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References from Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats. Local targets link to admitted publications; unresolved targets remain external evidence.
Ketamine treatment for depression: a review
10.1007/s44192-022-00012-3 · 2022 · External reference
Ketamine as a new treatment for depression: A review of its efficacy and adverse effects
10.1177/0004867413486842 · 2013 · External reference
Side-effects associated with ketamine use in depression: a systematic review
10.1016/s2215-0366(17)30272-9 · 2018 · External reference
Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression
10.1007/s12325-021-01732-8 · 2021 · External reference
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant
10.1016/j.bbr.2020.112548 · 2020 · External reference
Ketamine beyond anesthesia: Antidepressant effects and abuse potential
10.1016/j.bbr.2020.112841 · 2020 · External reference
Ketamine: A tale of two enantiomers
10.1177/0269881120959644 · 2021 · External reference
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
10.1038/s41380-021-01093-2 · 2021 · External reference
Risk of psychosis after repeated intermittent administration of (S)-ketamine, but not (R)-ketamine, in mice.
10.1016/j.jad.2020.03.040 · 2020 · External reference
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
10.1038/tp.2015.136 · 2015 · External reference
Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine
10.1016/j.pbb.2019.04.008 · 2019 · External reference
The effect of ketamine isomers on both mice behavioral responses and c-Fos expression in the posterior cingulate and retrosplenial cortices
10.1016/s0006-8993(99)02426-9 · 2000 · External reference
R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
10.1016/j.pbb.2013.11.033 · 2014 · External reference
Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine
10.1124/jpet.116.239228 · 2017 · External reference
Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity
10.1016/0014-2999(76)90299-5 · 1976 · External reference
Neurobiologic Processes in Drug Reward and Addiction
10.1080/10673220490910844 · 2004 · External reference
The neural basis of drug craving: an incentive-sensitization theory of addiction
10.1016/0165-0173(93)90013-p · 1993 · External reference
Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats
10.1016/j.neuropharm.2017.05.003 · 2017 · External reference
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis
10.1124/pr.116.012484 · 2016 · External reference
Comparative pharmacology of the optical isomers of ketamine in mice
10.1016/0014-2999(78)90217-0 · 1978 · External reference
Ketamine-induced locomotion in rats in an open-field
10.1016/0091-3057(85)90291-6 · 1985 · External reference
Ketamine sensitization: Influence of dose, environment, social isolation and treatment interval
10.1016/j.bbr.2019.112271 · 2020 · External reference
Differences between adolescents and adults in the acute effects of PCP and ketamine and in sensitization following intermittent administration
10.1016/j.pbb.2017.04.007 · 2017 · External reference
Long-Lasting Effects of Repeated Ketamine Administration in Adult and Adolescent Rats
10.1016/j.bbr.2019.111928 · 2019 · External reference
Ketamine, at a Dose that Disrupts Motor Behavior and Latent Inhibition, Enhances Prefrontal Cortex Synaptic Efficacy and Glutamate Release in the Nucleus Accumbens
10.1038/sj.npp.1301057 · 2007 · External reference
The repeated administration of ketamine induces an enhancement of its stimulant action in mice
10.1254/jjp.61.149 · 1993 · External reference
Dual action of ketamine confines addiction liability
10.1038/s41586-022-04993-7 · 2022 · External reference
Dose-response characteristics of intravenous ketamine on dissociative stereotypy, locomotion, sensorimotor gating, and nociception in male Sprague-Dawley rats
10.1016/j.pbb.2016.12.014 · 2017 · External reference
Sex-related differences in intravenous ketamine effects on dissociative stereotypy and antinociception in male and female rats
10.1016/j.pbb.2020.173042 · 2020 · External reference
Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats
10.1016/j.pbb.2013.05.005 · 2013 · External reference
The effect of route of administration on the enantioselective pharmacokinetics of ketamine and norketamine in rats
10.1177/0269881118780013 · 2018 · External reference
Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression
10.1111/acps.12572 · 2016 · External reference
Long-Lasting Effects of a Single Subcutaneous Dose of Ketamine for Treating Melancholic Depression: A Case Report
10.1016/j.biopsych.2013.12.010 · 2014 · External reference
Dissociative Conscious Sedation, An Alternative to General Anesthesia for Laparoscopic Peritoneal Dialysis Catheter Implantation: A Randomized Trial Comparing Intravenous and Subcutaneous Ketamine
10.3747/pdi.2010.00110 · 2011 · External reference
The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression
10.3389/fpsyt.2020.599588 · 2021 · External reference
Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant
2019 · External reference
Unresolved reference
External reference
Subcutaneous Compared with Intraperitoneal Ketamine–Xylazine for Anesthesia of Mice
2016 · External reference
Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?
10.1007/s11095-019-2745-x · 2019 · External reference
The effect of daily repeated sedation using ketamine or ketamine combined with medetomidine on physiology and anesthetic characteristics in Rhesus Macaques
10.1111/j.1600-0684.2009.00393.x · 2010 · External reference
Development of Tolerance to Ketamine in an Infant Undergoing Repeated Anesthesia
10.1097/00000542-198103000-00016 · 1981 · External reference
Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice
2022 · External reference
Safety and Tolerance of Repeated Anesthesia with CI 581 (Ketamine) in Monkeys
1967 · External reference
Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys
10.1007/s00213-010-1797-8 · 2010 · External reference
Long-Term Ketamine Self-Injections in Major Depressive Disorder: Focus on Tolerance in Ketamine’s Antidepressant Response and the Development of Ketamine Addiction
10.1080/02791072.2015.1072653 · 2015 · External reference
Lack of persistent effects of ketamine in rodent models of depression
10.1007/s00213-008-1158-z · 2008 · External reference
Repeated Ketamine Exposure Induces an Enduring Resilient Phenotype in Adolescent and Adult Rats
10.1016/j.biopsych.2013.04.027 · 2013 · External reference
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses
10.1111/bph.14683 · 2019 · External reference
Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers
10.1097/00000542-200202000-00022 · 2002 · External reference
Comparative Pharmacology of the Ketamine Isomers: Studies in Volunteers
10.1093/bja/57.2.197 · 1985 · External reference
Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis
10.1016/j.jad.2020.09.071 · 2021 · External reference
Ketamine for the treatment of major depression: a systematic review and meta-analysis
10.1016/j.eclinm.2023.102127 · 2023 · External reference
Intravenous arketamine for treatment-resistant depression: open-label pilot study
10.1007/s00406-020-01110-5 · 2021 · External reference
Arketamine as adjunctive therapy for treatment-resistant depression: A placebo-controlled pilot study
10.1016/j.jad.2023.02.151 · 2023 · External reference
(S)-ketamine, but not (R)-ketamine shows acute effects on depression-like behavior and sleep-wake architecture in rats
2023 · External reference
The antidepressant actions of ketamine and its enantiomers
10.1016/j.pharmthera.2023.108431 · 2023 · External reference
Sex Differences in the Behavioral, Molecular, and Structural Effects of Ketamine Treatment in Depression
10.1093/ijnp/pyab082 · 2021 · External reference
Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner
10.1038/srep21322 · 2016 · External reference
Sex differences in the antidepressant-like effects of ketamine
10.1016/j.neuropharm.2012.12.009 · 2013 · External reference
Dark-Phase Light Contamination Disrupts Circadian Rhythms in Plasma Measures of Endocrine Physiology and Metabolism in Rats
2010 · External reference
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
10.1038/s41593-022-01146-x · 2022 · External reference
Sex-specific stress and biobehavioral responses to human experimenters in rats
10.3389/fnins.2022.965500 · 2022 · External reference