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References from A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion. Local targets link to admitted publications; unresolved targets remain external evidence.
The European Union One Health 2023 Zoonoses report
2024 · External reference
Epidemiology of trichinellosis in the People’s Republic of China during 2009-2020
10.1016/j.actatropica.2022.106388 · 2022 · External reference
How does Trichinella spiralis make itself at home?
10.1016/s0169-4758(98)01287-3 · 1998 · External reference
Molecular characterization of a Trichinella spiralis serine proteinase
10.1186/s13567-020-00847-0 · 2020 · External reference
Trichinella spiralis galectin binding to toll-like receptor 4 induces intestinal inflammation and mediates larval invasion of gut mucosa
10.1186/s13567-023-01246-x · 2023 · External reference
Molecular characterization of a novel serine proteinase from Trichinella spiralis and its participation in larval invasion of gut epithelium
2023 · External reference
Invasion of epithelial cells by Trichinella spiralis: in vitro observations
10.1051/parasite/200108s2048 · 2001 · External reference
Screening and characterization of early diagnostic antigens in excretory-secretory proteins from Trichinella spiralis intestinal infective larvae by immunoproteomics
10.1007/s00436-015-4779-2 · 2016 · External reference
Immunomodulation in trichinellosis: does Trichinella really escape the host immune system?
10.2174/187153012799279081 · 2012 · External reference
Secretory products of Trichinella spiralis muscle larvae and immunomodulation: implication for autoimmune diseases, allergies, and malignancies
10.1155/2015/523875 · 2015 · External reference
Proteases secreted by Trichinella spiralis intestinal infective larvae damage the junctions of the intestinal epithelial cell monolayer and mediate larval invasion
10.1186/s13567-022-01032-1 · 2022 · External reference
Trichinella spiralis C-type lectin mediates larva invasion of gut mucosa via binding to syndecan-1 and damaging epithelial integrity in mice
10.1016/j.ijbiomac.2024.135958 · 2024 · External reference
Endoplasmic reticulum stress-mediated apoptosis is activated in intestines of mice with Trichinella spiralis infection
10.1016/j.exppara.2014.06.017 · 2014 · External reference
Regulatory effects of Trichinella spiralis and a serine protease inhibitor on the endoplasmic reticulum stress response of intestinal epithelial cells
10.1186/s13567-022-01036-x · 2022 · External reference
The draft genome of the parasitic nematode Trichinella spiralis
10.1038/ng.769 · 2011 · External reference
Comparative proteomic analysis of surface proteins of Trichinella spiralis muscle larvae and intestinal infective larvae
10.1016/j.actatropica.2015.07.002 · 2015 · External reference
A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway
2024 · External reference
Activation of MAPK kinase pathway by Gal/GalNAc adherence lectin of E. histolytica: gateway to host response
10.1007/s11010-005-3698-4 · 2005 · External reference
Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum
10.1136/gut.2006.100198 · 2007 · External reference
Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2
10.1186/s13567-023-01186-6 · 2023 · External reference
Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function
10.1186/s13567-022-01108-y · 2022 · External reference
Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption
2025 · External reference
PGAM5: A crucial role in mitochondrial dynamics and programmed cell death
10.1016/j.ejcb.2020.151144 · 2021 · External reference
Molecular cloning and characterization of a novel peptidase from Trichinella spiralis and protective immunity elicited by the peptidase in BALB/c mice
10.1186/s13567-020-00838-1 · 2020 · External reference
Refolding and Activation from Bacterial Inclusion Bodies of Trypsin I from Sardine (Sardinops sagax caerulea)
10.2174/0929866525666181019161114 · 2019 · External reference
A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway
2024 · External reference
Biological characteristics and functions of a novel glutamate dehydrogenase from Trichinella spiralis
10.1051/parasite/2024065 · 2024 · External reference
Trichinella spiralis cathepsin L induces macrophage M1 polarization via the NF-κB pathway and enhances the ADCC killing of newborn larvae
10.1186/s13071-023-06051-1 · 2023 · External reference
Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction
10.1016/j.immuni.2021.09.001 · 2021 · External reference
Characterization of a novel dipeptidyl peptidase 1 of Trichinella spiralis and its participation in larval invasion
10.1016/j.actatropica.2023.107076 · 2024 · External reference
Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway
10.1186/s13567-023-01209-2 · 2023 · External reference
Oral immunization of mice with recombinant Lactobacillus plantarum expressing a Trichinella spiralis galectin induces an immune protection against larval challenge
10.1186/s13071-022-05597-w · 2022 · External reference
A novel C-type lectin from Trichinella spiralis mediates larval invasion of host intestinal epithelial cells
10.1186/s13567-022-01104-2 · 2022 · External reference
Binding of Trichinella spiralis C-type lectin with syndecan-1 on intestinal epithelial cells mediates larval invasion of intestinal epithelium
10.1186/s13567-023-01217-2 · 2023 · External reference
Characterization of a Trichinella spiralis aminopeptidase and its participation in invasion, development and fecundity
