Research graph
References from Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition. Local targets link to admitted publications; unresolved targets remain external evidence.
p53 directs focused genomic responses in Drosophila
10.1038/sj.onc.1210328 · 2007 · External reference
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage
10.1128/mcb.24.3.1219-1231.2004 · 2004 · External reference
Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
10.1038/s41598-018-36277-4 · 2018 · External reference
Myc and Tor drive growth and cell competition in the regeneration blastema of Drosophila wing imaginal discs
2025 · External reference
The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function
10.7554/elife.71705 · 2022 · External reference
The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes
10.1242/dev.200795 · 2022 · External reference
Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status
10.1371/journal.pgen.1009946 · 2021 · External reference
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition
2018 · External reference
Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster
10.1534/g3.116.029421 · 2016 · External reference
Genetic landscaping of cell competition uncovers two core pathways mediated by Xrp1 or Eiger/TNF in Drosophila
10.1093/genetics/iyag067 · 2026 · External reference
Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α
10.1371/journal.pgen.1009958 · 2021 · External reference
Depletion of aneuploid cells is shaped by cell-to-cell interactions
10.1016/j.xgen.2025.100894 · 2025 · External reference
Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose
2021 · External reference
DNA repair defects in cancer and therapeutic opportunities
10.1101/gad.349431.122 · 2022 · External reference
The mutagenic consequences of defective DNA repair
10.1016/j.dnarep.2024.103694 · 2024 · External reference
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
10.1016/j.ajhg.2019.06.005 · 2019 · External reference
From DNA damage to mutations: All roads lead to aging
10.1016/j.arr.2021.101316 · 2021 · External reference
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
10.1016/j.ccr.2009.10.023 · 2009 · External reference
Chromosome missegregation causes colon cancer by APC loss of heterozygosity
10.4161/cc.9.9.11314 · 2010 · External reference
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
10.1038/ng1449 · 2004 · External reference
The p53 pathway: what questions remain to be explored?
10.1038/sj.cdd.4401910 · 2006 · External reference
Two-phase dynamics of p53 in the DNA damage response
10.1073/pnas.1100600108 · 2011 · External reference
p53 and Tumor Suppression: It Takes a Network
10.1016/j.tcb.2020.12.011 · 2021 · External reference
Deconstructing networks of p53-mediated tumor suppression in vivo
10.1038/cdd.2017.171 · 2018 · External reference
Emerging mechanisms of cell competition
10.1038/s41576-020-0262-8 · 2020 · External reference
Cell death, compensatory proliferation, and cell competition
2025 · External reference
Cell competition and cancer from Drosophila to mammals
10.1038/s41389-023-00505-y · 2024 · External reference
An expanded view of cell competition
10.1242/dev.204212 · 2024 · External reference
Cell competition and the regulation of protein homeostasis
10.1016/j.ceb.2024.102323 · 2024 · External reference
Mechanisms of cellular fitness and cell competition: Towards an integrated view
10.1016/j.ceb.2025.102571 · 2025 · External reference
Cell competition: A historical perspective
10.1016/j.ydbio.2021.02.012 · 2021 · External reference
Cell competition: emerging signaling and unsolved questions
10.1002/1873-3468.14822 · 2024 · External reference
Ribosomal protein mutations and cell competition: autonomous and nonautonomous effects on a stress response
10.1093/genetics/iyad080 · 2023 · External reference
Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica
10.1038/cdd.2014.218 · 2015 · External reference
p53-mediated hematopoietic stem and progenitor cell competition
10.1016/j.stem.2010.03.002 · 2010 · External reference
Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen
10.1126/science.1241628 · 2013 · External reference
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
10.1016/j.stem.2019.06.011 · 2019 · External reference
Irradiation selects for p53-deficient hematopoietic progenitors
10.1371/journal.pbio.1000324 · 2010 · External reference
Mechanical cell competition kills cells via induction of lethal p53 levels
10.1038/ncomms11373 · 2016 · External reference
