Research graph
References from Genetic architecture of basal heart rate and its modulation by dietary salt in Drosophila melanogaster. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
Epidemiology of cardiovascular disease in Europe
10.1038/s41569-021-00607-3 · 2022 · External reference
Unresolved reference
2025 · External reference
Associations between resting heart rate, hypertension, and stroke: A population-based cross-sectional study
10.1111/jch.13529 · 2019 · External reference
Elevated heart rate: a major risk factor for cardiovascular disease
10.1081/ceh-200031959 · 2004 · External reference
Heart rate and the cardiovascular risk
10.1097/00004872-199715010-00001 · 1997 · External reference
Resting heart rate and the risk of cardiovascular disease, total cancer, and all-cause mortality - A systematic review and dose-response meta-analysis of prospective studies
10.1016/j.numecd.2017.04.004 · 2017 · External reference
Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study
10.1177/1741826710394274 · 2012 · External reference
Assessment of the impact of resting heart rate on the risk of major adverse cardiovascular events after ischemic stroke: a retrospective observational study
10.1186/s12883-024-03772-3 · 2024 · External reference
Genetic insights into resting heart rate and its role in cardiovascular disease
10.1038/s41467-023-39521-2 · 2023 · External reference
Heart rate is associated with increased risk of major cardiovascular events, cardiovascular and all-cause death in patients with stable chronic cardiovascular disease: an analysis of ONTARGET/TRANSCEND
10.1007/s00392-013-0644-4 · 2014 · External reference
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
10.1038/ng.2610 · 2013 · External reference
Heart rate, lifespan, and mortality risk
10.1016/j.arr.2008.10.001 · 2009 · External reference
Drosophila, an emerging model for cardiac disease
10.1016/j.gene.2004.07.018 · 2004 · External reference
Drosophila models of cardiac disease
10.1016/b978-0-12-384878-9.00005-4 · 2011 · External reference
Heart development in Drosophila and vertebrates: conservation of molecular mechanisms
10.1002/(sici)1520-6408(1998)22:3<181::aid-dvg1>3.0.co;2-2 · 1998 · External reference
Drosophila Heart as a Model for Cardiac Development and Diseases
10.3390/cells10113078 · 2021 · External reference
D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
10.1073/pnas.91.12.5662 · 1994 · External reference
Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis
10.1242/dev.01899 · 2005 · External reference
Genetics on the Fly: A Primer on the Drosophila Model System
10.1534/genetics.115.183392 · 2015 · External reference
Drosophila, genetic screens, and cardiac function
10.1161/circresaha.111.244897 · 2011 · External reference
Pharmacological analysis of heartbeat in Drosophila
10.1002/neu.480280302 · 1995 · External reference
High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila
2017 · External reference
Quantitative measurements of zebrafish heartrate and heart rate variability: A survey between 1990-2020
2021 · External reference
Salt processing in larval Drosophila: choice, feeding, and learning shift from appetitive to aversive in a concentration-dependent way
10.1093/chemse/bjn037 · 2008 · External reference
Compared with usual sodium intake, low- and excessive-sodium diets are associated with increased mortality: a meta-analysis
10.1093/ajh/hpu028 · 2014 · External reference
Sodium and Its Role in Cardiovascular Disease - The Debate Continues
2016 · External reference
Is There Association between Altered Adrenergic System Activity and Microvascular Endothelial Dysfunction Induced by a 7-Day High Salt Intake in Young Healthy Individuals
10.3390/nu13051731 · 2021 · External reference
Salt and heart disease: a second round of “bad science”?
10.1016/s0140-6736(18)31724-0 · 2018 · External reference
The hidden hand of chloride in hypertension
10.1007/s00424-015-1690-8 · 2015 · External reference
Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter
10.1074/jbc.m003476200 · 2000 · External reference
Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heart salt-specific overexpression in Drosophila
10.18632/aging.203364 · 2021 · External reference
Methods to assess Drosophila heart development, function and aging
10.1016/j.ymeth.2014.03.031 · 2014 · External reference
The Drosophila melanogaster Genetic Reference Panel
10.1038/nature10811 · 2012 · External reference
Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines
10.1101/gr.171546.113 · 2014 · External reference
Unresolved reference
External reference
Monitoring heart function in larval Drosophila melanogaster for physiological studies
2009 · External reference
Heartbeat patterns during the postembryonic development of Drosophila melanogaster
10.1016/j.jinsphys.2004.11.016 · 2005 · External reference
Localized microinjection of intact Drosophila melanogaster larva to investigate the effect of serotonin on heart rate
10.1039/c9lc00963a · 2020 · External reference
GWAS: Fast-forwarding gene identification and characterization in temperate Cereals: lessons from Barley - A review
10.1016/j.jare.2019.10.013 · 2019 · External reference
PANGEA: a new gene set enrichment tool for Drosophila and common research organisms
2023 · External reference
Unresolved reference
2023 · External reference
A Drosophila RNAi collection is subject to dominant phenotypic effects
10.1038/nmeth.2856 · 2014 · External reference