10.1186/s13567-020-00805-w · 2020 · External reference
Application of a recombinant novel trypsin from Trichinella spiralis for serodiagnosis of trichinellosis
10.1186/s13071-023-06067-7 · 2024 · External reference
Trichinella spiralis cathepsin L damages the tight junctions of intestinal epithelial cells and mediates larval invasion
2023 · External reference
Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function
2025 · External reference
3,4-Dideoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells
10.2337/diabetes.54.8.2424 · 2005 · External reference
Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis
10.3892/ijo.2013.1973 · 2013 · External reference
Yogurt inhibits intestinal barrier dysfunction in Caco-2 cells by increasing tight junctions
10.1039/c6fo01592a · 2017 · External reference
Disruption of epithelial barrier of Caco-2 Cell monolayers by excretory secretory products of Trichinella spiralis might be related to serine protease
10.3389/fmicb.2021.634185 · 2021 · External reference
A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke
10.1016/j.apsb.2021.01.008 · 2021 · External reference
Aronia berry inhibits disruption of Caco-2 intestinal barrier function
10.1016/j.abb.2020.108409 · 2020 · External reference
Campylobacter jejuni disrupts protective Toll-like receptor 9 signaling in colonic epithelial cells and increases the severity of dextran sulfate sodium-induced colitis in mice
10.1128/iai.06066-11 · 2012 · External reference
Entamoeba histolytica EhCP112 dislocates and degrades Claudin-1 and Claudin-2 at tight junctions of the intestinal epithelium
10.3389/fcimb.2017.00372 · 2017 · External reference
A metalloproteinase Tsdpy31 from Trichinella spiralis participates in larval molting and development
10.1016/j.ijbiomac.2021.10.021 · 2021 · External reference
Co-immunoprecipitation assays
10.1007/978-1-0716-2217-9_8 · 2022 · External reference
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway
10.1016/j.metabol.2020.154334 · 2020 · External reference
Invasion of intestinal epithelia in vitro by the parasitic nematode Trichinella spiralis
10.1128/iai.65.11.4806-4812.1997 · 1997 · External reference
Biological characteristics of a new long-chain fatty acid transport protein 1 from Trichinella spiralis and its participation in lipid metabolism, larval moulting, and development
10.1186/s13567-024-01380-0 · 2024 · External reference
Modulatory mechanisms of enterocyte apoptosis by viral, bacterial and parasitic pathogens
10.3109/1040841x.2012.746952 · 2014 · External reference
Apoptosis and intestinal barrier function
10.1111/j.1749-6632.2000.tb05252.x · 2000 · External reference
The influence of selected gastrointestinal parasites on apoptosis in intestinal epithelial cells
10.3390/biom10050674 · 2020 · External reference
First line of defense: the role of the intestinal epithelium as an active component of the mucosal immune system
10.1007/s005350070017 · 2000 · External reference
Tight junction proteins in gastrointestinal and liver disease
10.1136/gutjnl-2018-316906 · 2019 · External reference
Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation
10.1111/nyas.13360 · 2017 · External reference
Paracellular permeability and tight junction regulation in gut health and disease
10.1038/s41575-023-00766-3 · 2023 · External reference
Tight junctions: from simple barriers to multifunctional molecular gates
10.1038/nrm.2016.80 · 2016 · External reference
Protease activated receptor-2 induces immune activation and visceral hypersensitivity in post-infectious irritable bowel syndrome mice
10.1007/s10620-018-5367-y · 2019 · External reference
Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells
10.1124/jpet.102.043844 · 2003 · External reference
Human ICE/CED-3 protease nomenclature
10.1016/s0092-8674(00)81334-3 · 1996 · External reference
Converging roles of caspases in inflammasome activation, cell death and innate immunity
10.1038/nri.2015.7 · 2016 · External reference
Interdimer processing mechanism of procaspase-8 activation
10.1093/emboj/cdg414 · 2003 · External reference
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3
10.1016/j.str.2011.07.001 · 2011 · External reference
Caspase activation: revisiting the induced proximity model
10.1016/j.cell.2004.06.007 · 2004 · External reference
A guide to cell death pathways
10.1038/s41580-023-00689-6 · 2024 · External reference
A primer on caspase mechanisms
10.1016/j.semcdb.2018.01.002 · 2018 · External reference
Caspases and their substrates
10.1038/cdd.2017.44 · 2017 · External reference
The Bcl2 family: regulators of the cellular life-or-death switch
10.1038/nrc883 · 2002 · External reference
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
10.1038/s41580-023-00629-4 · 2023 · External reference
Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK
10.1016/j.cell.2018.04.036 · 2018 · External reference
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
10.1016/j.cell.2011.11.030 · 2012 · External reference
PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release
10.1038/s41401-023-01151-1 · 2024 · External reference
The intestinal epithelium at the forefront of host-helminth interactions
10.1016/j.pt.2020.07.002 · 2020 · External reference
A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
10.1016/j.redox.2021.102186 · 2021 · External reference
AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability
10.1080/15548627.2021.2016233 · 2022 · External reference