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References from Novel inhibitors against Cryptosporidium parvum through blocking its energy metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence and molecular characterization of Cryptosporidium spp. from domestic pigeons (Columba livia domestica) in Anhui, China
2025 · External reference
Occurence and genotype distribution of Cryptosporidium spp., and Giardia duodenalis in sheep in Siirt, Turkey
2023 · External reference
Prevalence of neonatal calf diarrhea caused by Escherichia coli and investigation of virulence factors, serotypes, and antibiotic susceptibility
10.24425/pjvs.2023.145058 · 2023 · External reference
Calf morbidity, mortality, and management practices in dairy farms in Jimma City, Southwestern Ethiopia
10.1186/s12917-023-03815-w · 2023 · External reference
First report of Cryptosporidium andersoni and risk factors associated with the occurrence of Cryptosporidium spp. in pre-weaned native Korean calves with diarrhea
10.3389/fvets.2023.1145096 · 2023 · External reference
Cryptosporidiosis Outbreaks - United States, 2009-2017
10.15585/mmwr.mm6825a3 · 2019 · External reference
Bovine cryptosporidiosis: Impact, host-parasite interaction and control strategies
10.1186/s13567-017-0447-0 · 2017 · External reference
Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: A meta-analyses study
10.1016/s2214-109x(18)30283-3 · 2018 · External reference
The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: A 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS)
10.1016/s2214-109x(19)30076-2 · 2019 · External reference
Nitazoxanide in the treatment of acquired immune deficiency syndrome-related cryptosporidiosis: Results of the United States compassionate use program in 365 patients
10.1111/j.1365-2036.2006.03033.x · 2006 · External reference
Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: A randomised controlled trial
10.1016/s0140-6736(02)11401-2 · 2002 · External reference
Mining for crypto protection: A search for Cryptosporidium antibodies reveals antigens associated with immunity
2023 · External reference
Cryptosporidium parvum disrupts intestinal epithelial barrier in neonatal mice through downregulation of cell junction molecules
2024 · External reference
Cryptosporidium parvum gp40/15 is associated with the parasitophorous vacuole membrane and is a potential vaccine target
10.3390/microorganisms8030363 · 2020 · External reference
Interferon-λ3 promotes epithelial defense and barrier function against Cryptosporidium parvum infection
10.1016/j.jcmgh.2019.02.007 · 2019 · External reference
Microbiome diversity is a modifiable virulence factor for cryptosporidiosis
10.1080/21505594.2023.2273004 · 2023 · External reference
The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair
10.1053/j.gastro.2021.08.047 · 2021 · External reference
Indole-3-propionic acid improved the intestinal barrier by enhancing epithelial barrier and mucus barrier
10.1021/acs.jafc.0c05205 · 2021 · External reference
Cysteine proteases in protozoan parasites
2018 · External reference
The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6
10.1073/pnas.2007807118 · 2021 · External reference
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer
10.1186/s13046-023-02834-7 · 2023 · External reference
Annotation and characterization of Babesia gibsoni apicoplast genome
10.1186/s13071-020-04065-7 · 2020 · External reference
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
10.1126/science.1094786 · 2004 · External reference
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum
10.1038/s41467-024-44696-3 · 2024 · External reference
Lactate dehydrogenase in Toxoplasma gondii controls virulence, bradyzoite differentiation, and chronic infection
10.1371/journal.pone.0173745 · 2017 · External reference
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics
10.1371/journal.ppat.1005250 · 2015 · External reference
Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase
10.1016/j.ijbiomac.2014.12.019 · 2015 · External reference
Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies
10.1016/j.bmc.2021.116458 · 2021 · External reference
Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection
10.1126/scitranslmed.aax7161 · 2019 · External reference
Intestinal barrier
2019 · External reference
Keep calm: The intestinal barrier at the interface of peace and war
10.1038/s41419-019-2086-z · 2019 · External reference
High-throughput screen identifies host and microbiota regulators of intestinal barrier function
10.1053/j.gastro.2020.07.003 · 2020 · External reference
Milk: A natural guardian for the gut barrier
10.1021/acs.jafc.3c06861 · 2024 · External reference
Intestinal barrier function: Molecular regulation and disease pathogenesis
10.1016/j.jaci.2009.05.038 · 2009 · External reference
Tight junctions: From simple barriers to multifunctional molecular gates
10.1038/nrm.2016.80 · 2016 · External reference
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
10.1038/s41467-024-53144-1 · 2024 · External reference
Extracellular cysteine proteases of key intestinal protozoan pathogens-factors linked to virulence and pathogenicity
10.3390/ijms241612850 · 2023 · External reference
Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins
10.1111/j.1600-0854.2006.00484.x · 2006 · External reference
Gasdermin D in pyroptosis
10.1016/j.apsb.2021.02.006 · 2021 · External reference
A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
10.1016/j.cell.2023.04.025 · 2023 · External reference
Helminths’ therapeutic potential to treat intestinal barrier dysfunction
10.1111/all.15812 · 2023 · External reference
Brain autoimmunity and intestinal microbiota: 100 trillion game changers
10.1016/j.it.2017.03.008 · 2017 · External reference
Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice
10.1136/gutjnl-2020-322468 · 2021 · External reference
The firmicutes/bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients?