p53 pathway is involved in cell competition during mouse embryogenesis
10.1073/pnas.1617414114 · 2017 · External reference
Minutes: mutants of drosophila autonomously affecting cell division rate
10.1016/0012-1606(75)90330-9 · 1975 · External reference
The third-chromosome group of mutant characters of Drosophila melanogaster
1923 · External reference
The ribosomal protein genes and Minute loci of Drosophila melanogaster [Comparative Study Research Support N.I.H. Extramural Research support, non-U.S. gov’t]
10.1186/gb-2007-8-10-r216 · 2007 · External reference
Engulfment is required for cell competition
10.1016/j.cell.2007.03.054 · 2007 · External reference
An ancient defense system eliminates unfit cells from developing tissues during cell competition [Research support, non-U.S. gov’t]
10.1126/science.1258236 · 2014 · External reference
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
10.1038/416755a · 2002 · External reference
Parameters of cell competition in the compartments of the wing disc of Drosophila
10.1016/0012-1606(79)90284-7 · 1979 · External reference
Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
10.1016/j.devcel.2019.03.016 · 2019 · External reference
Roles of C/EBP class bZip proteins in the growth and cell competition of Rp (’Minute’) mutants in Drosophila
2020 · External reference
Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis
10.1073/pnas.1613508113 · 2016 · External reference
Networks of bZIP protein-protein interactions diversified over a billion years of evolution
10.1126/science.1233465 · 2013 · External reference
FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system
2011 · External reference
Drosophila RpS12 controls translation, growth, and cell competition through Xrp1
2019 · External reference
Ribosomal Protein S12e Has a Distinct Function in Cell Competition
10.1016/j.devcel.2017.12.007 · 2018 · External reference
Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer
2015 · External reference
Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1
10.1016/j.celrep.2026.117155 · 2026 · External reference
RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
10.1016/j.celrep.2026.117380 · 2026 · External reference
Proteotoxic stress is a driver of the loser status and cell competition
10.1038/s41556-020-00627-0 · 2021 · External reference
The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila
10.7554/elife.74047 · 2021 · External reference
The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models
10.1371/journal.pgen.1012203 · 2026 · External reference
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition
10.1038/s41556-020-00626-1 · 2021 · External reference
Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors
10.1038/s41467-024-55576-1 · 2025 · External reference
Reducing the aneuploid cell burden - cell competition and the ribosome connection
10.1242/dmm.049673 · 2022 · External reference
p53-independent apoptosis limits DNA damage-induced aneuploidy
10.1534/genetics.109.102327 · 2009 · External reference
Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster
10.1534/genetics.108.093625 · 2008 · External reference
Mutant p53 in cancer: new functions and therapeutic opportunities
10.1016/j.ccr.2014.01.021 · 2014 · External reference
Putting p53 in Context
10.1016/j.cell.2017.08.028 · 2017 · External reference
Temporal dissection of p53 function in vitro and in vivo
10.1038/ng1572 · 2005 · External reference
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
10.1038/nature05077 · 2006 · External reference
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
10.1016/j.cell.2012.04.026 · 2012 · External reference
A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila
10.1016/j.ydbio.2018.11.018 · 2019 · External reference
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
10.1016/j.molmet.2019.10.002 · 2020 · External reference
Mutant p53 in cell-cell interactions
10.1101/gad.347542.120 · 2021 · External reference
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
10.1016/j.cub.2006.07.046 · 2006 · External reference
Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster
10.1073/pnas.0510528103 · 2006 · External reference
Drosophila p53 directs nonapoptotic programs in postmitotic tissue
10.1091/mbc.e18-12-0791 · 2019 · External reference
Identification and characterization of a p53 homologue in Drosophila melanogaster
10.1073/pnas.97.13.7301 · 2000 · External reference
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 [Research support, U.S. Gov’t, P.H.S.]
