 · External reference
The creatine kinase/creatine connection to Alzheimer’s disease: CK-inactivation, APP-CK complexes and focal creatine deposits
2006 · External reference
(Phospho)creatine: the reserve and merry-go-round of brain energetics
10.4103/1673-5374.346470 · 2023 · External reference
A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain
10.1113/jphysiol.2003.055053 · 2004 · External reference
Lactate supply overtakes glucose when neural computational and cognitive loads scale up
10.1073/pnas.2212004119 · 2022 · External reference
Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity
10.7554/elife.71424 · 2021 · External reference
Blood lactate is an important energy source for the human brain
10.1038/jcbfm.2009.35 · 2009 · External reference
Seizure and redox rescue in a model of glucose transport deficiency
10.1371/journal.pcbi.1012959 · 2025 · External reference
Breakdown and repair of metabolism in the aging brain
10.3389/fsci.2025.1441297 · 2025 · External reference
In vivo evidence for lactate as a neuronal energy source
10.1523/jneurosci.0415-11.2011 · 2011 · External reference
Astrocyte-neuron lactate transport is required for long-term memory formation
10.1016/j.cell.2011.02.018 · 2011 · External reference
A thermodynamic function of glycogen in brain and muscle
10.1016/j.pneurobio.2020.101787 · 2020 · External reference
10.1007/bfb0035372
10.1007/bfb0035372 · External reference
The CSP method for simplifying kinetics
10.1002/kin.550260408 · 1994 · External reference
Fast and slow dynamics for the computational singular perturbation method
10.1137/040603577 · 2004 · External reference
Geometry of the Computational Singular Perturbation Method
10.1051/mmnp/201510303 · 2015 · External reference
Ignition delay control of DME/air and EtOH/air homogeneous autoignition with the use of various additives
10.1016/j.fuel.2015.11.081 · 2016 · External reference
Nitrogen chemistry controlling steps in methane-air premixed flames
2005 · External reference
H2/air autoignition: the nature and interaction of the developing explosive modes
10.1080/13647830.2015.1027273 · 2015 · External reference
10.1016/s0082-0784(06)80018-4
10.1016/s0082-0784(06)80018-4 · External reference
Post-stimulus response in hemodynamics observed by functional magnetic resonance imaging–difference between the primary sensorimotor area and the supplementary motor area
10.1016/s0730-725x(00)00217-4 · 2000 · External reference
Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients
10.1016/j.neuroimage.2003.08.040 · 2004 · External reference
The aerobic brain: lactate decrease at the onset of neural activity
10.1016/s0306-4522(02)00792-3 · 2003 · External reference
