Research graph
References from Evolutionary rescue model informs strategies for driving cancer cell populations to extinction. Local targets link to admitted publications; unresolved targets remain external evidence.
Biological heterogeneity of cancer
10.4161/hv.19643 · 2012 · External reference
Cancer heterogeneity--a multifaceted view
10.1038/embor.2013.92 · 2013 · External reference
Non-small-cell lung cancers: a heterogeneous set of diseases
10.1038/nrc3775 · 2014 · External reference
Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes
10.1158/0008-5472.can-14-2240 · 2015 · External reference
Clinical variability and molecular heterogeneity in prostate cancer
10.4103/1008-682x.178852 · 2016 · External reference
Ovarian cancer: A heterogeneous disease
10.1159/000479006 · 2017 · External reference
Updating the definition of cancer
10.1158/1541-7786.mcr-23-0411 · 2023 · External reference
Clonal adaptation during carcinogenesis
10.1016/0006-2952(90)90599-g · 1990 · External reference
Tumor clone dynamics in lethal prostate cancer
10.1126/scitranslmed.3009448 · 2014 · External reference
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
10.1016/j.cell.2014.02.031 · 2014 · External reference
The clonal evolution and therapeutic approaches of lung cancer
10.1007/s12013-014-9910-y · 2014 · External reference
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
10.1038/nm.3841 · 2015 · External reference
Tracking the evolution of non-small-cell lung cancer
10.1056/nejmoa1616288 · 2017 · External reference
The clonal evolution of metastatic colorectal cancer
2020 · External reference
Clonal competition within complex evolutionary hierarchies shapes AML over time
10.1038/s41467-019-14106-0 · 2020 · External reference
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
10.1016/j.ccell.2023.10.004 · 2023 · External reference
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
10.1200/jco.2010.33.2312 · 2011 · External reference
Therapy for metastatic melanoma: the past, present, and future
10.1186/1741-7015-10-23 · 2012 · External reference
Acquired resistance to KRASG12C inhibition in cancer
10.1056/nejmoa2105281 · 2021 · External reference
Evolution of acquired resistance in a ROS1+ KRAS G12C+ NSCLC through the MAPK pathway.
10.1038/s41698-023-00349-0 · 2023 · External reference
Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
10.1038/s41568-022-00454-5 · 2022 · External reference
Nonlinear simulation of tumor growth
10.1007/s00285-002-0174-6 · 2003 · External reference
A cellular automata model of tumor-immune system interactions
10.1016/j.jtbi.2005.08.002 · 2006 · External reference
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
10.1038/sj.bjc.6603922 · 2007 · External reference
An off-lattice hybrid discrete-continuum model of tumor growth and invasion
10.1016/j.bpj.2009.10.002 · 2010 · External reference
Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity
10.1158/0008-5472.can-09-3663 · 2010 · External reference
Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer
2016 · External reference
Hybrid multiscale modeling and prediction of cancer cell behavior
10.1371/journal.pone.0183810 · 2017 · External reference
Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer.
10.1021/mp200270v · 2011 · External reference
Cancer evolution: mathematical models and computational inference
10.1093/sysbio/syu081 · 2015 · External reference
Modeling cancer evolution: evolutionary escape under immune system control.
2017 · External reference
Modeling tumor evolutionary dynamics to predict clinical outcomes for patients with metastatic colorectal cancer: a retrospective analysis
10.1158/0008-5472.can-19-1940 · 2020 · External reference
Evolutionary dynamics of treatment-induced resistance in cancer informs understanding of rapid evolution in natural systems
10.3389/fevo.2021.681121 · 2021 · External reference
Cancer as an evolutionary and ecological process
10.1038/nrc2013 · 2006 · External reference
The evolutionary theory of cancer: challenges and potential solutions
10.1038/s41568-024-00734-2 · 2024 · External reference
When does evolution by natural selection prevent extinction?
