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References from Sex-dependent effects of Setd1a haploinsufficiency on development and adult behaviour. Local targets link to admitted publications; unresolved targets remain external evidence.
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
10.1126/science.1064150 · 2001 · External reference
SETD1A Mediated H3K4 Methylation and its role in neurodevelopmental and neuropsychiatric disorders
10.3389/fnmol.2021.772000 · 2021 · External reference
SETD1A protects from senescence through regulation of the mitotic gene expression program
10.1038/s41467-019-10786-w · 2019 · External reference
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response
10.1016/j.cell.2018.01.032 · 2018 · External reference
SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.
10.1038/ncomms9257 · 2015 · External reference
Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation.
10.1101/gad.303768.117 · 2017 · External reference
H3K4 Methyltransferase Set1a is a key Oct4 coactivator essential for generation of Oct4 positive inner cell mass
10.1002/stem.2250 · 2016 · External reference
The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation
10.1242/dev.098152 · 2014 · External reference
Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain
10.1016/j.celrep.2018.02.019 · 2018 · External reference
Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin
10.1083/jcb.201610014 · 2017 · External reference
SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18
10.1074/mcp.ra119.001518 · 2019 · External reference
Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
10.1016/j.molcel.2018.05.018 · 2018 · External reference
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
10.1038/nn.4267 · 2016 · External reference
10.1038/s41586-022-04556-w
10.1038/s41586-022-04556-w · 2022 · External reference
Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene
10.1016/j.neuron.2014.04.043 · 2014 · External reference
SETD1A variant-associated psychosis: A systematic review of the clinical literature and description of two new cases
10.1016/j.pnpbp.2023.110888 · 2024 · External reference
Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities
10.1016/j.celrep.2020.108126 · 2020 · External reference
Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis
10.1126/sciadv.abm1077 · 2022 · External reference
Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice
10.1016/j.neuron.2019.09.014 · 2019 · External reference
Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a(+/-) Mice
10.1016/j.biopsych.2020.01.004 · 2020 · External reference
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
10.1016/j.celrep.2022.110790 · 2022 · External reference
Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome
10.1038/s41380-020-0725-5 · 2021 · External reference
Maternal high-fat diet programming of the neuroendocrine system and behavior
10.1016/j.yhbeh.2015.04.008 · 2015 · External reference
Maternal Diets Trigger Sex-Specific Divergent Trajectories of Gene Expression and Epigenetic Systems in Mouse Placenta
10.1371/journal.pone.0047986 · 2012 · External reference
Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function
10.1093/hmg/ddac105 · 2022 · External reference
FastQC A Quality Control tool for High Throughput Sequence Data
2010 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
10.1038/nprot.2008.211 · 2009 · External reference
MAGMA: Generalized Gene-Set Analysis of GWAS Data.
10.1371/journal.pcbi.1004219 · 2015 · External reference
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
10.1038/s41588-018-0059-2 · 2018 · External reference
Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype
10.1046/j.1460-9568.1999.00701.x · 1999 · External reference
Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents
10.1016/j.bbr.2014.10.025 · 2015 · External reference
Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
10.1007/s002130100811 · 2001 · External reference
Realistic expectations of prepulse inhibition in translational models for schizophrenia research
10.1007/s00213-008-1072-4 · 2008 · External reference
Unresolved reference
1995 · External reference
Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder.
2019 · External reference
Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target
10.1016/j.schres.2016.10.022 · 2017 · External reference
An emerging role for mitochondrial dynamics in schizophrenia
10.1016/j.schres.2017.05.003 · 2017 · External reference
Mitochondrial dysfunction in schizophrenia: Pathways, mechanisms and implications.
10.1016/j.neubiorev.2014.11.005 · 2015 · External reference
Metabolic contributions to neuronal deficits caused by genomic disruption of schizophrenia risk gene SETD1A
10.1038/s41537-022-00326-9 · 2022 · External reference
Investigation of the Prenatal Expression Patterns of 108 Schizophrenia-Associated Genetic Loci.
10.1016/j.biopsych.2014.10.008 · 2015 · External reference
Dynamic expression of genes associated with schizophrenia and bipolar disorder across development
10.1038/s41398-019-0405-x · 2019 · External reference
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
10.1038/s41593-018-0197-y · 2018 · External reference
Primary Cilia in the Developing and Mature Brain
10.1016/j.neuron.2014.04.024 · 2014 · External reference
A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia
10.1371/journal.pone.0046647 · 2012 · External reference
The placenta-brain-axis
10.1002/jnr.24603 · 2021 · External reference
Placental programming of anxiety in adulthood revealed by Igf2-null models
10.1038/ncomms3311 · 2013 · External reference
Placental-specific IGF-II is a major modulator of placental and fetal growth
10.1038/nature00819 · 2002 · External reference
Placental Changes and Neuropsychological Development in Children-A Systematic Review
10.3390/cells12030435 · 2023 · External reference
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
10.1093/nar/23.24.5080 · 1995 · External reference
Convergence of placenta biology and genetic risk for schizophrenia
10.1038/s41591-018-0021-y · 2018 · External reference
The fetal origins of mental illness.
10.1016/j.ajog.2019.06.013 · 2019 · External reference
Sensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.
10.1016/j.neubiorev.2016.05.029 · 2017 · External reference
Sensory processing in schizophrenia: neither simple nor intact
10.1093/schbul/sbp110 · 2009 · External reference
Sensorimotor gating deficits in adults with autism
10.1016/j.biopsych.2005.09.025 · 2007 · External reference
The neurobiology of startle
10.1016/s0301-0082(98)00098-7 · 1999 · External reference
Repeated elicitation of the acoustic startle reflex leads to sensitisation in subsequent avoidance behaviour and induces fear conditioning
10.1186/1471-2202-12-30 · 2011 · External reference
The effects of sex and neonatal maternal separation on fear-potentiated and light-enhanced startle
10.1016/j.bbr.2005.02.004 · 2005 · External reference
Age- and sex-specific effects of maternal separation on the acoustic startle reflex in rats: early baseline enhancement in females and blunted response to ambiguous threat
10.3389/fnbeh.2022.1023513 · 2022 · External reference
High and low threshold for startle reactivity associated with PTSD symptoms but not PTSD risk: evidence from a prospective study of active duty marines
10.1002/da.22475 · 2016 · External reference
Sensitization and habituation of the acoustic startle reflex in patients with schizophrenia
10.1016/j.psychres.2004.01.003 · 2004 · External reference
Sex differences and personality in the modulation of the acoustic startle reflex
10.1016/j.physbeh.2018.07.020 · 2018 · External reference
Chronic risperidone administration leads to greater amphetamine-induced conditioned place preference
10.1016/j.neuropharm.2020.108276 · 2020 · External reference
Sex-Specific Association between Antioxidant Defense System and Therapeutic Response to Risperidone in Schizophrenia: A Prospective Longitudinal Study
10.2174/1570159x19666211111123918 · 2022 · External reference
The development of antipsychotic drugs
10.1177/2398212818817498 · 2018 · External reference
Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS
10.1128/mcb.00976-08 · 2008 · External reference
Anxiety comorbidity in schizophrenia
2013 · External reference
Is schizophrenia a neurodevelopmental disorder?
10.1136/bmj.295.6600.681 · 1987 · External reference
Implications of normal brain development for the pathogenesis of schizophrenia
10.1001/archpsyc.1987.01800190080012 · 1987 · External reference
Sex Differences in Cognition in Schizophrenia: What We Know and What We Do Not Know.
10.1007/7854_2022_394 · 2023 · External reference