10.1016/s0092-8674(00)80626-1 · 2000 · External reference
Census and evaluation of p53 target genes
10.1038/onc.2016.502 · 2017 · External reference
A global map of p53 transcription-factor binding sites in the human genome
10.1016/j.cell.2005.10.043 · 2006 · External reference
Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity
10.1101/gr.220533.117 · 2017 · External reference
Linking JNK Activity to the DNA Damage Response
10.1177/1947601913486347 · 2013 · External reference
Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila
10.1371/journal.pgen.1008133 · 2019 · External reference
Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
10.1038/onc.2014.42 · 2015 · External reference
Dual roles of Drosophila p53 in cell death and cell differentiation
10.1038/cdd.2009.182 · 2010 · External reference
Regulation of apoptosis of rbf mutant cells during Drosophila development
10.1016/j.ydbio.2008.11.035 · 2009 · External reference
Drosophila p53 binds a damage response element at the reaper locus
10.1016/s0092-8674(00)80627-3 · 2000 · External reference
Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53
10.1016/j.ydbio.2011.10.012 · 2012 · External reference
Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition
10.1016/j.devcel.2018.08.001 · 2018 · External reference
Toll signaling promotes JNK-dependent apoptosis in Drosophila
10.1186/s13008-020-00062-5 · 2020 · External reference
Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location
2025 · External reference
E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila
10.1016/j.ydbio.2010.07.023 · 2010 · External reference
INSECT: IN-silico SEarch for Co-occurring Transcription factors
10.1093/bioinformatics/btt506 · 2013 · External reference
The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster
10.1242/jcs.200782 · 2017 · External reference
The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γ-H2AV)
10.1534/g3.113.006833 · 2013 · External reference
Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control
10.7554/elife.61389 · 2022 · External reference
Coordination between cell proliferation and apoptosis after DNA damage in Drosophila
10.1038/s41418-021-00898-6 · 2022 · External reference
Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells
10.1371/journal.pgen.1004581 · 2014 · External reference
Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms
10.7554/elife.02200 · 2014 · External reference
Transcriptional control of human p53-regulated genes
10.1038/nrm2395 · 2008 · External reference
p53 in the DNA-Damage-Repair Process
10.1101/cshperspect.a026070 · 2016 · External reference
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
10.1016/j.bbadis.2013.08.014 · 2014 · External reference
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
10.1038/s41467-020-16796-3 · 2020 · External reference
Ordered and deterministic cancer genome evolution after p53 loss
10.1038/s41586-022-05082-5 · 2022 · External reference
Systems approaches identify the consequences of monosomy in somatic human cells
10.1038/s41467-021-25288-x · 2021 · External reference
The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.
10.1371/journal.pone.0268579 · 2022 · External reference
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
10.1093/genetics/153.1.135 · 1999 · External reference
Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila
10.1271/bbb.120756 · 2013 · External reference
A genome-scale shRNA resource for transgenic RNAi in Drosophila
10.1038/nmeth.1592 · 2011 · External reference
A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics
10.1006/dbio.1994.1203 · 1994 · External reference
A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence
10.1006/dbio.1995.1251 · 1995 · External reference
Organizing activity of wingless protein in Drosophila
10.1016/0092-8674(93)90072-x · 1993 · External reference
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
10.1242/dev.127.4.851 · 2000 · External reference
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
10.1016/s0092-8674(00)81385-9 · 1996 · External reference
Analysis of genetic mosaics in developing and adult Drosophila tissues
10.1242/dev.117.4.1223 · 1993 · External reference
Cell competition: emerging signaling and unsolved questions
10.1002/1873-3468.14822 · ExternalCitation · doi-reference
A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics
10.1006/dbio.1994.1203 · ExternalCitation · doi-reference
A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence
10.1006/dbio.1995.1251 · ExternalCitation · doi-reference
Minutes: mutants of drosophila autonomously affecting cell division rate
10.1016/0012-1606(75)90330-9 · ExternalCitation · doi-reference
Parameters of cell competition in the compartments of the wing disc of Drosophila
10.1016/0012-1606(79)90284-7 · ExternalCitation · doi-reference
Organizing activity of wingless protein in Drosophila
10.1016/0092-8674(93)90072-x · ExternalCitation · doi-reference
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
10.1016/j.ajhg.2019.06.005 · ExternalCitation · doi-reference
From DNA damage to mutations: All roads lead to aging
10.1016/j.arr.2021.101316 · ExternalCitation · doi-reference
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
10.1016/j.bbadis.2013.08.014 · ExternalCitation · doi-reference
Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity
10.1016/j.ccr.2009.10.023 · ExternalCitation · doi-reference
Mutant p53 in cancer: new functions and therapeutic opportunities
10.1016/j.ccr.2014.01.021 · ExternalCitation · doi-reference
Cell competition and the regulation of protein homeostasis
10.1016/j.ceb.2024.102323 · ExternalCitation · doi-reference
