Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA). Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Poverty, Migration, and Chagas Disease
10.1007/s40475-020-00225-y · 2021 · External reference
Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study
10.5334/gh.1150 · 2022 · External reference
Chagas Disease: From Discovery to a Worldwide Health Problem
10.3389/fpubh.2019.00166 · 2019 · External reference
Chagas disease in Latin America: an epidemiological update based on 2010 estimates = Maladie de Chagas en Amérique latine: le point épidémiologique basé sur les estimations de 2010
2015 · External reference
Use of benznidazole to treat chronic Chagas disease: An updated systematic review with a meta-analysis
10.1371/journal.pntd.0010386 · 2022 · External reference
Clinical and epidemiological aspects of Chagas disease
10.1016/s1473-3099(01)00065-2 · 2001 · External reference
Chagas disease
10.1016/s0140-6736(17)31612-4 · 2018 · External reference
Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation
10.1128/aac.05135-11 · 2012 · External reference
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial
10.7326/0003-4819-144-10-200605160-00006 · 2006 · External reference
Benznidazole decreases the risk of chronic Chagas disease progression and cardiovascular events: A long-term follow up study
10.1016/j.eclinm.2020.100694 · 2020 · External reference
Unresolved reference
External reference
Adverse events associated with benznidazole treatment for Chagas disease in children and adults
10.1111/bcp.16214 · 2024 · External reference
Benznidazole treatment safety: the Médecins Sans Frontières experience in a large cohort of Bolivian patients with Chagas’ disease
10.1093/jac/dkx180 · 2017 · External reference
Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières
2009 · External reference
Drug discovery for chagas disease: A viewpoint
10.1016/j.actatropica.2019.105107 · 2019 · External reference
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas
10.1590/0037-8682-0477-2019 · 2020 · External reference
A New Epoch in Antitrypanosomal Treatment for Chagas Disease
10.1016/j.jacc.2016.12.016 · 2017 · External reference
Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)
10.1016/b978-0-12-385863-4.00004-6 · 2011 · External reference
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi
10.1128/aac.01742-09 · 2010 · External reference
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial
10.1016/j.jacc.2016.12.023 · 2017 · External reference
Randomized trial of posaconazole and benznidazole for chronic Chagas’ disease
10.1056/nejmoa1313122 · 2014 · External reference
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial
10.1016/s1473-3099(17)30538-8 · 2018 · External reference
Efficacy of Oral Administration of E1224 in Combination with Benznidazole on Experimental Trypanosoma cruzi Infection
2015 · External reference
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments
2013 · External reference
Multiple-dose kinetics of the trypanosomicide benznidazole in man
1980 · External reference
Single-dose pharmacokinetics of the trypanosomicide benznidazole in man
1979 · External reference
Difference of effective antitrypanosomal dosages of benznidazole in mice and man. Chemotherapeutic and pharmacokinetic results
1980 · External reference
Population pharmacokinetics of benznidazole in adult patients with Chagas disease
10.1128/aac.05018-14 · 2015 · External reference
Population pharmacokinetic study of benznidazole in pediatric Chagas disease suggests efficacy despite lower plasma concentrations than in adults
10.1371/journal.pntd.0002907 · 2014 · External reference
Population pharmacokinetics of benznidazole in neonates, infants and children using a new pediatric formulation
10.1371/journal.pntd.0010850 · 2023 · External reference
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial
10.1016/s1473-3099(20)30844-6 · 2021 · External reference
Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia
10.1093/trstmh/trs004 · 2013 · External reference
Longitudinal study and specific chemotherapy in children with chronic Chagas’ disease, residing in a low endemicity area of Argentina
2004 · External reference
Efficacy of three benznidazole dosing strategies for adults living with chronic Chagas disease (MULTIBENZ): an international, randomised, double-blind, phase 2b trial
10.1016/s1473-3099(23)00629-1 · 2024 · External reference
Seronegative conversion after incomplete benznidazole treatment in chronic Chagas disease
10.1016/j.trstmh.2012.07.010 · 2012 · External reference
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial
10.1186/s13063-020-4226-2 · 2020 · External reference
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients
10.1128/aac.00745-15 · 2015 · External reference
New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi: Clinical, parasitological, and serological assessment after three years of follow-up
10.1128/aac.00439-20 · 2020 · External reference
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice
10.1093/infdis/jit420 · 2014 · External reference
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease
10.1126/scitranslmed.abb7656 · 2020 · External reference
Benznidazole therapy for Chagas disease in asymptomatic Trypanosoma cruzi -seropositive former blood donors: evaluation of the efficacy of different treatment regimens
10.1590/0037-8682-0165-2016 · 2016 · External reference
Review of pharmacological options for the treatment of Chagas disease
10.1111/bcp.14700 · 2022 · External reference
Translational challenges of animal models in Chagas disease drug development: a review
10.2147/dddt.s90208 · 2015 · External reference
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: an individual patient data meta-analysis of two proof of concept trials
2024 · External reference
Analytical performance of a multiplex Real-Time PCR assay using TaqMan probes for quantification of Trypanosoma cruzi satellite DNA in blood samples
10.1371/journal.pntd.0002000 · 2013 · External reference
Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment
10.1128/aac.00845-18 · 2018 · External reference
Systematic review and meta-analysis of the pharmacokinetics of benznidazole in the treatment of Chagas disease
10.1128/aac.01567-16 · 2016 · External reference
Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming
10.1016/j.cmpb.2003.11.003 · 2004 · External reference
Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM
10.1016/j.cmpb.2010.04.018 · 2011 · External reference
10.32614/rj-2017-066
10.32614/rj-2017-066 · External reference
Disentangling effects of induced plant defenses and food quantity on herbivores by fitting nonlinear models
10.1086/286067 · 1997 · External reference
Unresolved reference
External reference
Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study
10.1038/sj.ki.5002374 · 2007 · External reference
Population Pharmacokinetics to Model the Time-Varying Clearance of the PEGylated Asparaginase Oncaspar® in Children with Acute Lymphoblastic Leukemia
10.1007/s13318-017-0410-5 · 2017 · External reference
Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies
10.1007/s10928-007-9066-0 · 2007 · External reference
Pharmacokinetics of Benznidazole in Healthy Volunteers and Implications in Future Clinical Trials
10.1128/aac.01912-16 · 2017 · External reference
New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia
10.1136/bmjopen-2021-052897 · 2021 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers
10.1128/aac.02150-19 · 2021 · External reference
Unresolved reference
1982 · External reference
Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
10.1590/0074-02760150401 · 2016 · External reference
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
10.1590/0074-0276140156 · 2014 · External reference
The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications
10.1016/j.meegid.2011.12.009 · 2012 · External reference
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development
10.1038/srep04703 · 2014 · External reference
Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
2018 · External reference
In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution
2020 · External reference
Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate
10.1098/rsob.200261 · 2020 · External reference
Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
10.1371/journal.ppat.1011627 · 2023 · External reference
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease
10.1128/aac.00689-15 · 2015 · External reference
Benznidazole treatment: time- and dose-dependence varies with the Trypanosoma cruzi strain
2021 · External reference
Time and dose-dependence evaluation of nitroheterocyclic drugs for improving efficacy following Trypanosoma cruzi infection: A pre-clinical study
10.1016/j.bcp.2018.01.005 · 2018 · External reference
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas’ disease drug discovery
10.1371/journal.pntd.0008487 · 2020 · External reference
Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease
10.1371/journal.pntd.0012968 · 2025 · External reference