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References from Glycosomal ABC transporter 3 (GAT3) deletion enhances the oxidative stress responses and reduces the infectivity of Trypanosoma cruzi. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Chagas disease in northern Chile: Detection of Trypanosoma cruzi in children, dogs and triatomine bugs
10.1016/j.actatropica.2022.106631 · 2022 · External reference
The impact of climate change on neglected tropical diseases: a systematic review
10.1093/trstmh/traa192 · 2021 · External reference
Oral transmission of Chagas disease from a One Health approach: A systematic review
10.1111/tmi.13915 · 2023 · External reference
Experimental and Clinical Treatment of Chagas Disease: A Review
10.4269/ajtmh.16-0761 · 2017 · External reference
Gene and Chromosomal Copy Number Variations as an Adaptive Mechanism Towards a Parasitic Lifestyle in Trypanosomatids
2018 · External reference
Genome plasticity driven by aneuploidy and loss of heterozygosity in Trypanosoma cruzi
2022 · External reference
Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations
10.1186/s13071-023-05775-4 · 2023 · External reference
Compartmentation of carbohydrate metabolism in trypanosomes
10.1146/annurev.mi.41.100187.001015 · 1987 · External reference
Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5
10.1038/81930 · 2000 · External reference
Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes
10.1128/ec.00084-07 · 2007 · External reference
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase of Trypanosomatidae and the glycosomal redox balance of insect stages of Trypanosoma brucei and Leishmania spp
10.1016/j.molbiopara.2006.05.006 · 2006 · External reference
Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting
10.1080/09687860500460124 · 2006 · External reference
Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes
10.1016/j.molbiopara.2019.02.008 · 2019 · External reference
Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi
10.3389/fcimb.2020.00025 · 2020 · External reference
Peroxisomal ABC transporters
10.1016/j.febslet.2005.12.095 · 2006 · External reference
Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists
10.3389/fcell.2022.979269 · 2022 · External reference
Glycosomal ABC transporters of Trypanosoma brucei: characterisation of their expression, topology and substrate specificity
10.1016/j.ijpara.2010.11.002 · 2011 · External reference
Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole
10.1016/j.actatropica.2006.10.004 · 2006 · External reference
Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole
10.1007/s00436-008-1264-1 · 2009 · External reference
The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide
10.1590/s0074-02762012000400009 · 2012 · External reference
MAFFT-DASH: integrated protein sequence and structural alignment
2019 · External reference
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023
10.1093/nar/gkad1003 · 2024 · External reference
Unresolved reference
2011 · External reference
InterProScan 5: genome-scale protein function classification
10.1093/bioinformatics/btu031 · 2014 · External reference
Unipro UGENE: a unified bioinformatics toolkit
10.1093/bioinformatics/bts091 · 2012 · External reference
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping
10.1371/journal.pntd.0006388 · 2018 · External reference
EuPaGDT: a web tool tailored to design CRISPR guide RNAs for eukaryotic pathogens
2015 · External reference
Expanding an expanded genome: long-read sequencing of Trypanosoma cruzi
2018 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
Basic local alignment search tool
10.1016/s0022-2836(05)80360-2 · 1990 · External reference
In vitro and in vivo experimental models for drug screening and development for Chagas disease
10.1590/s0074-02762010000200022 · 2010 · External reference
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics
10.1371/journal.pntd.0002844 · 2014 · External reference
Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi
10.1093/clinids/6.2.223 · 1984 · External reference
Trypanocidal drugs: mechanisms, resistance and new targets
10.1017/s1462399409001252 · 2009 · External reference
Unveiling benznidazole’s mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi
10.1002/em.21839 · 2014 · External reference
Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi
10.1186/1756-3305-5-161 · 2012 · External reference
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
10.1073/pnas.0711014105 · 2008 · External reference
Unresolved reference
2020 · External reference
Mapping benznidazole resistance in trypanosomatids and exploring evolutionary histories of nitroreductases and ABCG transporter protein sequences
10.1016/j.actatropica.2019.105161 · 2019 · External reference
Glycosomes: A comprehensive view of their metabolic roles in T. brucei
10.1016/j.biocel.2017.01.015 · 2017 · External reference
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin
10.1074/jbc.m111126200 · 2002 · External reference
A Global Analysis of Enzyme Compartmentalization to Glycosomes
10.3390/pathogens9040281 · 2020 · External reference
Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites
10.1016/j.bbamcr.2015.09.015 · 2016 · External reference
Glycosomal targets for anti-trypanosomatid drug discovery
10.2174/09298673113209990139 · 2014 · External reference