A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
10.1038/ncomms10368 · 2016 · External reference
The Transgenic RNAi Project at Harvard Medical School: Resources and Validation
10.1534/genetics.115.180208 · 2015 · External reference
Tailup expression in Drosophila larval and adult cardiac valve cells
10.1002/dvg.23506 · 2023 · External reference
Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel
2018 · External reference
Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart
10.1007/s00360-015-0934-4 · 2016 · External reference
Age-associated cardiac dysfunction in Drosophila melanogaster
10.1161/hh1001.090857 · 2001 · External reference
Optogenetic stimulation of Drosophila heart rate at different temperatures and Ca2+ concentrations
2016 · External reference
The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family
10.1016/0092-8674(95)90539-1 · 1995 · External reference
Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila
10.1002/(sici)1520-6408(1998)22:3<187::aid-dvg2>3.0.co;2-2 · 1998 · External reference
Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism
10.1242/dev.02561 · 2006 · External reference
Clinical and genetic associations of asymmetric apical and septal left ventricular hypertrophy
10.1093/ehjdh/ztae060 · 2024 · External reference
Slo2/KNa Channels in Drosophila Protect against Spontaneous and Induced Seizure-like Behavior Associated with an Increased Persistent Na+ Current
10.1523/jneurosci.0290-21.2021 · 2021 · External reference
The sodium-activated potassium channel is encoded by a member of the Slo gene family
10.1016/s0896-6273(03)00096-5 · 2003 · External reference
Cardiac phenotypic spectrum of KCNT1 mutations
10.1017/s1047951120002735 · 2020 · External reference
Identifying genetic variants for heart rate variability in the acetylcholine pathway
10.1371/journal.pone.0112476 · 2014 · External reference
Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy
10.1096/fj.201801057r · 2019 · External reference
Nociceptor-Enriched Genes Required for Normal Thermal Nociception
10.1016/j.celrep.2016.06.003 · 2016 · External reference
Identifying shared genetic factors underlying epilepsy and congenital heart disease in Europeans
10.1007/s00439-022-02502-4 · 2023 · External reference
Novel SCYL2 mutations and arthrogryposis multiplex congenita 4: case report and review of the literature
10.3390/ijms26073079 · 2025 · External reference
The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress
10.1038/s41598-020-58923-6 · 2020 · External reference
The evolution of mammalian Rem2: unraveling the impact of purifying selection and coevolution on protein function, and implications for human disorders
10.3389/fbinf.2024.1381540 · 2024 · External reference
Rem-GTPase regulates cardiac myocyte L-type calcium current
10.4161/chan.20192 · 2012 · External reference
ER membrane complex (EMC): Structure, functions, and roles in diseases
2024 · External reference
The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis
10.1007/s11427-021-1941-7 · 2021 · External reference
Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
10.1007/s11357-025-01851-y · 2026 · External reference
Proteostatic imbalance drives the pathogenesis and age-related exacerbation of heart failure with preserved ejection fraction
2025 · External reference
The ubiquitin proteasome system in human cardiomyopathies and heart failure
2013 · External reference
Modulation of Drosophila heartbeat by neurotransmitters
10.1007/s003600050051 · 1997 · External reference
Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations
10.1016/j.ajhg.2022.03.015 · 2022 · External reference
A role for adenosine deaminase in Drosophila larval development
10.1371/journal.pbio.0030201 · 2005 · External reference
Early-onset stroke and vasculopathy associated with mutations in ADA2
10.1056/nejmoa1307361 · 2014 · External reference
The emerging role of adenosine deaminases in insects
10.1016/j.ibmb.2004.12.009 · 2005 · External reference
Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML
10.3892/ijo.2013.1924 · 2013 · External reference
ZC3H15 promotes glioblastoma progression through regulating EGFR stability
10.1038/s41419-021-04496-9 · 2022 · External reference
NF-kappaB activation is required for adaptive cardiac hypertrophy
10.1093/cvr/cvp237 · 2009 · External reference
Epidermal growth factor receptor-dependent maintenance of cardiac contractility
10.1093/cvr/cvab149 · 2022 · External reference
Molecular mechanisms of heart failure: insights from Drosophila
10.1007/s10741-016-9590-3 · 2017 · External reference
Unresolved reference
2005 · External reference
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
10.1242/dev.118.2.401 · 1993 · External reference
Genetic architecture of natural variation of cardiac performance from flies to humans
10.7554/elife.82459 · 2022 · External reference
Dual color optogenetic tool enables heart arrest, bradycardic, and tachycardic pacing in Drosophila melanogaster
10.1038/s42003-024-06703-7 · 2024 · External reference
Reduction of Drosophila Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia
10.3389/fcell.2022.788516 · 2022 · External reference
Hedgehog signaling protocols.
2007 · External reference
Unresolved reference
2025 · External reference
The genetic architecture of quantitative traits: lessons from Drosophila
10.1016/j.gde.2004.04.003 · 2004 · External reference
Epistasis for head morphology in Drosophila melanogaster
10.1093/g3journal/jkab285 · 2021 · External reference