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References from Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells. Local targets link to admitted publications; unresolved targets remain external evidence.
The Metabolic Landscape of RAS-Driven Cancers from biology to therapy
10.1038/s43018-021-00184-x · 2021 · External reference
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
10.1038/nature12040 · 2013 · External reference
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
10.1073/pnas.0810199105 · 2008 · External reference
Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells
10.1016/j.tem.2019.03.003 · 2019 · External reference
Glutamine addiction: a new therapeutic target in cancer
10.1016/j.tibs.2010.05.003 · 2010 · External reference
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs
10.1038/onc.2014.207 · 2015 · External reference
Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle
10.1080/15384101.2015.1046653 · 2015 · External reference
Metabolic vulnerability of KRAS-driven cancer cells
2014 · External reference
ATP citrate lyase: A central metabolic enzyme in cancer
10.1016/j.canlet.2019.12.010 · 2020 · External reference
ATP citrate lyase inhibition can suppress tumor cell growth
10.1016/j.ccr.2005.09.008 · 2005 · External reference
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
10.1158/2159-8290.cd-18-0567 · 2019 · External reference
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
10.1074/jbc.m116.772988 · 2017 · External reference
Where is mTOR and what is it doing there?
10.1083/jcb.201306041 · 2013 · External reference
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
10.1073/pnas.1302455110 · 2013 · External reference
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
10.1074/jbc.m204681200 · 2002 · External reference
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
10.1038/ncomms11971 · 2016 · External reference
Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
10.1158/1078-0432.ccr-17-1115 · 2017 · External reference
Brick by brick: metabolism and tumor cell growth
10.1016/j.gde.2008.02.003 · 2008 · External reference
Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells
10.1074/jbc.m115.710145 · 2016 · External reference
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
10.1073/pnas.1307237110 · 2013 · External reference
Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin
10.1158/1535-7163.mct-13-0762 · 2014 · External reference
The Emerging Hallmarks of Cancer Metabolism
10.1016/j.cmet.2015.12.006 · 2016 · External reference
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
10.1016/j.ccr.2012.02.014 · 2012 · External reference
The hallmarks of cancer metabolism: Still emerging
10.1016/j.cmet.2022.01.007 · 2022 · External reference
Defective TGF-beta signaling sensitizes human cancer cells to rapamycin
10.1038/sj.onc.1210721 · 2008 · External reference
Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin
10.1016/j.canlet.2021.09.020 · 2021 · External reference
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
1998 · External reference
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
10.1038/nature12138 · 2013 · External reference
Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle
10.1371/journal.pone.0074157 · 2013 · External reference
Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)
10.1177/1947601910392989 · 2010 · External reference
A non-canonical tricarboxylic acid cycle underlies cellular identity
10.1038/s41586-022-04475-w · 2022 · External reference
