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References from LIPL-1 and LIPL-2 are TCER-1-regulated lysosomal lipases with distinct roles in immunity and fertility. Local targets link to admitted publications; unresolved targets remain external evidence.
Reproduction-Immunity Trade-Offs in Insects
10.1146/annurev-ento-010715-023924 · 2016 · External reference
Sperm success and immunity
10.1016/bs.ctdb.2019.04.002 · 2019 · External reference
Elevated expression of ageing and immunity genes in queens of the black garden ant
10.1016/j.exger.2018.03.020 · 2018 · External reference
Sexual healing: mating induces a protective immune response in bumblebees
10.1111/jeb.12964 · 2017 · External reference
Sexual conflict over nuptial gifts in insects
10.1146/annurev.ento.53.103106.093423 · 2008 · External reference
Fetomaternal immune cross-talk and its consequences for maternal and offspring’s health
10.1038/nm.3160 · 2013 · External reference
Pregnancy and infection
10.1056/nejmra1213566 · 2014 · External reference
Immune mechanisms at the maternal-fetal interface: perspectives and challenges
10.1038/ni.3131 · 2015 · External reference
Immune Regulation in Pregnancy: A Matter of Perspective?
10.1016/j.ogc.2016.07.004 · 2016 · External reference
Are all eggs created equal? Food availability and the fitness trade‐off between reproduction and immunity
10.1111/1365-2435.12071 · 2013 · External reference
Reproduction Immunity Trade-Off in a Mollusk: Hemocyte Energy Metabolism Underlies Cellular and Molecular Immune Responses
10.3389/fphys.2019.00077 · 2019 · External reference
Implications of pregnancy on cardiometabolic disease risk: preeclampsia and gestational diabetes
10.1152/ajpcell.00293.2024 · 2024 · External reference
Association of dietary inflammatory index with risk of gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis
10.1017/s0007114523001678 · 2024 · External reference
Unresolved reference
2025 · External reference
The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms
10.1002/bies.202000103 · 2020 · External reference
The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity
10.1038/s41467-019-10759-z · 2019 · External reference
CEH-60/PBX and UNC-62/MEIS coordinate a metabolic switch that supports reproduction in C. elegans
10.1016/j.devcel.2019.03.002 · 2019 · External reference
More is not better: brood size and population growth in a self-fertilizing nematode
10.1098/rspb.1991.0119 · 1991 · External reference
Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity
10.1371/journal.pgen.1000273 · 2008 · External reference
Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans
10.1073/pnas.1514012112 · 2015 · External reference
Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
10.1073/pnas.1909666116 · 2019 · External reference
Identification of transforming growth factor-beta- regulated genes in caenorhabditis elegans by differential hybridization of arrayed cDNAs
10.1073/pnas.96.26.15020 · 1999 · External reference
Inducible antibacterial defense system in C. elegans
10.1016/s0960-9822(02)00928-4 · 2002 · External reference
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
10.1038/ni1060 · 2004 · External reference
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins
10.1073/pnas.0404073101 · 2004 · External reference
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses
10.1073/pnas.0603424103 · 2006 · External reference
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
10.1371/journal.pgen.0020183 · 2006 · External reference
Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing
10.1371/journal.pone.0139812 · 2015 · External reference
Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes Associated with Cellular Morphology and Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in Neuroblastoma Cells and Primary Neuronal Cultures
10.1007/s12035-016-0284-6 · 2017 · External reference
A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana
10.3389/fpls.2019.01019 · 2019 · External reference
Effects of follicle size and oocyte maturation conditions on maternal messenger RNA regulation and gene expression in rhesus monkey oocytes and embryos
10.1095/biolreprod.104.035881 · 2005 · External reference
Maternal age-related differential global expression profiles observed in human oocytes
10.1016/s1472-6483(10)60671-2 · 2007 · External reference
DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans
2016 · External reference
Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans
10.1371/journal.pgen.1004829 · 2014 · External reference
Wolman’s disease and cholesteryl ester storage disorder: the phenotypic spectrum of lysosomal acid lipase deficiency
10.1016/s2468-1253(17)30052-3 · 2017 · External reference
Recent insights into lysosomal acid lipase deficiency
10.1016/j.molmed.2023.03.001 · 2023 · External reference
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
10.1038/ncb2741 · 2013 · External reference
Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans
10.1016/j.celrep.2019.06.064 · 2019 · External reference
Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival
10.1371/journal.pbio.3000245 · 2019 · External reference
Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans
10.1016/j.bbalip.2019.158539 · 2020 · External reference
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