10.1111/j.1558-5646.1995.tb05971.x · 1995 · External reference
Population extinction and the genetics of adaptation
10.1086/589460 · 2008 · External reference
Evolutionary rescue can prevent extinction following environmental change
10.1111/j.1461-0248.2009.01350.x · 2009 · External reference
The population genetics of evolutionary rescue
2014 · External reference
Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy
10.1002/1097-0142(19930201)71:3+<1059::aid-cncr2820711426>3.0.co;2-6 · 1993 · External reference
Molecular-targeted agents combination therapy for cancer: developments and potentials
10.1002/ijc.28261 · 2014 · External reference
Combination therapy in combating cancer
10.18632/oncotarget.16723 · 2017 · External reference
Combination cancer therapy can confer benefit via patient-to-patient variability without drug additivity or synergy
10.1016/j.cell.2017.11.009 · 2017 · External reference
Drug combinations in breast cancer therapy
10.2174/2211738507666190122111224 · 2019 · External reference
Independent drug action in combination therapy: implications for precision oncology
10.1158/2159-8290.cd-21-0212 · 2022 · External reference
First strike-second strike strategies in metastatic cancer: lessons from the evolutionary dynamics of extinction
10.1158/0008-5472.can-19-0807 · 2019 · External reference
Eradicating metastatic cancer and the eco-evolutionary dynamics of anthropocene extinctions
10.1158/0008-5472.can-19-1941 · 2020 · External reference
Integrating evolutionary dynamics into cancer therapy
10.1038/s41571-020-0411-1 · 2020 · External reference
Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma
10.1016/bs.acr.2021.02.003 · 2021 · External reference
Preventing evolutionary rescue in cancer using two-strike therapy
10.1093/genetics/iyaf255 · 2026 · External reference
Mathematical modeling of cancer radiovirotherapy
10.1016/j.mbs.2005.11.001 · 2006 · External reference
Classical mathematical models for description and prediction of experimental tumor growth
10.1371/journal.pcbi.1003800 · 2014 · External reference
Mathematical modeling and computational prediction of cancer drug resistance
10.1093/bib/bbx065 · 2018 · External reference
Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes. Perry GH, editor.
10.7554/elife.76284 · 2022 · External reference
Selection in spatial stochastic models of cancer: migration as a key modulator of fitness
10.1186/1745-6150-5-21 · 2010 · External reference
Spatial stochastic models of cancer: fitness, migration, invasion
10.3934/mbe.2013.10.761 · 2013 · External reference
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
10.1038/nature14971 · 2015 · External reference
Simulating non-small cell lung cancer with a multiscale agent-based model
10.1186/1742-4682-4-50 · 2007 · External reference
Multiscale agent-based cancer modeling
10.1007/s00285-008-0211-1 · 2009 · External reference
Agent-based simulation patient model for colon and colorectal cancer care trajectory
10.1016/j.procs.2016.09.140 · 2016 · External reference
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
10.1098/rsif.2017.0320 · 2017 · External reference
SLiM 4: multispecies eco-evolutionary modeling.
10.1086/723601 · 2023 · External reference
Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations
2024 · External reference
Understanding evolutionary and ecological dynamics using a continuum limit
10.1002/ece3.7205 · 2021 · External reference
Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance
10.1016/j.canlet.2014.12.039 · 2015 · External reference
Effects of single versus combinations of insecticides on the development of resistance
10.1093/ee/14.5.582 · 1985 · External reference
Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting
10.1073/pnas.2023467118 · 2021 · External reference
Mechanisms of drug resistance in cancer chemotherapy
10.1159/000086183 · 2005 · External reference
Mechanisms of multidrug resistance in cancer chemotherapy
10.3390/ijms21093233 · 2020 · External reference
Understanding resistance to combination chemotherapy
10.1016/j.drup.2012.10.003 · 2012 · External reference
Lessons from applied ecology: cancer control using an evolutionary double bind
10.1158/0008-5472.can-09-1354 · 2009 · External reference
Exploiting evolution to treat drug resistance: combination therapy and the double bind
10.1021/mp200458e · 2012 · External reference
Population genomics of rapid adaptation by soft selective sweeps
10.1016/j.tree.2013.08.003 · 2013 · External reference
Evolution and extinction in a changing environment: a quantitative-genetic analysis
1995 · External reference
Evolutionary rescue in a linearly changing environment: limits on predictability
10.1007/s11538-018-0504-5 · 2019 · External reference
Harnessing the extinction vortex against acute lymphoblastic leukemia
10.1093/emph/eoaf035 · 2025 · External reference
Evolutionary rescue under demographic and environmental stochasticity
