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References from Early events in dengue virus infection inducing cytokine storm: The dynamic interplay of pattern-recognition receptors, inflammasome activation, and biphasic NF-κB and STAT1-dependent inflammatory responses in human mononuclear phagocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
Climate change and viral emergence: evidence from Aedes-borne arboviruses
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Global warming and arboviral infections
10.7861/clinmedicine.19-2-149 · 2019 · External reference
Dengue in Latin America: Systematic Review of Molecular Epidemiological Trends
10.1371/journal.pntd.0005224 · 2017 · External reference
Dengue epidemiology: virus epidemiology, ecology, and emergence
10.1016/s0065-3527(03)61006-7 · 2003 · External reference
Population at risk of dengue virus transmission has increased due to coupled climate factors and population growth
10.1038/s43247-024-01639-6 · 2024 · External reference
Unresolved reference
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Unresolved reference
2016 · External reference
Markers of dengue disease severity
2010 · External reference
Cytokine signature of dengue patients at different severity of the disease
2021 · External reference
Dengue hemorrhagic fever with special emphasis on immunopathogenesis
10.1016/j.cimid.2007.05.010 · 2007 · External reference
Cellular and cytokine correlates of severe dengue infection
10.1371/journal.pone.0050387 · 2012 · External reference
Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever
10.1097/inf.0b013e31826fd456 · 2012 · External reference
Delivering safe dengue vaccines
10.1016/s2214-109x(24)00226-2 · 2024 · External reference
The mannose receptor mediates dengue virus infection of macrophages
10.1371/journal.ppat.0040017 · 2008 · External reference
Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
10.1074/jbc.m504337200 · 2005 · External reference
The Low-Density Lipoprotein Receptor-Related Protein-1 Is Essential for Dengue Virus Infection
10.3390/v16111692 · 2024 · External reference
Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex
2016 · External reference
TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
10.1038/s41467-020-16849-7 · 2020 · External reference
Dengue-3 Virus Entry into Vero Cells: Role of Clathrin-Mediated Endocytosis in the Outcome of Infection
10.1371/journal.pone.0140824 · 2015 · External reference
Atomic-level functional model of dengue virus Envelope protein infectivity
10.1073/pnas.1310962110 · 2013 · External reference
Structures of dengue virus RNA replicase complexes
10.1016/j.molcel.2023.06.023 · 2023 · External reference
Molecular Insights into the Flavivirus Replication Complex
10.3390/v13060956 · 2021 · External reference
Control of translation by the 5’- and 3’-terminal regions of the dengue virus genome
10.1128/jvi.79.13.8303-8315.2005 · 2005 · External reference
Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins
10.1038/s41467-021-21505-9 · 2021 · External reference
Evaluation of the maturation of individual Dengue virions with flow virometry
10.1016/j.virol.2015.10.021 · 2016 · External reference
High-dose of vitamin D supplement is associated with reduced susceptibility of monocyte-derived macrophages to dengue virus infection and pro-inflammatory cytokine production: An exploratory study
10.1016/j.cca.2017.12.044 · 2018 · External reference
Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells
10.1007/s11010-019-03658-w · 2020 · External reference
Human TLR3 recognizes dengue virus and modulates viral replication in vitro
10.1111/j.1462-5822.2008.01277.x · 2009 · External reference
Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity
10.1126/scitranslmed.aaa3863 · 2015 · External reference
Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico
10.3390/v12111230 · 2020 · External reference
Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
10.4049/jimmunol.177.10.7114 · 2006 · External reference
NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN-α Production and Virus Titers
10.3390/pathogens13040306 · 2024 · External reference
Dengue Virus M Protein Promotes NLRP3 Inflammasome Activation To Induce Vascular Leakage in Mice
2019 · External reference
RIG-I Recognizes the 5’ Region of Dengue and Zika Virus Genomes
10.1016/j.celrep.2018.06.047 · 2018 · External reference
Distinct expression of interferon-induced protein with tetratricopeptide repeats (IFIT) 1/2/3 and other antiviral genes between subsets of dendritic cells induced by dengue virus 2 infection
10.1111/imm.12615 · 2016 · External reference
PKR-mediated stress response enhances dengue and Zika virus replication
10.1128/mbio.00934-23 · 2023 · External reference
Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response
10.1128/jvi.03114-13 · 2014 · External reference
Vitamin D modulates inflammatory response of DENV-2-infected macrophages by inhibiting the expression of inflammatory-liked miRNAs
10.1080/20477724.2022.2101840 · 2023 · External reference
Interferon lambda inhibits dengue virus replication in epithelial cells
2015 · External reference
Infection dynamics of sylvatic dengue virus in a natural primate host, the African Green Monkey
10.4269/ajtmh.13-0492 · 2014 · External reference
Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2
10.1371/journal.pntd.0009873 · 2021 · External reference
Unresolved reference
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Mayaro virus infection elicits a robust pro-inflammatory and antiviral response in human macrophages