10.1126/science.1258857 · 2015 · External reference
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity
10.1016/j.devcel.2018.12.022 · 2019 · External reference
Lysosome lipid signalling from the periphery to neurons regulates longevity
10.1038/s41556-022-00926-8 · 2022 · External reference
NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection
10.1128/iai.00130-20 · 2020 · External reference
NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase
2021 · External reference
The increasing threat of Pseudomonas aeruginosa high-risk clones
10.1016/j.drup.2015.08.002 · 2015 · External reference
Dissociation of immune responses from pathogen colonization supports pattern recognition in C. elegans
10.1371/journal.pone.0035400 · 2012 · External reference
Defining characteristics and conservation of poorly annotated genes in Caenorhabditis elegans using WormCat 2.0
10.1093/genetics/iyac085 · 2022 · External reference
FOXO transcription factors at the interface between longevity and tumor suppression
10.1038/sj.onc.1209086 · 2005 · External reference
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
10.1096/fj.03-0860fje · 2004 · External reference
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
10.1126/science.1083701 · 2003 · External reference
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
10.1016/j.cell.2008.01.030 · 2008 · External reference
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
10.1126/science.1223560 · 2012 · External reference
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection
10.1038/nature13818 · 2014 · External reference
Hierarchical assembly of the eggshell and permeability barrier in C. elegans
10.1083/jcb.201206008 · 2012 · External reference
The eggshell in the C. elegans oocyte-to-embryo transition
10.1002/dvg.20823 · 2012 · External reference
A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans
10.3389/fcell.2022.856474 · 2022 · External reference
Loss of the seipin gene perturbs eggshell formation in Caenorhabditiselegans
2020 · External reference
LipidClock: A Lipid-Based Predictor of Biological Age
10.3389/fragi.2022.828239 · 2022 · External reference
Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging
10.1093/gerona/gly100 · 2019 · External reference
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
10.1038/ni.2956 · 2014 · External reference
Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism
10.3389/fcell.2015.00003 · 2015 · External reference
Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans
10.1371/journal.pgen.1003651 · 2013 · External reference
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
10.1016/j.cmet.2009.10.002 · 2009 · External reference
Sphingolipids and their metabolism in physiology and disease
10.1038/nrm.2017.107 · 2018 · External reference
Ceramides and other sphingolipids as drivers of cardiovascular disease
10.1038/s41569-021-00536-1 · 2021 · External reference
The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging
10.18632/aging.204515 · 2023 · External reference
Protection of C. elegans from anoxia by HYL-2 ceramide synthase
10.1126/science.1168532 · 2009 · External reference
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans
2024 · External reference
Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis
10.1038/cddis.2015.82 · 2015 · External reference
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
10.2337/db08-1228 · 2009 · External reference
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance
10.1016/j.cmet.2014.08.002 · 2014 · External reference
Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes
10.1002/oby.21117 · 2015 · External reference
Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans
10.1371/journal.pbio.3001431 · 2021 · External reference
LC–MS-based metabolomics identification of novel biomarkers of chorioamnionitis and its associated perinatal neurological damage
10.1021/pr501087x · 2015 · External reference
Metabolomic biomarkers in midtrimester maternal plasma can accurately predict the development of preeclampsia
10.1038/s41598-020-72852-4 · 2020 · External reference
Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
10.1152/ajplung.00335.2003 · 2004 · External reference
Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation
10.1016/j.bbalip.2019.01.007 · 2019 · External reference
Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration
10.1016/j.molmet.2023.101737 · 2023 · External reference
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering
10.1534/genetics.115.182162 · 2016 · External reference
Transposon-Assisted Genetic Engineering with Mos1-Mediated Single-Copy Insertion (MosSCI)
10.1007/978-1-4939-2842-2_5 · 2015 · External reference
The C. elegans lifespan assay toolkit
10.1016/j.ymeth.2014.04.002 · 2014 · External reference
OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research
10.18632/oncotarget.11269 · 2016 · External reference
WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data
10.1534/genetics.119.302919 · 2020 · External reference
Targeted lipidomics reveals a novel role for glucosylceramides in glucose response
10.1016/j.jlr.2023.100394 · 2023 · External reference
13C- and 15N-Labeling Strategies Combined with Mass Spectrometry Comprehensively Quantify Phospholipid Dynamics in C. elegans
2015 · External reference