Research graph
References from Candida albicans’ inorganic phosphate transport and evolutionary adaptation to phosphate scarcity. Local targets link to admitted publications; unresolved targets remain external evidence.
Protein synthesis controls phosphate homeostasis
10.1101/gad.309245.117 · 2018 · External reference
Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis
10.1093/nar/gkad063 · 2023 · External reference
Diversity of Phosphate Chemical Forms in Soils and Their Contributions on Soil Microbial Community Structure Changes.
10.3390/microorganisms10030609 · 2022 · External reference
Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity
10.1038/nature07659 · 2009 · External reference
The Role of Phosphorus Limitation in Shaping Soil Bacterial Communities and Their Metabolic Capabilities.
10.1128/mbio.01718-20 · 2020 · External reference
Disorders of plasma phosphate and indications for its measurement
10.1177/000456329603300502 · 1996 · External reference
Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae
10.1074/jbc.m312202200 · 2004 · External reference
Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition
2017 · External reference
Phosphate transporters from the higher plant Arabidopsis thaliana
10.1073/pnas.93.19.10519 · 1996 · External reference
Overexpression of an Arabidopsis thaliana high-affinity phosphate transporter gene in tobacco cultured cells enhances cell growth under phosphate-limited conditions
10.1073/pnas.94.13.7098 · 1997 · External reference
Novel mechanisms in the regulation of phosphorus homeostasis.
2009 · External reference
The Complexities of Organ Crosstalk in Phosphate Homeostasis: Time to Put Phosphate Sensing Back in the Limelight.
10.3390/ijms22115701 · 2021 · External reference
Phosphate permeases of Saccharomyces cerevisiae: structure, function and regulation
10.1016/s0304-4157(99)00010-6 · 1999 · External reference
Derepression of the high-affinity phosphate uptake in the yeast Saccharomyces cerevisiae
10.1016/0005-2736(84)90071-3 · 1984 · External reference
Regulation of inorganic phosphate transport systems in Saccharomyces cerevisiae
10.1128/jb.164.2.964-968.1985 · 1985 · External reference
Identification, cloning and characterization of a derepressible Na+-coupled phosphate transporter in Saccharomyces cerevisiae.
10.1007/s004380050776 · 1998 · External reference
The PHO84 gene of Saccharomyces cerevisiae encodes an inorganic phosphate transporter
1991 · External reference
Expression and purification of the high-affinity phosphate transporter of Saccharomyces cerevisiae
10.1111/j.1432-1033.1995.tb20426.x · 1995 · External reference
The Transporter Classification Database (TCDB): 2021 update.
10.1093/nar/gkaa1004 · 2021 · External reference
Cotransport of phosphate and sodium by yeast
10.1016/0005-2736(77)90242-5 · 1977 · External reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · 2023 · External reference
The IUPHAR/BPS Guide to PHARMACOLOGY in 2024
10.1093/nar/gkad944 · 2024 · External reference
Phosphate transport and sensing in Saccharomyces cerevisiae
10.1093/genetics/159.4.1491 · 2001 · External reference
Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae
10.1091/mbc.e07-05-0457 · 2007 · External reference
Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
10.1042/bj20101118 · 2011 · External reference
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
10.1371/journal.ppat.1007076 · 2018 · External reference
Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance.
2020 · External reference
The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis
10.1111/j.1574-6976.2008.00101.x · 2008 · External reference
The Pho regulon: a huge regulatory network in bacteria.
10.3389/fmicb.2015.00402 · 2015 · External reference
Interplay between genetic regulation of phosphate homeostasis and bacterial virulence.
10.4161/viru.29307 · 2014 · External reference
Phosphate Acquisition and Virulence in Human Fungal Pathogens.
10.3390/microorganisms5030048 · 2017 · External reference
Phosphate Starvation: A Novel Signal that Triggers ESX-5 Secretion in Mycobacterium tuberculosis
2016 · External reference
ESX secretion systems: mycobacterial evolution to counter host immunity.
10.1038/nrmicro.2016.131 · 2016 · External reference
Phosphate Import in Plants: Focus on the PHT1 Transporters.
10.3389/fpls.2011.00083 · 2011 · External reference
Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae
10.1016/s0006-291x(03)01068-4 · 2003 · External reference
Positive feedback regulates switching of phosphate transporters in S. cerevisiae
10.1016/j.molcel.2007.07.022 · 2007 · External reference
Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood
10.1111/j.1365-2958.2005.04557.x · 2005 · External reference
In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion
10.1111/j.1365-2958.2007.05614.x · 2007 · External reference
In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination
10.1111/j.1462-5822.2007.01009.x · 2007 · External reference
Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney
10.1016/j.fgb.2008.10.012 · 2009 · External reference
Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions.
10.1038/srep36055 · 2016 · External reference
Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH.
2017 · External reference
Phosphate in Virulence of Candida albicans and Candida glabrata
2020 · External reference
The art and design of genetic screens: yeast
10.1038/35088500 · 2001 · External reference
Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.
10.1021/acschembio.6b01037 · 2017 · External reference
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.
10.1021/acsinfecdis.7b00276 · 2018 · External reference
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
10.1126/science.aan4472 · 2018 · External reference
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
10.1126/science.aat9446 · 2018 · External reference
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
10.1126/science.1106753 · 2005 · External reference
Aneuploidy and isochromosome formation in drug-resistant Candida albicans
10.1126/science.1128242 · 2006 · External reference
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
10.1111/j.1365-2958.2008.06176.x · 2008 · External reference
Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
10.1371/journal.pgen.1000705 · 2009 · External reference
Evolutionary dynamics of Candida albicans during in vitro evolution
10.1128/ec.05168-11 · 2011 · External reference
Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.
