Research graph
References from Hope for vascular cognitive impairment: Ac-YVAD-cmk as a novel treatment against white matter rarefaction. Local targets link to admitted publications; unresolved targets remain external evidence.
Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging
10.1152/ajpheart.00581.2016 · 2017 · External reference
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association
10.1161/str.0b013e3182299496 · 2011 · External reference
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
2019 · External reference
Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
10.1016/s1474-4422(10)70104-6 · 2010 · External reference
Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain
10.1016/j.exger.2012.05.023 · 2012 · External reference
Neuroscience. Change in the brain’s white matter
10.1126/science.1199139 · 2010 · External reference
Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review
10.3389/fnhum.2021.662031 · 2021 · External reference
The Axon-Myelin Unit in Development and Degenerative Disease
10.3389/fnins.2018.00467 · 2018 · External reference
White matter microstructure underlying default mode network connectivity in the human brain
10.1016/j.neuroimage.2009.10.067 · 2010 · External reference
Neuroimaging in vascular cognitive impairment: a state-of-the-art review
10.1186/s12916-016-0725-0 · 2016 · External reference
Cerebral hypoperfusion and white matter disease in healthy elderly and patients with Alzheimer’s disease
10.1111/j.1468-1331.2012.03865.x · 2013 · External reference
White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
2019 · External reference
Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging
10.1016/j.pscychresns.2008.11.006 · 2009 · External reference
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
10.1136/bmj.c3666 · 2010 · External reference
The association between cognitive function and white matter lesion location in older adults: a systematic review
10.1186/1471-2377-12-126 · 2012 · External reference
White matter hyperintensities, cognitive impairment and dementia: an update
10.1038/nrneurol.2015.10 · 2015 · External reference
White matter hyperintensities are common in midlife and already associated with cognitive decline
10.1093/braincomms/fcz041 · 2019 · External reference
Trajectory of white matter hyperintensity burden preceding mild cognitive impairment
10.1212/wnl.0b013e3182661f2b · 2012 · External reference
Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
10.1001/archneurol.2007.23 · 2008 · External reference
Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults
10.1212/nxi.0000000000000521 · 2019 · External reference
Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment
10.3389/fneur.2021.786840 · 2021 · External reference
Inflammasomes link vascular disease with neuroinflammation and brain disorders
10.1177/0271678x16662043 · 2016 · External reference
Inflammasomes in neuroinflammation and changes in brain function: a focused review
10.3389/fnins.2014.00315 · 2014 · External reference
Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases
10.3389/fnagi.2022.827263 · 2022 · External reference
Inflammasomes: mechanism of action, role in disease, and therapeutics
10.1038/nm.3893 · 2015 · External reference
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
10.1038/s41577-019-0165-0 · 2019 · External reference
White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion
10.1161/01.str.0000143725.19053.60 · 2004 · External reference
Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in mice
10.1038/s41598-017-08227-z · 2017 · External reference
Tamoxifen promotes white matter recovery and cognitive functions in male mice after chronic hypoperfusion
10.1016/j.neuint.2019.104566 · 2019 · External reference
Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis
10.1038/srep32179 · 2016 · External reference
A novel mouse model of subcortical infarcts with dementia
10.1523/jneurosci.3970-14.2015 · 2015 · External reference
The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion
10.1177/0271678x17694904 · 2018 · External reference
A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis
10.1177/0271678x231154597 · 2023 · External reference
A mouse model of subcortical vascular dementia reflecting degeneration of cerebral white matter and microcirculation
10.1177/0271678x17736963 · 2019 · External reference
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia
10.1038/s41380-020-00971-5 · 2021 · External reference
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion
10.1161/strokeaha.107.490151 · 2007 · External reference
Cognitive Impairments and blood-brain Barrier Damage in a Mouse Model of Chronic Cerebral Hypoperfusion
10.1007/s11064-022-03799-3 · 2022 · External reference
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions
10.1016/j.neuint.2016.02.012 · 2016 · External reference
Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate
10.3390/ijms20246176 · 2019 · External reference
Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion
10.1161/atvbaha.113.302440 · 2014 · External reference
Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice
10.1371/journal.pone.0195765 · 2018 · External reference
MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment
10.1161/atvbaha.118.310822 · 2018 · External reference
Inflammation and Rho-Associated Protein Kinase-Induced Brain Changes in Vascular Dementia
2022 · External reference
Blood-brain barrier permeability abnormalities in vascular cognitive impairment
10.1161/strokeaha.110.611731 · 2011 · External reference
Inflammasomes in neuroinflammatory and neurodegenerative diseases
10.15252/emmm.201810248 · 2019 · External reference
AIM2 in health and disease: Inflammasome and beyond
10.1111/imr.12903 · 2020 · External reference
Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome
10.1016/j.brainres.2020.146779 · 2020 · External reference
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
10.1073/pnas.1415756111 · 2014 · External reference
Caspase-1: is IL-1 just the tip of the ICEberg?