10.1016/j.actatropica.2024.107146 · 2024 · External reference
Interleukin 27 as an inducer of antiviral response against chikungunya virus infection in human macrophages
10.1016/j.cellimm.2021.104411 · 2021 · External reference
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
10.1038/s41587-019-0201-4 · 2019 · External reference
StringTie enables improved reconstruction of a transcriptome from RNA-seq reads
10.1038/nbt.3122 · 2015 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
ComBat-seq: batch effect adjustment for RNA-seq count data
2020 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages
2024 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells
10.1371/journal.ppat.1004566 · 2014 · External reference
Contrasting behavior between the three human monocyte subsets in dengue pathophysiology
10.1016/j.isci.2022.104384 · 2022 · External reference
TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles
10.1371/journal.ppat.1010499 · 2022 · External reference
Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target
10.3390/microorganisms8060891 · 2020 · External reference
Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages
10.3389/fcell.2022.812110 · 2022 · External reference
IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
10.1016/j.celrep.2021.108891 · 2021 · External reference
Toll-like receptors in antiviral innate immunity
10.1016/j.jmb.2013.11.024 · 2014 · External reference
The inflammasome NLRs in immunity, inflammation, and associated diseases
10.1146/annurev-immunol-031210-101405 · 2011 · External reference
The inflammasomes
10.1016/j.cell.2010.01.040 · 2010 · External reference
T cell immunopathogenesis of dengue virus infection
2005 · External reference
In vivo Differentiation of Human Monocytes
10.3389/fimmu.2019.01907 · 2019 · External reference
Antiviral response and immunopathogenesis of interleukin 27 in COVID-19
2023 · External reference
Differential regulation of toll-like receptor-2, toll-like receptor-4, CD16 and human leucocyte antigen-DR on peripheral blood monocytes during mild and severe dengue fever
10.1111/j.1365-2567.2009.03224.x · 2010 · External reference
Pathogenesis of vascular leak in dengue virus infection
10.1111/imm.12748 · 2017 · External reference
Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability
10.1016/j.virol.2011.10.030 · 2012 · External reference
Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity
10.1002/(sici)1096-9071(199911)59:3<329::aid-jmv12>3.0.co;2-g · 1999 · External reference
Cytokine storm and vascular leakage in severe dengue: insights from single-cell RNA profiling
10.26508/lsa.202403008 · 2025 · External reference
Dengue virus infection induces interferon-lambda1 to facilitate cell migration
10.1038/srep24530 · 2016 · External reference
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin
10.1371/journal.pntd.0002178 · 2013 · External reference
ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
10.1186/1743-422x-8-468 · 2011 · External reference
High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue
10.1093/infdis/jiv321 · 2015 · External reference
Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant
10.1128/mbio.00553-15 · 2015 · External reference
Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex
10.1128/jvi.01051-10 · 2010 · External reference
IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
10.1186/s40425-019-0652-7 · 2019 · External reference
Interleukin-15 as an Activator of Natural Killer Cell-Mediated Antiviral Response
10.1182/blood.v94.12.4210 · 1999 · External reference
The Role of TRAIL in Apoptosis and Immunosurveillance in Cancer
10.3390/cancers15102752 · 2023 · External reference
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
10.1084/jem.189.11.1747 · 1999 · External reference
BAFF and BAFF-Receptor in B Cell Selection and Survival
10.3389/fimmu.2018.02285 · 2018 · External reference
Key chemokines direct migration of immune cells in solid tumors
10.1038/s41417-021-00303-x · 2022 · External reference
Chemokines and immunity
10.1590/s1679-45082015rb3438 · 2015 · External reference
Endothelial PPARδ Ablation Exacerbates Vascular Hyperpermeability via STAT1/CXCL10 Signaling in Acute Lung Injury
10.1161/circresaha.124.325855 · 2025 · External reference
The role of mononuclear phagocytes in Ebola virus infection
10.1002/jlb.4ri0518-183r · 2018 · External reference
Ebolaviruses Associated with Differential Pathogenicity Induce Distinct Host Responses in Human Macrophages
10.1128/jvi.00179-17 · 2017 · External reference
The Mechanism behind Influenza Virus Cytokine Storm
10.3390/v13071362 · 2021 · External reference
Human influenza virus infection elicits distinct patterns of monocyte and dendritic cell mobilization in blood and the nasopharynx
10.7554/elife.77345 · 2023 · External reference
Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysis
10.1111/eci.13429 · 2021 · External reference
An inflammatory cytokine signature predicts COVID-19 severity and survival
10.1038/s41591-020-1051-9 · 2020 · External reference
Characterization of Yellow Fever Virus Infection of Human and Non-human Primate Antigen Presenting Cells and Their Interaction with CD4+ T Cells
10.1371/journal.pntd.0004709 · 2016 · External reference
Emergence of New Immunopathogenic Factors in Human Yellow Fever: Polarisation of the M1/M2 Macrophage Response in the Renal Parenchyma
10.3390/v14081725 · 2022 · External reference
Yellow Fever: Global Impact, Epidemiology, Pathogenesis, and Integrated Prevention Approaches
2024 · External reference