Mechanisms of cellular fitness and cell competition: Towards an integrated view
10.1016/j.ceb.2025.102571 · ExternalCitation · doi-reference
A global map of p53 transcription-factor binding sites in the human genome
10.1016/j.cell.2005.10.043 · ExternalCitation · doi-reference
Engulfment is required for cell competition
10.1016/j.cell.2007.03.054 · ExternalCitation · doi-reference
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
10.1016/j.cell.2012.04.026 · ExternalCitation · doi-reference
Putting p53 in Context
10.1016/j.cell.2017.08.028 · ExternalCitation · doi-reference
Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1
10.1016/j.celrep.2026.117155 · ExternalCitation · doi-reference
RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
10.1016/j.celrep.2026.117380 · ExternalCitation · doi-reference
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
10.1016/j.cub.2006.07.046 · ExternalCitation · doi-reference
Ribosomal Protein S12e Has a Distinct Function in Cell Competition
10.1016/j.devcel.2017.12.007 · ExternalCitation · doi-reference
Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition
10.1016/j.devcel.2018.08.001 · ExternalCitation · doi-reference
Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
10.1016/j.devcel.2019.03.016 · ExternalCitation · doi-reference
The mutagenic consequences of defective DNA repair
10.1016/j.dnarep.2024.103694 · ExternalCitation · doi-reference
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
10.1016/j.molmet.2019.10.002 · ExternalCitation · doi-reference
p53-mediated hematopoietic stem and progenitor cell competition
10.1016/j.stem.2010.03.002 · ExternalCitation · doi-reference
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
10.1016/j.stem.2019.06.011 · ExternalCitation · doi-reference
p53 and Tumor Suppression: It Takes a Network
10.1016/j.tcb.2020.12.011 · ExternalCitation · doi-reference
Depletion of aneuploid cells is shaped by cell-to-cell interactions
10.1016/j.xgen.2025.100894 · ExternalCitation · doi-reference
Regulation of apoptosis of rbf mutant cells during Drosophila development
10.1016/j.ydbio.2008.11.035 · ExternalCitation · doi-reference
E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila
10.1016/j.ydbio.2010.07.023 · ExternalCitation · doi-reference
Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53
10.1016/j.ydbio.2011.10.012 · ExternalCitation · doi-reference
A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila
10.1016/j.ydbio.2018.11.018 · ExternalCitation · doi-reference
Cell competition: A historical perspective
10.1016/j.ydbio.2021.02.012 · ExternalCitation · doi-reference
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 [Research support, U.S. Gov’t, P.H.S.]
10.1016/s0092-8674(00)80626-1 · ExternalCitation · doi-reference
Drosophila p53 binds a damage response element at the reaper locus
10.1016/s0092-8674(00)80627-3 · ExternalCitation · doi-reference
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
10.1016/s0092-8674(00)81385-9 · ExternalCitation · doi-reference
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
10.1038/416755a · ExternalCitation · doi-reference
Dual roles of Drosophila p53 in cell death and cell differentiation
10.1038/cdd.2009.182 · ExternalCitation · doi-reference
Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica
10.1038/cdd.2014.218 · ExternalCitation · doi-reference
Deconstructing networks of p53-mediated tumor suppression in vivo
10.1038/cdd.2017.171 · ExternalCitation · doi-reference
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
10.1038/nature05077 · ExternalCitation · doi-reference
Mechanical cell competition kills cells via induction of lethal p53 levels
10.1038/ncomms11373 · ExternalCitation · doi-reference
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
10.1038/ng1449 · ExternalCitation · doi-reference
Temporal dissection of p53 function in vitro and in vivo
10.1038/ng1572 · ExternalCitation · doi-reference
A genome-scale shRNA resource for transgenic RNAi in Drosophila
10.1038/nmeth.1592 · ExternalCitation · doi-reference
Transcriptional control of human p53-regulated genes
10.1038/nrm2395 · ExternalCitation · doi-reference
Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
10.1038/onc.2014.42 · ExternalCitation · doi-reference
Census and evaluation of p53 target genes
10.1038/onc.2016.502 · ExternalCitation · doi-reference
Cell competition and cancer from Drosophila to mammals
10.1038/s41389-023-00505-y · ExternalCitation · doi-reference
Coordination between cell proliferation and apoptosis after DNA damage in Drosophila
10.1038/s41418-021-00898-6 · ExternalCitation · doi-reference
Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism
10.1038/s41467-020-16796-3 · ExternalCitation · doi-reference
Systems approaches identify the consequences of monosomy in somatic human cells
10.1038/s41467-021-25288-x · ExternalCitation · doi-reference
Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors
10.1038/s41467-024-55576-1 · ExternalCitation · doi-reference
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition
10.1038/s41556-020-00626-1 · ExternalCitation · doi-reference
Proteotoxic stress is a driver of the loser status and cell competition
10.1038/s41556-020-00627-0 · ExternalCitation · doi-reference
Emerging mechanisms of cell competition
10.1038/s41576-020-0262-8 · ExternalCitation · doi-reference
Ordered and deterministic cancer genome evolution after p53 loss
10.1038/s41586-022-05082-5 · ExternalCitation · doi-reference
Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
10.1038/s41598-018-36277-4 · ExternalCitation · doi-reference
The p53 pathway: what questions remain to be explored?
