Research graph
References from Data-driven modeling of spatiotemporal dynamics using multimodal imaging data. Local targets link to admitted publications; unresolved targets remain external evidence.
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · 2023 · External reference
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · 2023 · External reference
Alzheimer’s disease drug development pipeline: 2023
2023 · External reference
ARIA in patients treated with lecanemab in the phase 3 Clarity AD study
2023 · External reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer’s disease
10.1007/s00401-022-02472-x · 2022 · External reference
The amyloid hypothesis of Alzheimer’s disease at 25 years
10.15252/emmm.201606210 · 2016 · External reference
The path forward in Alzheimer’s disease therapeutics: A new generation of amyloid-targeting agents
2020 · External reference
MRI and CSF studies in the early diagnosis of Alzheimer’s disease
10.1111/j.1365-2796.2004.01381.x · 2004 · External reference
Spectral graph model for fMRI: A biophysical, connectivity-based generative model for the analysis of frequency-resolved resting-state fMRI
2024 · External reference
Defining imaging biomarker cut points for brain aging and Alzheimer’s disease
10.1016/j.jalz.2016.08.005 · 2017 · External reference
Spatio-spectral relationships between pathological neural dynamics and cognitive impairment along the Alzheimer’s disease spectrum
2021 · External reference
A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice
10.3390/jpm12050807 · 2022 · External reference
Data Driven Mathematical Model of Colon Cancer Progression
10.3390/jcm9123947 · 2020 · External reference
Investigating Optimal Chemotherapy Options for Osteosarcoma Patients through a Mathematical Model
10.3390/cells10082009 · 2021 · External reference
Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening
10.1371/journal.pcbi.1005929 · 2018 · External reference
Mathematical modeling for glioblastoma treatment: scenario generation and validation for clinical patient counseling
10.3389/fonc.2025.1647144 · 2025 · External reference
Go-or-grow-or-die as a framework for the mathematical modeling of glioblastoma dynamics
10.1016/j.mbs.2025.109520 · 2025 · External reference
Mathematical Models of Androgen Resistance in Prostate Cancer Patients under Intermittent Androgen Suppression Therapy
10.3390/app6110352 · 2016 · External reference
Oscillations in a tumor-immune system interaction model with immune response delay
10.1093/imammb/dqae016 · 2025 · External reference
Mathematical model on Alzheimer’s disease
10.1186/s12918-016-0348-2 · 2016 · External reference
The amyloid cascade hypothesis and Alzheimer’s disease: A mathematical model
10.1017/s0956792520000339 · 2020 · External reference
Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer’s Disease
2025 · External reference
Alzheimer’s disease and the mathematical mind
10.1016/j.brain.2024.100094 · 2024 · External reference
Computational Drug Repurposing for Alzheimer’s Disease via Sheaf Theoretic Population-Scale Analysis of snRNA-seq Data
2025 · External reference
Optimal anti-amyloid-beta therapy for Alzheimer’s disease via a personalized mathematical model
2022 · External reference
A multidimensional ODE-based model of Alzheimer’s disease progression
10.1038/s41598-023-29383-5 · 2023 · External reference
Mathematical Models to Shed Light on Amyloid-Beta and Tau Protein Dependent Pathologies in Alzheimer’s Disease
10.1016/j.neuroscience.2019.09.017 · 2020 · External reference
The role of Aβ and Tau proteins in Alzheimer’s disease: a mathematical model on graphs
10.1007/s00285-023-01985-7 · 2023 · External reference
Mathematical modelling of Alzheimer’s disease biomarkers: Targeting Amyloid beta, Tau protein, Apolipoprotein E and Apoptotic pathways
10.62347/ujqf5204 · 2024 · External reference
A multiscale model to explain the spatiotemporal progression of amyloid beta and tau pathology in Alzheimer’s disease
10.1016/j.ijbiomac.2025.142887 · 2025 · External reference
ptimal Control For Anti-Abeta Treatment in Alzheimer’s Disease using a Reaction-Diffusion Model
2025 · External reference
Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s Disease
10.1016/j.pneurobio.2025.102750 · 2025 · External reference
Data-driven causal model discovery and personalized prediction in Alzheimer’s disease
10.1038/s41746-022-00632-7 · 2022 · External reference