10.1128/mbio.03333-20 · 2021 · External reference
The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
10.1093/nar/gkr945 · 2012 · External reference
Unearthing the root of amino acid similarity
10.1007/s00239-013-9565-0 · 2013 · External reference
Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans
10.1093/emboj/cdg256 · 2003 · External reference
Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits.
2021 · External reference
CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species
10.1128/iai.73.2.1239-1242.2005 · 2005 · External reference
Nonfilamentous C. albicans mutants are avirulent
10.1016/s0092-8674(00)80358-x · 1997 · External reference
Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis
10.1128/ec.00171-12 · 2012 · External reference
Fungal commensalism modulated by a dual-action phosphate transceptor
10.1016/j.celrep.2021.110293 · 2022 · External reference
Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats.
10.1371/journal.ppat.1010089 · 2022 · External reference
Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis
2016 · External reference
Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans
10.1111/mmi.13130 · 2015 · External reference
Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence
10.1074/jbc.m113.505735 · 2013 · External reference
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.
10.7554/elife.63910 · 2021 · External reference
Isogenic strain construction and gene mapping in Candida albicans
10.1093/genetics/134.3.717 · 1993 · External reference
The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data.
10.1093/nar/gkw924 · 2017 · External reference
Robust utilization of phospholipase-generated metabolites, glycerophosphodiesters, by Candida albicans: role of the CaGit1 permease
10.1128/ec.05160-11 · 2011 · External reference
Phosphate starvation in fungi induces the replacement of phosphatidylcholine with the phosphorus-free betaine lipid diacylglyceryl-N,N,N-trimethylhomoserine
10.1128/ec.00004-14 · 2014 · External reference
The MAP kinase-activated protein kinase Rck2p plays a role in rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans
10.1111/j.1567-1364.2008.00402.x · 2008 · External reference
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3.
10.4161/fly.19695 · 2012 · External reference
Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity
10.1091/mbc.e12-06-0477 · 2013 · External reference
Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator
10.1099/00221287-148-1-29 · 2002 · External reference
Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans
10.1128/iai.01607-14 · 2014 · External reference
The rule of declining adaptability in microbial evolution experiments
10.3389/fgene.2015.00099 · 2015 · External reference
Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity
10.1126/science.1250939 · 2014 · External reference
Why is a functional PHO pathway required by fungal pathogens to disseminate within a phosphate-rich host: A paradox explained by alkaline pH-simulated nutrient deprivation and expanded PHO pathway function.
10.1371/journal.ppat.1007021 · 2018 · External reference
Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway
2017 · External reference
The phosphate language of fungi
10.1016/j.tim.2021.08.002 · 2022 · External reference
The Role of Inorganic Phosphate Transporters in Highly Proliferative Cells: From Protozoan Parasites to Cancer Cells.
2022 · External reference
Glycerophosphocholine provision rescues Candida albicans growth and signaling phenotypes associated with phosphate limitation.
10.1128/msphere.00231-23 · 2023 · External reference
The TOR signal transduction cascade controls cellular differentiation in response to nutrients
10.1091/mbc.12.12.4103 · 2001 · External reference
YMAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
2014 · External reference
A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans
10.1099/mic.0.000478 · 2017 · External reference
Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans.
10.1128/mbio.02272-21 · 2021 · External reference
Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity.
10.1101/cshperspect.a019604 · 2014 · External reference
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
10.1126/science.1142210 · 2007 · External reference
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
2018 · External reference
Precise estimates of mutation rate and spectrum in yeast
2014 · External reference
Chromosomal duplication is a transient evolutionary solution to stress
10.1073/pnas.1211150109 · 2012 · External reference
Gene copy-number alterations: a cost-benefit analysis
10.1016/j.cell.2012.11.043 · 2013 · External reference
The fitness costs and benefits of trisomy of each Candida albicans chromosome
10.1093/genetics/iyab056 · 2021 · External reference
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
10.1534/genetics.105.054767 · 2006 · External reference
Sulfolipids dramatically decrease phosphorus demand by picocyanobacteria in oligotrophic marine environments
10.1073/pnas.0600540103 · 2006 · External reference
The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency.
10.1371/journal.pone.0212651 · 2019 · External reference
An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.
10.1371/journal.pgen.1008908 · 2020 · External reference
Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.
10.1074/jbc.m706770200 · 2007 · External reference
The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata
10.1111/1567-1364.12043 · 2013 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression
10.1371/journal.pgen.1002613 · 2012 · External reference
Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicans
10.1128/ec.00292-13 · 2014 · External reference
Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p
10.1111/j.1365-2958.2004.04350.x · 2004 · External reference
The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation
10.1073/pnas.0809147105 · 2008 · External reference
Sequential gene disruption in Candida albicans by FLP-mediated site-specific recombination
10.1046/j.1365-2958.1999.01393.x · 1999 · External reference
Assay of inorganic phosphate, total phosphate and phosphatases
10.1016/0076-6879(66)08014-5 · 1966 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Unresolved reference
External reference
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
10.1101/gr.107524.110 · 2010 · External reference
10.1101/201178
10.1101/201178 · 2017 · External reference
Twelve years of SAMtools and BCFtools.
10.1093/gigascience/giab008 · 2021 · External reference
