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References from Rutin (quercetin-3-rutinoside) administered orally after experimental Bothrops jararaca envenomation prevents hemostatic, inflammatory and hemorrhagic disturbances. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Acidente por serpentes do gênero Bothrops: Série de 3.139 casos
10.1590/s0037-86821997000600006 · 1997 · External reference
What are the characteristics and where is the highest risk of snakebite accidents in the state of São Paulo?
2025 · External reference
Acidente botrópico.
2009 · External reference
Acute kidney injury induced by thrombotic microangiopathy in two cases of Bothrops envenomation
10.1080/15563650.2018.1510129 · 2019 · External reference
Epidemiological, clinical and therapeutic aspects of Bothrops asper bites
10.1016/j.toxicon.2009.07.001 · 2009 · External reference
Acute compartment syndrome in Bothrops atrox envenomation: A case-control study in the Brazilian Amazon
2026 · External reference
Hemoperitoneum after a Bothrops snakebite: Case report
10.1016/j.toxicon.2023.107350 · 2024 · External reference
Long-term hospital care needs after Bothrops atrox envenomation with hemorrhagic stroke in the Brazilian Amazon: “From social to physical death” - A case report
10.1016/j.toxicon.2024.107682 · 2024 · External reference
Fatal Bothrops atrox snakebite with thrombotic microangiopathy, hemorrhagic stroke and acute kidney injury
10.1016/j.toxicon.2025.108610 · 2025 · External reference
Symptomatology, pathology, and treatment of snake bites in South America.
10.1016/b978-0-12-138902-4.50021-0 · 1971 · External reference
Unresolved reference
2008 · External reference
Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in São Paulo, Brazil
10.1093/oxfordjournals.qjmed.a068818 · 1993 · External reference
Assessment of efficacy of bothropic antivenom therapy on microcirculatory effects induced by Bothrops jararaca snake venom
10.1016/s0041-0101(02)00389-6 · 2003 · External reference
Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming
10.1371/journal.pntd.0007059 · 2019 · External reference
Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations
10.3389/fimmu.2022.842576 · 2022 · External reference
Antivenoms, recombinant antibodies, inhibitors, and the future of snakebite envenoming therapy
10.1016/j.toxicon.2025.108964 · 2026 · External reference
Plant-derived secondary metabolites against Bothrops envenomation: A review
10.1016/j.toxicon.2025.108340 · 2025 · External reference
Varespladib (LY315920) appears to be a potent, broad-spectrum, inhibitor of snake venom phospholipase A2 and a possible pre-referral treatment for envenomation
10.3390/toxins8090248 · 2016 · External reference
Varespladib inhibits the phospholipase A2 and coagulopathic activities of venom components from hemotoxic snakes
10.3390/biomedicines8060165 · 2020 · External reference
Therapeutic potency of kaempferol against Naja haje venom induced neurotoxicity, inflammation, biological activities, and antioxidant system damage: A pre-clinical antivenom evaluation
10.1007/s00210-024-03678-4 · 2025 · External reference
Flavonoids: A review of probable mechanisms of action and potential applications
10.1093/ajcn/74.4.418 · 2001 · External reference
The bioflavonoids rutin and rutin succinate neutralize the toxins of B. jararaca venom and inhibit its lethality
10.3389/fphar.2022.828269 · 2022 · External reference
Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice
2018 · External reference
Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability
10.1016/j.tifs.2017.07.008 · 2017 · External reference
Efficient radiolabeling of rutin with 125I and biodistribution study of radiolabeled rutin
10.1007/s10967-015-4415-8 · 2015 · External reference
The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
10.1080/10715760600771400 · 2006 · External reference
Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition
10.1080/10717544.2022.2083726 · 2022 · External reference
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
10.3390/toxins12090528 · 2020 · External reference
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
2020 · External reference
Comparative analysis of newborn and adult Bothrops jararaca snake venoms
10.1016/j.toxicon.2010.08.011 · 2010 · External reference
Liver gene regulation of hemostasis-related factors is altered by experimental snake envenomation in mice
2020 · External reference
Haematological evaluation of patients bitten by the jararaca, Bothrops jararaca, in Brazil
10.1016/j.toxicon.2008.03.018 · 2008 · External reference
Collaborative study of a proposed international standard for plasma fibrinogen measurement
10.1055/s-0038-1646291 · 1992 · External reference
Unresolved reference
2001 · External reference
An improved technique for the assessment of venom-induced haemorrhage in a murine model
10.1016/j.toxicon.2017.10.005 · 2017 · External reference
Toxic activities of venoms from nine Bothrops species and their correlation with lethality and necrosis
10.1016/0041-0101(92)90032-z · 1992 · External reference
Colorimetric determination of DNase I activity with a DNA-methyl green substrate
10.1006/abio.1994.1502 · 1994 · External reference
Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom
10.1371/journal.pntd.0009715 · 2021 · External reference
G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
10.3758/bf03193146 · 2007 · External reference
Beyond organoleptic characteristics: The pharmacological potential of flavonoids and their role in leukocyte migration and in L-selectin and β2-integrin expression during inflammation
10.1002/ptr.5144 · 2014 · External reference
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms
10.1016/s0041-0101(99)00227-5 · 2000 · External reference
Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells
10.1155/2014/169370 · 2014 · External reference
Characterization of inflammatory reaction induced by neuwiedase, a P-I metalloproteinase isolated from Bothrops neuwiedi venom
10.1016/j.toxicon.2009.03.007 · 2009 · External reference