10.3390/nu12051474 · 2020 · External reference
Gut Bacteroides species in health and disease
10.1080/19490976.2020.1848158 · 2021 · External reference
Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis
10.1016/j.chom.2023.11.005 · 2024 · External reference
Microbial degradation of complex carbohydrates in the gut
10.4161/gmic.19897 · 2012 · External reference
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
10.1038/nrmicro3050 · 2013 · External reference
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
10.1016/j.phrs.2020.105314 · 2021 · External reference
Intestine microbiota and SCFAs response in naturally Cryptosporidium-infected plateau yaks
10.3389/fcimb.2023.1105126 · 2023 · External reference
Cryptosporidium infection induced the dropping of SCFAS and dysbiosis in intestinal microbiome of Tibetan pigs
10.1016/j.micpath.2022.105922 · 2023 · External reference
Gut Fungal Microbiome Responses to Natural Cryptosporidium Infection in Horses
10.3389/fmicb.2022.877280 · 2022 · External reference
Synergistic effects of Ligilactobacillus salivarius Li01 and psyllium husk prevent mice from developing loperamide-induced constipation
10.1039/d4fo04444d · 2024 · External reference
Akkermansia muciniphila ameliorates alcoholic liver disease in experimental mice by regulating serum metabolism and improving gut dysbiosis
10.3390/metabo13101057 · 2023 · External reference
Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease
10.1080/19490976.2021.1968257 · 2021 · External reference
Chlorogenic acid/linoleic acid-fortified wheat-resistant starch ameliorates high-fat diet-induced gut barrier damage by modulating gut metabolism
10.1021/acs.jafc.4c01595 · 2024 · External reference
Draft Genome Sequence of Faecalimonas umbilicata JCM 30896T, an Acetate-Producing Bacterium Isolated from Human Feces
10.1128/mra.01091-18 · 2018 · External reference
Effects of gabexate mesylate on the gut microbiota and metabolomics in rats with sepsis
10.2147/jir.s392060 · 2022 · External reference
Ruminococcus gnavus: Friend or foe for human health
10.1093/femsre/fuad014 · 2023 · External reference
The Influence of the Protozoan Giardia lamblia on the Modulation of the Immune System and Alterations in Host Glucose and Lipid Metabolism
10.3390/ijms25168627 · 2024 · External reference
Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: Effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway
10.1039/d4fo03591g · 2024 · External reference
Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria
2019 · External reference
Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer
2023 · External reference
The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD
10.3389/fimmu.2022.1028953 · 2022 · External reference
The krebs uric acid cycle: A forgotten krebs cycle
10.1016/j.tibs.2018.04.012 · 2018 · External reference
Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages
10.1371/journal.pntd.0012763 · 2025 · External reference
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα
10.1016/j.bcp.2022.115379 · 2023 · External reference
Redox metabolism: ROS as specific molecular regulators of cell signaling and function
10.1016/j.molcel.2021.08.018 · 2021 · External reference
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
10.1038/nm.3804 · 2015 · External reference