10.1111/jeb.14224 · 2023 · External reference
Adaptive therapy
10.1158/0008-5472.can-08-3658 · 2009 · External reference
Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
10.1038/s41467-017-01968-5 · 2017 · External reference
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
10.1038/s41467-021-26870-z · 2021 · External reference
Spatial structure governs the mode of tumour evolution
10.1038/s41559-021-01615-9 · 2022 · External reference
Spatial biology of cancer evolution
10.1038/s41576-022-00553-x · 2023 · External reference
Single-species models of the Allee effect: extinction boundaries, sex ratios and mate encounters
10.1006/jtbi.2002.3084 · 2002 · External reference
Feedback regulation in a cancer stem cell model can cause an allee effect
10.1007/s11538-016-0161-5 · 2016 · External reference
Aggregation effects and population-based dynamics as a source of therapy resistance in cancer
10.1109/tbme.2016.2623564 · 2017 · External reference
Autocrine signaling can explain the emergence of Allee effects in cancer cell populations
10.1371/journal.pcbi.1009844 · 2022 · External reference
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy
2015 · External reference
Principles and mechanisms of non-genetic resistance in cancer
10.1038/s41416-019-0648-6 · 2020 · External reference
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
10.1016/j.cell.2010.02.027 · 2010 · External reference
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
10.1038/nature22794 · 2017 · External reference
Cycling cancer persister cells arise from lineages with distinct programs
10.1038/s41586-021-03796-6 · 2021 · External reference
The fitness trade-off between growth and stress resistance determines the phenotypic landscape
10.1186/s12915-024-01856-7 · 2024 · External reference
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
10.1016/j.devcel.2021.07.009 · 2021 · External reference
Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy
10.1002/1097-0142(19930201)71:3+<1059::aid-cncr2820711426>3.0.co;2-6 · ExternalCitation · doi-reference
Understanding evolutionary and ecological dynamics using a continuum limit
10.1002/ece3.7205 · ExternalCitation · doi-reference
Molecular-targeted agents combination therapy for cancer: developments and potentials
10.1002/ijc.28261 · ExternalCitation · doi-reference
Single-species models of the Allee effect: extinction boundaries, sex ratios and mate encounters
10.1006/jtbi.2002.3084 · ExternalCitation · doi-reference
Nonlinear simulation of tumor growth
10.1007/s00285-002-0174-6 · ExternalCitation · doi-reference
Multiscale agent-based cancer modeling
10.1007/s00285-008-0211-1 · ExternalCitation · doi-reference
Feedback regulation in a cancer stem cell model can cause an allee effect
10.1007/s11538-016-0161-5 · ExternalCitation · doi-reference
Evolutionary rescue in a linearly changing environment: limits on predictability
10.1007/s11538-018-0504-5 · ExternalCitation · doi-reference
The clonal evolution and therapeutic approaches of lung cancer
10.1007/s12013-014-9910-y · ExternalCitation · doi-reference
Clonal adaptation during carcinogenesis
10.1016/0006-2952(90)90599-g · ExternalCitation · doi-reference
Treatment-induced evolutionary dynamics in nonmetastatic locally advanced rectal adenocarcinoma
10.1016/bs.acr.2021.02.003 · ExternalCitation · doi-reference
An off-lattice hybrid discrete-continuum model of tumor growth and invasion
10.1016/j.bpj.2009.10.002 · ExternalCitation · doi-reference
Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance
10.1016/j.canlet.2014.12.039 · ExternalCitation · doi-reference
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
10.1016/j.ccell.2023.10.004 · ExternalCitation · doi-reference
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
10.1016/j.cell.2010.02.027 · ExternalCitation · doi-reference
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing
10.1016/j.cell.2014.02.031 · ExternalCitation · doi-reference
Combination cancer therapy can confer benefit via patient-to-patient variability without drug additivity or synergy
10.1016/j.cell.2017.11.009 · ExternalCitation · doi-reference
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
10.1016/j.devcel.2021.07.009 · ExternalCitation · doi-reference
Understanding resistance to combination chemotherapy
10.1016/j.drup.2012.10.003 · ExternalCitation · doi-reference
A cellular automata model of tumor-immune system interactions
10.1016/j.jtbi.2005.08.002 · ExternalCitation · doi-reference
Mathematical modeling of cancer radiovirotherapy
10.1016/j.mbs.2005.11.001 · ExternalCitation · doi-reference
Agent-based simulation patient model for colon and colorectal cancer care trajectory
10.1016/j.procs.2016.09.140 · ExternalCitation · doi-reference
Population genomics of rapid adaptation by soft selective sweeps
10.1016/j.tree.2013.08.003 · ExternalCitation · doi-reference
Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer.
