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References from Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
10.1016/s0166-2236(96)20019-0 · 1996 · External reference
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs.
10.1097/00004647-200109000-00001 · 2001 · External reference
Trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) decreases synaptic excitation in rat striatal slices through a presynaptic action.
10.1016/0304-3940(91)90710-b · 1991 · External reference
Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3.
10.1152/jn.1995.73.3.1076 · 1995 · External reference
In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats.
10.1016/s0304-3940(97)00442-4 · 1997 · External reference
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2′-carboxy-3′-phenylcyclopropyl)glycine, a new potent and selective antagonist.
10.1111/j.1460-9568.1997.tb01489.x · 1997 · External reference
The metabotropic glutamate receptors: structure and functions.
10.1016/0028-3908(94)00129-g · 1995 · External reference
Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes.
10.1085/jgp.109.4.477 · 1997 · External reference
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling.
10.1523/jneurosci.17-06-01891.1997 · 1997 · External reference
Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-β.
10.1523/jneurosci.18-23-09594.1998 · 1998 · External reference
Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes.
10.1002/(sici)1098-1136(199909)27:3<275::aid-glia9>3.0.co;2-0 · 1999 · External reference
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
10.1046/j.1471-4159.2001.00435.x · 2001 · External reference
Group-II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP<sup>+</sup>-induced neurotoxicity along with brain-derived neurotrophic factor induction.
10.1046/j.1471-4159.2001.00056.x · 2001 · External reference
The use of knockout mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.
10.1523/jneurosci.1889-07.2007 · 2007 · External reference
Metabotropic glutamate receptors in the basal ganglia motor circuit.
10.1038/nrn1763 · 2005 · External reference
DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury.
10.1016/s0306-4522(02)00232-4 · 2002 · External reference
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity.
10.1523/jneurosci.22-06-02135.2002 · 2002 · External reference
Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
10.1016/s0028-3908(03)00146-1 · 2003 · External reference
Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
10.1523/jneurosci.3831-03.2004 · 2004 · External reference
Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigro-striatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
10.1523/jneurosci.1595-06.2006 · 2006 · External reference
Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP.
10.1016/j.brainres.2004.11.040 · 2005 · External reference
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
10.1126/science.8493557 · 1993 · External reference
Neuroprotective and neurorestorative properties of GDNF.
10.1002/ana.410440718 · 1998 · External reference
In vivo gene delivery of glial cell line-derived neurotrophic factor for Parkinson's disease.
10.1002/ana.10485 · 2003 · External reference
Assessment in primate models of Parkinson's disease: comparison with human studies.
10.1515/revneuro.2005.16.4.303 · 2005 · External reference
GDNF family complexes are emerging drug targets.
10.1016/j.tips.2006.12.005 · 2007 · External reference
GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-β for its neuroprotective action.
10.1016/j.nbd.2006.10.005 · 2007 · External reference
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
10.1021/jm980616n · 1999 · External reference
The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease.
10.1016/j.brainres.2004.06.005 · 2004 · External reference
Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGlu(2/3) receptor agonist LY379268.
10.1007/s00213-004-2127-9 · 2005 · External reference
Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice.
10.1016/j.alcohol.2008.01.007 · 2008 · External reference
Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain.
10.1016/j.pain.2008.03.017 · 2008 · External reference
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity.
10.1007/s00213-007-0974-x · 2008 · External reference
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
10.1038/nm1632 · 2007 · External reference
Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).
10.1124/jpet.108.136861 · 2008 · External reference
Identification of a serotonin/glutamate receptor complex implicated in psychosis.
10.1038/nature06612 · 2008 · External reference
Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats.
10.1016/0169-328x(94)90106-6 · 1994 · External reference
Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system.
10.1007/s004410050688 · 1996 · External reference
Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
10.1016/s0028-3908(99)00092-1 · 1999 · External reference
The GDNF family: signalling, biological functions and therapeutic value.
10.1038/nrn812 · 2002 · External reference
Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-β as cofactor in vivo.
10.1523/jneurosci.19-06-02008.1999 · 1999 · External reference
TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.
10.1016/0896-6273(94)90062-0 · 1994 · External reference
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease.
10.1002/1531-8249(199909)46:3<419::aid-ana21>3.0.co;2-q · 1999 · External reference
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease.
10.1038/nm850 · 2003 · External reference
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor.
10.3171/jns.2005.102.2.0216 · 2005 · External reference
Randomized controlled trial of intraputamenal glial cell line-derived growth factor infusion in Parkinson's disease.
10.1002/ana.20737 · 2006 · External reference
PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.
10.1096/fj.07-095398 · 2008 · External reference
Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway.
10.1007/s11064-007-9351-8 · 2007 · External reference
Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy.
10.1196/annals.1403.011 · 2007 · External reference
LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats.
10.1007/pl00005284 · 1998 · External reference
The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat.
10.1038/sj.bjp.0703105 · 2000 · External reference
Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.
10.1126/science.273.5275.645 · 1996 · External reference
Cytotoxicity in murine neocortical cell cultures.
1992 · External reference
The mouse brain in stereotaxic coordinates
1997 · External reference
Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS.
10.1523/jneurosci.17-10-03554.1997 · 1997 · External reference
Atlas stereotaxique du cerveau de la souris. Ed.
External reference
Transcription factor gene expression profiling after acute intermittent nicotine treatment in the rat cerebral cortex.
10.1016/j.neuroscience.2005.01.061 · 2005 · External reference
The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.
10.1111/j.1699-0463.1988.tb00954.x · 1988 · External reference
The efficiency of systematic sampling in stereology: reconsidered.
10.1046/j.1365-2818.1999.00457.x · 1999 · External reference
Total number of neurons and glial cells in human brain nuclei estimated by disector and fractionator.
10.1111/j.1365-2818.1988.tb04582.x · 1988 · External reference
“If you assume, you can make an ass out of u and me”: a decade of the dissector for stereological counting of particles in 3D space.
1996 · External reference
