Research graph
References from CAF-associated genes putatively representing distinct prognosis by in silico landscape of stromal components of colon cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Amplification units containing human N-myc and c-myc genes
10.1073/pnas.83.4.1031 · 1986 · External reference
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung
10.1126/science.3014659 · 1986 · External reference
Characterization of N-myc amplification units in human neuroblastoma cells
1988 · External reference
Loss of genes on the short arm of chromosome 11 in bladder cancer
10.1038/318377a0 · 1985 · External reference
Clonal analysis of human colorectal tumors
10.1126/science.2889267 · 1987 · External reference
Genetic alterations during colorectal-tumor development
10.1056/nejm198809013190901 · 1988 · External reference
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
10.1126/science.2649981 · 1989 · External reference
Prevalence of ras gene mutations in human colorectal cancers
10.1038/327293a0 · 1987 · External reference
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
10.1126/science.7761852 · 1995 · External reference
APC mutations occur early during colorectal tumorigenesis
10.1038/359235a0 · 1992 · External reference
The impact of DNA testing on management of patients with colorectal cancer
10.1002/ags3.12526 · 2022 · External reference
Accumulation of driver and passenger mutations during tumor progression
10.1073/pnas.1010978107 · 2010 · External reference
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
10.1073/pnas.1710366114 · 2017 · External reference
WiNTRLINC1/ASCL2/c-Myc Axis Characteristics of Colon Cancer with Differentiated Histology at Young Onset and Essential for Cell Viability
10.1245/s10434-019-07780-3 · 2019 · External reference
Myc deletion rescues Apc deficiency in the small intestine
10.1038/nature05674 · 2007 · External reference
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer
10.1038/ng.3764 · 2017 · External reference
Minimal functional driver gene heterogeneity among untreated metastases
10.1126/science.aat7171 · 2018 · External reference
Epigenetic biomarkers of promoter DNA methylation in the new era of cancer treatment
10.1111/cas.13812 · 2018 · External reference
The heterogeneity of cancer-associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment
10.1111/cas.15609 · 2023 · External reference
Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters
10.1158/1078-0432.ccr-11-1078 · 2012 · External reference
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer
10.1053/j.gastro.2009.11.005 · 2010 · External reference
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
10.1038/ng.3818 · 2017 · External reference
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · 2020 · External reference
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
10.1038/s41467-018-07582-3 · 2018 · External reference
Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy
10.1016/j.celrep.2023.112437 · 2023 · External reference
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
10.1016/j.ccell.2021.04.004 · 2021 · External reference
Microenvironmental regulation of tumour angiogenesis
10.1038/nrc.2017.51 · 2017 · External reference
Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli
10.1016/s0002-9440(10)64337-4 · 2003 · External reference
Tumor cell-secreted caveolin-1 has proangiogenic activities in prostate cancer
10.1158/0008-5472.can-07-2668 · 2008 · External reference
Caveola-forming proteins caveolin-1 and PTRF in prostate cancer
10.1038/nrurol.2013.168 · 2013 · External reference
ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
10.1038/s41590-022-01285-0 · 2022 · External reference
MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
10.1016/j.xcrm.2023.101006 · 2023 · External reference
The role of CD8(+) T cells in immune responses to colorectal cancer
10.1007/s00262-002-0276-4 · 2002 · External reference
Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation
10.1530/erc-17-0384 · 2018 · External reference
Application of the ELISPOT assay to the characterization of CD8(+) responses to Epstein-Barr virus antigens
10.1182/blood.v95.1.241 · 2000 · External reference
The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin
10.1084/jem.166.4.1098 · 1987 · External reference
Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
10.4049/jimmunol.177.5.3260 · 2006 · External reference
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
10.1016/j.immuni.2022.07.007 · 2022 · External reference
Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response
10.1080/2162402x.2022.2141011 · 2022 · External reference
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
10.1038/ncomms12150 · 2016 · External reference
Identification of the haemoglobin scavenger receptor
10.1038/35051594 · 2001 · External reference
CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood
10.2353/ajpath.2006.050215 · 2006 · External reference
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
10.1038/nature01023 · 2002 · External reference
L-arginine metabolism in myeloid cells controls T-lymphocyte functions
10.1016/s1471-4906(03)00132-7 · 2003 · External reference
Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway
10.1016/j.ajpath.2021.01.004 · 2021 · External reference
The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis
10.1038/s41388-020-01517-3 · 2021 · External reference
Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice
10.1073/pnas.0901324106 · 2009 · External reference
Metastatic potential correlates with enzymatic degradation of basement membrane collagen
10.1038/284067a0 · 1980 · External reference
Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)
10.3389/fimmu.2022.1060957 · 2022 · External reference
Fibrosis and cancer: A strained relationship
10.1016/j.bbcan.2020.188356 · 2020 · External reference
Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche
10.1038/s41586-018-0144-9 · 2018 · External reference
Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
10.1038/s41467-022-32255-7 · 2022 · External reference
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer
10.1038/s41467-023-36691-x · 2023 · External reference
Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells
10.1152/ajplung.00347.2009 · 2010 · External reference
SPARC modulates expression of extracellular matrix genes in human trabecular meshwork cells
2012 · External reference
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
10.1056/nejmoa1604958 · 2016 · External reference
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
10.1038/s41467-017-01062-w · 2017 · External reference
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects
10.1038/s41586-022-05593-1 · 2023 · External reference
IFNγ is a central node of cancer immune equilibrium
10.1016/j.celrep.2023.112219 · 2023 · External reference
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment
10.1126/sciimmunol.aax8189 · 2019 · External reference
Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
10.1158/0008-5472.can-07-6621 · 2008 · External reference
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
10.1158/0008-5472.can-09-1882 · 2010 · External reference
Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
10.1200/jco.2008.18.7229 · 2009 · External reference
Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer
10.1093/annonc/mdz287 · 2019 · External reference
The consensus molecular subtypes of colorectal cancer
10.1038/nm.3967 · 2015 · External reference
Expression, prognostic value and potential immunotherapeutic target of COL1A1 in colon cancer
10.14715/cmb/2023.69.15.21 · 2023 · External reference
Increased RAB31 Expression in Cancer-Associated Fibroblasts Promotes Colon Cancer Progression Through HGF-MET Signaling
10.3389/fonc.2020.01747 · 2020 · External reference
Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study.
10.1200/jco.22.02760 · 2023 · External reference
Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
10.1056/nejmoa2017699 · 2020 · External reference
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors
10.1016/j.ccell.2017.10.005 · 2017 · External reference