10.1021/mp200270v · ExternalCitation · doi-reference
Exploiting evolution to treat drug resistance: combination therapy and the double bind
10.1021/mp200458e · ExternalCitation · doi-reference
Cancer heterogeneity--a multifaceted view
10.1038/embor.2013.92 · ExternalCitation · doi-reference
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
10.1038/nature14971 · ExternalCitation · doi-reference
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
10.1038/nature22794 · ExternalCitation · doi-reference
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
10.1038/nm.3841 · ExternalCitation · doi-reference
Cancer as an evolutionary and ecological process
10.1038/nrc2013 · ExternalCitation · doi-reference
Non-small-cell lung cancers: a heterogeneous set of diseases
10.1038/nrc3775 · ExternalCitation · doi-reference
Principles and mechanisms of non-genetic resistance in cancer
10.1038/s41416-019-0648-6 · ExternalCitation · doi-reference
Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
10.1038/s41467-017-01968-5 · ExternalCitation · doi-reference
Clonal competition within complex evolutionary hierarchies shapes AML over time
10.1038/s41467-019-14106-0 · ExternalCitation · doi-reference
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
10.1038/s41467-021-26870-z · ExternalCitation · doi-reference
Spatial structure governs the mode of tumour evolution
10.1038/s41559-021-01615-9 · ExternalCitation · doi-reference
Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
10.1038/s41568-022-00454-5 · ExternalCitation · doi-reference
The evolutionary theory of cancer: challenges and potential solutions
10.1038/s41568-024-00734-2 · ExternalCitation · doi-reference
Integrating evolutionary dynamics into cancer therapy
10.1038/s41571-020-0411-1 · ExternalCitation · doi-reference
Spatial biology of cancer evolution
10.1038/s41576-022-00553-x · ExternalCitation · doi-reference
Cycling cancer persister cells arise from lineages with distinct programs
10.1038/s41586-021-03796-6 · ExternalCitation · doi-reference
Evolution of acquired resistance in a ROS1+ KRAS G12C+ NSCLC through the MAPK pathway.
10.1038/s41698-023-00349-0 · ExternalCitation · doi-reference
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
10.1038/sj.bjc.6603922 · ExternalCitation · doi-reference
Tracking the evolution of non-small-cell lung cancer
10.1056/nejmoa1616288 · ExternalCitation · doi-reference
Acquired resistance to KRASG12C inhibition in cancer
10.1056/nejmoa2105281 · ExternalCitation · doi-reference
Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting
10.1073/pnas.2023467118 · ExternalCitation · doi-reference
Population extinction and the genetics of adaptation
10.1086/589460 · ExternalCitation · doi-reference
SLiM 4: multispecies eco-evolutionary modeling.
10.1086/723601 · ExternalCitation · doi-reference
Mathematical modeling and computational prediction of cancer drug resistance
10.1093/bib/bbx065 · ExternalCitation · doi-reference
Effects of single versus combinations of insecticides on the development of resistance
10.1093/ee/14.5.582 · ExternalCitation · doi-reference
Harnessing the extinction vortex against acute lymphoblastic leukemia
10.1093/emph/eoaf035 · ExternalCitation · doi-reference
Preventing evolutionary rescue in cancer using two-strike therapy
10.1093/genetics/iyaf255 · ExternalCitation · doi-reference
Cancer evolution: mathematical models and computational inference
10.1093/sysbio/syu081 · ExternalCitation · doi-reference
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
10.1098/rsif.2017.0320 · ExternalCitation · doi-reference
Aggregation effects and population-based dynamics as a source of therapy resistance in cancer
10.1109/tbme.2016.2623564 · ExternalCitation · doi-reference
Evolutionary rescue can prevent extinction following environmental change
10.1111/j.1461-0248.2009.01350.x · ExternalCitation · doi-reference
When does evolution by natural selection prevent extinction?
