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References from The candidate proteins associated with keratoconus: A meta-analysis and bioinformatic analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
The prevalence and risk factors for keratoconus: a systematic review and meta-analysis
10.1097/ico.0000000000002150 · 2020 · External reference
Keratoconus and related noninflammatory corneal thinning disorders.
10.1016/0039-6257(84)90094-8 · 1984 · External reference
Updates on managements for keratoconus.
10.1016/j.joco.2017.11.002 · 2018 · External reference
Management of keratoconus: an updated review
10.3389/fmed.2023.1212314 · 2023 · External reference
Prospective clinical study of keratoconus progression in patients awaiting corneal cross-linking
2020 · External reference
Pediatric keratoconus—Current perspectives and clinical challenges
10.4103/ijo.ijo_1263_20 · 2021 · External reference
The impact of repetitive and prolonged eye rubbing on corneal biomechanics.
10.3928/1081597x-20220715-03 · 2022 · External reference
Ultraviolet radiation oxidative stress affects eye health
10.1002/jbio.201700377 · 2018 · External reference
Mitochondrial profile and responses to TGF-beta ligands in keratoconus
10.3109/02713683.2015.1078361 · 2016 · External reference
Is keratoconus an inflammatory disease? the implication of inflammatory pathways.
2022 · External reference
Inflammatory biomarkers profile as microenvironmental expression in keratoconus
10.1155/2016/1243819 · 2016 · External reference
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis
10.1038/s41421-022-00397-z · 2022 · External reference
Nationwide epidemiological approach to identify associations between keratoconus and immune-mediated diseases
10.1136/bjophthalmol-2021-318804 · 2022 · External reference
Integrative transcriptomics analysis and experimental validation reveal immunomodulatory patterns in keratoconus
10.1016/j.exer.2023.109460 · 2023 · External reference
Further evaluation of differential expression of keratoconus candidate genes in human corneas.
10.7717/peerj.9793 · 2020 · External reference
RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients
10.1038/s41598-017-18480-x · 2018 · External reference
RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses
10.1038/s41598-020-66735-x · 2020 · External reference
Altered regulation of mRNA and miRNA expression in epithelial and stromal tissue of keratoconus corneas
10.1167/iovs.63.8.7 · 2022 · External reference
Transcriptomic and immunohistochemical analysis of progressive keratoconus reveal altered Wnt10a in epithelium and bowman’s layer
10.1167/iovs.62.6.16 · 2021 · External reference
Collagen synthesis disruption and downregulation of core elements of TGF-beta, Hippo, and Wnt pathways in keratoconus corneas
10.1038/ejhg.2017.4 · 2017 · External reference
Comprehensive Transcriptome Analysis of patients with keratoconus highlights the regulation of immune responses and inflammatory processes
10.3389/fgene.2022.782709 · 2022 · External reference
Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta-analysis.
2021 · External reference
Tear levels of inflammatory cytokines in keratoconus: a meta-analysis of case-control and cross-sectional studies
2021 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
Mean Difference, Standardized mean difference (SMD), and their use in meta-analysis: as simple as it gets.
2020 · External reference
Understanding the role of corneal biomechanics-associated genetic variants by bioinformatic analyses.
10.1007/s10792-021-02081-9 · 2022 · External reference
Differential epithelial and stromal protein profiles in cone and non-cone regions of keratoconus corneas
2019 · External reference
Mapping keratoconus molecular substrates by multiplexed high-resolution proteomics of unpooled corneas
10.1089/omi.2019.0143 · 2019 · External reference
Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus
10.1167/iovs.16-19677 · 2016 · External reference
Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A
10.1167/iovs.14-14831 · 2015 · External reference
Altered tear inflammatory profile in indian keratoconus patients—the 2015 col rangachari award paper
External reference
Tear film inflammatory mediators in patients with keratoconus.
10.1007/s10792-014-9971-3 · 2015 · External reference
Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity
2015 · External reference
Tear levels of SFRP1 are significantly reduced in keratoconus patients
2013 · External reference
Tear proteomics in keratoconus: a quantitative SWATH-MS analysis
10.1167/iovs.62.10.30 · 2021 · External reference
Levels of lactoferrin, lysozyme and albumin in the tear film of keratoconus patients and their correlations with important parameters of the disease.
10.2478/rrlm-2020-0018 · 2020 · External reference
Overexpression of tear inflammatory cytokines as additional finding in keratoconus patients and their first degree family members.
2018 · External reference
Tear mediators in corneal ectatic disorders
2016 · External reference
Gross cystic disease fluid protein-15/prolactin-inducible protein as a biomarker for keratoconus disease.
