Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from A multi-layer encoder prediction model for individual sample specific gene combination effect (MLEC-iGeneCombo). Local targets link to admitted publications; unresolved targets remain external evidence.
A Highly Specific Complementary Lethal System in Drosophila Melanogaster
10.1093/genetics/41.1.118 · 1956 · External reference
Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster
10.1093/genetics/59.1.37 · 1968 · External reference
Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome
10.1016/j.celrep.2021.109597 · 2021 · External reference
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings
10.1016/j.molonc.2011.07.001 · 2011 · External reference
Synthetic lethal gene pairs: Experimental approaches and predictive models
10.3389/fgene.2022.961611 · 2022 · External reference
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
10.1073/pnas.1517883113 · 2016 · External reference
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
10.1038/nbt.3834 · 2017 · External reference
Mapping the Genetic Landscape of Human Cells
10.1016/j.cell.2018.06.010 · 2018 · External reference
Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice
10.1007/s11427-017-9008-8 · 2017 · External reference
CRISPR/dCas9-mediated multiplex gene repression in Streptomyces
10.1002/biot.201800121 · 2018 · External reference
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
10.1038/s41588-021-00967-z · 2021 · External reference
Combinatorial CRISPR screen identifies fitness effects of gene paralogues
10.1038/s41467-021-21478-9 · 2021 · External reference
Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs
10.1016/j.xpro.2022.101556 · 2022 · External reference
Minimized combinatorial CRISPR screens identify genetic interactions in autophagy
10.1093/nar/gkab309 · 2021 · External reference
GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens
10.1186/s13059-019-1745-9 · 2019 · External reference
SLKB: synthetic lethality knowledge base
10.1093/nar/gkad806 · 2024 · External reference
SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets
2016 · External reference
SynLethDB 2.0: a web-based knowledge graph database on synthetic lethality for novel anticancer drug discovery
10.1093/database/baac030 · 2022 · External reference
Unresolved reference
External reference
Dual-dropout graph convolutional network for predicting synthetic lethality in human cancers
10.1093/bioinformatics/btaa211 · 2020 · External reference
Graph contextualized attention network for predicting synthetic lethality in human cancers
10.1093/bioinformatics/btab110 · 2021 · External reference
KG4SL: knowledge graph neural network for synthetic lethality prediction in human cancers
10.1093/bioinformatics/btab271 · 2021 · External reference
PiLSL: pairwise interaction learning-based graph neural network for synthetic lethality prediction in human cancers
2022 · External reference
Multi-view graph convolutional network for cancer cell-specific synthetic lethality prediction
10.3389/fgene.2022.1103092 · 2023 · External reference
Synthetic lethal connectivity and graph transformer improve synthetic lethality prediction
2024 · External reference
Next-generation characterization of the Cancer Cell Line Encyclopedia
10.1038/s41586-019-1186-3 · 2019 · External reference
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
10.1038/ng.3984 · 2017 · External reference
BioGRID interaction database: 2019 update
10.1093/nar/gky1079 · 2019 · External reference
Unresolved reference
External reference
Unresolved reference
2019 · External reference
Unresolved reference
External reference
Compact integration of multi-network topology for functional analysis of genes
10.1016/j.cels.2016.10.017 · 2016 · External reference
Predicting synthetic lethal interactions using heterogeneous data sources
10.1093/bioinformatics/btz893 · 2020 · External reference
Essential gene profiles in breast, pancreatic, and ovarian cancer cells
10.1158/2159-8290.cd-11-0224 · 2012 · External reference
