Research graph
References from Integrative AI-assisted modeling suggests CPPF binding at a composite α/β-tubulin interface pocket dominated by β-tubulin contacts. Local targets link to admitted publications; unresolved targets remain external evidence.
Microtubule polymerization dynamics
10.1146/annurev.cellbio.13.1.83 · 1997 · External reference
Building the neuronal microtubule cytoskeleton
10.1016/j.neuron.2015.05.046 · 2015 · External reference
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
10.1083/jcb.201510015 · 2015 · External reference
Microtubules
10.1146/annurev.bi.42.070173.002451 · 1973 · External reference
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry
10.1021/bi0350147 · 2003 · External reference
Multiple forms of tubulin: Different gene products and covalent modifications
10.1016/s0074-7696(08)62138-5 · 1997 · External reference
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening
10.1016/j.neo.2024.101100 · 2025 · External reference
βIII-tubulin gene regulation in health and disease
10.3389/fcell.2022.851542 · 2022 · External reference
Microtubules as a target for anticancer drugs
10.1038/nrc1317 · 2004 · External reference
Paclitaxel (Taxol)
10.1056/nejm199504133321507 · 1995 · External reference
Structure of the alpha beta tubulin dimer by electron crystallography
10.1038/34465 · 1998 · External reference
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis
10.1016/j.cell.2014.03.053 · 2014 · External reference
High-resolution model of the microtubule
10.1016/s0092-8674(00)80961-7 · 1999 · External reference
Lattice defects in microtubules: Protofilament numbers vary within individual microtubules
10.1083/jcb.117.5.1031 · 1992 · External reference
Characterization of microtubule protofilament numbers. How does the surface lattice accommodate?
10.1016/0022-2836(90)90236-f · 1990 · External reference
Mechanical properties of tubulin intra- and inter-dimer interfaces and their implications for microtubule dynamic instability
2019 · External reference
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives
10.1016/j.sbi.2006.03.005 · 2006 · External reference
Tubulin Rings: Which Way Do They Curve?
10.1016/s0959-440x(03)00029-0 · 2003 · External reference
The contribution of αβ-tubulin curvature to microtubule dynamics
10.1083/jcb.201407095 · 2014 · External reference
CPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers
10.3390/ijms21134800 · 2020 · External reference
Mutations in human tubulin proximal to the kinesin-binding site alter dynamic instability at microtubule plus- and minus-ends
10.1016/j.devcel.2016.03.003 · 2016 · External reference
Increased levels of tyrosinatedα-,βIII-, andβIV-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells
10.1016/s0006-291x(02)00269-3 · 2002 · External reference
Generalized biomolecular modeling and design with RoseTTAFold All-Atom
10.1126/science.adl2528 · 2024 · External reference
Protenix: Advancing structure prediction through a comprehensive AlphaFold3 reproduction
2025 · External reference
ProteinsPlus: A comprehensive collection of web-based molecular modeling tools
10.1093/nar/gkac305 · 2022 · External reference
Structure prediction of protein-ligand complexes from sequence information with Umol
10.1038/s41467-024-48837-6 · 2024 · External reference
PLIP 2021: Expanding the scope of the protein-ligand interaction profiler to DNA and RNA
10.1093/nar/gkab294 · 2021 · External reference
Inference of macromolecular assemblies from crystalline state
10.1016/j.jmb.2007.05.022 · 2007 · External reference
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
Nextflow enables reproducible computational workflows
10.1038/nbt.3820 · 2017 · External reference
Unresolved reference
2025 · External reference
SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
ProTox 3.0: a webserver for the prediction of toxicity of chemicals
10.1093/nar/gkae303 · 2024 · External reference
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery
10.1111/febs.13555 · 2016 · External reference
SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina
10.1093/nar/gkae300 · 2024 · External reference
Chai-1: Decoding the molecular interactions of life
2024 · External reference
Biopython: freely available Python tools for computational molecular biology and bioinformatics
10.1093/bioinformatics/btp163 · 2009 · External reference
DoGSiteScorer: A web server for automatic binding site prediction, analysis and druggability assessment
10.1093/bioinformatics/bts310 · 2012 · External reference
The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization
10.1016/j.jmb.2014.02.005 · 2014 · External reference
Exploring the origin of differential binding affinities of human tubulin isotypes αβII, αβIII and αβIV for DAMA-colchicine using homology modelling, molecular docking and molecular dynamics simulations
10.1371/journal.pone.0156048 · 2016 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
10.1038/s41589-024-01638-w · 2024 · External reference
Characterization of microtubule protofilament numbers. How does the surface lattice accommodate?
