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References from Interplay of human macrophage response and natural resistance of infection by L. (V.) panamensis to pentavalent antimony. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study
2017 · External reference
10.1111/j.1365-4632.2008.03417.x
10.1111/j.1365-4632.2008.03417.x · External reference
Systematic Review of Treatment Failure and Clinical Relapses in Leishmaniasis from a Multifactorial Perspective: Clinical Aspects, Factors Associated with the Parasite and Host
10.3390/tropicalmed8090430 · 2023 · External reference
Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: clinical findings and diagnostic approach
10.1086/319990 · 2001 · External reference
Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis
10.1086/518041 · 2007 · External reference
Molecular epidemiology and in vitro evidence suggest that Leishmania braziliensis strain helps determine antimony response among American tegumenary leishmaniasis patients Silvana
2018 · External reference
Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia
10.4269/ajtmh.2002.66.738 · 2002 · External reference
Geographical distribution of Leishmania species in Colombia, 1985-2017
10.7705/biomedica.v39i3.4312 · 2019 · External reference
Geographic distribution of Leishmania species isolated from patients at the National Institute of Dermatology Federico Lleras Acosta E.S.E., 1995-2005
10.7705/biomedica.v26i1.1508 · 2006 · External reference
Miltefosine and antimonial drug susceptibility of Leishmania Viannia species and populations in regions of high transmission in Colombia
10.1371/journal.pntd.0002871 · 2014 · External reference
Natural resistance to meglumine antimoniate is associated with treatment failure in cutaneous leishmaniasis caused by Leishmania (Viannia) panamensis
10.1371/journal.pntd.0012156 · 2024 · External reference
Antimony resistance and trypanothione in experimentally selected and clinical strains of Leishmania panamensis
10.1128/aac.01075-08 · 2008 · External reference
Molecular mechanisms of antimony resistance in Leishmania
10.1099/jmm.0.46841-0 · 2007 · External reference
Antimony resistance and gene expression in Leishmania: spotlight on molecular and proteomic aspects
10.1017/s0031182023001129 · 2024 · External reference
Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
10.1590/0074-02760190111 · 2019 · External reference
Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility
10.1016/j.actatropica.2017.08.017 · 2017 · External reference
Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates
10.1021/acsinfecdis.2c00457 · 2023 · External reference
Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1
10.1073/pnas.1213839110 · 2013 · External reference
Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism
10.1016/j.cytox.2020.100041 · 2020 · External reference
Human monocyte infection by Leishmania (Viannia) panamensis. Role of complement receptors and correlation of susceptibility in vitro with clinical phenotype
10.4049/jimmunol.152.3.1265 · 1994 · External reference
Chronicity of dermal leishmaniasis caused by Leishmania panamensis is associated with parasite-mediated induction of chemokine gene expression
10.1128/iai.01133-13 · 2014 · External reference
Epidemiologic, genetic, and clinical associations among phenotypically distinct populations of Leishmania (Viannia) in Colombia
10.4269/ajtmh.1998.59.86 · 1998 · External reference
10.1016/j.isci.2024.109773
10.1016/j.isci.2024.109773 · External reference
Epidemiologic, genetic, and clinical associations among phenotypically distinct populations of Leishmania (Viannia) in Colombia
10.4269/ajtmh.1998.59.86 · 1998 · External reference
Novel approach to in vitro drug susceptibility assessment of clinical strains of Leishmania spp
10.1128/jcm.00216-12 · 2012 · External reference
Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate
10.1086/510860 · 2007 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
HISAT: a fast spliced aligner with low memory requirements
10.1038/nmeth.3317 · 2015 · External reference
Tabix: fast retrieval of sequence features from generic TAB-delimited files
10.1093/bioinformatics/btq671 · 2011 · External reference
HTSeq--a Python framework to work with high-throughput sequencing data
10.1093/bioinformatics/btu638 · 2015 · External reference
Count-based differential expression analysis of RNA sequencing data using R and Bioconductor
10.1038/nprot.2013.099 · 2013 · External reference