10.1038/sj.cdd.4401910 · ExternalCitation · doi-reference
p53 directs focused genomic responses in Drosophila
10.1038/sj.onc.1210328 · ExternalCitation · doi-reference
Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster
10.1073/pnas.0510528103 · ExternalCitation · doi-reference
Two-phase dynamics of p53 in the DNA damage response
10.1073/pnas.1100600108 · ExternalCitation · doi-reference
Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis
10.1073/pnas.1613508113 · ExternalCitation · doi-reference
p53 pathway is involved in cell competition during mouse embryogenesis
10.1073/pnas.1617414114 · ExternalCitation · doi-reference
Identification and characterization of a p53 homologue in Drosophila melanogaster
10.1073/pnas.97.13.7301 · ExternalCitation · doi-reference
Drosophila p53 directs nonapoptotic programs in postmitotic tissue
10.1091/mbc.e18-12-0791 · ExternalCitation · doi-reference
INSECT: IN-silico SEarch for Co-occurring Transcription factors
10.1093/bioinformatics/btt506 · ExternalCitation · doi-reference
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
10.1093/genetics/153.1.135 · ExternalCitation · doi-reference
Ribosomal protein mutations and cell competition: autonomous and nonautonomous effects on a stress response
10.1093/genetics/iyad080 · ExternalCitation · doi-reference
Genetic landscaping of cell competition uncovers two core pathways mediated by Xrp1 or Eiger/TNF in Drosophila
10.1093/genetics/iyag067 · ExternalCitation · doi-reference
p53 in the DNA-Damage-Repair Process
10.1101/cshperspect.a026070 · ExternalCitation · doi-reference
Mutant p53 in cell-cell interactions
10.1101/gad.347542.120 · ExternalCitation · doi-reference
DNA repair defects in cancer and therapeutic opportunities
10.1101/gad.349431.122 · ExternalCitation · doi-reference
Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity
10.1101/gr.220533.117 · ExternalCitation · doi-reference
Networks of bZIP protein-protein interactions diversified over a billion years of evolution
10.1126/science.1233465 · ExternalCitation · doi-reference
Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen
10.1126/science.1241628 · ExternalCitation · doi-reference
An ancient defense system eliminates unfit cells from developing tissues during cell competition [Research support, non-U.S. gov’t]
10.1126/science.1258236 · ExternalCitation · doi-reference
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage
10.1128/mcb.24.3.1219-1231.2004 · ExternalCitation · doi-reference
Linking JNK Activity to the DNA Damage Response
10.1177/1947601913486347 · ExternalCitation · doi-reference
The ribosomal protein genes and Minute loci of Drosophila melanogaster [Comparative Study Research Support N.I.H. Extramural Research support, non-U.S. gov’t]
10.1186/gb-2007-8-10-r216 · ExternalCitation · doi-reference
Toll signaling promotes JNK-dependent apoptosis in Drosophila
10.1186/s13008-020-00062-5 · ExternalCitation · doi-reference
Analysis of genetic mosaics in developing and adult Drosophila tissues
10.1242/dev.117.4.1223 · ExternalCitation · doi-reference
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
10.1242/dev.127.4.851 · ExternalCitation · doi-reference
The CRL4 E3 ligase Mahjong/DCAF1 controls cell competition through the transcription factor Xrp1, independently of polarity genes
10.1242/dev.200795 · ExternalCitation · doi-reference
An expanded view of cell competition
10.1242/dev.204212 · ExternalCitation · doi-reference
Reducing the aneuploid cell burden - cell competition and the ribosome connection
10.1242/dmm.049673 · ExternalCitation · doi-reference
The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster
10.1242/jcs.200782 · ExternalCitation · doi-reference
Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila
10.1271/bbb.120756 · ExternalCitation · doi-reference
Irradiation selects for p53-deficient hematopoietic progenitors
10.1371/journal.pbio.1000324 · ExternalCitation · doi-reference
Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells
10.1371/journal.pgen.1004581 · ExternalCitation · doi-reference
Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila
10.1371/journal.pgen.1008133 · ExternalCitation · doi-reference
Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status
10.1371/journal.pgen.1009946 · ExternalCitation · doi-reference
Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α
10.1371/journal.pgen.1009958 · ExternalCitation · doi-reference
The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models
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