10.1016/0022-2836(90)90236-f · ExternalCitation · doi-reference
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis
10.1016/j.cell.2014.03.053 · ExternalCitation · doi-reference
Mutations in human tubulin proximal to the kinesin-binding site alter dynamic instability at microtubule plus- and minus-ends
10.1016/j.devcel.2016.03.003 · ExternalCitation · doi-reference
Inference of macromolecular assemblies from crystalline state
10.1016/j.jmb.2007.05.022 · ExternalCitation · doi-reference
The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization
10.1016/j.jmb.2014.02.005 · ExternalCitation · doi-reference
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening
10.1016/j.neo.2024.101100 · ExternalCitation · doi-reference
Building the neuronal microtubule cytoskeleton
10.1016/j.neuron.2015.05.046 · ExternalCitation · doi-reference
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives
10.1016/j.sbi.2006.03.005 · ExternalCitation · doi-reference
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
10.1016/j.softx.2015.06.001 · ExternalCitation · doi-reference
Increased levels of tyrosinatedα-,βIII-, andβIV-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells
10.1016/s0006-291x(02)00269-3 · ExternalCitation · doi-reference
Multiple forms of tubulin: Different gene products and covalent modifications
10.1016/s0074-7696(08)62138-5 · ExternalCitation · doi-reference
High-resolution model of the microtubule
10.1016/s0092-8674(00)80961-7 · ExternalCitation · doi-reference
Tubulin Rings: Which Way Do They Curve?
10.1016/s0959-440x(03)00029-0 · ExternalCitation · doi-reference
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry
10.1021/bi0350147 · ExternalCitation · doi-reference
Structure of the alpha beta tubulin dimer by electron crystallography
10.1038/34465 · ExternalCitation · doi-reference
Nextflow enables reproducible computational workflows
10.1038/nbt.3820 · ExternalCitation · doi-reference
Microtubules as a target for anticancer drugs
10.1038/nrc1317 · ExternalCitation · doi-reference
Structure prediction of protein-ligand complexes from sequence information with Umol
10.1038/s41467-024-48837-6 · ExternalCitation · doi-reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · ExternalCitation · doi-reference
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
10.1038/s41589-024-01638-w · ExternalCitation · doi-reference
SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · ExternalCitation · doi-reference
Paclitaxel (Taxol)
10.1056/nejm199504133321507 · ExternalCitation · doi-reference
Lattice defects in microtubules: Protofilament numbers vary within individual microtubules
10.1083/jcb.117.5.1031 · ExternalCitation · doi-reference
The contribution of αβ-tubulin curvature to microtubule dynamics
10.1083/jcb.201407095 · ExternalCitation · doi-reference
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
10.1083/jcb.201510015 · ExternalCitation · doi-reference
Biopython: freely available Python tools for computational molecular biology and bioinformatics
10.1093/bioinformatics/btp163 · ExternalCitation · doi-reference
DoGSiteScorer: A web server for automatic binding site prediction, analysis and druggability assessment
10.1093/bioinformatics/bts310 · ExternalCitation · doi-reference
PLIP 2021: Expanding the scope of the protein-ligand interaction profiler to DNA and RNA
10.1093/nar/gkab294 · ExternalCitation · doi-reference
ProteinsPlus: A comprehensive collection of web-based molecular modeling tools
10.1093/nar/gkac305 · ExternalCitation · doi-reference
SwissDock 2024: major enhancements for small-molecule docking with Attracting Cavities and AutoDock Vina
10.1093/nar/gkae300 · ExternalCitation · doi-reference
ProTox 3.0: a webserver for the prediction of toxicity of chemicals
10.1093/nar/gkae303 · ExternalCitation · doi-reference
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery
10.1111/febs.13555 · ExternalCitation · doi-reference
Generalized biomolecular modeling and design with RoseTTAFold All-Atom
10.1126/science.adl2528 · ExternalCitation · doi-reference
Microtubules
10.1146/annurev.bi.42.070173.002451 · ExternalCitation · doi-reference
Microtubule polymerization dynamics
10.1146/annurev.cellbio.13.1.83 · ExternalCitation · doi-reference
Exploring the origin of differential binding affinities of human tubulin isotypes αβII, αβIII and αβIV for DAMA-colchicine using homology modelling, molecular docking and molecular dynamics simulations
10.1371/journal.pone.0156048 · ExternalCitation · doi-reference
βIII-tubulin gene regulation in health and disease
10.3389/fcell.2022.851542 · ExternalCitation · doi-reference
CPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers
10.3390/ijms21134800 · ExternalCitation · doi-reference