The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells
10.1016/s0041-0101(01)00131-3 · 2001 · External reference
The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells
10.1515/bc.2005.044 · 2005 · External reference
Nano-Rutin: A promising solution for alleviating various disorders
10.2174/0118722105310674240822115457 · 2025 · External reference
Rutin : Therapeutic potential and recent advances in drug delivery
10.1517/13543784.2013.805744 · 2013 · External reference
Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats
10.1016/j.ejphar.2015.12.021 · 2016 · External reference
Studies on blood coagulation and fibrinolysis in patients bitten by Bothrops jararaca (jararaca)
10.1055/s-0038-1645064 · 1990 · External reference
Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation
10.1371/journal.pntd.0002814 · 2014 · External reference
Hemorrhage caused by snake venom metalloproteinases: A journey of discovery and understanding
10.3390/toxins8040093 · 2016 · External reference
Efeitos vasculares do veneno de “Bothrops atrox” sua inibição pela rutina e um antihistaminico
1949 · External reference
Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
10.1016/j.toxicon.2010.07.001 · 2010 · External reference
Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom
10.1016/s0041-0101(98)00145-7 · 1998 · External reference
Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis
10.1177/1535370215590818 · 2015 · External reference
Acute-phase reactions, including cytokines, in patients bitten by Bothrops and Crotalus snakes in Brazil
10.1590/s0104-79301995000100003 · 1995 · External reference
Systemic vascular leakage induced in mice by Russell’s viper venom from Pakistan
10.1038/s41598-018-34363-1 · 2018 · External reference
Inhibitory effects of rutin on the endothelial protein C receptor shedding in vitro and in vivo
10.1007/s10753-014-9866-5 · 2014 · External reference
Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis
10.1002/eji.200324475 · 2003 · External reference
Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: Effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA
10.4269/ajtmh.2000.63.313 · 2000 · External reference
Therapeutic benefits of rutin and its nanoformulations
10.1002/ptr.6904 · 2021 · External reference
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
10.1016/j.jprot.2011.03.026 · 2011 · External reference
Dermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon
10.1371/journal.pntd.0012704 · 2024 · External reference
Neuroprotective effects of rutin in ischemic stroke: A review
10.1007/s10787-025-01861-4 · 2025 · External reference
Anti-inflammatory effects of quercetin, rutin, and troxerutin result from the inhibition of NO production and the reduction of COX-2 levels in RAW 264.7 cells treated with LPS
10.1007/s12010-024-05003-4 · 2024 · External reference
Circulating cell-free DNA differentiates severity of inflammation
10.1177/1099800416642571 · 2016 · External reference
Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms
10.1161/atvbaha.114.304114 · 2014 · External reference
Putative origins of cell-free DNA in humans: A review of active and passive nucleic acid release mechanisms
10.3390/ijms21218062 · 2020 · External reference
The nexus of cfDNA and nuclease biology
10.1016/j.tig.2021.04.005 · 2021 · External reference
A DNA methylation atlas of normal human cell types
10.1038/s41586-022-05580-6 · 2023 · External reference
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
10.1038/s41467-018-07466-6 · 2018 · External reference
The value of cell-free circulating DNA profiling in patients with skin diseases
10.1007/978-1-0716-3346-5_17 · 2023 · External reference
Free DNA--new potential analyte in clinical laboratory diagnostics?
10.11613/bm.2012.004 · 2012 · External reference
Circulating nucleosomes as a predictor of sepsis and organ dysfunction in critically ill patients
10.1016/j.ijid.2012.03.007 · 2012 · External reference
Changes in circulating cell-free DNA and nucleosomes in patients with exacerbated psoriasis
10.1007/s00403-017-1785-5 · 2017 · External reference
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
10.1182/blood-2016-09-741298 · 2017 · External reference
Deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma
10.1155/2012/149560 · 2012 · External reference
Murine serum nucleases--contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3)
10.1111/j.1742-4658.2008.06849.x · 2009 · External reference
Mouse deoxyribonuclease I (DNase I): Biochemical and immunological characterization, cDNA structure and tissue distribution
1997 · External reference
Macrophage DNases limit neutrophil extracellular trap-mediated defective efferocytosis in atherosclerosis
10.1161/circresaha.125.326353 · 2025 · External reference
Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells
10.4049/jimmunol.1901304 · 2020 · External reference
Association of cfDNA levels and Bothrops envenomation
10.1016/j.toxicon.2021.01.015 · 2021 · External reference
Polymorphonuclear neutrophil leukocytes in snakebite envenoming
10.1016/j.toxicon.2020.09.006 · 2020 · External reference
Molecular mechanisms and therapeutic target of NETosis in diseases
2022 · External reference
NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction
10.1038/ncomms11361 · 2016 · External reference
Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram)
10.1371/journal.pntd.0008596 · 2021 · External reference
Plant DNases are potent therapeutic agents against Echis carinatus venom-induced tissue necrosis in mice
10.1002/jcb.28115 · 2019 · External reference
The action of Echis carinatus and Naja naja venoms on human neutrophils; An emphasis on NETosis
10.1016/j.bbagen.2020.129561 · 2020 · External reference
Effect of Bothrops bilineata snake venom on neutrophil function
10.1016/j.toxicon.2013.09.019 · 2013 · External reference
Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of calyces from Physalis peruviana
10.1016/j.jddst.2021.102797 · 2021 · External reference
Unresolved reference
2006 · External reference