Research graph
References from NF-κB Is Activated in CD4+ iNKT Cells by Sickle Cell Disease and Mediates Rapid Induction of Adenosine A2A Receptors. Local targets link to admitted publications; unresolved targets remain external evidence.
Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor
10.1152/ajpgi.00041.2009 · 2009 · External reference
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
10.1084/jem.20061097 · 2006 · External reference
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury
10.4049/jimmunol.178.9.5899 · 2007 · External reference
Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytes
10.1074/jbc.m407631200 · 2004 · External reference
Modulation of erythrocyte-endothelial interactions and the vasocclusive severity of sickling disorders
10.1182/blood.v58.5.947.947 · 1981 · External reference
Sickle cell anemia as an inflammatory disease
10.1172/jci10726 · 2000 · External reference
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines
10.1182/blood-2009-02-205492 · 2009 · External reference
10.1182/blood-2010-06-290643
10.1182/blood-2010-06-290643 · External reference
Role of adenosine in response to vascular inflammation
10.1161/atvbaha.112.247874 · 2012 · External reference
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
10.1084/jem.20061097 · 2006 · External reference
Pain in sickle cell disease. Rates and risk factors
10.1056/nejm199107043250103 · 1991 · External reference
Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies
10.1016/s0026-895x(24)12188-8 · 1999 · External reference
Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system
10.1002/(sici)1096-9861(19981116)401:2<163::aid-cne2>3.0.co;2-d · 1998 · External reference
IL-2 triggers specific signaling pathways in human NKT cells leading to the production of pro- and anti-inflammatory cytokines
10.1189/jlb.1007669 · 2008 · External reference
On the road: progress in finding the unique pathway of invariant NKT cell differentiation
10.1016/j.coi.2007.02.009 · 2007 · External reference
Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop
10.1002/eji.200737389 · 2008 · External reference
Distinct and overlapping effector functions of expanded human CD4+, CD8alpha + and CD4-CD8alpha- invariant natural killer T cells
10.1371/journal.pone.0028648 · 2011 · External reference
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-κ B. Journal of immunology
2004 · External reference
10.1182/blood-2012-11-465963
10.1182/blood-2012-11-465963 · External reference
Shared principles in NF-κB signaling
10.1016/j.cell.2008.01.020 · 2008 · External reference
Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum
10.1002/1096-9861(20010312)431:3<331::aid-cne1074>3.0.co;2-w · 2001 · External reference
Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia
10.1152/ajpheart.00743.2005 · 2007 · External reference
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes
10.1161/circulationaha.106.649244 · 2006 · External reference
Transgenic sickle mice have vascular inflammation
10.1182/blood-2002-10-3313 · 2003 · External reference
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice
10.1152/ajpheart.00986.2004 · 2005 · External reference
Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion
10.1182/blood.v96.7.2451 · 2000 · External reference
P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease
10.1161/atvbaha.110.211615 · 2010 · External reference
Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining
10.1084/jem.20011786 · 2002 · External reference
Distinct functional lineages of human V(alpha)24 natural killer T cells
10.1084/jem.20011908 · 2002 · External reference
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells
10.1182/blood-2007-01-066217 · 2007 · External reference
Nuclear factor-κ B (NFκB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease
10.1016/j.trsl.2009.10.004 · 2010 · External reference
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
10.1038/ni.2143 · 2011 · External reference
The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production
10.1002/eji.200838575 · 2009 · External reference
Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation
10.1084/jem.20111024 · 2012 · External reference
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists
10.1038/sj.bjp.0703893 · 2001 · External reference
Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-κB in A(2A) adenosine receptor induction
10.1042/bj20050888 · 2005 · External reference
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells
10.4049/jimmunol.174.2.1073 · 2005 · External reference
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
10.1084/jem.20062512 · 2007 · External reference
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
10.1182/blood-2007-03-081646 · 2008 · External reference
Regulation of lymphocyte function by adenosine
10.1161/atvbaha.111.226837 · 2012 · External reference
Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice
10.1165/rcmb.2011-0097oc · 2012 · External reference
Asthma in children with sickle cell disease and its association with acute chest syndrome
10.1136/thx.2004.029165 · 2005 · External reference
Airway hyperresponsiveness in children with sickle cell anemia
10.1378/chest.10-1243 · 2011 · External reference
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
10.1084/jem.20062512 · 2007 · External reference
A2A-adenosine receptor reserve for coronary vasodilation
10.1161/01.cir.98.7.711 · 1998 · External reference
