Research graph
References from Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice. Local targets link to admitted publications; unresolved targets remain external evidence.
The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
10.4161/auto.6.5.12434 · 2010 · External reference
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death
10.1038/sj.bjc.6600547 · 2002 · External reference
Glycolysis inhibition by 2-deoxy-D-glucose reverts the metastatic phenotype in vitro and in vivo
10.1007/s10585-011-9417-5 · 2011 · External reference
Inhibitory effect of 2-deoxy-D-glucose on liver tumor growth in rats
1992 · External reference
A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors
10.1007/s00280-012-2045-1 · 2013 · External reference
Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury
2019 · External reference
AI-19 Metabolic inhibition by 2-deoxyglucose prevents and reverses lupus in mice
2016 · External reference
2-Deoxy-D-glucose Alleviates Collagen-Induced Arthritis of Rats and Is Accompanied by Metabolic Regulation of the Spleen and Liver
10.3389/fimmu.2021.713799 · 2021 · External reference
2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart
10.1038/s41598-022-10168-1 · 2022 · External reference
2-deoxy-D-glucose as an adjunct to standard of care in the medical management of COVID-19: a proof-of-concept and dose-ranging randomised phase II clinical trial.
10.1186/s12879-022-07642-6 · 2022 · External reference
The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic Viruses.
10.3390/molecules27185928 · 2022 · External reference
Role of 2-Deoxy-D-Glucose (2-DG) in COVID-19 disease: A potential game-changer.
10.4103/jfmpc.jfmpc_1338_21 · 2021 · External reference
2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.
10.3390/ijms21010234 · 2019 · External reference
2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion
10.1007/s00280-010-1391-0 · 2011 · External reference
2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation.
10.3389/fimmu.2017.00637 · 2017 · External reference
2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase.
10.1371/journal.pone.0017234 · 2011 · External reference
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer’s disease.
10.1371/journal.pone.0021788 · 2011 · External reference
Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.
10.3389/fimmu.2018.01973 · 2018 · External reference
Triggering unfolded protein response by 2-Deoxy-D-glucose inhibits porcine epidemic diarrhea virus propagation
10.1016/j.antiviral.2014.03.007 · 2014 · External reference
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
10.1038/s41467-018-06686-0 · 2018 · External reference
Fast gapped-read alignment with Bowtie 2.
10.1038/nmeth.1923 · 2012 · External reference
Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
10.1093/nar/gks042 · 2012 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
From reads to genes to pathways: differential expression analysis of RNA-Seq experiments using Rsubread and the edgeR quasi-likelihood pipeline.
2016 · External reference
Unresolved reference
2022 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Fast R Functions for Robust Correlations and Hierarchical Clustering.
2012 · External reference
gprofiler2: Interface to the ’g:Profiler’ Toolset.
External reference
Unresolved reference
2021 · External reference
The Aligned Rank Transform for Nonparametric Factorial Analyses Using Only ANOVA Procedures
2011 · External reference
mediation: R Package for Causal Mediation Analysis.
2014 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data.
2013 · External reference
10.1201/9781315204963
10.1201/9781315204963 · 2016 · External reference
Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids.
10.3389/fendo.2020.00617 · 2020 · External reference
Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease.
10.3389/fcvm.2021.789267 · 2021 · External reference
Glycogen metabolism in humans
10.1016/j.bbacli.2016.02.001 · 2016 · External reference
NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential
10.1038/s41392-020-00311-7 · 2020 · External reference
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
10.1016/j.cmet.2018.03.018 · 2018 · External reference
N-linked protein glycosylation in the ER
10.1016/j.bbamcr.2013.04.001 · 2013 · External reference
The Randle cycle revisited: a new head for an old hat
10.1152/ajpendo.00093.2009 · 2009 · External reference
Regulation of lipid metabolism by the unfolded protein response
10.1111/jcmm.16255 · 2021 · External reference
Branched-chain amino acids and immunity
2006 · External reference
Effects of branched-chain amino acids on immune status of young racing horses
10.1292/jvms.21-0529 · 2022 · External reference
Immunometabolism—The Role of Branched-Chain Amino Acids
10.3389/fimmu.2022.886822 · 2022 · External reference
Long-Term Effects of Dietary Protein and Branched-Chain Amino Acids on Metabolism and Inflammation in Mice.
2018 · External reference
ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2alpha Phosphorylation and GADD45alpha.
2019 · External reference
Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy.
10.2217/fon.09.44 · 2009 · External reference
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.
10.1038/cddis.2014.285 · 2014 · External reference
2-Deoxy-d-Glucose Ameliorates PKD Progression
10.1681/asn.2015030231 · 2016 · External reference
By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737
10.1038/s41418-018-0244-y · 2019 · External reference
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
10.1161/circulationaha.115.020226 · 2016 · External reference
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.
10.1016/j.cmet.2018.10.013 · 2019 · External reference
Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
10.1002/pros.21172 · 2010 · External reference
The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies
2021 · External reference
The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner
10.1016/j.molimm.2021.10.007 · 2021 · External reference
The Biochemistry and Physiology of Mitochondrial Fatty Acid beta-Oxidation and Its Genetic Disorders
10.1146/annurev-physiol-021115-105045 · 2016 · External reference
Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation
10.1371/journal.pone.0115642 · 2014 · External reference
Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases.
10.3390/molecules27030951 · 2022 · External reference
Brain-specific disruption of the eIF2alpha kinase PERK decreases ATF4 expression and impairs behavioral flexibility
10.1016/j.celrep.2012.04.010 · 2012 · External reference
Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia.
10.1038/s41380-019-0537-7 · 2021 · External reference
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
10.1038/s41419-022-05153-5 · 2022 · External reference
Mitogen-activated protein kinase signaling is necessary for the maintenance of skeletal muscle mass
10.1152/ajpcell.00475.2008 · 2009 · External reference
Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition.
10.1371/journal.pone.0013604 · 2010 · External reference
Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions
10.1128/mcb.01071-14 · 2015 · External reference
Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis
10.1016/j.exer.2020.108079 · 2020 · External reference
Signaling pathways in obesity: mechanisms and therapeutic interventions.
10.1038/s41392-022-01149-x · 2022 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