Discovering a reaction–diffusion model for Alzheimer’s disease by combining PINNs with symbolic regression
10.1016/j.cma.2023.116647 · 2024 · External reference
Learning Patient-Specific Spatial Biomarker Dynamics via Operator Learning for Alzheimer’s Disease Progression
2025 · External reference
Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade
10.14283/jpad.2023.134 · 2024 · External reference
Mathematical model and artificial intelligence for diagnosis of Alzheimer’s disease
10.1140/epjp/s13360-023-04128-5 · 2023 · External reference
Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease
10.1155/2019/6216530 · 2019 · External reference
10.1002/alz70855_107645
10.1002/alz70855_107645 · External reference
Back to the Future: Predicting Individual Tau Progression in Alzheimer’s Disease
2025 · External reference
A network-level transport model of tau progression in the Alzheimer’s brain
10.1093/imammb/dqaf003 · 2025 · External reference
Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study
10.3174/ajnr.a7903 · 2023 · External reference
Directionality bias underpins divergent spatiotemporal progression of Alzheimer-related tauopathy in mouse models
10.1002/alz.70092 · 2025 · External reference
Characterizing the spatiotemporal variability of Alzheimer’s disease pathology
2020 · External reference
Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer’s disease
10.1016/j.neurobiolaging.2025.04.011 · 2025 · External reference
Clinicopathologic and 11C-PiB PET correlates of three Alzheimer’s disease subtypes: typical, limbic-predominant, and hippocampal-sparing
2015 · External reference
Is Alzheimer disease a disease
10.1038/s41582-024-00940-4 · 2024 · External reference
Neuropathological stageing of Alzheimer-related changes
10.1007/bf00308809 · 1991 · External reference
Phases of A beta-deposition in the human brain and its relevance for the development of AD
10.1212/wnl.58.12.1791 · 2002 · External reference
Structural progression of Alzheimer’s disease over decades: the MRI staging scheme
10.1093/braincomms/fcac109 · 2022 · External reference
Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer’s disease
10.1093/brain/awl256 · 2006 · External reference
Different regional patterns of cortical thinning in Alzheimer’s disease and frontotemporal dementia
2007 · External reference
Tau PET imaging in aging and early Alzheimer’s disease
10.1002/ana.24546 · 2016 · External reference
Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis
10.1212/wnl.0000000000200148 · 2022 · External reference
Declarative memory impairments in Alzheimer’s disease and semantic dementia
10.1016/j.neuroimage.2005.10.008 · 2006 · External reference
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease
10.1093/brain/aww027 · 2016 · External reference
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
10.1093/brain/awab114 · 2021 · External reference
Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI
10.1073/pnas.052587399 · 2002 · External reference
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD
10.1212/01.wnl.0000320055.57329.34 · 2008 · External reference
Contributions of connectional pathways to shaping Alzheimer’s disease pathologies
10.1093/braincomms/fcae459 · 2025 · External reference
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis
10.1016/j.trsl.2022.08.008 · 2023 · External reference
Editorial: Advances in brain functional and structural networks modeling via graph theory
10.3389/fnins.2022.1031280 · 2022 · External reference
Accelerating Causal Network Discovery of Alzheimer Disease Biomarkers via Scientific Literature-based Retrieval Augmented Generation
2025 · External reference
Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory
10.1038/nm1782 · 2008 · External reference
MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
10.1212/wnl.0b013e31823efc6c · 2012 · External reference
Alzheimer-signature MRI biomarker predicts AD dementia: Regional cortical thinning in relation to future AD dementia
2011 · External reference
Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults
10.1002/alz.12249 · 2021 · External reference
Early-onset Alzheimer’s disease MRI signature: a replication and extension
10.1093/cercor/bhae475 · 2024 · External reference
The personalized Alzheimer’s disease cortical thickness index: characterization and replication in independent cohorts. Alzheimer’s & Dementia: Diagnosis