10.1371/journal.pone.0113310 · 2014 · External reference
Tear proteomic profile in three distinct ocular surface diseases: keratoconus, pterygium, and dry eye related to graft-versus-host disease
10.1186/s12014-020-09307-5 · 2020 · External reference
Higher expression of toll-like receptors 2 and 4 in blood cells of keratoconus patiens
10.1038/s41598-017-13525-7 · 2017 · External reference
Expression of SFRP family proteins in human keratoconus corneas
10.1371/journal.pone.0066770 · 2013 · External reference
Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus.
2012 · External reference
IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis
10.1080/13816810.2021.1925926 · 2021 · External reference
Association of common variants inlox with keratoconus: a meta-analysis
2015 · External reference
The association between keratoconus and allergic eye diseases: a systematic review and meta-analysis.
2023 · External reference
Serum inflammation biomarkers in patients with keratoconus
10.1080/09273948.2020.1741648 · 2021 · External reference
Systemic associations with keratoconus
2023 · External reference
Matrix metalloproteinases in keratoconus—Too much of a good thing
10.1016/j.exer.2019.03.016 · 2019 · External reference
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
10.1083/jcb.200211091 · 2003 · External reference
Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin’s family by multi-omics analysis.
2020 · External reference
Integrated stress response and decreased ecm in cultured stromal cells from keratoconus corneas
10.1167/iovs.18-24367 · 2018 · External reference
HspB1 (Hsp 27) expression and neuroprotection in the retina.
10.1007/s12035-010-8143-3 · 2010 · External reference
The protective role of HSP27 in ocular diseases
10.1007/s11033-022-07222-6 · 2022 · External reference
Role of lactoferrin in the tear film
10.1016/j.biochi.2008.07.007 · 2009 · External reference
Wnt/beta-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells
10.1167/iovs.10-6486 · 2011 · External reference
Clinical ocular biomechanics: where are we after 20 years of progress
2023 · External reference
Biomechanics of keratoconus: two numerical studies
2023 · External reference
Induction of MMP‑1 and ‑3 by cyclical mechanical stretch is mediated by IL‑6 in cultured fibroblasts of keratoconus
2017 · External reference
Outcomes of corneal cross-linking correlate with cone- specific lysyl oxidase expression in patients with keratoconus
10.1097/ico.0000000000001478 · 2018 · External reference
The research progress on the molecular mechanism of corneal cross-linking in keratoconus treatment
10.1016/j.clae.2022.101795 · 2023 · External reference
Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies.
10.1167/iovs.11-9268 · 2012 · External reference
Human in vitro model reveals the effects of collagen cross-linking on keratoconus pathogenesis
10.1038/s41598-017-12598-8 · 2017 · External reference
Collagen cross-linking impact on keratoconus extracellular matrix
2018 · External reference
Evaluation of keratoconus disease with tear cytokine and chemokine levels before and after corneal cross-linking treatment
2023 · External reference
The impact of non-coding RNAs in the pathobiology of eye disorders
10.1016/j.ijbiomac.2023.124245 · 2023 · External reference
Are mirnas dynamic biomarkers in keratoconus? a review of the literature
2022 · External reference
Histological and microRNA signatures of corneal epithelium in keratoconus
10.3928/1081597x-20171215-02 · 2018 · External reference
Keratoconus diagnosis and treatment: recent advances and future directions
10.2147/opth.s392665 · 2023 · External reference
Vitamin d supplementation impacts systemic biomarkers of collagen degradation and copper metabolism in patients with keratoconus
10.1167/tvst.11.12.16 · 2022 · External reference
Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway
2018 · External reference
Quercetin attenuates lactate production and extracellular matrix secretion in keratoconus
10.1038/srep09003 · 2015 · External reference
Keratoconus in africa: a systematic review and meta-analysis
10.1111/opo.12825 · 2021 · External reference
Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis
10.1007/s00417-021-05081-8 · 2021 · External reference
Measuring inconsistency in meta-analyses
10.1136/bmj.327.7414.557 · 2003 · External reference
A basic introduction to fixed-effect and random-effects models for meta-analysis.
10.1002/jrsm.12 · 2010 · External reference
Interleukin-6 and tumor necrosis factor-alpha levels in tear film of Keratoconus patients
10.4103/jrms.jrms_35_21 · 2021 · External reference
Matrix Metalloproteinase-9 drives disease progression of Keratoconus.
2013 · External reference
Keratoconus: An updated review
10.1016/j.clae.2021.101559 · 2022 · External reference
Collagen cross-linking impact on keratoconus extracellular matrix
2018 · External reference