10.1038/cddis.2012.86 · 2012 · External reference
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
10.1073/pnas.1722041115 · 2018 · External reference
Vascular Endothelial Cell Biology: An Update
10.3390/ijms20184411 · 2019 · External reference
Blood-brain barrier tight junction permeability and ischemic stroke
10.1016/j.nbd.2008.08.005 · 2008 · External reference
Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis
10.1016/j.bbamem.2007.09.003 · 2008 · External reference
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
10.1186/2045-8118-9-23 · 2012 · External reference
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions
10.1189/jlb.0710432 · 2011 · External reference
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery
10.1016/j.stemcr.2020.03.011 · 2020 · External reference
Altered expression of claudin family proteins in Alzheimer’s disease and vascular dementia brains
2010 · External reference
Occludin is overexpressed in Alzheimer’s disease and vascular dementia
10.1111/j.1582-4934.2007.00047.x · 2007 · External reference
Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression
10.1093/brain/awz011 · 2019 · External reference
The blood-brain barrier in systemic inflammation
10.1016/j.bbi.2016.03.010 · 2017 · External reference
Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats
10.1016/j.intimp.2019.105771 · 2019 · External reference
AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage
2018 · External reference
Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study
10.1007/bf00294175 · 1994 · External reference
Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro
10.1016/j.scr.2015.05.001 · 2015 · External reference
Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease
10.1038/cdd.2008.70 · 2008 · External reference
Oligodendrocyte Development and Plasticity
10.1101/cshperspect.a020453 · 2015 · External reference
The Absolute Number of Oligodendrocytes in the Adult Mouse Brain
10.3389/fnana.2018.00090 · 2018 · External reference
Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1beta in Intracerebral Hemorrhage Mouse Model
10.1007/s12975-009-0002-z · 2010 · External reference
Inhibition of human caspases by peptide-based and macromolecular inhibitors
10.1074/jbc.273.49.32608 · 1998 · External reference
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
10.4049/jimmunol.2000373 · 2020 · External reference
Unresolved reference
External reference
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
10.1016/s2468-2667(21)00249-8 · 2022 · External reference
Neuroimaging studies on cognitive impairment due to cerebral small vessel disease
10.1136/svn-2018-000209 · 2019 · External reference
Regional contribution of vascular dysfunction in white matter dementia: clinical and neuropathological insights
10.3389/fneur.2023.1199491 · 2023 · External reference
Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging
10.1002/mrm.20705 · 2005 · External reference
The energetics of CNS white matter
10.1523/jneurosci.3430-11.2012 · 2012 · External reference
Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature
10.1016/j.cell.2020.01.028 · 2020 · External reference
Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia
10.1212/wnl.0000000000207113 · 2023 · External reference
Inflammation and white matter damage in vascular cognitive impairment
2009 · External reference
Inflammation in white matter: clinical and pathophysiological aspects
10.1002/mrdd.20100 · 2006 · External reference
The role of inflammasomes in vascular cognitive impairment
10.1186/s13024-021-00506-8 · 2022 · External reference
NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
10.1007/s10753-018-0894-4 · 2019 · External reference
Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis
10.1155/2021/6636621 · 2021 · External reference
The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities
10.1038/srep24166 · 2016 · External reference
Abnormalities of cortical thickness, subcortical shapes, and white matter integrity in subcortical vascular cognitive impairment
10.1002/hbm.22330 · 2014 · External reference
Strongly reduced volumes of putamen and thalamus in Alzheimer’s disease: an MRI study
10.1093/brain/awn278 · 2008 · External reference
The Human Thalamus Is an Integrative Hub for Functional Brain Networks
10.1523/jneurosci.0067-17.2017 · 2017 · External reference
The Caudal Part of Putamen Represents the Historical Object Value Information
2019 · External reference
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
10.3389/fncel.2020.00198 · 2020 · External reference
Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants
10.1089/ars.2010.3522 · 2011 · External reference
Neuroinflammation in Vascular Cognitive Impairment and Dementia: Current Evidence, Advances, and Prospects
10.3390/ijms23116224 · 2022 · External reference
Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-[alpha] in endothelial cells
10.1161/01.atv.0000106321.63667.24 · 2004 · External reference
Shear stress modulates VCAM-1 expression in response to TNF-alpha and dietary lipids via interferon regulatory factor-1 in cultured endothelium
10.1152/ajpheart.00311.2013 · 2013 · External reference
Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress
10.1161/01.atv.15.1.2 · 1995 · External reference
Vascular inflammation in the central nervous system
10.4103/1673-5374.332140 · 2022 · External reference
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
10.1371/journal.ppat.1007886 · 2019 · External reference
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1beta-, IL-18- and sirtuin-1-independent pathways
10.1186/s13045-017-0406-2 · 2017 · External reference
Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia
10.1161/strokeaha.122.037156 · 2023 · External reference
Xenograft of Human Umbilical Mesenchymal Stem Cells Promotes Recovery from Chronic Ischemic Stroke in Rats
2022 · External reference
Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1beta generation
10.1038/sj.cdd.4401644 · 2005 · External reference
Reduction in pericyte coverage leads to blood-brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion
10.1186/s12987-021-00255-2 · 2021 · External reference
Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models
10.3390/ijms242115739 · 2023 · External reference
Elevated Markers of Inflammation Are Associated With Longitudinal Changes in Brain Function in Older Adults
10.1093/gerona/glx199 · 2018 · External reference
Inflammatory mechanisms after ischemia and stroke
10.1093/jnen/62.2.127 · 2003 · External reference
Vertigo in Acute Stroke Is a Predictor of Brain Location but Is Not Related to Early Outcome: The Experience of Sagrat Cor Hospital of Barcelona Stroke Registry
10.3390/biomedicines10112830 · 2022 · External reference
Gut Dysbiosis: A New Avenue for Stroke Prevention and Therapeutics
2023 · External reference
Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines
10.3390/ijms21072431 · 2020 · External reference
Vascular risk factors and dementia: how to move forward?
10.1212/01.wnl.0000341271.90478.8e · 2009 · External reference
