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References from Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection. Local targets link to admitted publications; unresolved targets remain external evidence.
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Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy
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Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
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Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection
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The Role of Metabolic Dysfunction in T-Cell Exhaustion During Chronic Viral Infection
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T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
10.3389/fimmu.2018.02569 · 2018 · External reference
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
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Metabolic switching and fuel choice during T-cell differentiation and memory development
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Enhancing CD8 T-cell memory by modulating fatty acid metabolism
10.1038/nature08097 · 2009 · External reference
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion
10.1016/j.immuni.2016.07.008 · 2016 · External reference
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
10.1038/ncomms7692 · 2015 · External reference
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013 · External reference
T cell metabolism. The protein LEM promotes CD8(+) T cell immunity through effects on mitochondrial respiration
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Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia
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Predictors of mortality in the Amsterdam cohort of human immunodeficiency virus (HIV)-positive and HIV-negative drug users
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Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course
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10.1016/j.jim.2018.12.002 · 2019 · External reference
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MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4(+) T Cell Infection in HIV-1-Infected Individuals
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Fuel feeds function: energy metabolism and the T-cell response
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Metabolic pathways in immune cell activation and quiescence
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Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
10.1038/nm.4275 · 2017 · External reference
Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host
10.1016/j.celrep.2016.06.078 · 2016 · External reference
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF
10.1038/nm.2232 · 2010 · External reference
T-cell exhaustion in HIV infection
10.1111/imr.12823 · 2019 · External reference
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
10.1371/journal.ppat.1005761 · 2016 · External reference
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Memory CD8 T-cell differentiation during viral infection
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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
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HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition
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HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag
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A whole-genome association study of major determinants for host control of HIV-1
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10.1086/605892 · 2009 · External reference
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
10.1086/596067 · 2009 · External reference
Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8(+) T Cell Functionality: An Alternative Viral Adaptation Strategy
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HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3
10.1038/ni.3647 · 2017 · External reference
Cytomegalovirus (CMV)-specific CD8+ T cells in individuals with HIV infection: correlation with protection from CMV disease
10.1093/jac/dkl049 · 2006 · External reference
The hallmarks of CMV-specific CD8 T-cell differentiation
10.1007/s00430-019-00608-7 · 2019 · External reference
Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells
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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
10.1038/ni.1779 · 2009 · External reference
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
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Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial Dysfunction
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Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues
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Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms
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PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
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