Research graph
References from Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep. Local targets link to admitted publications; unresolved targets remain external evidence.
A family of potassium channel genes related to eag in Drosophila and mammals
10.1073/pnas.91.8.3438 · 1994 · External reference
The eag family of K+ channels in Drosophila and mammals
10.1111/j.1749-6632.1999.tb11297.x · 1999 · External reference
Ether-à-go-go K+ channels: Effective modulators of neuronal excitability
10.1113/jp275477 · 2018 · External reference
Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism
10.1126/science.aaf8070 · 2016 · External reference
Cryo-EM structure of the open human ether-à-go-go-Related K+ channel hERG
10.1016/j.cell.2017.03.048 · 2017 · External reference
Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
10.1080/19336950.2020.1816107 · 2020 · External reference
The enigmatic cytoplasmic regions of KCNH channels
10.1016/j.jmb.2014.08.008 · 2015 · External reference
Similarities in amino acid sequences of Drosophila eag and cyclic nucleotide-gated channels
10.1126/science.1658932 · 1991 · External reference
Structure of the carboxy-terminal region of a KCNH channel
10.1038/nature10735 · 2012 · External reference
Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel
10.1016/j.jmb.2012.06.025 · 2012 · External reference
Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels
2017 · External reference
The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation
10.1085/jgp.201611701 · 2017 · External reference
The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure
10.1085/jgp.201812129 · 2019 · External reference
Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels
10.1085/jgp.201310995 · 2013 · External reference
The structural mechanism of KCNH-channel regulation by the eag domain
10.1038/nature12487 · 2013 · External reference
Sleep-active neurons: Conserved motors of sleep
10.1534/genetics.117.300521 · 2018 · External reference
Cellular stress induces a protective sleep-like state in C. elegans
10.1016/j.cub.2014.08.040 · 2014 · External reference
A mechanism for sickness sleep: Lessons from invertebrates
10.1113/jp273009 · 2017 · External reference
Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans
10.1038/nn1981 · 2007 · External reference
Epidermal growth factor signaling promotes sleep through a combined series and parallel neural circuit
10.1016/j.cub.2019.10.048 · 2020 · External reference
Sleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1
10.1038/s41467-024-55252-4 · 2024 · External reference
FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans
10.1016/j.cub.2014.08.037 · 2014 · External reference
C. elegans stress-induced sleep emerges from the collective action of multiple neuropeptides
10.1016/j.cub.2016.07.048 · 2016 · External reference
Orcokinin neuropeptides regulate sleep in Caenorhabditis elegans
10.1080/01677063.2020.1830084 · 2020 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans
10.1523/jneurosci.19-22-09831.1999 · 1999 · External reference
Succinate dehydrogenase-regulated phosphoenolpyruvate carboxykinase sustains copulation fitness in aging C. elegans males.
10.1016/j.isci.2020.100990 · 2020 · External reference
Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein
10.1038/nbt1044 · 2005 · External reference
NATF (Native and Tissue-Specific Fluorescence): A strategy for bright, tissue-specific GFP labeling of native proteins in Caenorhabditis elegans
10.1534/genetics.119.302063 · 2019 · External reference
Ultrasensitive fluorescent proteins for imaging neuronal activity
10.1038/nature12354 · 2013 · External reference
An efficient genome editing strategy to generate putative null mutants in Caenorhabditis elegans using CRISPR/Cas9
10.1534/g3.118.200662 · 2018 · External reference
Mutations in the K+ channel signature sequence
10.1016/s0006-3495(94)80887-2 · 1994 · External reference
The structure of the potassium channel: Molecular basis of K+ conduction and selectivity
10.1126/science.280.5360.69 · 1998 · External reference
A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels
10.1073/pnas.0505909103 · 2006 · External reference
Caenorhabditis elegans UNC-103 ERG-like potassium channel regulates contractile behaviors of sex muscles in males before and during mating
10.1523/jneurosci.23-07-02696.2003 · 2003 · External reference
Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans
10.1523/jneurosci.3896-12.2013 · 2013 · External reference
Unresolved reference
2004 · External reference
HERG, a human inward rectifier in the voltage-gated potassium channel family
10.1126/science.7604285 · 1995 · External reference
Reduced sleep in Drosophila Shaker mutants
10.1038/nature03486 · 2005 · External reference
Melatonin promotes sleep by activating the BK channel in C. elegans
10.1073/pnas.2010928117 · 2020 · External reference
