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References from Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids. Local targets link to admitted publications; unresolved targets remain external evidence.
A tale of three genomes: the kinetoplastids have arrived
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Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
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Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription
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Nucleotide excision repair in mammalian cells
10.1074/jbc.272.38.23465 · 1997 · External reference
Trypanosoma brucei and Trypanosoma cruzi DNA mismatch repair proteins act differently in the response to DNA damage caused by oxidative stress
10.3389/fcimb.2020.00154 · 2020 · External reference
Mechanisms and biological effects of mismatch repair
10.1146/annurev.ge.25.120191.001305 · 1991 · External reference
Emerging roles of DNA glycosylases and the base excision repair pathway
10.1016/j.tibs.2019.04.006 · 2019 · External reference
DNA repair pathways in trypanosomatids: from DNA repair to drug resistance
10.1128/mmbr.00045-13 · 2014 · External reference
Base excision repair in the mitochondria
10.1002/jcb.25103 · 2015 · External reference
Mechanisms of DNA repair in Trypanosoma cruzi: what do we know so far?
10.1016/j.dnarep.2020.102873 · 2020 · External reference
DNA polymerase family X: function, structure, and cellular roles
10.1016/j.bbapap.2009.07.008 · 2010 · External reference
DNA repair in mammalian cells: Base excision repair: the long and short of it
10.1007/s00018-009-8736-z · 2009 · External reference
Recent advances in the structural mechanisms of DNA glycosylases
10.1016/j.bbapap.2012.10.005 · 2013 · External reference
Oxidative DNA damage: mechanisms, mutation, and disease
10.1096/fj.02-0752rev · 2003 · External reference
Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability
2013 · External reference
8-oxoguanine DNA glycosylases: one lesion, three subfamilies
10.3390/ijms13066711 · 2012 · External reference
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
10.1126/science.1112631 · 2005 · External reference
Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi
10.1371/journal.pone.0042484 · 2012 · External reference
Characterization of Trypanosoma cruzi MutY DNA glycosylase ortholog and its role in oxidative stress response
10.1016/j.meegid.2017.09.030 · 2017 · External reference
Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: mechanism, metals and medicine
10.1016/j.freeradbiomed.2017.01.008 · 2017 · External reference
Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis
10.1093/nar/gkab1162 · 2021 · External reference
Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1
10.1128/mcb.00791-07 · 2007 · External reference
Expression and the peculiar enzymatic behavior of the Trypanosoma cruzi NTH1 DNA glycosylase
10.1371/journal.pone.0157270 · 2016 · External reference
Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage
10.1016/j.mrfmmm.2012.12.003 · 2013 · External reference
Variations on a theme: eukaryotic Y-family DNA polymerases
10.1016/j.bbapap.2009.07.004 · 2010 · External reference
Analysis of DNA polymerases reveals specific genes expansion in Leishmania and Trypanosoma spp
10.3389/fcimb.2020.570493 · 2020 · External reference
DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria
10.1016/j.dnarep.2017.10.011 · 2017 · External reference
The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis
10.1371/journal.pntd.0000658 · 2010 · External reference
Nuclear DNA replication and repair in parasites of the genus Leishmania: exploiting differences to develop innovative therapeutic approaches
10.1080/1040841x.2016.1188758 · 2017 · External reference
Nuclear DNA polymerase beta from Leishmania infantum. cloning, molecular analysis and developmental regulation
10.1093/nar/29.18.3822 · 2001 · External reference
DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions
10.1016/j.molbiopara.2012.02.007 · 2012 · External reference
Trypanosoma brucei has two distinct mitochondrial DNA polymerase beta enzymes
10.1074/jbc.m308565200 · 2003 · External reference
Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi
10.1371/journal.pntd.0006220 · 2018 · External reference
Molecular and functional characteristics of DNA polymerase beta-like enzymes from trypanosomatids
10.3389/fcimb.2021.670564 · 2021 · External reference
Non-homologous DNA end joining and alternative pathways to double-strand break repair
10.1038/nrm.2017.48 · 2017 · External reference
Genome maintenance functions of a putative Trypanosoma brucei translesion DNA polymerase include telomere association and a role in antigenic variation
10.1093/nar/gkaa686 · 2020 · External reference
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome
10.1016/j.molcel.2013.10.034 · 2013 · External reference
Cloning and characterization of DNA polymerase eta from Trypanosoma cruzi: roles for translesion bypass of oxidative damage
10.1002/em.20450 · 2009 · External reference
DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediate
10.1111/j.1365-2958.2008.06521.x · 2009 · External reference
Unveiling benznidazole’s mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi
10.1002/em.21839 · 2014 · External reference
Mechanisms and consequences of double-strand DNA break formation in chromatin
10.1002/jcp.25048 · 2016 · External reference
The molecular basis and disease relevance of non-homologous DNA end joining
10.1038/s41580-020-00297-8 · 2020 · External reference
Causes and effects of loss of classical nonhomologous end joining pathway in parasitic eukaryotes
10.1128/mbio.01541-19 · 2019 · External reference
Homologous recombination and the repair of DNA double-strand breaks
10.1074/jbc.tm118.000372 · 2018 · External reference
Homologous recombination in protozoan parasites and recombinase inhibitors
10.3389/fmicb.2017.01716 · 2017 · External reference
Escaping the immune system by DNA repair and recombination in African trypanosomes
10.1098/rsob.190182 · 2019 · External reference
Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication
10.1371/journal.pgen.1008828 · 2020 · External reference
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania
10.1038/s41467-025-56785-y · 2025 · External reference
Chromosomal translocations in the parasite Leishmania by a MRE11/RAD50-independent microhomology-mediated end joining mechanism
2016 · External reference
Microhomology-mediated end joining: good, bad and ugly
10.1016/j.mrfmmm.2017.07.002 · 2018 · External reference
Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway?
