Research graph
References from JUN mRNA translation regulation is mediated by multiple 5’ UTR and start codon features. Local targets link to admitted publications; unresolved targets remain external evidence.
A hierarchy of ATP-consuming processes in mammalian cells
10.1042/bj3120163 · 1995 · External reference
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
10.1016/j.cell.2009.01.042 · 2009 · External reference
mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways
10.1101/sqb.2011.76.010785 · 2011 · External reference
Principles of translational control: an overview.
2012 · External reference
Dysregulation of mRNA translation and energy metabolism in cancer
10.1016/j.jbior.2017.11.001 · 2018 · External reference
Eukaryotic translation initiation: there are (at least) two sides to every story.
10.1038/75120 · 2000 · External reference
The mechanism of eukaryotic translation initiation and principles of its regulation
10.1038/nrm2838 · 2010 · External reference
Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes
10.1128/mmbr.00008-11 · 2011 · External reference
A mechanistic overview of translation initiation in eukaryotes
10.1038/nsmb.2303 · 2012 · External reference
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo
10.1093/emboj/cdg030 · 2003 · External reference
The Scanning Mechanism of Eukaryotic Translation Initiation
10.1146/annurev-biochem-060713-035802 · 2014 · External reference
Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation
10.1093/emboj/20.9.2326 · 2001 · External reference
Development and characterization of a reconstituted yeast translation initiation system
10.1017/s1355838202029527 · 2002 · External reference
Mammalian Translation Initiation Factor eIF1 Functions with eIF1A and eIF3 in the Formation of a Stable 40 S Preinitiation Complex*
10.1074/jbc.m210357200 · 2003 · External reference
Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association
10.1261/rna.7215305 · 2005 · External reference
Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons
10.1038/29703 · 1998 · External reference
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection
10.1101/gad.1020902 · 2002 · External reference
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
10.1038/nature14267 · 2015 · External reference
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
10.1038/nature18954 · 2016 · External reference
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation.
10.7554/elife.74272 · 2021 · External reference
Eukaryotic Translation Initiation Factor 3, Subunit a, Regulates the Extracellular Signal-Regulated Kinase Pathway
10.1128/mcb.05770-11 · 2012 · External reference
Repression of ferritin light chain translation by human eIF3.
10.7554/elife.48193 · 2019 · External reference
PTBP1 mRNA isoforms and regulation of their translation
10.1261/rna.070193.118 · 2019 · External reference
Human eIF3: from ‘blobology’ to biological insight.
10.1098/rstb.2016.0176 · 2017 · External reference
eIF3: a factor for human health and disease
10.1080/15476286.2017.1391437 · 2017 · External reference
A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress
10.1126/science.abb0993 · 2020 · External reference
eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health
10.1016/j.molcel.2020.06.003 · 2020 · External reference
eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease
10.1093/jmcb/mjaa018 · 2020 · External reference
eIF3d controls the persistent integrated stress response
10.1016/j.molcel.2023.08.008 · 2023 · External reference
eIF3 engages with 3′-UTR termini of highly translated mRNAs in neural progenitor cells.
2023 · External reference
The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure.
10.1017/s135583820100108x · 2001 · External reference
Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation
10.1186/s13059-014-0476-1 · 2014 · External reference
Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
10.1038/nature17978 · 2016 · External reference
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA
10.1016/j.molcel.2018.11.026 · 2019 · External reference
Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation
10.1101/gad.6.7.1229 · 1992 · External reference
Structure and interactions of the translation initiation factor eIF1
10.1093/emboj/18.9.2631 · 1999 · External reference
Eukaryotic translation initiation factors and regulators
10.1016/s0959-440x(03)00009-5 · 2003 · External reference
Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5
10.1093/nar/gkr1192 · 2012 · External reference
uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologs
10.1073/pnas.0801590105 · 2008 · External reference
Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1).
10.1073/pnas.1009269107 · 2010 · External reference
Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
10.1073/pnas.2117226119 · 2022 · External reference
eIF3: a versatile scaffold for translation initiation complexes
10.1016/j.tibs.2006.08.005 · 2006 · External reference
The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo
10.1101/gad.1065403 · 2003 · External reference
Eukaryotic Translation Initiation Factor 3 (eIF3) and eIF2 Can Promote mRNA Binding to 40S Subunits Independently of eIF4G in Yeast.
10.1128/mcb.26.4.1355-1372.2006 · 2006 · External reference
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
10.1128/mcb.00280-10 · 2010 · External reference
The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway
10.1016/j.molcel.2010.08.021 · 2010 · External reference
Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis
10.1073/pnas.1302934110 · 2013 · External reference
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
10.1093/emboj/18.1.188 · 1999 · External reference
c-Jun, at the crossroad of the signaling network
10.1007/s13238-011-1113-3 · 2011 · External reference
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
10.1038/354494a0 · 1991 · External reference
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
10.1126/science.2825349 · 1987 · External reference
A gene activated by growth factors is related to the oncogene v-jun
10.1073/pnas.85.5.1487 · 1988 · External reference
Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation.
10.1073/pnas.1203659109 · 2012 · External reference
Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor
1991 · External reference
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
10.1016/0092-8674(88)90143-2 · 1988 · External reference
Induction of proto-oncogene JUN/AP-1 by serum and TPA
10.1038/334629a0 · 1988 · External reference
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial–mesenchymal transition of lung cancer cells
10.1016/j.jbc.2022.102554 · 2022 · External reference
eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions.
10.3389/fmolb.2021.787664 · 2022 · External reference
A thermodynamic study of unusually stable RNA and DNA hairpins
10.1093/nar/19.21.5901 · 1991 · External reference
Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity.
10.1128/mbio.00844-17 · 2017 · External reference
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
10.1016/0092-8674(86)90762-2 · 1986 · External reference
NCBI Taxonomy: a comprehensive update on curation, resources and tools.
10.1093/database/baaa062 · 2020 · External reference
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
10.1038/nrm.2017.103 · 2018 · External reference
Pervasive downstream RNA hairpins dynamically dictate start-codon selection
10.1038/s41586-023-06500-y · 2023 · External reference
Translational regulation of GCN4 and the general amino acid control of yeast
10.1146/annurev.micro.59.031805.133833 · 2005 · External reference
Translation from the 5′ untranslated region shapes the integrated stress response
10.1126/science.aad3867 · 2016 · External reference
Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish.
10.1038/ncomms11663 · 2016 · External reference
Determinants of genome-wide distribution and evolution of uORFs in eukaryotes
10.1038/s41467-021-21394-y · 2021 · External reference
Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo
10.1093/nar/gki248 · 2005 · External reference
Close spacing of AUG initiation codons confers dicistronic character on a eukaryotic mRNA
10.1261/rna.67906 · 2006 · External reference
Mutational processes shape the landscape of TP53 mutations in human cancer
10.1038/s41588-018-0204-y · 2018 · External reference
A highly efficient human cell-free translation system
2023 · External reference
WebLogo: A Sequence Logo Generator.
10.1101/gr.849004 · 2004 · External reference
Sequence logos: a new way to display consensus sequences
10.1093/nar/18.20.6097 · 1990 · External reference
GenBank.
10.1093/nar/gky989 · 2019 · External reference