Dynamic- and frequency-specific regulation of sleep oscillations by cortical potassium channels
10.1016/j.cub.2019.07.056 · 2019 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of K+ channelopathies
10.1038/s41431-021-00818-9 · 2021 · External reference
Potassium channels in C. elegans
2005 · External reference
Molecular topography of an entire nervous system
10.1016/j.cell.2021.06.023 · 2021 · External reference
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia
10.1073/pnas.0306005101 · 2004 · External reference
In vivo analysis of a gain-of-function mutation in the Drosophila eag-encoded K+ channel
10.1534/genetics.105.048777 · 2006 · External reference
hERG gating microdomains defined by S6 mutagenesis and molecular modeling
10.1085/jgp.200810083 · 2008 · External reference
KCNH1 variants associated with neurodevelopmental disorders exhibit prominent gain-of-function
2026 · External reference
hERG potassium channel gating is mediated by N- and C-terminal region interactions
10.1085/jgp.201010582 · 2011 · External reference
Structure of the C-terminal region of an ERG channel and functional implications
10.1073/pnas.1306887110 · 2013 · External reference
Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome
10.1038/ncomms6535 · 2014 · External reference
Dynamics of potassium ion currents in squid axon membrane. A re-examination
10.1016/s0006-3495(81)84760-1 · 1981 · External reference
Potassium currents expressed from Drosophila and mouse eag cDNAs in Xenopus oocytes
10.1016/0028-3908(96)00113-x · 1996 · External reference
Functional expression of a rat homologue of the voltage gated either á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart
10.1002/j.1460-2075.1994.tb06767.x · 1994 · External reference
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
10.1085/jgp.201110761 · 2012 · External reference
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways
10.1016/j.bpj.2015.02.014 · 2015 · External reference
Hysteretic hERG channel gating current recorded at physiological temperature
10.1038/s41598-022-10003-7 · 2022 · External reference
Regulation of Eag1 gating by its intracellular domains
10.7554/elife.49188 · 2019 · External reference
Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel
10.1038/s41467-023-37204-6 · 2023 · External reference
Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms
10.7554/elife.91420 · 2024 · External reference
Voltage-sensor movements in the Eag Kv channel under an applied electric field
10.1073/pnas.2214151119 · 2022 · External reference
Food deprivation attenuates seizures through CaMKII and EAG K+ channels
10.1371/journal.pgen.0030156 · 2007 · External reference
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans
10.1242/dev.128.11.1951 · 2001 · External reference
Characterizing a strong pan-muscular promoter (Pmlc-1) as a fluorescent co-injection marker to select for single-copy insertions
2020 · External reference
Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep
2016 · External reference
An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans
10.1093/g3journal/jkad183 · 2023 · External reference
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences
10.1002/j.1460-2075.1991.tb04966.x · 1991 · External reference
Efficient transgenesis in Caenorhabditis elegans using Flp recombinase-mediated cassette exchange
10.1534/genetics.120.303388 · 2020 · External reference
Rapid generation of C. elegans single-copy transgenes combining RMCE and drug selection
10.1093/genetics/iyad072 · 2023 · External reference
Modular safe-harbor transgene insertion for targeted single-copy and extrachromosomal array integration in Caenorhabditis elegans
10.1093/g3journal/jkac184 · 2022 · External reference
Improved CRISPR/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans
2021 · External reference
A versatile site-directed gene trap strategy to manipulate gene activity and control gene expression in Caenorhabditis elegans
10.1371/journal.pgen.1011541 · 2025 · External reference
Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans
10.1534/genetics.114.169730 · 2014 · External reference
Caenorhabditis elegans AF4/FMR2 family homolog affl-2 regulates heat-shock-induced gene expression
10.1534/genetics.120.302923 · 2020 · External reference
C. elegans mutant identification with a one-step whole-genome-sequencing and SNP mapping strategy
10.1371/journal.pone.0015435 · 2010 · External reference
Unresolved reference
2018 · External reference
The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor
10.1186/1471-2202-14-156 · 2013 · External reference
A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans
10.1371/journal.pbio.0060198 · 2008 · External reference
Light and hydrogen peroxide inhibit C. elegans feeding through gustatory receptor orthologs and pharyngeal neurons
10.1016/j.neuron.2014.12.061 · 2015 · External reference
