Research graph
References from Bioactivity-driven prediction of antibacterial synergy using machine learning models. Local targets link to admitted publications; unresolved targets remain external evidence.
Antimicrobial resistance: A growing serious threat for global public health
10.3390/healthcare11131946 · 2023 · External reference
Unresolved reference
2023 · External reference
Addressing urgent priorities in antibiotic development: insights from WHO 2023 antibacterial clinical pipeline analyses
10.1016/j.lanmic.2024.100992 · 2025 · External reference
Drug combinations targeting antibiotic resistance
10.1038/s44259-024-00047-2 · 2024 · External reference
Antibiotic synergy and antagonism
10.1016/s0025-7125(05)70294-7 · 2000 · External reference
Rationale for use of antimicrobial combinations
10.1016/0002-9343(83)90088-8 · 1983 · External reference
Antibiotic combinations: should they be tested?
10.1128/cmr.1.2.139 · 1988 · External reference
Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution
10.1016/j.mib.2015.05.008 · 2015 · External reference
Species-specific activity of antibacterial drug combinations
10.1038/s41586-018-0278-9 · 2018 · External reference
Systematic analysis of drug combinations against Gram-positive bacteria
10.1038/s41564-023-01486-9 · 2023 · External reference
Within-species variability of antibiotic interactions in Gram-negative bacteria
2024 · External reference
Machine learning approaches for drug combination therapies
2021 · External reference
Harnessing machine learning to find synergistic combinations for FDA-approved cancer drugs
10.1038/s41598-024-52814-w · 2024 · External reference
A systematic evaluation of deep learning methods for the prediction of drug synergy in cancer
10.1371/journal.pcbi.1010200 · 2023 · External reference
Machine learning to design antimicrobial combination therapies: Promises and pitfalls
10.1016/j.drudis.2022.04.006 · 2022 · External reference
Pharmacokinetic and molecular docking studies to design antimalarial compounds targeting Actin I
2021 · External reference
MDbDMRP: A novel molecular descriptor-based computational model to identify drug-miRNA relationships
10.1016/j.ijbiomac.2024.138580 · 2025 · External reference
Prediction of antibiotic interactions using descriptors derived from molecular structure
10.1021/acs.jmedchem.7b00204 · 2017 · External reference
Chemogenomics and orthology-based design of antibiotic combination therapies
10.15252/msb.20156777 · 2016 · External reference
Prediction of synergistic antibiotic combinations by graph learning
10.3389/fphar.2022.849006 · 2022 · External reference
Unresolved reference
2024 · External reference
Extending the small-molecule similarity principle to all levels of biology with the Chemical Checker
10.1038/s41587-020-0502-7 · 2020 · External reference
Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data
10.1186/s13321-023-00723-x · 2023 · External reference
CCSynergy: an integrative deep-learning framework enabling context-aware prediction of anti-cancer drug synergy
2023 · External reference
Bio-Mol: Pretraining multimodality bioactivity profile for enhancing small molecule property prediction
2023 · External reference
Unresolved reference
2023 · External reference
APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions
10.1186/s13321-025-00961-1 · 2025 · External reference
Prediction of effective drug combinations by chemical interaction, protein interaction and target enrichment of KEGG pathways
2013 · External reference
ACDB: An antibiotic combination database
10.3389/fphar.2022.869983 · 2022 · External reference
SynergyFinder 3.0: An interactive analysis and consensus interpretation of multi-drug synergies across multiple samples
10.1093/nar/gkac382 · 2022 · External reference
Systematic exploration of synergistic drug pairs
10.1038/msb.2011.71 · 2011 · External reference
Design of high-order antibiotic combinations against M. tuberculosis by ranking and exclusion
10.1038/s41598-019-48410-y · 2019 · External reference
Penicillin-binding proteins and beta-lactam resistance
10.1111/j.1574-6976.2007.00095.x · 2008 · External reference
Penicillin plus Ceftriaxone versus Ampicillin plus ceftriaxone synergistic potential against clinical enterococcus faecalis blood isolates
10.1128/spectrum.00621-22 · 2022 · External reference
Potent synergy and sustained bactericidal activity of polymyxins combined with Gram-positive only class of antibiotics versus four Gram-negative bacteria
10.1186/s12941-024-00720-4 · 2024 · External reference
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli
10.1021/bi6025165 · 2007 · External reference
Intra-cellular accumulation and trans-epithelial transport of aivlosin, tylosin and tilmicosin
2007 · External reference
Discovery of macrolide antibiotics effective against multi-drug resistant gram-negative pathogens
10.1021/acs.accounts.1c00020 · 2021 · External reference
Molecular basis of bacterial outer membrane permeability revisited
10.1128/mmbr.67.4.593-656.2003 · 2003 · External reference
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding
10.1073/pnas.0709412104 · 2007 · External reference
Antibacterial drug discovery targeting the lipopolysaccharide biosynthetic enzyme LpxC
10.1101/cshperspect.a025304 · 2016 · External reference
TP0586532, a novel non-hydroxamate LpxC inhibitor: Potentiating effect on in vitro activity of meropenem against carbapenem-resistant Enterobacteriaceae
10.1128/spectrum.00828-22 · 2022 · External reference
Effect of non-beta-lactam antibiotics on penicillin-binding protein synthesis of Enterococcus hirae ATCC 9790
10.1093/jac/27.3.263 · 1991 · External reference
Integration of diverse bioactivity data into the Chemical Checker compound universe
10.1038/s41596-025-01167-3 · 2025 · External reference
A unified approach to interpreting model predictions
2017 · External reference