10.1016/j.tibs.2015.08.006 · 2015 · External reference
Genome protection by DNA polymerase θ
10.1146/annurev-genet-072920-041046 · 2022 · External reference
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
10.1038/s41580-021-00405-2 · 2022 · External reference
DNA polymerase POLQ and cellular defense against DNA damage
10.1016/j.dnarep.2012.10.004 · 2013 · External reference
Making 3’ ends meet
2025 · External reference
Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
10.1038/s41598-019-39348-2 · 2019 · External reference
Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
10.1093/nar/gkac119 · 2022 · External reference
Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology-mediated end-joining pathway
10.1016/j.str.2015.10.014 · 2015 · External reference
Ku heterodimer-independent end joining in Trypanosoma brucei cell extracts relies upon sequence microhomology
10.1128/ec.00212-07 · 2007 · External reference
Microhomology-mediated deletion and gene conversion in African trypanosomes
10.1093/nar/gkq981 · 2011 · External reference
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes
10.1093/nar/gkn104 · 2008 · External reference
DNA repair pathway choices in CRISPR-Cas9-mediated genome editing
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CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi
10.1128/mbio.02097-14 · 2014 · External reference
CRISPR-Cas9-mediated genome editing in Leishmania donovani
2015 · External reference
Optimized CRISPR-Cas9 genome editing for Leishmania and its use to target a multigene family, induce chromosomal translocation, and study DNA break repair mechanisms
10.1128/msphere.00340-16 · 2017 · External reference
DNA double-strand breaks and telomeres play important roles in trypanosoma brucei antigenic variation
10.1128/ec.00207-14 · 2015 · External reference
Beyond base excision repair: an evolving picture of mitochondrial DNA repair
10.1042/bsr20211320 · 2021 · External reference
Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
10.1091/mbc.e15-05-0260 · 2016 · External reference
Dynamic localization of Trypanosoma brucei mitochondrial DNA polymerase ID
10.1128/ec.05291-11 · 2012 · External reference
Cell cycle localization dynamics of mitochondrial DNA polymerase IC in African trypanosomes
10.1091/mbc.e18-02-0127 · 2018 · External reference
Multiple mitochondrial DNA polymerases in Trypanosoma brucei
10.1016/s1097-2765(02)00571-3 · 2002 · External reference
Phage origin of mitochondrion-localized family A DNA polymerases in kinetoplastids and diplonemids
10.1093/gbe/evab003 · 2021 · External reference
DNA polymerase θ increases mutational rates in mitochondrial DNA
10.1021/acschembio.8b00072 · 2018 · External reference
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
10.1093/nar/gkaa1265 · 2021 · External reference
Persistent DNA damage foci and dna replication with a broken chromosome in the African trypanosome
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Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
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Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates
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How Trypanosoma cruzi deals with oxidative stress: antioxidant defence and DNA repair pathways
10.1016/j.mrrev.2015.12.003 · 2016 · External reference
Redox balance keepers and possible cell functions managed by redox homeostasis in Trypanosoma cruzi
10.3389/fcimb.2019.00435 · 2019 · External reference
The DNA damage response is developmentally regulated in the African trypanosome
10.1016/j.dnarep.2018.11.005 · 2019 · External reference
Unique thiol metabolism in trypanosomatids: Redox homeostasis and drug resistance
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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
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Oxidative stress fuels Trypanosoma cruzi infection in mice
10.1172/jci58525 · 2012 · External reference
Are reactive oxygen species always detrimental to pathogens?
10.1089/ars.2013.5447 · 2014 · External reference
ROS and Trypanosoma cruzi: Fuel to infection, poison to the heart
10.1371/journal.ppat.1006928 · 2018 · External reference
Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production
10.1016/j.freeradbiomed.2017.03.027 · 2017 · External reference
Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS
2011 · External reference
Trypanosoma cruzi needs a signal provided by reactive oxygen species to infect macrophages
2016 · External reference
ROS regulate differentiation of visceralizing
2018 · External reference
Redox-sensitive alteration of replisome architecture safeguards genome integrity
10.1126/science.aao3172 · 2017 · External reference
Effects of trypanocidal drugs on DNA synthesis: new insights into melarsoprol growth inhibition
10.1017/s0031182021000317 · 2021 · External reference
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase
10.1074/jbc.m010352200 · 2001 · External reference
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
10.1111/j.1365-2958.2009.06761.x · 2009 · External reference
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
10.1016/j.freeradbiomed.2014.05.007 · 2014 · External reference
The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication, and evolution
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The complete mitochondrial DNA of Trypanosoma cruzi: maxicircles and minicircles
10.3389/fcimb.2021.672448 · 2021 · External reference
Redox potential regulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin
10.1128/ec.3.2.277-287.2004 · 2004 · External reference
Mitochondrial Ca2+ and reactive oxygen species in trypanosomatids
10.1089/ars.2021.0058 · 2022 · External reference
An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase
10.1016/j.ijpddr.2015.05.002 · 2015 · External reference
Kinetoplastid phylogenetics, with special reference to the evolution of parasitic trypanosomes
10.1051/parasite/2008153226 · 2008 · External reference
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling
10.1371/journal.pntd.0006980 · 2018 · External reference
Host DNA repair response to oxidative damage is modulated by Trypanosoma cruzi in a strain-dependent manner
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Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage: requirement of additional factors and detection of phosphorylation of the native form
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DNA metabolism and genetic diversity in Trypanosomes
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis
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Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
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A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage
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