Research graph
References from Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans. Local targets link to admitted publications; unresolved targets remain external evidence.
Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease
10.1371/journal.pbio.3001822 · 2023 · External reference
Within-Host Genomic Diversity of Candida albicans in Healthy Carriers
10.1038/s41598-019-38768-4 · 2019 · External reference
High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis
10.1038/s41591-019-0709-7 · 2020 · External reference
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
10.1038/nature08064 · 2009 · External reference
Aneuploidy and isochromosome formation in drug-resistant Candida albicans
10.1126/science.1128242 · 2006 · External reference
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
10.1111/j.1365-2958.2008.06176.x · 2008 · External reference
Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
10.1371/journal.pgen.1000705 · 2009 · External reference
The fitness costs and benefits of trisomy of each Candida albicans chromosome
10.1093/genetics/iyab056 · 2021 · External reference
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
10.1126/science.1142210 · 2007 · External reference
Single-chromosome Gains Commonly Function as Tumor Suppressors
10.1016/j.ccell.2016.12.004 · 2017 · External reference
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype
10.1371/journal.pgen.1008137 · 2019 · External reference
Aneuploidy and gene dosage regulate filamentation and host colonization by Candida albicans
10.1073/pnas.2218163120 · 2023 · External reference
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
2018 · External reference
A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains
10.1073/pnas.2211687120 · 2023 · External reference
Gene flow contributes to diversification of the major fungal pathogen Candida albicans
10.1038/s41467-018-04787-4 · 2018 · External reference
Genetic and phenotypic intra-species variation in Candida albicans
10.1101/gr.174623.114 · 2015 · External reference
The evolution of drug resistance in clinical isolates of Candida albicans
2015 · External reference
Experimental evolution of a fungal pathogen into a gut symbiont
10.1126/science.aat0537 · 2018 · External reference
Variation in Candida albicans EFG1 expression enables host-dependent changes in colonizing fungal populations
10.1128/mbio.00117-12 · 2012 · External reference
Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism
2019 · External reference
Discovery of a “white-gray-opaque” tristable phenotypic switching system in candida albicans: roles of non-genetic diversity in host adaptation
2014 · External reference
Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions
10.1016/j.micinf.2007.01.012 · 2007 · External reference
The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity
10.1038/mi.2017.2 · 2017 · External reference
Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract
10.1128/mbio.02878-21 · 2021 · External reference
A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis
2021 · External reference
Genome Sequence for Candida albicans Clinical Oral Isolate 529L
10.1128/mra.00554-19 · 2019 · External reference
YMAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
2014 · External reference
Aneuploid yeast strains exhibit defects in cell growth and passage through START
10.1091/mbc.e12-07-0520 · 2013 · External reference
Hypo-osmotic-like stress underlies general cellular defects of aneuploidy
10.1038/s41586-019-1187-2 · 2019 · External reference
Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production
10.1038/s41522-020-00149-5 · 2020 · External reference
Significant variation of filamentation phenotypes in clinical Candida albicans strains
10.3389/fcimb.2023.1207083 · 2023 · External reference
Nonfilamentous C. albicans mutants are avirulent
10.1016/s0092-8674(00)80358-x · 1997 · External reference
Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits
2021 · External reference
Filamentation Involves Two Overlapping, but Distinct, Programs of Filamentation in the Pathogenic Fungus Candida albicans
10.1534/g3.117.300224 · 2017 · External reference
Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation
10.1371/journal.ppat.1010012 · 2022 · External reference
Candida albicans-epithelial interactions and induction of mucosal innate immunity
10.1016/j.mib.2017.10.030 · 2017 · External reference
NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction
10.1093/emboj/20.17.4753 · 2001 · External reference
Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans
10.1073/pnas.95.9.5150 · 1998 · External reference
A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans
10.1099/mic.0.000478 · 2017 · External reference
Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans
10.1128/ec.00209-09 · 2009 · External reference
Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans
10.1101/gr.166322.113 · 2014 · External reference
The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination
2018 · External reference
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism
10.1128/mbio.01521-23 · 2023 · External reference
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
10.1534/genetics.105.054767 · 2006 · External reference
The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans
10.1007/s40588-023-00190-w · 2023 · External reference
Growthcurver: an R package for obtaining interpretable metrics from microbial growth curves
10.1186/s12859-016-1016-7 · 2016 · External reference
The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis
10.1128/mbio.00025-17 · 2017 · External reference
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
10.1128/mcb.20.4.1436-1447.2000 · 2000 · External reference
Host cell invasion and virulence mediated by Candida albicans Ssa1
2010 · External reference
Mouse model of oropharyngeal candidiasis
10.1038/nprot.2012.011 · 2012 · External reference
CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans
10.1128/iai.02604-14 · 2015 · External reference
Unresolved reference
External reference
Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants
10.1111/j.1567-1364.2009.00563.x · 2009 · External reference