10.1111/j.1558-5646.1995.tb05971.x · ExternalCitation · doi-reference
Evolutionary rescue under demographic and environmental stochasticity
10.1111/jeb.14224 · ExternalCitation · doi-reference
Tumor clone dynamics in lethal prostate cancer
10.1126/scitranslmed.3009448 · ExternalCitation · doi-reference
Adaptive therapy
10.1158/0008-5472.can-08-3658 · ExternalCitation · doi-reference
Lessons from applied ecology: cancer control using an evolutionary double bind
10.1158/0008-5472.can-09-1354 · ExternalCitation · doi-reference
Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity
10.1158/0008-5472.can-09-3663 · ExternalCitation · doi-reference
Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes
10.1158/0008-5472.can-14-2240 · ExternalCitation · doi-reference
First strike-second strike strategies in metastatic cancer: lessons from the evolutionary dynamics of extinction
10.1158/0008-5472.can-19-0807 · ExternalCitation · doi-reference
Modeling tumor evolutionary dynamics to predict clinical outcomes for patients with metastatic colorectal cancer: a retrospective analysis
10.1158/0008-5472.can-19-1940 · ExternalCitation · doi-reference
Eradicating metastatic cancer and the eco-evolutionary dynamics of anthropocene extinctions
10.1158/0008-5472.can-19-1941 · ExternalCitation · doi-reference
Updating the definition of cancer
10.1158/1541-7786.mcr-23-0411 · ExternalCitation · doi-reference
Independent drug action in combination therapy: implications for precision oncology
10.1158/2159-8290.cd-21-0212 · ExternalCitation · doi-reference
Mechanisms of drug resistance in cancer chemotherapy
10.1159/000086183 · ExternalCitation · doi-reference
Ovarian cancer: A heterogeneous disease
10.1159/000479006 · ExternalCitation · doi-reference
Therapy for metastatic melanoma: the past, present, and future
10.1186/1741-7015-10-23 · ExternalCitation · doi-reference
Simulating non-small cell lung cancer with a multiscale agent-based model
10.1186/1742-4682-4-50 · ExternalCitation · doi-reference
Selection in spatial stochastic models of cancer: migration as a key modulator of fitness
10.1186/1745-6150-5-21 · ExternalCitation · doi-reference
The fitness trade-off between growth and stress resistance determines the phenotypic landscape
10.1186/s12915-024-01856-7 · ExternalCitation · doi-reference
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
10.1200/jco.2010.33.2312 · ExternalCitation · doi-reference
Classical mathematical models for description and prediction of experimental tumor growth
10.1371/journal.pcbi.1003800 · ExternalCitation · doi-reference
Autocrine signaling can explain the emergence of Allee effects in cancer cell populations
10.1371/journal.pcbi.1009844 · ExternalCitation · doi-reference
Hybrid multiscale modeling and prediction of cancer cell behavior
10.1371/journal.pone.0183810 · ExternalCitation · doi-reference
Combination therapy in combating cancer
10.18632/oncotarget.16723 · ExternalCitation · doi-reference
Drug combinations in breast cancer therapy
10.2174/2211738507666190122111224 · ExternalCitation · doi-reference
Evolutionary dynamics of treatment-induced resistance in cancer informs understanding of rapid evolution in natural systems
10.3389/fevo.2021.681121 · ExternalCitation · doi-reference
Mechanisms of multidrug resistance in cancer chemotherapy
10.3390/ijms21093233 · ExternalCitation · doi-reference
Spatial stochastic models of cancer: fitness, migration, invasion
10.3934/mbe.2013.10.761 · ExternalCitation · doi-reference
Clinical variability and molecular heterogeneity in prostate cancer
10.4103/1008-682x.178852 · ExternalCitation · doi-reference
Biological heterogeneity of cancer
10.4161/hv.19643 · ExternalCitation · doi-reference
Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes. Perry GH, editor.
10.7554/elife.76284 · ExternalCitation · doi-reference