2018 · External reference
Rates of cortical thinning in Alzheimer’s disease signature regions predict disease progression. Journal of Neurology
2024 · External reference
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
10.1016/j.neuroimage.2006.01.021 · 2006 · External reference
Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease
10.1038/s41467-024-49300-2 · 2024 · External reference
An equation-by-equation method for solving the multidimensional moment constrained maximum entropy problem
10.2140/camcos.2018.13.189 · 2018 · External reference
A Homotopy Method for Parameter Estimation of Nonlinear Differential Equations with Multiple Optima
10.1007/s10915-017-0518-4 · 2017 · External reference
About the use of rank transformation in sensitivity analysis of model output
10.1016/0951-8320(95)00099-2 · 1995 · External reference
Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
10.1016/s0378-4754(00)00270-6 · 2001 · External reference
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · ExternalCitation · doi-reference
Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults
10.1002/alz.12249 · ExternalCitation · doi-reference
Directionality bias underpins divergent spatiotemporal progression of Alzheimer-related tauopathy in mouse models
10.1002/alz.70092 · ExternalCitation · doi-reference
10.1002/alz70855_107645
10.1002/alz70855_107645 · ExternalCitation · doi-reference
Tau PET imaging in aging and early Alzheimer’s disease
10.1002/ana.24546 · ExternalCitation · doi-reference
Neuropathological stageing of Alzheimer-related changes
10.1007/bf00308809 · ExternalCitation · doi-reference
The role of Aβ and Tau proteins in Alzheimer’s disease: a mathematical model on graphs
10.1007/s00285-023-01985-7 · ExternalCitation · doi-reference
Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer’s disease
10.1007/s00401-022-02472-x · ExternalCitation · doi-reference
A Homotopy Method for Parameter Estimation of Nonlinear Differential Equations with Multiple Optima
10.1007/s10915-017-0518-4 · ExternalCitation · doi-reference
About the use of rank transformation in sensitivity analysis of model output
10.1016/0951-8320(95)00099-2 · ExternalCitation · doi-reference
Alzheimer’s disease and the mathematical mind
10.1016/j.brain.2024.100094 · ExternalCitation · doi-reference
Discovering a reaction–diffusion model for Alzheimer’s disease by combining PINNs with symbolic regression
10.1016/j.cma.2023.116647 · ExternalCitation · doi-reference
A multiscale model to explain the spatiotemporal progression of amyloid beta and tau pathology in Alzheimer’s disease
10.1016/j.ijbiomac.2025.142887 · ExternalCitation · doi-reference
Defining imaging biomarker cut points for brain aging and Alzheimer’s disease
10.1016/j.jalz.2016.08.005 · ExternalCitation · doi-reference
Go-or-grow-or-die as a framework for the mathematical modeling of glioblastoma dynamics
10.1016/j.mbs.2025.109520 · ExternalCitation · doi-reference
Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer’s disease
10.1016/j.neurobiolaging.2025.04.011 · ExternalCitation · doi-reference
Declarative memory impairments in Alzheimer’s disease and semantic dementia
10.1016/j.neuroimage.2005.10.008 · ExternalCitation · doi-reference
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
10.1016/j.neuroimage.2006.01.021 · ExternalCitation · doi-reference
Mathematical Models to Shed Light on Amyloid-Beta and Tau Protein Dependent Pathologies in Alzheimer’s Disease
10.1016/j.neuroscience.2019.09.017 · ExternalCitation · doi-reference
Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer’s Disease
10.1016/j.pneurobio.2025.102750 · ExternalCitation · doi-reference
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis
10.1016/j.trsl.2022.08.008 · ExternalCitation · doi-reference
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · ExternalCitation · doi-reference
Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
10.1016/s0378-4754(00)00270-6 · ExternalCitation · doi-reference
The amyloid cascade hypothesis and Alzheimer’s disease: A mathematical model
10.1017/s0956792520000339 · ExternalCitation · doi-reference
Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory
10.1038/nm1782 · ExternalCitation · doi-reference
Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease
10.1038/s41467-024-49300-2 · ExternalCitation · doi-reference