Neutrophil Activation: Influence of Antimony Tolerant and Susceptible Clinical Strains of L. (V.) panamensis and Meglumine Antimoniate
10.3389/fcimb.2021.710006 · 2021 · External reference
variancePartition: interpreting drivers of variation in complex gene expression studies
10.1186/s12859-016-1323-z · 2016 · External reference
The sva package for removing batch effects and other unwanted variation in high-throughput experiments
10.1093/bioinformatics/bts034 · 2012 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments
10.1093/bioinformatics/btt087 · 2013 · External reference
g:Profiler-a web server for functional interpretation of gene lists (2016 update)
10.1093/nar/gkw199 · 2016 · External reference
Analyzing and interpreting genome data at the network level with ConsensusPathDB
10.1038/nprot.2016.117 · 2016 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages
10.1128/aac.02099-16 · 2017 · External reference
Skin-derived ABCB5 mesenchymal stem cells for high-medical-need inflammatory diseases: from discovery to entering clinical routine
10.3390/ijms24010066 · 2023 · External reference
ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa
10.1016/j.jcyt.2023.01.015 · 2023 · External reference
Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63
10.1371/journal.ppat.1001148 · 2010 · External reference
Suppression of host PTEN gene expression for Leishmania donovani survival in Indian visceral leishmaniasis
10.1016/j.micinf.2015.12.008 · 2016 · External reference
Kynurenine Pathway in Respiratory Diseases
10.1177/11786469241232871 · 2024 · External reference
Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target
2023 · External reference
IL-10: A Multifunctional Cytokine in Viral Infections
10.1155/2017/6104054 · 2017 · External reference
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
10.1038/nature04734 · 2006 · External reference
The IL4I1 Enzyme: A New Player in the Immunosuppressive Tumor Microenvironment
10.3390/cells8070757 · 2019 · External reference
IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer
10.1016/j.jbc.2023.104827 · 2023 · External reference
Oxidative stress in microbial diseases
10.1007/978-981-13-8763-0 · 2019 · External reference
Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages
10.1128/aac.50.5.1788-1797.2006 · 2006 · External reference
Macrophage metallothioneins participate in the antileishmanial activity of antimonials
10.3389/fpara.2023.1242727 · 2023 · External reference
Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival
10.1093/jac/dkt334 · 2014 · External reference
Redefining the progeroid form of Ehlers-Danlos syndrome: report of the fourth patient with B4GALT7 deficiency and review of the literature
2013 · External reference
MAFB shapes human monocyte-derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expression
10.1172/jci.insight.172862 · 2023 · External reference
Self-defense of macrophages against oxidative injury: Fighting for their own survival
10.1016/j.redox.2019.101261 · 2019 · External reference
IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease
2021 · External reference
Indoleamine 2,3-dioxygenase and tolerance: where are we now?
10.3389/fimmu.2017.01360 · 2017 · External reference
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis
10.3389/fimmu.2024.1363938 · 2024 · External reference
Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression
10.1093/infdis/jiq095 · 2011 · External reference
Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells
10.1111/j.1365-3024.2012.01380.x · 2012 · External reference
The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection
10.4049/jimmunol.1400728 · 2014 · External reference
Regulatory T cells in the pathogenesis and healing of chronic human dermal leishmaniasis caused by Leishmania (Viannia) species
2012 · External reference
IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production
2015 · External reference
Functions of ROS in Macrophages and Antimicrobial Immunity
10.3390/antiox10020313 · 2021 · External reference
Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro
10.1371/journal.pone.0129744 · 2015 · External reference
A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization
10.1016/j.cell.2021.02.046 · 2021 · External reference
Different macrophage polarization between drug-susceptible and multidrug-resistant pulmonary tuberculosis
10.1186/s12879-020-4802-9 · 2020 · External reference
Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection
2020 · External reference
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
10.1172/jci76468 · 2015 · External reference