Research graph
References from Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina. Local targets link to admitted publications; unresolved targets remain external evidence.
Regulation of chromatin by histone modifications
10.1038/cr.2011.22 · 2011 · External reference
The bromodomain interaction module
10.1016/j.febslet.2012.04.045 · 2012 · External reference
The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis
10.1016/j.neuron.2017.04.022 · 2017 · External reference
Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease
10.1073/pnas.1922501117 · 2020 · External reference
Histone acylation at a glance
10.1242/jcs.261250 · 2024 · External reference
Metabolism-driven chromatin dynamics: Molecular principles and technological advances
10.1016/j.molcel.2024.12.012 · 2025 · External reference
Metabolic regulation of gene expression by histone lactylation
10.1038/s41586-019-1678-1 · 2019 · External reference
Epigenetics and metabolism
10.1161/circresaha.116.303936 · 2015 · External reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · 2020 · External reference
Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcription
10.1042/ebc20180061 · 2019 · External reference
Infection-induced lysine lactylation enables herpesvirus immune evasion
2025 · External reference
Histone lactylation boosts reparative gene activation post-myocardial infarction
10.1161/circresaha.122.320488 · 2022 · External reference
Histone lactylation exacerbates cerebral ischemia-reperfusion injury via NSUN2-mediated epigenetic activation of astrocytic neuroinflammation
10.1080/01616412.2025.2530215 · 2026 · External reference
Histone lactylation couples cellular metabolism with developmental gene regulatory networks
10.1038/s41467-023-44121-1 · 2024 · External reference
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory
10.1016/j.cell.2025.03.048 · 2025 · External reference
On the origin of cancer cells
10.1126/science.123.3191.309 · 1956 · External reference
Metabolic differentiation in the embryonic retina
10.1038/ncb2531 · 2012 · External reference
Glycolytic reliance promotes anabolism in photoreceptors
10.7554/elife.25946 · 2017 · External reference
The neuronal organization of the retina
10.1016/j.neuron.2012.10.002 · 2012 · External reference
The major cell populations of the mouse retina
10.1523/jneurosci.18-21-08936.1998 · 1998 · External reference
Evolution of phototransduction, vertebrate photoreceptors and retina
10.1016/j.preteyeres.2013.06.001 · 2013 · External reference
Energy metabolism of rabbit retina as related to function: high cost of Na+ transport
10.1523/jneurosci.12-03-00840.1992 · 1992 · External reference
Rod outer segment disk shedding in rat retina: relationship to cyclic lighting
10.1126/science.982063 · 1976 · External reference
Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina
10.1074/jbc.m115.698985 · 2016 · External reference
ATP consumption by mammalian rod photoreceptors in darkness and in light
10.1016/j.cub.2008.10.029 · 2008 · External reference
The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases
2016 · External reference
Energy metabolism of the visual system
10.2147/eb.s9078 · 2010 · External reference
Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa
10.1016/j.celrep.2018.04.111 · 2018 · External reference
Glucose, lactate, and shuttling of metabolites in vertebrate retinas
10.1002/jnr.23583 · 2015 · External reference
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
10.7554/elife.28899 · 2017 · External reference
Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection
10.1146/annurev-vision-100419-115156 · 2021 · External reference
In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium
2024 · External reference
Lactate transport and receptor actions in retina: potential roles in retinal function and disease
10.1007/s11064-015-1792-x · 2016 · External reference
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis
10.1038/s41467-023-39672-2 · 2023 · External reference
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
10.1038/nn.2234 · 2009 · External reference
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
2022 · External reference
H3K18 lactylation marks tissue-specific active enhancers
10.1186/s13059-022-02775-y · 2022 · External reference
Improved Retinal Organoid Differentiation by Modulating Signaling Pathways Revealed by Comparative Transcriptome Analyses with Development In Vivo
10.1016/j.stemcr.2019.09.009 · 2019 · External reference
Epigenetic control of gene regulation during development and disease: A view from the retina
10.1016/j.preteyeres.2018.03.002 · 2018 · External reference
Epigenome-metabolism nexus in the retina: implications for aging and disease
10.1016/j.tig.2024.04.012 · 2024 · External reference
Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions
10.1146/annurev-vision-100419-114940 · 2021 · External reference
Histone lactylation: epigenetic mark of glycolytic switch
10.1016/j.tig.2021.09.009 · 2022 · External reference
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation
10.1038/s12276-020-00539-x · 2020 · External reference
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer
2024 · External reference
NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors
10.1016/j.celrep.2016.10.074 · 2016 · External reference
Sparsification of neuronal activity in the visual cortex at eye-opening
10.1073/pnas.0907660106 · 2009 · External reference
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade
10.1038/s42255-020-0267-9 · 2020 · External reference
Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism
10.1016/j.celrep.2020.107525 · 2020 · External reference
Renormalization of metabolic coupling treats age-related degenerative disorders: an oxidative RPE niche fuels the more glycolytic photoreceptors
10.1038/s41433-021-01726-4 · 2022 · External reference
WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor cells in diabetic retinopathy
10.1186/s12967-024-05046-5 · 2024 · External reference
Adherence to the Mediterranean Diet and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2
10.1016/j.ophtha.2020.04.030 · 2020 · External reference
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2
10.1016/j.ophtha.2020.08.018 · 2021 · External reference
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors
10.1073/pnas.0508214103 · 2006 · External reference
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
10.1016/j.cell.2011.08.008 · 2011 · External reference
Determination of mitochondrial respiration and glycolysis in ex vivo retinal tissue samples
10.3791/62914 · 2021 · External reference
An optimized protocol for retina single-cell RNA sequencing
2020 · External reference
The nf-core framework for community-curated bioinformatics pipelines
10.1038/s41587-020-0439-x · 2020 · External reference
ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
10.1093/bioinformatics/btv145 · 2015 · External reference
csaw: a Bioconductor package for differential binding analysis of ChIP-seq data using sliding windows
2016 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Developmental genome-wide occupancy analysis of bZIP transcription factor NRL uncovers the role of c-Jun in early differentiation of rod photoreceptors in the mammalian retina
10.1093/hmg/ddac143 · 2022 · External reference
Identification of transcription factor binding sites using ATAC-seq
10.1186/s13059-019-1642-2 · 2019 · External reference
BEDTools: a flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
10.1186/1471-2105-11-165 · 2010 · External reference
HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human and mouse transcription factors
10.1093/nar/gkad1077 · 2024 · External reference