Is Alzheimer disease a disease
10.1038/s41582-024-00940-4 · ExternalCitation · doi-reference
A multidimensional ODE-based model of Alzheimer’s disease progression
10.1038/s41598-023-29383-5 · ExternalCitation · doi-reference
Data-driven causal model discovery and personalized prediction in Alzheimer’s disease
10.1038/s41746-022-00632-7 · ExternalCitation · doi-reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · ExternalCitation · doi-reference
Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI
10.1073/pnas.052587399 · ExternalCitation · doi-reference
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
10.1093/brain/awab114 · ExternalCitation · doi-reference
Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer’s disease
10.1093/brain/awl256 · ExternalCitation · doi-reference
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease
10.1093/brain/aww027 · ExternalCitation · doi-reference
Structural progression of Alzheimer’s disease over decades: the MRI staging scheme
10.1093/braincomms/fcac109 · ExternalCitation · doi-reference
Contributions of connectional pathways to shaping Alzheimer’s disease pathologies
10.1093/braincomms/fcae459 · ExternalCitation · doi-reference
Early-onset Alzheimer’s disease MRI signature: a replication and extension
10.1093/cercor/bhae475 · ExternalCitation · doi-reference
Oscillations in a tumor-immune system interaction model with immune response delay
10.1093/imammb/dqae016 · ExternalCitation · doi-reference
A network-level transport model of tau progression in the Alzheimer’s brain
10.1093/imammb/dqaf003 · ExternalCitation · doi-reference
MRI and CSF studies in the early diagnosis of Alzheimer’s disease
10.1111/j.1365-2796.2004.01381.x · ExternalCitation · doi-reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · ExternalCitation · doi-reference
Mathematical model and artificial intelligence for diagnosis of Alzheimer’s disease
10.1140/epjp/s13360-023-04128-5 · ExternalCitation · doi-reference
Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease
10.1155/2019/6216530 · ExternalCitation · doi-reference
Mathematical model on Alzheimer’s disease
10.1186/s12918-016-0348-2 · ExternalCitation · doi-reference
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD
10.1212/01.wnl.0000320055.57329.34 · ExternalCitation · doi-reference
Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis
10.1212/wnl.0000000000200148 · ExternalCitation · doi-reference
MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
10.1212/wnl.0b013e31823efc6c · ExternalCitation · doi-reference
Phases of A beta-deposition in the human brain and its relevance for the development of AD
10.1212/wnl.58.12.1791 · ExternalCitation · doi-reference
Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening
10.1371/journal.pcbi.1005929 · ExternalCitation · doi-reference
Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade
10.14283/jpad.2023.134 · ExternalCitation · doi-reference
The amyloid hypothesis of Alzheimer’s disease at 25 years
10.15252/emmm.201606210 · ExternalCitation · doi-reference
An equation-by-equation method for solving the multidimensional moment constrained maximum entropy problem
10.2140/camcos.2018.13.189 · ExternalCitation · doi-reference
Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study
10.3174/ajnr.a7903 · ExternalCitation · doi-reference
Editorial: Advances in brain functional and structural networks modeling via graph theory
10.3389/fnins.2022.1031280 · ExternalCitation · doi-reference
Mathematical modeling for glioblastoma treatment: scenario generation and validation for clinical patient counseling
10.3389/fonc.2025.1647144 · ExternalCitation · doi-reference
Mathematical Models of Androgen Resistance in Prostate Cancer Patients under Intermittent Androgen Suppression Therapy
10.3390/app6110352 · ExternalCitation · doi-reference
Investigating Optimal Chemotherapy Options for Osteosarcoma Patients through a Mathematical Model
10.3390/cells10082009 · ExternalCitation · doi-reference
Data Driven Mathematical Model of Colon Cancer Progression
10.3390/jcm9123947 · ExternalCitation · doi-reference
A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice
10.3390/jpm12050807 · ExternalCitation · doi-reference
Mathematical modelling of Alzheimer’s disease biomarkers: Targeting Amyloid beta, Tau protein, Apolipoprotein E and Apoptotic pathways
10.62347/ujqf5204 · ExternalCitation · doi-reference
